The invention provides a device for stabilizing a video image sequence capable of doing multi-degree of freedom movement in real time. The device comprises a programmable logic device, a programmable logic device connecting analog-digital converter, a digital analog converter, two digital signal processors, an image sequence buffer, a parameter configuration static memory and an image sequence buffer. The invention further provides a method for stabilizing the video image sequence capable of doing the multi-degree freedom of movement in real time, an image sequence interframe epipole converting model is adopted, the accurate positions, where a feature point is located, on image frames are forecasted, the image sequence interframe multi-degree of freedom movement is drawn by establishing a video image forecast feature point set virtual curve family, the accurate position, where the forecast feature point is located, on a corresponding stabilizing image is obtained by utilizing the dimensionality reduction image data processing method, a constraint matrix is established, and a stable output video is obtained by reestablishing an output image. According to the device and method, an electronic stabilized image can be fast achieved in a high-precision mode, and the processing efficiency of the system is greatly improved.