3results about How to "Inhibit overexpression" patented technology

The present application relates to a kind of antibacterial and anti-adhesion catheter based on intelligent response nanofiber membrane, which is composed of medical polymer catheter substrate, silane coupling agent transition layer grafted on the outer surface of the substrate and nanofunctional fiber membrane layer formed on the outer surface of the transition layer by electrospinning process, the nanofunctional fiber membrane layer is composed of polyvinyl alcohol loaded hyaluronic acid grafted copper-doped carbon dots (CCDH), CCDH takes copper-doped carbon dots as core, and forms core-shell structure by grafting hyaluronic acid on the surface. The present application solves the problem of easy peeling of catheter coating by chemical bonding, and the formed antibacterial and anti-adhesion catheter has very low water contact angle and friction coefficient, not only effectively blocks the initial adhesion of bacteria at the physical level by constructing hydration layer, but also releases copper ions and carbon dots by enzymatic hydrolysis of hyaluronic acid under bacterial infection microenvironment, induces the production of reactive oxygen species to kill bacteria efficiently, and has broad application prospect in reducing the risk of catheter-related urinary tract infection.

The application belongs to the technical field of microorganisms, and provides a daka aeromonas bacteriophage vB_AdhP_L12 and an application thereof. The taxonomic name of a daka aeromonas bacteriophage vB_AdhP_L12 is daka aeromonas bacteriophage vB_AdhP_L12 Aeromonas dhakensis The daka aeromonas bacteriophage vB_AdhP_L12 has a preservation number of CCTCC NO: M 2026249, and was preserved in the China Center for Type Culture Collection (CCTCC) on January 26, 2026. The application enriches the treatment strategy for daka aeromonas, and lays a foundation for inhibiting daka aeromonas disease infection in crocodile breeding.

This invention belongs to the field of pharmaceutical technology and relates to a drug-excipient combined Senecio scandens swelling microneedle patch, its preparation method, and its application. This invention innovatively uses the extract of the traditional Chinese medicine Senecio scandens as the active ingredient, while utilizing its molecular properties to participate in the construction of the microneedle framework, realizing the design concept of "drug-excipient integration." Combined with cross-linking technology, the drug loading capacity of the microneedles in this invention can reach 40-45 wt%, greatly increasing the drug dosage per unit area patch and meeting the demand for high-dose drugs in the acute phase of Alzheimer's disease (AD). This invention forms a stable gel framework through physical and chemical dual cross-linking, giving the microneedles the characteristic of "swelling without dissolving." After drug administration, the water-absorbing and swollen matrix framework can be completely peeled off with the substrate, leaving no synthetic polymers in the body, greatly improving the safety of clinical use, and is especially suitable for patients with chronic skin diseases requiring long-term, repeated drug administration.