8results about How to "Inhibit overexpression" patented technology

The invention belongs to the technical field of biological medicines, and discloses ceramide derived from asiatic acid, which has a structure shown in a general formula I or an isomer shown in the general formula I: # imgabs0, in which R1 is selected from one of the following structures: # imgabs1 # R2 is a hydroxyl group or a hydrogen atom. The invention further discloses a synthesis method and application of the ceramide derived from the asiatic acid, the asiatic acid or madecassic acid fragment with good fat solubility is introduced, the solubility of the ceramide is improved, and the ceramide is more convenient to apply in a formula; the compound disclosed by the invention has an obvious inhibiting effect on interleukin 6 (IL-6) inflammatory factors, can also inhibit the overexpression of a TRPV1 receptor of sensitive skin, and can obviously reduce the expression of hyaluronidase, so that the compound has a very good soothing effect.

The present application relates to a kind of antibacterial and anti-adhesion catheter based on intelligent response nanofiber membrane, which is composed of medical polymer catheter substrate, silane coupling agent transition layer grafted on the outer surface of the substrate and nanofunctional fiber membrane layer formed on the outer surface of the transition layer by electrospinning process, the nanofunctional fiber membrane layer is composed of polyvinyl alcohol loaded hyaluronic acid grafted copper-doped carbon dots (CCDH), CCDH takes copper-doped carbon dots as core, and forms core-shell structure by grafting hyaluronic acid on the surface. The present application solves the problem of easy peeling of catheter coating by chemical bonding, and the formed antibacterial and anti-adhesion catheter has very low water contact angle and friction coefficient, not only effectively blocks the initial adhesion of bacteria at the physical level by constructing hydration layer, but also releases copper ions and carbon dots by enzymatic hydrolysis of hyaluronic acid under bacterial infection microenvironment, induces the production of reactive oxygen species to kill bacteria efficiently, and has broad application prospect in reducing the risk of catheter-related urinary tract infection.

The invention provides a traditional Chinese medicine extract for treating bronchial asthma and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine extraction. The preparation method comprises the following steps: soaking rhizoma belamcandae, schisandra chinensis, ginger, jujube and ephedra with water, decocting with water, extracting, soaking ephedra independently, adding rhizoma belamcandae, schisandra chinensis, ginger and jujube, decocting together, and filtering to obtain a total water extract; soaking aster tataricus, tussilago farfara and rhizoma pinellinae praeparata with an ethanol aqueous solution, and performing percolation extraction to obtain a percolate; mixing the total water extract and the percolation liquid, and concentrating to obtain an extract; and soaking the herba asari with water, performing distillation extraction to obtain volatile oil, and mixing the extract and the volatile oil to obtain the rhizoma belamcandae and herba ephedrae decoction extract. The blackberry lily and ephedra decoction extract provided by the invention can remarkably improve release of inflammatory factors and airway remodeling factors related to allergic asthma in an airway, delay airway remodeling, regulate immune balance and inhibit pathological conditions such as overexpression of mucoprotein and inflammatory protein.

The invention provides a co-therapeutic ionizable lipid nanoparticle for hepatitis as well as a preparation method and application of the co-therapeutic ionizable lipid nanoparticle for hepatitis, and the co-therapeutic ionizable lipid nanoparticle for hepatitis comprises ionizable lipid, auxiliary lipid, cholesterol, hepatitis therapeutic lipid, a phospholipid polyethylene glycol derivative and a siRNA (small interfering ribonucleic acid) medicine, the co-therapeutic ionizable lipid nanoparticle for hepatitis has dual effects, can simultaneously realize targeted delivery and treatment effects, improves the bioavailability and biocompatibility of the drug, and has a synergistic curative effect with the siRNA drug, so that the treatment effect on liver inflammation diseases is remarkably improved.

The application belongs to the technical field of microorganisms, and provides a daka aeromonas bacteriophage vB_AdhP_L12 and an application thereof. The taxonomic name of a daka aeromonas bacteriophage vB_AdhP_L12 is daka aeromonas bacteriophage vB_AdhP_L12 Aeromonas dhakensis The daka aeromonas bacteriophage vB_AdhP_L12 has a preservation number of CCTCC NO: M 2026249, and was preserved in the China Center for Type Culture Collection (CCTCC) on January 26, 2026. The application enriches the treatment strategy for daka aeromonas, and lays a foundation for inhibiting daka aeromonas disease infection in crocodile breeding.

This invention belongs to the field of pharmaceutical technology and relates to a drug-excipient combined Senecio scandens swelling microneedle patch, its preparation method, and its application. This invention innovatively uses the extract of the traditional Chinese medicine Senecio scandens as the active ingredient, while utilizing its molecular properties to participate in the construction of the microneedle framework, realizing the design concept of "drug-excipient integration." Combined with cross-linking technology, the drug loading capacity of the microneedles in this invention can reach 40-45 wt%, greatly increasing the drug dosage per unit area patch and meeting the demand for high-dose drugs in the acute phase of Alzheimer's disease (AD). This invention forms a stable gel framework through physical and chemical dual cross-linking, giving the microneedles the characteristic of "swelling without dissolving." After drug administration, the water-absorbing and swollen matrix framework can be completely peeled off with the substrate, leaving no synthetic polymers in the body, greatly improving the safety of clinical use, and is especially suitable for patients with chronic skin diseases requiring long-term, repeated drug administration.

The present invention relates to the field of genetic engineering, and particularly to the construction of a system comprising a gene fragment expressing an anti-VEGF antibody, and use thereof in the treatment of neovascularization, including age-related macular degeneration, and diabetic macular edema, etc. The system has the advantages of stable expression, long-lasting effectiveness, and low risk of tissue damage.

The present application provides use of Compound (I), an optical isomer thereof or a pharmaceutically acceptable salt thereof in manufacture of a medicament useful in treating a disease related to high expression or abnormal activation of JAK and SYK kinases, comprising an autoimmune disease, such as an immune-mediated skin disease, in particular psoriasis, atopic dermatitis and SLE. Compound (I), an optical isomer thereof or a pharmaceutically acceptable salt thereof according to the present invention can improve the skin lesions in mice with psoriasis, atopic dermatitis and SLE, alleviate the injury of kidney, inhibit the expansion of immune organs, reduce the level of inflammation, inhibit the increase of SLE related antibodies and cytokines in serum, and has a certain safe therapeutic window, which has a good clinical application prospect.