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Chinese medicinal compound preparation for preventing and controlling chronic kidney disease and renal fibrosis, and preparation method thereof

A chronic kidney disease and compound preparation technology, applied in the field of traditional Chinese medicine, can solve problems such as unsatisfactory effects and limitations in animal experiments, and achieve the effects of increasing antioxidant capacity, improving renal tissue pathology, and reducing the degree of glomerulosclerosis

Inactive Publication Date: 2015-04-15
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the in-depth study of the pathogenesis of renal fibrosis, especially the research of cell biology and molecular biology, relevant technical personnel have established a variety of anti-renal interstitial fibrosis methods for different links of collagen and ECM metabolism , such as anti-TGF-β1 antibody, Prifenidon (PFD), ACEI, angiotensin II and its receptor antagonists and other anti-renal fibrosis western medicine research and application, so that anti-renal fibrosis research has been greatly developed, but its The effect is not ideal, and currently it is mostly limited to the stage of animal experiments, there is still a distance to enter the actual clinical treatment, and the curative effect needs to be further improved

Method used

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  • Chinese medicinal compound preparation for preventing and controlling chronic kidney disease and renal fibrosis, and preparation method thereof
  • Chinese medicinal compound preparation for preventing and controlling chronic kidney disease and renal fibrosis, and preparation method thereof
  • Chinese medicinal compound preparation for preventing and controlling chronic kidney disease and renal fibrosis, and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] Take raw materials: 10g of purple salvia miltiorrhiza, 10g of whole angelica, 5g of peach kernel, 10g of Achyranthes bidentata, 3g of rhubarb, add 7 times the amount of 90% ethanol, heat reflux for 1 hour, and obtain the extract; add 7 times the amount of 50 % ethanol, heat reflux for 1 hour, and then obtain an extract, combine and concentrate the two extracts until the crude drug content per ml of the extract is 2g, and a Chinese medicine compound preparation is obtained. Prepare dosage forms such as granules, tablets or granules according to conventional methods.

Embodiment 2

[0041] Take raw materials: 50g of purple salvia miltiorrhiza, 50g of whole angelica, 30g of peach kernel, 50g of Achyranthes bidentata, 30g of rhubarb, add 7 times the amount of 90% ethanol, heat reflux for 1 hour, and obtain the extract; add 7 times the amount of 50 % ethanol, heat reflux for 1 hour, and then obtain an extract, combine and concentrate the two extracts until the crude drug content per ml of the extract is 2g, and a Chinese medicine compound preparation is obtained. Prepare dosage forms such as granules, tablets or granules according to conventional methods.

Embodiment 3

[0043] Take raw materials: 15g of purple salvia miltiorrhiza, 15g of whole angelica, 12g of peach kernel, 15g of Achyranthes bidentata, 9g of rhubarb, add 7 times the amount of 90% ethanol, heat reflux for 1 hour, and obtain the extract; add 7 times the amount of 50% of the dregs Ethanol, heat reflux for 1 hour, and then obtain an extract, combine and concentrate the two extracts until the crude drug content per ml of the extract is 2g, and a Chinese medicine compound preparation is obtained. Prepare dosage forms such as granules, tablets or granules according to conventional methods.

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Abstract

The invention belongs to the field of Chinese medicines, and relates to a Chinese medicinal compound preparation for preventing and controlling chronic kidney disease and renal fibrosis and a preparation method thereof. On the basis of the theory of 'body resistance weakened while pathogenic factors prevailing, insufficiency of Qi and blood, and blood stasis and collaterals obstruction' in traditional Chinese medical science, the Chinese medicinal compound preparation is prepared from Chinese medicines such as Danshen root, angelica sinensis, peach kernel, twotooth achyranthes root and processed rhubarb. Through animal experiment and clinical trial, the Chinese medicinal compound preparation can improve renal haemodynamics, adjust lipid metabolic disturbance, enhance oxidation resistance, and inhibit over expression of cell factors so as to improve glomerulosclerosis and interstitial fibrosis degree, protect residual renal structures and functions, and delay the process of early-stage and medium-stage chronic renal failure deterioration. The Chinese medicinal compound preparation is particularly suitable for treating patients who suffer from chronic kidney disease (CKD2-4) and renal fibrosis which comprise renal insufficiency, proteinuria, atrophy of kidney and the like.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine compound preparation for preventing and treating chronic kidney disease renal fibrosis, in particular to a traditional Chinese medicine compound preparation and a preparation method for preventing and treating chronic kidney disease (CKD stage 2-4) renal fibrosis. Background technique [0002] Chronic kidney disease (CKD) is a major disease that seriously endangers human health, and it is currently growing at an alarming rate worldwide. According to the news announcement of the International Society of Nephrology on February 20, 2007: At present, more than 500 million people in the world suffer from different kidney diseases, and more than one million people die of cardiovascular and cerebrovascular diseases related to CKD every year. CKD, which will eventually develop into end-stage renal disease (ESRD), has become another important disea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/73A61P13/12
Inventor 何立群
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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