31 results about "CKD - chronic kidney disease" patented technology

The invention provides a diabetic nephropathy-non-diabetic nephropathy differential diagnosis device and relates to the biological detection technology field. Defects that a standard in a traditionalchronic kidney disease clinical practice guide (KDOQI) is not objective and unified and is not suitable for serving as a diagnosis standard, and a traditional kidney puncture biopsy technology is large in trauma, can cause complications after operation and is high in technical difficulty. In a diabetic nephropathy-non-diabetic nephropathy differential diagnosis process provided in the invention, anew index is selected by adopting a machine learning method to construct a diabetic nephropathy and non-diabetic nephropathy differential diagnosis model, pain of a patient can be reduced, a diagnosis result is accurate, an application range is wide, and a good auxiliary diagnosis effect is provided for clinical practice.

The invention belongs to the field of Chinese medicines, and relates to a Chinese medicinal compound preparation for preventing and controlling chronic kidney disease and renal fibrosis and a preparation method thereof. On the basis of the theory of 'body resistance weakened while pathogenic factors prevailing, insufficiency of Qi and blood, and blood stasis and collaterals obstruction' in traditional Chinese medical science, the Chinese medicinal compound preparation is prepared from Chinese medicines such as Danshen root, angelica sinensis, peach kernel, twotooth achyranthes root and processed rhubarb. Through animal experiment and clinical trial, the Chinese medicinal compound preparation can improve renal haemodynamics, adjust lipid metabolic disturbance, enhance oxidation resistance, and inhibit over expression of cell factors so as to improve glomerulosclerosis and interstitial fibrosis degree, protect residual renal structures and functions, and delay the process of early-stage and medium-stage chronic renal failure deterioration. The Chinese medicinal compound preparation is particularly suitable for treating patients who suffer from chronic kidney disease (CKD2-4) and renal fibrosis which comprise renal insufficiency, proteinuria, atrophy of kidney and the like.

The invention relates to a balance mechanism and a limb exercise device for rehabilitation of chronic kidney disease. The balance mechanism includes a base, a horizontal plate fixedly installed above and parallel to the base through a vertical plate, and also includes two lower limbs. Stepping assembly, the double lower limbs treading assembly is installed on the base, used for exercising the user's double lower limbs, and the double lower limbs treading assembly is connected to the reciprocating sliding assembly installed on the lower part of the horizontal plate through a transmission assembly , during use, the user exercises both lower limbs through the double lower limb stepping assembly, and the user's double upper limbs are fixed on the two reciprocating plates through the flexible limiting assembly. At this time, the double lower limb stepping assembly is driven by the transmission assembly. The reciprocating sliding component moves, and the reciprocating sliding component drives the two reciprocating plates to drive the user's double upper limbs to swing back and forth, which plays an effective role in balancing exercise for the double upper limbs and the double lower limbs in use.

The invention belongs to the field of application of traditional Chinese medicines to adjuvant improvement in the treatment of a kidney function of a chronic kidney disease patient. Renal tubulointerstitial fibrosis is a common pathological process from CKD progress caused by various disease causes to end-stage renal failure, and the anti-renal fibrosis treatment becomes an important link of preventing and delaying the CKD progress. A traditional Chinese medicine composition with a function of adjuvant improvement in the kidney function of the chronic kidney disease patient consists of the following components in parts by weight: 200-600 parts of astragalus membranaceus, 200-600 parts of radix polygonum multiflorum preparata, 100-300 parts of prepared rhubarb, 100-300 parts of ligusticum wallichii, 10-120 parts of leech particles, 200-600 parts of charred fructus crataegi, 200-800 parts of exocarpium benincasae, 100-400 parts of peach kernels, 100-600 parts of centella asiatica and 100-300 parts of herba lycopi. In the formula, the astragalus membranaceus and the radix polygonum multiflorum preparata as monarchs have the efficacies of benefiting Qi and tonifying kidney; the leech particles as ministers have the efficacies of breaking glycogen storage disease, removing blood stasis, promoting blood circulation and prmoting diuresis through channel tunnels; the peach kernels, the ligusticum wallichii, theherba lycopi and the fructus crataegi have the efficacy of promoting blood circulation to remove blood stasis; the prepared rhubarb has the efficacy of dispelling caramelized, damp and turbid blood stasis; the exocarpium benincasae, the herba lycopi and the centella asiatica as adjuvant medicines have the efficacies of dissipating diuresis and dampness. Experiments and clinical trials show that the traditional Chinese medicine composition has the effect of adjuvant treatment on renal insufficiency.

The invention provides all-starch bicomponent self-raising powder, flour bicomponent self-raising powder and an optimized preparation method. According to the bottleneck that all-starch self-raising powder and flour self-raising powder are instable in product quality generally, a bicomponent form is adopted, so that activity of dry yeast is ensured. Aiming at the circumstance that starch self-raising powder lacks of gluten, gelatinized starch and modified starch are used to replace gluten, so that all-starch like wheat flour can be made into food like steamed buns, healthy staple food can be provided for patients with chronic kidney diseases, and a reliable path is provided for quality stability of the flour self-raising powder. Edible starch or flour is taken as a raw material, and the dry yeast is taken as a fermentation raising agent. Storage activity of the dry yeast declines quickly when the dry yeast is in a high-moisture condition and in an aerobic environment, and activity lossof the dry yeast is small due to bicomponent packaging. The optimized preparation method is also suitable for the flour bicomponent self-raising powder, and storage period and quality stability of the flour self-raising powder are improved.

The invention relates to a balancing mechanism and a four-limb exercise device for chronic kidney disease rehabilitation. The balancing mechanism comprises a base and a transverse plate which is fixedly mounted above the base through a vertical plate and is parallel to the base. The balancing mechanism further comprises a double-lower-limb treading assembly, wherein the double-lower-limb treading assembly is mounted on the base, and is used for exercising the double lower limbs of a user; the double-lower-limb treading assembly is connected with a reciprocating sliding assembly installed on the lower portion of the transverse plate through a transmission assembly; during use, the user exercises the double lower limbs through the double-lower-limb treading assembly, and the double upper limbs of the user are fixed to two reciprocating plates through flexible limiting assemblies; at the moment, the double-lower-limb treading assembly drives the reciprocating sliding assembly to move through the transmission assembly, the reciprocating sliding assembly drives the two reciprocating plates to drive the double upper limbs of the user to swing in a reciprocating mode, and the effective balance exercise effect on the double upper limbs and the double lower limbs in the using process is achieved.

The invention belongs to the field of Chinese medicines, and relates to a Chinese medicinal compound preparation for preventing and controlling chronic kidney disease and renal fibrosis and a preparation method thereof. On the basis of the theory of 'body resistance weakened while pathogenic factors prevailing, insufficiency of Qi and blood, and blood stasis and collaterals obstruction' in traditional Chinese medical science, the Chinese medicinal compound preparation is prepared from Chinese medicines such as Danshen root, angelica sinensis, peach kernel, twotooth achyranthes root and processed rhubarb. Through animal experiment and clinical trial, the Chinese medicinal compound preparation can improve renal haemodynamics, adjust lipid metabolic disturbance, enhance oxidation resistance, and inhibit over expression of cell factors so as to improve glomerulosclerosis and interstitial fibrosis degree, protect residual renal structures and functions, and delay the process of early-stage and medium-stage chronic renal failure deterioration. The Chinese medicinal compound preparation is particularly suitable for treating patients who suffer from chronic kidney disease (CKD2-4) and renal fibrosis which comprise renal insufficiency, proteinuria, atrophy of kidney and the like.

Bilateral congenital anomalies of the kidney and urinary tract (CAKUT) are the main cause of childhood chronic kidney disease (CKD). Accurate and non-biased prenatal prediction of postnatal disease evolution is currently lacking, but is essential for prenatal counseling and disease management. Here the inventors aimed to develop an objective and quantifiable risk prediction method based on amniotic fluid (AF) peptides. 178 fetuses with bilateral CAKUT were included in a prospective multicenter study. The AF peptide content was studied using capillary electrophoresis coupled to mass spectrometry. The endpoint was early-onset renal failure (CKD stage 3-5) or death due to end-stage renal disease at two years of age. Among the ˜7000 peptide candidates, 98 were associated with early severe renal failure. The most frequently found peptides associated with severe disease were fragments from extracellular matrix proteins and thymosin-P4. Combination of those 98 peptides in a classifier lead to the prediction of postnatal renal outcome in a blinded validation set of 51 patients with a 88% (95% CI: 64-98) sensitivity, 97% (95% CI: 85-100) specificity and an AUC of 0.96 (95% CI: 0.87-1.00), outperforming predictions based on currently used clinical methods. The classifier also predicted normal postnatal renal function in 75% of terminated pregnancies where fetopathology showed kidneys compatible with normal life. Analysis of AF peptides thus allows a precise and quantifiable prediction of postnatal renal function in bilateral CAKUT with potential major impact on pre- and postnatal disease management.

The invention belongs to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating vascular calcification caused by chronic kidney disease. The traditional Chinese medicine composition is prepared from salted Eucommia ulmoides, Achyranthes bidentata, cooked rhubarb and raw oysters. The weight ratio of each raw material in the traditional Chinese medicine composition is: 1-100 parts of Eucommia ulmoides, 1-100 parts of Achyranthes bidentata, 1-100 parts of cooked rhubarb and 1-100 parts of raw oyster. The traditional Chinese medicine composition of the invention can effectively treat vascular calcification caused by chronic kidney disease.

The invention relates to a novel application of a micro-molecule polypeptide KP-1, and in particular to an application of the micro-molecule polypeptide KP-1 in preparing a medicine for treating chronic kidney diseases (CKD). The invention provides the application of the KP-1 in treating the CKD; and the KP-1 is obvious in curative effect and is free from obvious toxic and side effects. Therefore,the KP-1 provided by the invention can be used for preparing a pharmaceutical preparation for treating the CKD.

The invention relates to a medicine, and particularly relates to a traditional Chinese medicine preparation used for adjusting immune state of chronic kidney disease. The invention further relates to a preparation method for the medicine, comprising the following steps of: based on astragalus mongholicus, divaricate saposhnikovia root, bighead atractylodes rhizome, rhizoma alismatis, corn stigma, semen euryales, rhizoma nelumbinis and salvia miltiorrhiza as raw materials, adding water and decocting the raw material medicines in parts aforementioned by weight for three times and for two hours every time; combining the three times of decoctions; filtering the combined decoction and concentrating the combined decoction into a thick paste having a relative density of 1.20-1.24; drying and crushing the thick paste into a fine powder having a grain diameter of 100-150 meshes, and then filling the fine powder in capsules; and sterilizing and disinfecting, and then preparing the capsules. The medicine disclosed by the invention can be used for improving the immune state of the patient with early diabetic nephropathy, thus playing roles of reducing proteinuria, protecting the kidney, and delaying the progress of diabetic nephropathy.

The invention discloses a convenient detection device for a chronic kidney disease marker superpolar. The swing mechanism is arranged on the bottom plate in a rotating mode. The pumping assembly is installed on the top part and connected with the swing mechanism through a transmission assembly, and the rotating mechanism is arranged on the bottom plate, connected with the swing mechanism and the pumping assembly and used for driving a test tube on the swing mechanism to rotate when the pumping assembly works. The pumping assembly works to drive the swing mechanism to act, reciprocating swing drives the test tube to shake, meanwhile, citric acid is continuously dripped into the test tube through the pumping assembly, and the shaken test tube enables a blood sample to be premixed with the citric acid. The working pumping assembly drives the rotating mechanism to act, and the rotating mechanism applies torque to the test tube, so that the test tube continuously rotates while shaking, andcitric acid is fully mixed with a blood sample.

The invention discloses an evaluation method for diet protein intake (DPI) of a chronic kidney disease (CKD) patient. Through research of relationships between a fasting serum blood urea nitrogen / creatinine ratio (BUN / Cr) and a single-time urine urea nitrogen / creatinine ratio (UUN / Cr) of a CKD third-phase patient with a stable illness state, and the diet protein intake (DPI), a DPI simple calculation formula based on the fasting serum BUN / Cr and / or random urine UUN / Cr is established. According to the final calculation formula, it is expected that a traditional method for evaluating the DPI through subsistence of the urine within 24 hours can be replaced by a biochemical detection result of a single-time blood or urine in clinical follow-up. Defects such as complexity, long detection time, poor accuracy, difficult sample subsistence or low patient compliance in the traditional method are overcome. Clinically, the method can be used for clinical follow-up, simple blood drawing or single-time urination, thereby evaluating the DPI. The method can be used for managing the diet protein intake of the CKD patient well, fast and conveniently.

The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine preparation for treating vascular calcification caused by chronic kidney disease. It consists of traditional Chinese medicine composition and auxiliary materials. The weight ratio of the traditional Chinese medicine composition to the auxiliary materials is 1:7 to 10, and the traditional Chinese medicinal composition is made from salt Eucommia ulmoides, Achyranthes huai, cooked rhubarb and raw oysters. The weight ratio of each raw material in the traditional Chinese medicine composition is: 1-100 parts of salt Eucommia ulmoides, 1-100 parts of Achyranthes huai, 1-100 parts of cooked rhubarb and 1-100 parts of raw oysters.

The invention belongs to the field of biological medicine, and relates to application of micromolecular polypeptide KP-6, in particular to application of micromolecular polypeptide KP-6 in preparing a drug for treating a chronic kidney disease (CKD). An amino acid sequence of the polypeptide KP-6 is shown as SEQ ID NO. 1. The micromolecular polypeptide KP-6 has a significant effect of inhibiting kidney tissue fibrosis and CKD development, has no obvious toxic or side effects, and therefore can be used for preparing the drug for effectively treating the chronic kidney disease.

The invention belongs to the application field of traditional Chinese medicine in assisting the treatment of improving renal function of patients with chronic kidney disease. Tubulointerstitial fibrosis is a common pathological process that causes CKD to progress to end-stage renal failure caused by various etiologies. Anti-renal fibrosis therapy has become an important link to prevent and delay the progression of CKD. The traditional Chinese medicine composition for assisting in improving renal function of patients with chronic kidney disease of the present invention is composed of the following ingredients in weight ratio: 200-600 parts of astragalus, 200-600 parts of Polygonum multiflorum, 100-300 parts of rhubarb, and 100-300 parts of Ligusticum chuanxiong , 10‑120 parts of leech granules, 200‑600 parts of burnt hawthorn, 200‑800 parts of wax gourd skin, 100‑400 parts of peach kernel, 100‑600 parts of Luo De Da, and 100‑300 parts of Zeilan. In the prescription, Astragalus and Radix Shouwu benefit Qi and kidney as king; leech breaks disease accumulation, removes blood stasis, unblocks blood vessels, and sharpens meridians and tunnels as minister; peach kernel, Chuanxiong, Zelan, hawthorn promote blood circulation and remove blood stasis, rhubarb removes damp turbidity and blood stasis in lower Jiao, Winter melon rind, Zeilan, and Luode are used as adjuvant medicines to relieve water and turbidity. Both experiments and clinics show that the present invention has the effect of auxiliary treatment of renal insufficiency.

The invention relates to the field of medical information intelligent processing, in particular to a rough evidence pellet Spark method for chronic kidney disease medical record classification. The method comprises the following steps: firstly, reading chronic kidney disease medical record data on a main node, and dividing a data set into a training set and a test set; the training subset samples are divided in parallel on the child nodes to generate a plurality of rough evidence particle balls; then obtaining a pathological attribute reduction subset of the training subsets by using a Spark parallel pathological attribute reduction method based on a rough evidence particle ball, and updating pathological attribute sets of all the training subsets and the test set; and finally, obtaining a prediction category label result of a test set sample through a Spark parallelized rough evidence particle ball neighborhood classification method. According to the method, redundant pathological attributes in the large-scale chronic kidney medical record data can be effectively removed, and the influence of redundant samples and abnormal samples on a decision-making process is reduced by utilizing rough evidence, so that the classification precision and the calculation efficiency of the large-scale chronic kidney medical record data are improved.