Composition for preventing and/or treating chronic kidney disease and preparation method and application thereof

Abstract

The invention relates to a composition for preventing and / or treating a chronic kidney disease. The composition for preventing and / or treating the chronic kidney disease is prepared from the followingcomponents in parts by weight: icariin, rheum emodin, ferulic acid and ligustrazine, wherein the ratio of the icariin to the rheum emodin to the ferulic acid to the ligustrazine is 1.3 to 1.2 to 1.3to 1. An experiment result shows that the composition interferes with signaling pathway activation of a fibrosis promoting central event TGF-beta / Smad / EZH2 by restraining Smad3 phosphorylation and EZH2 activity, and renal interstitial fibrosis is resisted. By protecting renal innate cells, a hypoxia-inducible factor HIF-2alpha is stabilized, synthesis of endogenous EPO is increased, an iron metabolism disorder caused by high expression of Hepcidin-25 is antagonized, renal anemia is improved, and a renal failure is delayed. The invention further relates to application of the composition to preparation of drugs for preventing and / or treating the chronic kidney disease. The composition for preventing and / or treating the chronic kidney disease has the advantages that a preparation method is simple and convenient, the components work collaboratively, the therapeutic effect is good, and good application prospects are achieved.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a composition for preventing and / or treating chronic kidney disease, a preparation method and application thereof. Background technique [0002] The morbidity and mortality of chronic kidney disease (CKD) are increasing year by year with the arrival of an aging society and have been recognized as an important global health problem. Regardless of the initial etiology, renal fibrosis is the main pathological manifestation of CKD. Although in the early stage of the disease, the appearance of fibrosis is conducive to promoting local cell self-repair and mechanically stabilizing the basic structure of the nephron, however, excessive deposition of extracellular matrix (ECM) in the renal interstitium will change the capillary network around the renal tubules, Insufficient blood and oxygen supply further accelerates nephron damage and eventually leads to renal failure. [0003] During...

AI Technical Summary

Problems solved by technology

At present, there is no information about the effect of pSmad3 and EZH2 inhibitors on chronic renal insufficiency / chronic renal failure / renal insufficiency / chronic renal failure / renal fibrosis caused by myofibroblast proliferation (extracellular matrix increase, renal fibrosis) caused by the transdifferentiation of renal fibroblasts and renal tubular epithelial cells. For the application of fibrosis, the inventor has studied a composition for the prevention and / or treatment of chronic kidney disease, including active ingredients icariin, emodin, ferulic acid, ligustrazine, In addition, the optimal ratio of active ingredients has been screened, and the ingredients work synergistically, resulting in good curative effect.

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