A traditional Chinese medicine composition for treating vascular calcification caused by chronic kidney disease

A chronic kidney disease, vascular calcification technology, applied in the field of traditional Chinese medicine, can solve the problems of chronic kidney disease vascular calcification in its infancy and other problems

Inactive Publication Date: 2017-08-11
HEILONGJIANG UNIV OF CHINESE MEDICINE
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AI Technical Summary

Problems solved by technology

[0005] In recent years, great progress has been made in the prevention and treatment of chronic kidney disease, bone disease, and atherosclerosis by traditional Chinese medicine, but the research on the prevention and treatment of vascular calcification in chronic kidney disease is still in its infancy

Method used

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  • A traditional Chinese medicine composition for treating vascular calcification caused by chronic kidney disease
  • A traditional Chinese medicine composition for treating vascular calcification caused by chronic kidney disease
  • A traditional Chinese medicine composition for treating vascular calcification caused by chronic kidney disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0018] The preparation of embodiment 1-4 Chinese medicine composition

[0019] Take salt Eucommia ulmoides, Achyranthes bidentata, cooked rhubarb and raw oysters, add 10 times the amount of water, soak for 120 minutes, decoct twice, 60 minutes each time, filter, and concentrate under reduced pressure to 2g·mL -1 (crude drug), sterilized and filtered, and stored at 4°C for later use.

[0020] The consumption of four medicinal materials in embodiment 1-4 is as follows:

[0021]

Embodiment 5

[0023] Healthy male SD rats were used and randomly divided into a model group, an administration group 1-4 (the traditional Chinese medicine compositions prepared in Examples 1-4, respectively), and a normal control group. 0.75% adenine plus high-protein, high-phosphorus diet feeding method to establish chronic renal failure vascular calcification rat model, after feeding for 4 weeks, the administration group began to administer drugs, the administration dose was 2g (crude drug) / kg, normal The control group was fed normal diet. After 12 weeks of administration, the rats were sacrificed and tested as follows.

[0024] ①Serological testing: automatic biochemical analyzer to detect changes in blood urea nitrogen, blood calcium and blood phosphorus, radioimmunoassay to measure serum parathyroid hormone (PTH), and ELISA to measure serum BMP-2 level.

[0025] ②Aortic detection:

[0026] A Determination of calcium content in aortic wall tissue: take thoracic aortic tissue and add c...

Embodiment 6

[0049] Example 6 Effects of Traditional Chinese Medicine Composition on Rat Thoracic Aortic Vascular Smooth Muscle Cell Calcification

[0050] The thoracic aorta of 5-week-old male healthy SD rats was used for primary culture of vascular smooth muscle cells by tissue-adherence method, and the 3rd to 5th passage cells were used for experiments. 10mmol / L β-glycerophosphate was used to induce VSMCs calcification, and at the same time, a traditional Chinese medicine composition was added to the administration group with a final concentration of 1mg / L. The same amount of cell culture medium was added to the model group, and β-glycerophosphate was not added to the normal group. After culturing for 14 days, the cells of each group were collected, and the intracellular calcium content and alkaline phosphatase content were measured. The specific results are as follows:

[0051]

[0052] The extraction method of the four single herb groups in this example is the same as in Example 1....

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Abstract

The invention belongs to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating vascular calcification caused by chronic kidney disease. The traditional Chinese medicine composition is prepared from salted Eucommia ulmoides, Achyranthes bidentata, cooked rhubarb and raw oysters. The weight ratio of each raw material in the traditional Chinese medicine composition is: 1-100 parts of Eucommia ulmoides, 1-100 parts of Achyranthes bidentata, 1-100 parts of cooked rhubarb and 1-100 parts of raw oyster. The traditional Chinese medicine composition of the invention can effectively treat vascular calcification caused by chronic kidney disease.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating vascular calcification caused by chronic kidney disease. Background technique [0002] Cardiovascular disease is a major fatal complication in patients with chronic kidney disease (CKD). Vascular calcification is one of the main causes of cardiovascular disease in CKD population, and osteoporosis is also one of the common and serious complications of chronic kidney disease. [0003] In addition to the traditional factors leading to cardiovascular disease, CKD patients have a unique risk factor—vascular calcification, which is one of the main causes of cardiovascular disease in the CKD population. Significant predictive flags. At present, there have been many discussions on the mechanism of CKD vascular calcification, but the exact mechanism is still not very clear, and the treatment is limited to general measur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/708A61P13/12A61P9/14A61P19/10A61K35/618
Inventor 于思明郭丹丹
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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