Application of endothelin-1 as marker for evaluating asymptomatic cardiovascular organ injury of patient with primary chronic kidney disease

Abstract

The invention discloses an application of endothelin-1 as a marker for evaluating asymptomatic cardiovascular organ injury of a patient with primary chronic kidney disease. By detecting the level of endothelin-1 in an in-vitro sample of the patient suffering from primary chronic kidney diseases, when the value of endothelin-1 is greater than 1.60 pg / mL, no symptomatic cardiovascular organ injury is caused. The endothelin-1 can precisely evaluate the risk and morbidity of the non-symptomatic cardiovascular injury event of the patient with the primary chronic kidney disease, so that the endothelin-1 can be used as an evaluation risk factor of the patient with the chronic kidney disease for discovering the cardiovascular injury event of the patient with the primary chronic kidney disease in the early stage; in addition, cardiovascular events of patient with chronic kidney diseases can be predicted and prevented, and cardiovascular organ damage can be effectively intervened in the early stage.

Description

technical field [0001] The invention belongs to the technical field of endothelin-1, in particular to the application of endothelin-1 as a marker for evaluating asymptomatic cardiovascular organ damage in patients with primary chronic kidney disease. Background technique [0002] The prevalence of chronic kidney disease is increasing day by day, and cardiovascular disease is one of the leading causes of death in patients with chronic kidney disease. As an intermediate state between health status and cardiovascular disease, "asymptomatic cardiovascular organ damage" has received high attention, especially in the risk and prediction of cardiovascular events. [0003] At present, the definition and detection methods of "asymptomatic cardiovascular organ injury" have been clarified, but there is a lack of indicators to effectively predict "asymptomatic cardiovascular organ injury", and the research on the transition period from healthy to "asymptomatic cardiovascular organ injur...

AI Technical Summary

Problems solved by technology

[0005] The technology for evaluating "asymptomatic cardiovascular organ injury" in the prior art lacks precision and directness, which are specifically manifested in: (1) Individuals often need to complete examinations including cardiac color Doppler ultrasound, arterial color Doppler ultrasound, and electrocardiogram before doctors can make comprehensive judgments

(2) The accuracy of the above inspection methods is easily affected by different instruments and operators

Cardiac color Doppler ultrasound, arterial color Doppler ultrasound, electrocardiogram and other examinations performed after the emergence of clear symptoms are difficult to make early warning of "asymptomatic cardiovascular organ injury"

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