Evaluation method for diet protein intake of chronic kidney disease patient

A chronic kidney disease and protein technology, applied in the field of medicine, can solve problems such as poor accuracy, difficulty in taking specimens, and poor patient compliance

Active Publication Date: 2017-11-17
GUANGDONG GENERAL HOSPITAL
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Problems solved by technology

[0010] Among them: GU(mg/min)=Curea(ml/min)(BUN(mg/ml),Curea(ml/min)=[Uurea(mg/ml)/BUN(mg/ml)]×[urine output( ml)/time (min)] (Note: GU is urea generation rate; Curea is urea clearance rate; Uurea is urine urea nitrogen concentration; BUN is blood urea nitrogen); this formula calculates the relevant biochemical indicators that need to be detected simultaneously in blood and urine , becaus

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  • Evaluation method for diet protein intake of chronic kidney disease patient

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[0027] The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0028] Implementation object and time: recruit patients with chronic kidney disease stage 3 (CKD3) in stable condition, and plan to enroll 108 cases. Each patient was followed up for 7 days and is expected to be completed within 1 year.

[0029] Diet plan: In a low-protein diet, the daily dietary protein intake is about 0.7 grams / kg body weight, the daily dietary calorie intake is about 30 kcal / kg body weight, the daily salt intake is less than 6 grams, and the daily phosphorus intake is 0.8- 1.0 grams, the total daily calcium intake is less than 1500 mg (including meals and drugs).

[0030] Main indicators: blood urea nitrogen (BUN) and creatinine (sCr), serum albumin, transferrin, prealbumin, C-reactive protein, morning random urine urea nitrogen (UUN) and creatinine (Cr), urine albumin / creatinine Ratio (ACR), urine protein / creatin...

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Abstract

The invention discloses an evaluation method for diet protein intake (DPI) of a chronic kidney disease (CKD) patient. Through research of relationships between a fasting serum blood urea nitrogen/creatinine ratio (BUN/Cr) and a single-time urine urea nitrogen/creatinine ratio (UUN/Cr) of a CKD third-phase patient with a stable illness state, and the diet protein intake (DPI), a DPI simple calculation formula based on the fasting serum BUN/Cr and/or random urine UUN/Cr is established. According to the final calculation formula, it is expected that a traditional method for evaluating the DPI through subsistence of the urine within 24 hours can be replaced by a biochemical detection result of a single-time blood or urine in clinical follow-up. Defects such as complexity, long detection time, poor accuracy, difficult sample subsistence or low patient compliance in the traditional method are overcome. Clinically, the method can be used for clinical follow-up, simple blood drawing or single-time urination, thereby evaluating the DPI. The method can be used for managing the diet protein intake of the CKD patient well, fast and conveniently.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an evaluation method for dietary protein intake of patients with chronic kidney disease. Background technique [0002] The currently commonly used methods for evaluating dietary protein intake (DPI) mainly include dietary survey, 24-hour urine measurement of urea nitrogen, urea nitrogen expression rate, protein equivalent, and protein decomposition rate. Among them, 1) dietary survey: dietary survey as An important tool in nutrition research, most patients review their 24-hour diet or record their own diet for 3 to 7 days, and use the conversion of common food nutrients to calculate protein intake; this method requires experienced physicians or nutritionists. Time-consuming, highly subjective, and prone to errors. Some studies believe that this method tends to overestimate the patient’s real protein intake. Therefore, it is difficult for doctors to complete dietary s...

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Application Information

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IPC IPC(8): G06F19/00G01N31/00G01N33/50G01N33/68
CPCG01N31/002G01N33/50G01N33/6893G01N2800/34
Inventor 王文健汪延辉谢剑腾文枫王端李真李盛李静黄建中付蕾李锐钊叶智明章斌刘双信梁馨苓
Owner GUANGDONG GENERAL HOSPITAL
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