44results about How to "Significant anti-inflammatory" patented technology

The invention discloses an oral composition containing Ectoine and hyaluronic acid and application of the oral composition. The oral composition is prepared from, by mass, 0.1-5% of high molecular weight hyaluronic acid or salt thereof, 0.1-5% of low molecular weight hyaluronic acid or salt thereof, 0.01-1% of tea polyphenol, 1-3% of xylitol, 0.1-1% of Ectoine and the balance water, and the totalpercentage is 100%. Accordingly, the Ectoine, different molecular weights of hyaluronic acid or salt thereof, tea polyphenol and xylitol are compounded, the bio-safety is high, the synergetic effect is achieved, the effects of nursing wound surfaces, diminishing inflammation, promoting healing and the like are achieved, and the oral composition is applicable to oral care application such as oral care after cancer chemotherapy and oral ulcer care and can also be applied to the field of medical products, medical equipment and disinfection products.

The present invention discloses one kinds of ointment for treating piles and other anorectal diseases and its preparation process. The medicine is prepared with Vaseline, bezoars, pearl, calamine, borax and other five kinds of Chinese medicinal materials and through crushing, mixing and other steps. The present invention has simple preparation process and obvious treating effect and is suitable for industrial production.

The present invention belongs to the field of Chinese medicine technology, and is especially one kind of Chinese medicine for treating piles. The Chinese medicine is prepared with flavescent sophora root, bupleurum root, phellodendron bark, dandelion, pyrrosia leaf and other nine kinds of Chinese medicinal materials, and through mixing and grinding to obtain powdered medicine. All the Chinese medicinal materials synergies to reach excellent treating effect on different types of pile, including internal pile, external pile, mixed pile and thrombused external pile. The Chinese medicine possesses functions of astringing, stopping bleeding, bacteriostasis, promoting blood circulation to disperse blood clots, etc.

The invention provides a thrombin activity based chimeric peptide with double targeting effects, a preparation method and an application thereof. The chimeric peptide provided by the invention contains three segments: segment 1 has an amino acid sequence having 20th to 90th amino acid from N-terminal of HMGB1 protein; segment 2 has an amino acid sequence of Exendin-4 protein; and segment 3 which contains cleavage sites of thrombin and dipeptidyl peptidase is a junction fragment of segment 1 and segment 2. According to the preparation method provided by the invention, the thrombin activity based chimeric peptide with double targeting effects can be obtained by synthesis of a polypeptide synthesis technology or construction of an expression vector which contains nucleotide sequence encoding the chimeric peptide, expression of the protein in a gene engineering strain and purification of the protein. The chimeric peptide provided by the invention has double targeting effects of inhibiting inflammatory response and decreasing blood glucose, and can be applied in the preparation of anti-inflammatory and/or hypoglycemic drugs.

The invention belongs to the technical field of drugs and relates to an oral ulcer treatment patch film and a preparation method thereof. The oral ulcer treatment patch film mainly comprises oleanolic acid, polysaccharide sulfate, vitamin B6, chitosan, a film forming agent, glucoside, tributyl citrate and distilled water. The oral ulcer treatment patch film has a reasonable and scientific formula. Components of the oral ulcer treatment patch film interact with each other and have effects of inhibiting bacteria, diminishing inflammation and easing pain so that the oral ulcer treatment patch film can effectively relieve oral ulcer and shorten cure time. The oral ulcer treatment patch film has the advantages of good adhesion, fast dissolving speed and good uncovered film integrity, guarantees drug effects and is an ideal oral ulcer patch film.

The invention provides a benzoyl fluorobenzene salicylamide compound and a preparation method and an application thereof. The benzoyl fluorobenzene salicylamide compound with a structure shown in a formula (I) is formed by the substitution reaction of benzoyl fluorobenzene salicyloylchloride as shown in a formula (III) and R1R2NH in an organic solvent at a temperature of between 0 and 160 DEG C. Derivatives of the benzoyl fluorobenzene salicylamide compound and the preparation method and the application thereof of the invention have the advantages of: (1) providing a novel anti-inflammatory and analgesic drug with remarkable anti-inflammatory and analgesic activities, and providing a research basis for selecting novel drugs; (2) simple preparation process and applicability industrialized production.

The invention provides an ailanthus flower extract as well as a preparation method and an application of active ingredients brevifolin of the ailanthus flower extract. The ailanthus flower extract and a total isocoumarin active part are prepared through researching the chemical components of ailanthus flower, and three types of cyclopentanone isocoumarin, i.e. brevifolin, brevifolin-carboxylic acid and methyl brevifolincarboxylat are obtained through separation. A biological activity research shows that the ailanthus flower extract has the remarkable anti-oxidation, anti-inflammation and anti-tumor effects. Experimental results show that the ailanthus flower extract (including effective part) and ailanthus flower elements with active compounds can be used for preparing drugs and health care products for oxidation resistance, inflammation resistance, tumor resistance and other relevant diseases treatment.

An anti-inflammatory, antalgic and anticancer capsule is prepared from muskone and 9 Chinese-medicinal materials including wild aconite root, myrrh, earthworm, Chinese angelica root, etc through granulating, and ordinary-temp drying.

The invention discloses toothpaste containing a fructus viticis composition, which comprises a basic material composition and a functional composition, wherein the basic material composition comprises humectants, abrasive, foaming agent, essence, thickening agent, sweetening agent and water, the functional composition is chaste tree extracts, and the percentage by weight of the functional composition is 0.01%-5%. The toothpaste containing the fructus viticis composition uses fructus viticis extracts as a functional component to add into toothpaste for the first time, clearly determines effective radio of the fructus viticis extracts and other base components in the toothpaste, and supplies effective adding range simultaneously. The toothpaste containing a fructus viticis composition has the obvious effects of antibiosis, antiphlogosis and pain stopping, and can thoroughly relieve the oral problems of red and swollen gums, pain and bleeding and the like.

The invention discloses a female genital cleaning and care solution. The female genital cleaning and care solution is prepared from the following components: 10 to 15 parts of chitosan quaternary ammonium salt hydrogel, 10 to 25 parts of itching stopping agent, 6 to 12 parts of inorganic nano antibacterial agent, 4 to 7 parts of nano lecithin and 20 to 35 parts of auxiliary agent. The cleaning andcare solution disclosed by the invention can be used for absorbing tissue fluid oozed from skin with inflammations and also can have remarkable antibacterial, anti-inflammation and repairing-promoting effects; the cleaning and care solution is easily absorbed in a percutaneous manner through an external bathing manner and genitals keep clean and sanitary; the cleaning and care solution also can be used for preventing and treating genital flora imbalance and reducing the risk of bacterial genital diseases; the multi-effects of cleaning, nutrition, sterilization and care are realized.

The invention relates to a kind of compound medicine made of vitro cultured ox gallstone and nitroimidazole medicine, the ratio of the two kinds of medicine is 1:1-1000. The invention has combined the traditional Chinese medicine theory and modern pharmacodynamics theory and chosen nitroimidazole antibiotics (with great antibacterial activity) and vitro cultured ox gallstone (with obvious effects of anti-inflammatory and relieving fever) as the main material medicine. The combining effects of the medicine is very good with the advantage of quick to relieve pain and eliminate inflammation, radical cure, difficult to recur and low side effects.

The invention provides essence containing natural astaxanthin. The essence is prepared by adding a free-state astaxanthin nano microemulsion into an esterified-state astaxanthin microcapsule system. The free-state astaxanthin nano microemulsion is prepared by adding free-state astaxanthin into carrier oil and dissolving to form a free-state astaxanthin oil solution, uniformly stirring and evaporating to remove a solvent under low-temperature and low-pressure conditions after stirring is completed; the esterified-state astaxanthin microcapsule system is obtained by adding esterified-state astaxanthin into a macromolecular substance water solution, then adding a wall material molecule water solution and a water-soluble antioxidant, stirring for sufficient dissolution, then adjusting the pH (Potential of hydrogen) of the system to 2.5-5.5 with acid and standing. The astaxanthin essence provided by the invention has remarkable antioxidative, anti-inflammatory and anti-wrinkle effects. Different molecular shapes of the astaxanthin and different delivery system designs are adopted, so that whole care of the astaxanthin essence is realized, and the skin care effect is more efficient; no greasy feeling is generated after the essence is used.

The invention discloses a preparation method and application of a drug-carrying keratin film. As cross link is performed on wool keratin through catalysis of glutamine transaminase to form a film, the tensile strength and water-soluble stability of the keratin film are improved; and when the cross-linked keratin film serves as a drug carrier, the release rate of a drug can be delayed and reduced by 20%, thus the drug-carrying keratin film has good application prospect.

The invention discloses an implantable bandage for promoting bone injury repair and a preparation method thereof. The bandage is composed of a porous grid sheet-shaped object and organic-inorganic composite superfine fiber porous film covering objects on the surfaces of the two sides of the porous grid sheet-shaped object, the lower layer is a superfine fiber porous network containing bioglass particles, the middle layer is a polymer porous grid, and the upper layer is a superfine fiber porous network containing inorganic mineral particles; inorganic matters in the superfine fibers on the surfaces of the two sides are bioglass particles for inhibiting inflammation, resisting infection and promoting soft tissue regeneration and repair and inorganic mineral particles for inhibiting inflammation and promoting bone regeneration and repair, and the bandage is prepared through three-dimensional printing and electrostatic spinning processes. The method is convenient to operate, has a remarkable inhibition effect on inflammation in soft and hard tissues such as muscles, periosteum and bones with various fractures or bone defects, promotes rapid healing and repair of the soft and hard tissues, is adjustable in degradation rate of the implantable bandage, and has a remarkable bacteriostasis effect on common pathogenic bacteria and fungi.

The invention belongs to the field of medicines, and particularly relates to a traditional Chinese medicine composition for treating infant jaundice and a preparation method thereof, aiming to overcome the defects in the prior art that the existing chemical therapeutic medicines for treating infant jaundice have large toxicity to the liver and have poor curative effect. The traditional Chinese medicine composition for preventing or treating infant jaundice comprises the following components: turmeric, oriental wormwood, mangnolia officinalis, common yam rhizome, cape jasmine, poria, radix pseudostellariae, ginseng, wolfberry, astragalus membranaceus, coptis chinensis, rhizoma alismatis, radix ophiopogonis, radix paeoniae alba, leonurus and liquorice. The traditional Chinese medicine composition has good effect on treating and preventing infant jaundice, has low side effects, and has remarkable clinical promotion value.

The present invention provides choerospondias axillaris enzymes and a preparation method thereof, and overcomes the defects of the prior art. The choerospondias axillaris enzymes comprise fermented raw materials and sugar component raw materials, and are prepared by fermentation of mixed organisms. The fermented raw materials consist of the following components in mass percentages: 50-60% of denucleated choerospondias axillaris fruit flesh, 10-20% of opuntia milpa alta juice, 10-15% of kiwi fruits, 5-10% of Chinese wolfberry fruits, 5-10% of dragon fruits, 2-6% of blueberries, 2-7% of watermelons, 3-8% of papayas and 2-5% of maca. The raw materials are mixed to produce the choerospondias axillaris synthetical enzymes having health-care functions, the production technology is simple, and the produced choerospondias axillaris enzyme products are high in nutritional values.

The invention relates to non-clarified type NFC aronia melanocarpa compound juice. The compound juice comprises components in parts by weight as follows: 50-80 parts of aronia melanocarpa juice and 20-50 parts of other NFC juices. Aronia melanocarpa is taken as a main characteristic component of the juice and compounded with the other NFC juices, the other juices specifically comprise one or moreof mulberry juice, grape juice, lycium ruthenicum juice, jujube juice and apple juice, no pigment or essence is added, and the unique flavor of the aronia melanocarpa is reserved greatly; meanwhile, anthocyanin and flavonoids contained in the aronia melanocarpa have very high anti-oxidation and anti-inflammatory functions, so that the product not only reserves natural active components, but also has good taste and can meet multiple demands of consumers; and the finished NFC compound juice has rich nutrients, moderate sourness and sweetness and significant anti-oxidation, anti-inflammatory andanti-aging functions.

The invention provides a novel enol non-steroidal compound represented by a formula (I) or a a pharmaceutically acceptable salt, hydrate, solvate, polymorph, enantiomer or racemic mixture thereof, wherein m is 0 or 1; n is an integer from 0 to 6; R1 and R2 are independently hydrogen or C1-C6 alkyl or optionally substituted C1-C6 alkyl, halogen, acylamino, sulfonylamino, acyloxy or C(O)R', and R' is hydrogen, C1-C10 alkyl, C1-C10 alkenyl, C1-C10 alkoxy, aryl C1-C10 alkyl, halogen, acylamino, sulfonylamino or acyloxy; R3 or R4 is independently hydrogen or C1-C6 alkyl or optionally substituted C1-C6 alkyl; R5 or R6 is independently hydrogen, a sodium salt, a potassium salt, a magnesium salt, a calcium salt, an ammonium salt, a meglumine salt, a choline salt, or an amino acid salt. The compound has obvious anti-inflammatory, analgesic and antipyretic effects, and the bioavailability of the compound is obviously higher than that of meloxicam. The invention also provides a preparation methodof the compound, a pharmaceutical composition containing the compound, and pharmaceutical applications of the compound and the pharmaceutical composition.

The invention relates to an extraction process of a moringa fat-soluble polyphenol compound and application of the compound, and belongs to the fields of phytochemical techniques and cosmetics. According to the extraction process, a fat-soluble polyphenol extract is extracted from an alcohol extract of moringa; then, separation and purification are performed by sequentially adopting medium-pressure reversed-phase silica gel column chromatography, Sephadex LH-20 gel column chromatography, and semi-preparative high performance liquid chromatography to obtain the moringa fat-soluble polyphenol compound as shown in a formula (I). The compound has good anti-aging, antioxidant and anti-inflammatory effects. When the compound is applied to neck cream, and is compounded with substances such as moringa seed oil, moringa oil and chondroitin sulfate, remarkable moisturizing, repairing, anti-inflammatory and anti-aging efficacy on neck skin can be achieved; the neck skin is obviously improved; meanwhile, a very good curative effect on neck wrinkles, acne and the like is achieved; the application range is relatively wide.

The present invention relates to a burn ointment for treating burns and scalds and the preparation method thereof, which pertains to the Chinese traditional patent medicines and the preparation technical field, the present invention aims at solving the technical problem of: providing the burn ointment which can promote the wound healing as soon as possible, prevent the wound infection, prevent and reduce the scar formation and the preparation method thereof. The parts by weight of the raw materials of the burn ointment are: champion bauhinia: 15 to 90; anoectochilus formosanus: 3 to 18; stearate: 1 to 10; glycerol stearate: 0.2 to 2; sesame oil: 2 to 20; liquid paraffin: 1 to 10; beeswax: 1 to 10; glycerol: 3 to 30; triethanolamine: 0.15 to 1.5; ethyl paraben: 0.01 to 0.2; distilled water: 5 to 50; borneol: 0.02 to 0.5. The preparation method is that the base materials are added in proportion after the pretreatments of powder making and solvent extraction according to the different characteristics of raw materials, so as to prepare the ointment. The external application of the present invention has the treatment effects of rapid pain stopping, fast wound healing, strong anti-infective ability and no scars, furthermore the use is convenient, the operation is simple and the cost is low.

The present invention relates to the technical field of medicines, and particularly relates to a drug for treatment of rheumatism, stroke and other diseases and a preparation method thereof; the drug comprises the following components: radix aconiti agrestis, Radix Aconiti, Polygonum multiflorum, frankincense, Typhonium giganteum Engl, aconite, monkshood, pig's trotters and rock candy, the preparation method comprises the following steps: 1) processing with water and cutting; 2) hydrolyzing for extraction and detoxification; and 3) concentrating to obtain paste; through the improvement of the preparation method, especially vinegar frying of the frankincense, toxic ingredients in the radix aconiti agrestis and the Radix Aconiti can be completely removed, and the added frankincense and licorice are cooperated with main medicines in the formula, so that a better rheumatism treatment effect can be achieved.

The invention belongs to the technical field of medicines, relates to a traditional Chinese medicine composition and a preparation method thereof and in particular relates to a traditional Chinese medicine composition for treating acute nephritis and a preparation method thereof. Aiming at the current situation that an existing chemical medicine for treating acute nephritis is high in hepatotoxicity and is not good in curative effect, the invention provides a traditional Chinese medicine composition for treating or preventing acute nephritis. The traditional Chinese medicine composition comprises the following components: fructus forsythiae, cassia twig, cicada slough, houttuynia cordata, the root of bidentate achyranthes, lily, motherwort, rhizoma alismatis, dried tangerine or orange peel, pericarpium arecae, ephedra, poria peel, lalang grass rhizome, isatis root, the root bark of white mulberry and liquorice. The traditional Chinese medicine composition has good treatment effects in aspects of treatment or prevention of acute nephritis, is low in drug side effects and has obvious clinical popularization values.

The invention discloses a traditional Chinese medicine composition for treating rheumatism bone disease. The traditional Chinese medicine composition comprises the active parts by the mass percentage: 40%-60% of glycyrrhizin, 10%-20% of licoflavone, 5%-20% of ephedra alkaloids, 5%-20% of radix cyathulae saponins, and 5%-10% of strychnos alkaloids. A method for preparing Chinese patent medicines according to the traditional Chinese medicine composition comprises the following steps: (1) preparing the glycyrrhizin; (2) preparing the licoflavone; (3) preparing the ephedra alkaloids; (4) preparing the radix cyathulae saponins; (5) preparing the strychnos alkaloids; (6) preparing the active part composition; and (7) producing the Chinese patent medicines for treating rheumatism bone disease. The Chinese patent medicines comprise capsules, soft capsules and tablets. The Chinese patent medicines prepared according to the traditional Chinese medicine composition and used for treating rheumatism bone disease can be applied in easing pain, resisting inflammatory, promoting blood circulation, removing blood stasis, tonifying middle-jiao, replenishing qi, enhancing immunity and treating rheumatic arthritis and arthralgia caused by cold-dampness blocking meridians and collaterals.

The invention discloses a four-hole antibacterial quilt, comprising a quilt cover and a quilt core, wherein the quilt core is arranged inside the quilt sleeve, and the quilt core is composed of a heatpreservation layer, an antibacterial layer and a skin-affinity layer, and the antibacterial layer is composed of a No. 1 fiber layer, a No. 2 fiber layer and a three-dimensional fiber layer, whereinthe three-dimensional fiber layer is compounded between the No. 1 fiber layer and the No. 2 fiber layer, and a cavity is arranged inside the three-dimensional fiber layer, and the cavity is of an elliptical structure. As the multi-layer sterilization is carried out, quilt germicidal efficiency is improved, and a cavity is arranged inside the three-dimensional fiber layer, the cavity is elliptical,and the elastic strips are stitched at both ends of the cavity, and the cavity is filled with nanometer bactericidal particles. The four-hole antibacterial quilt is novel in structure and excellent in heat preservation; the nanometer bactericidal particles have obvious antibacterial, anti-inflammatory, anti-odor, anti-mould and antipruritic effects, and can completely kill harmful bacteria contacting with fabric. The novel design has novelty, remarkable antibacterial effect, lightweight and beautiful appearance, and is nontoxic to human body and can effectively prevent disease transmission.

The invention relates to application of a trichosanthes kirilowii Maxim and semen armeniacae amarae compound extract or a trichosanthes kirilowii Maxim and semen armeniacae amarae compound refined product in preparation of cosmetics and medicines for improving inflammatory aging. The trichosanthes kirilowii Maxim and semen armeniacae amarae compound extract and the compound refined product have weak cytotoxic effect on macrophages and are high in safety. The obvious anti-inflammatory and anti-aging effects are shown on an LPS (Lipopolysaccharide) and H2O2 induced macrophage inflammation and aging model.

The invention provides an external liniment which has the functions of analgesia, antiphlogosis, detumescence and itching-relieving and uses Zingiber corallinum Hance essential oil as the main pharmaceutical ingredient. The product comprises the following components in parts by weight: 1-5 parts of Zingiber corallinum Hance essential oil, 1-5 parts of zanthoxylum oil, 1-5 parts of glycerin, 1-3 parts of Tween 80 and 82-96 parts of alcohol with 50-75% of concentration of volume percent. The preparation method comprises the following steps: pouring all the components in alcohol, and fully shaking to dissolve and mix evenly. The invention has remarkable analgesia effect and also the effects of detumescence, antiphlogosis and sterilization, cures the microcirculatory disturbance, promotes the blood circulation, increases the nutrition of tissue cells, accelerates the self-renewing and self-repairing abilities of the injured tissue cells, takes effect fast, has short treatment period and high recovery rate, and can be used to perform symptomatic treatment to burns and scalds of the superficial layers of the skin, traumatic injuries and skin itches caused by various reasons.

The invention belongs to the technical field of Chinese medicine and particularly relates to a Chinese medicinal composition for treating allergic dermatitis and a preparation method thereof. The Chinese medicinal composition comprises, by weight, 5-25 parts of flos lonicerae, 5-25 parts of mint, 5-35 parts of radix glycyrrhizae, 5-35 parts of radix sophorae flavescentis and 5-30 parts of herba andrographitis. The Chinese medicinal composition is composed of five medicinal components for cooperative use, has the effects of dispelling rheumatic pain, relieving itch, relieving pain and swellingsand clearing away internal heat and toxic materials, achieves a good curative effect on different symptoms such as red swellings, fever, itch and rash, and has an obvious curative effect on red swellings, fever and pain which are generated after laser treatment, contact dermatitis, allergic dermatitis, cosmetic dermatitis and rosacea. A research result shows that the Chinese medicinal compositioncan be used for treating allergic dermatitis, rapidly alleviate clinical symptoms, improve physical signs and shorten the treatment time and is safe and reliable to use.

The invention discloses a pogostemon cablin freeze-dried powder and a preparation method thereof. The pogostemon cablin freeze-dried powder is prepared from the following raw materials in percentage by weight: 2-10% of mannitol, 0.1-2% of trehalose, 0.1-1% of pullulan polysaccharide, 1-15% of a pogostemon cablin extracting solution, 0.01-0.1% of hyaluronic acid and the balance of water. The freeze-dried powder can retain active ingredients in pogostemon cablin. The freeze-dried powder has significant anti-inflammatory, anti-redness-swelling, antibacterial, astringent, wound repair and anti-oxidant effects, and has excellent heat resistance and cold resistance, has good antibacterial properties against bacteria such as molds and yeasts, and is long in shelf life.

The invention provides a traditional Chinese medicine extract for treating respiratory diseases. The traditional Chinese medicine extract comprises the following raw materials in parts by weight: 1 to10 parts of adenophora tetraphylla, 1 to 10 parts of gnaphalium affine, 1 to 10 parts of flos farfarae, 1 to 10 parts of ophiopogon japonicus, 1 to 6 parts of platycodon grandiflorum, 1 to 10 parts of radices trichosanthis and 1 to 6 parts of licorice. The invention also provides a preparation method of the traditional Chinese medicine extract and use thereof, and a pharmaceutical preparation containing the traditional Chinese medicine extract and a preparation method thereof. The traditional Chinese medicine extract of the invention has the effects of clearing away heat and relieving exterior syndrome, relieving cough and removing phlegm, has significant anti-inflammatory, antibacterial and anti-viral effects, and has the effect of treating both respiratory diseases and cough caused by respiratory diseases, and especially children with chronic cough. The pharmaceutical preparation of the invention has the characteristics of convenient carrying, high bioavailability, and good controllability and stability.

The invention discloses pure traditional Chinese medicine granules suitable for being taken by pregnant women with cold and a preparation method thereof. The granules are prepared from by weight,270-330 parts of rhizoma imperatae,270-330 parts of taraxacum mongolicum,270-330 parts of hawthorn fruits,270-330 parts of fructus hordei germinatus and 90-110 parts of rhizoma zingiberis recens. The coldis treated through the cooperation of rhizoma imperatae,taraxacum mongolicum and rhizoma zingiberis recens,the granules have the remarkable functions of reducing inflammation,cooling blood and relieving exterior syndrome,and decoction liquid has a dietary flavor which is preferred by people; all the raw materials are listed in a medicine and food homologous catalogue published by the nation,the safety of all the raw materials is verified by thousands of years of traditional Chinese edible history,and the granules have a statutory basis; rhizoma zingiberis recens is soaked in vinegar,three flavors are combined,the effect of treating the cold is highlighted,the medicine properties are mild,and the good protective effect is achieved on the pregnant women and fetuses.