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Ailanthus flower extract as well as preparation method and application of active ingredients brevifolin of ailanthus flower extract

A technique of breve hematoxylin and active ingredients, which is applied in the field of biomedicine, can solve the problems that chemical ingredients and biological activities are not reported in literature, etc., and achieve a significant antioxidant effect.

Inactive Publication Date: 2012-09-12
INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] As a renewable natural plant resource, Ailanthus sinensis has no literature reports on its chemical composition and biological activity at home and abroad.

Method used

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  • Ailanthus flower extract as well as preparation method and application of active ingredients brevifolin of ailanthus flower extract
  • Ailanthus flower extract as well as preparation method and application of active ingredients brevifolin of ailanthus flower extract
  • Ailanthus flower extract as well as preparation method and application of active ingredients brevifolin of ailanthus flower extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1. Preparation of Ailanthus sinensis extract

[0022] Get the inflorescence of Ailanthus sinensis, (10Kg, fresh product), chop, carry out heating and reflux extraction with 5 times the amount (w / v) of 95% ethanol, the extraction time is 2 hours / time, a total of three times, the extracts are combined, concentrated under reduced pressure Become thick extract shape, obtain Ailanthi sinensis flower extract (380g).

Embodiment 2

[0023] Embodiment 2. Preparation of total isocoumarin active site in Ailanthus sinensis extract

[0024] Example 1:

[0025] Get the inflorescence of Ailanthus sinensis, (10Kg, fresh product), according to the extraction method of embodiment 1, obtain extract extract (about 380g), extract extract extract (300g) is diluted with 10 times of amount distilled water, dissolves, and does clarification , get the supernatant, absorb through DM-130 macroporous resin (3.0Kg), wash the macroporous resin column with distilled water until the color is lighter, then carry out elution with 20% ethanol, show magnesium hydrochloride powder reaction to eluate Up to the time, collect this part eluent, recover under reduced pressure, concentrate into thick extract, and obtain the total isocoumarin active site (50g) of Ailanthus sinensis extract.

[0026] Example 2:

[0027] Get the inflorescence of Ailanthus altissima, (10Kg, fresh product), chop, extract by percolation with 5% NaOH solution of...

Embodiment 3

[0028] Example 3. Preparation of active ingredient brevifolia hematoxylin in Ailanthus sinensis extract

[0029] Get the total isocoumarin active parts (30g) of Ailanthus sinensis extract, dissolve in an appropriate amount of methanol, mix the sample with 100g thick silica gel, and carry out column chromatography with 200-300 mesh silica gel 500g column packing, CH 2 CL 2 -Elute with MeOH at a ratio of 9:1 to 8:2, detect by thin-layer chromatography, collect the eluate containing brevifolia, recover the solvent to dryness, and then dissolve it in methanol for recrystallization to obtain brevichematoxylin crystallization of phenol.

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Abstract

The invention provides an ailanthus flower extract as well as a preparation method and an application of active ingredients brevifolin of the ailanthus flower extract. The ailanthus flower extract and a total isocoumarin active part are prepared through researching the chemical components of ailanthus flower, and three types of cyclopentanone isocoumarin, i.e. brevifolin, brevifolin-carboxylic acid and methyl brevifolincarboxylat are obtained through separation. A biological activity research shows that the ailanthus flower extract has the remarkable anti-oxidation, anti-inflammation and anti-tumor effects. Experimental results show that the ailanthus flower extract (including effective part) and ailanthus flower elements with active compounds can be used for preparing drugs and health care products for oxidation resistance, inflammation resistance, tumor resistance and other relevant diseases treatment.

Description

technical field [0001] The invention relates to the technical field of biomedicine (including biopesticide), and uses the flower of Ailanthusaltissima (Mill.) Swingle as raw materials to prepare extracts and active compounds and their applications in medicine and health care. Background technique [0002] Ailanthus altissima (Mill.) Swingle, formerly known as Ailanthus altissima (Mill.) Swingle, has another name called Chinese toon tree and wood huller tree. It is native to northeastern and central China and Taiwan. Grows in temperate climates. The tree grows rapidly and can reach a height of 15 meters in 25 years. There are about 10 to 15 species of Ailanthus genus, which are mainly produced in southeastern Asia. There are 6 types 3 variants 1 variant in China. Deciduous tree, up to 30 meters high, more than 1 meter in diameter at breast height, and the crown is oblate or umbrella-shaped. The bark is off-white or gray-black, smooth, slightly cracked, and the branches a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/94A61K31/352A61P39/06A61P29/00A61P35/00A23L1/29A23L33/00
Inventor 唐文照王晓静姚庆强仲浩孙敏耀贾献慧杜成林娄可芹
Owner INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI
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