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Traditional Chinese medicine composition for treating rheumatism bone disease, and preparation method and application of Chinese patent medicines

A technology for rheumatic bone disease and Chinese patent medicine, which is applied in the field of Chinese patent medicine, can solve the problems of large dosage, high potential safety risks, toxic and side effects, etc. Ability, TNF-α-promoting effect

Inactive Publication Date: 2014-02-19
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The above-mentioned existing Chinese patent medicines and invention patents contain a wide variety of medicines with complex ingredients, poor quality controllability, large safety hazards, and large dosages.
Moreover, the medicinal materials used are all powdered medicines, which contain many ineffective substances, some of which have toxic and side effects, and are not suitable for long-term use.

Method used

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  • Traditional Chinese medicine composition for treating rheumatism bone disease, and preparation method and application of Chinese patent medicines
  • Traditional Chinese medicine composition for treating rheumatism bone disease, and preparation method and application of Chinese patent medicines
  • Traditional Chinese medicine composition for treating rheumatism bone disease, and preparation method and application of Chinese patent medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] A traditional Chinese medicine prescription for treating rheumatic bone disease, the formula mass percentage of each active part is as follows:

[0068] Glycyrrhizin 54%;

[0069] Licorice Flavonoids 18%;

[0070] Ephedra alkaloids 12 %;

[0071] Achyranthes saponins 9%;

[0072] Nuxychon alkaloids 7%.

[0073] The method for preparing the Chinese patent medicine for the treatment of rheumatic bone disease according to the Chinese medicine prescription of the present invention, comprises the following steps:

[0074] (1) Preparation of Glycyrrhizin

[0075] ① Extract licorice powder with 0.5% ammoniacal 70% ethanol (the percentages of the reagents mentioned below are all mass percentages) and ultrasonically extract twice, each time for 1 hour;

[0076] ② Extract by filtration and centrifugation, rotary steam to about 300mL, add deionized water, let stand overnight, and centrifuge;

[0077] ③ Pass through the HZ-816 macroporous resin column (use 1200mL deionized wa...

Embodiment 2

[0103] According to the Chinese medicine prescription of the present invention, the method for preparing a Chinese patent medicine for the treatment of rheumatic bone disease comprises the following steps:

[0104] Preparation method and step are substantially the same as Example 1, and the difference from Example 1 is:

[0105] Glycyrrhizin, licorice flavonoids, ephedra alkaloids, achyranthes saponins and strychnium alkaloids prepared in steps (1)-(5) were prepared according to the traditional Chinese medicine prescription for treating rheumatic bone disease, and the quality of each active part The percentage is:

[0106] Glycyrrhizin 40%;

[0107] Licorice Flavonoids 10%;

[0108] Ephedra alkaloids 20%;

[0109] Sichuan achyranthes saponins 20%;

[0110] Nuxychon alkaloids 10%.

Embodiment 3

[0112] According to the Chinese medicine prescription of the present invention, the method for preparing a Chinese patent medicine for the treatment of rheumatic bone disease comprises the following steps:

[0113] Preparation method and step are substantially the same as Example 1, and the difference from Example 1 is:

[0114] Glycyrrhizin, licorice flavonoids, ephedra alkaloids, achyranthes saponins and strychnium alkaloids prepared in steps (1)-(5) were prepared according to the traditional Chinese medicine prescription for treating rheumatic bone disease, and the quality of each active part The percentage is:

[0115] Glycyrrhizin 60%;

[0116] Licorice Flavonoids 20%;

[0117] Ephedra alkaloids 10%;

[0118] Achyranthes saponins 5%;

[0119] Nuxychon alkaloids 5%.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating rheumatism bone disease. The traditional Chinese medicine composition comprises the active parts by the mass percentage: 40%-60% of glycyrrhizin, 10%-20% of licoflavone, 5%-20% of ephedra alkaloids, 5%-20% of radix cyathulae saponins, and 5%-10% of strychnos alkaloids. A method for preparing Chinese patent medicines according to the traditional Chinese medicine composition comprises the following steps: (1) preparing the glycyrrhizin; (2) preparing the licoflavone; (3) preparing the ephedra alkaloids; (4) preparing the radix cyathulae saponins; (5) preparing the strychnos alkaloids; (6) preparing the active part composition; and (7) producing the Chinese patent medicines for treating rheumatism bone disease. The Chinese patent medicines comprise capsules, soft capsules and tablets. The Chinese patent medicines prepared according to the traditional Chinese medicine composition and used for treating rheumatism bone disease can be applied in easing pain, resisting inflammatory, promoting blood circulation, removing blood stasis, tonifying middle-jiao, replenishing qi, enhancing immunity and treating rheumatic arthritis and arthralgia caused by cold-dampness blocking meridians and collaterals.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and relates to a traditional Chinese medicine, in particular to a preparation method and application of a traditional Chinese medicine prescription for treating rheumatic bone disease and a Chinese patent medicine (hereinafter referred to as "Chinese patent medicine"). Background technique [0002] Rheumatic diseases, commonly known as "rheumatism", are caused by wind, cold, dampness, and trauma invading the human body, forming arthralgia poison and attaching to human bones, thereby damaging bones and hard tissues related to bones, resulting in muscle, ligament, synovial bursa, tendon A type of disease caused by poor nutrient supply of membranes. Among these diseases, 99% are rheumatic bone diseases, which is one of the most common chronic bone diseases today. As early as in ancient Chinese medicine, there were relevant descriptions of the disease. Rheumatism belongs to the category o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/56A61P29/00A61P19/02A61P37/04A61K31/352
Inventor 倪力军张立国吴婷婷赵雯雯欧阳霄雯徐晓玲郭燕子薛志斌何婉瑛潘洁文郑帅赵丽丽马东升
Owner EAST CHINA UNIV OF SCI & TECH
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