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Essence containing natural astaxanthin

A technology of natural astaxanthin and astaxanthin, which is applied in the field of essence containing natural astaxanthin, can solve the problems of continuous exertion of effects, inability to give full play to skin care efficacy, and low bioavailability, so as to enhance the effect of skin care and health care , Excellent transdermal utilization rate, high skin care effect

Active Publication Date: 2019-08-30
RIZHAO POLYTECHNIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, due to its long conjugated olefin structure, astaxanthin has defects such as poor solubility, poor stability, and low bioavailability, which severely limit its application.
When adding it to the essence, you will encounter the following problems: ① Astaxanthin cannot be effectively absorbed and utilized by skin tissue, and the skin care effect cannot be fully exerted; ② During storage and use, astaxanthin is unstable and affects the effect ③The phenomenon of oil-water separation in skin care products is prone to occur, which affects the texture and coagulation state of the product; ④When the amount of astaxanthin added is slightly higher, the color of the essence will be too dark, causing the skin to appear red after use, affecting the quality of the product. Beautiful to use

Method used

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  • Essence containing natural astaxanthin
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  • Essence containing natural astaxanthin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation method of astaxanthin essence provided by the present invention comprises the following steps:

[0035] 1) Preparation of free astaxanthin:

[0036] Using Haematococcus pluvialis as the biological raw material for preparing esterified astaxanthin, weigh 1kg of Haematococcus pluvialls powder, add 10 times the weight of raw material (W / V) absolute ethanol, and repeatedly extract 2 times, each Sub-extract for 1h, combine the extracts, then concentrate the extracts under reduced pressure, remove the solvent, and obtain the crude extract; then add the crude extract to 30 times the volume of the mass concentration of 2% potassium hydroxide solution, in The saponification reaction was carried out at 4°C and filled with nitrogen. After the reaction, the reaction system was placed at -2°C for 2 hours, and then filtered to collect the crystallized purple-red substance to obtain refined free astaxanthin;

[0037] 2) Preparation of esterified astaxanthin:

[0038]...

Embodiment 2

[0047]A preparation method of astaxanthin essence, comprising the following steps:

[0048] 1) Preparation of free astaxanthin: use Haematococcus pluvialls as the biological raw material for preparing esterified astaxanthin, weigh 100g of Haematococcus pluvialls powder, add 20 times the raw material quality (W / V) of ethyl acetate to soak After extracting for 4 hours, the extract was collected by filtration, and then the extract was concentrated under reduced pressure, and the solvent was removed to obtain a crude extract. Then, homogeneously emulsify with 1 times the mass of Tween 80, and then add lipase-containing phosphate buffer, the amount of enzyme is 10U / μg total astaxanthin, the enzymatic hydrolysis conditions are 40°C, pH5.5, and the enzymatic hydrolysis time for 12h. After the enzymatic hydrolysis, add ethyl acetate to the system until the emulsion is broken, collect the oil phase, and concentrate under reduced pressure to obtain free astaxanthin;

[0049] 2) Prepar...

Embodiment 3

[0055] A preparation method of astaxanthin essence, comprising the following steps:

[0056] 1) Preparation of free astaxanthin: Weigh 100g of Haematococcus pluvialis powder, put it in the extraction kettle of a 1L supercritical extraction device, set the temperature of the extraction kettle to 40°C, the pressure to 30MPa, and the extraction agent CO 2 The flow rate is set at 20L / h, the temperature and pressure of the separation tank I are 35°C and 10MPa respectively, the temperature of the separation tank II is 40°C, and the CO 2 The flow rate of the fluid is 30L / h, the continuous dynamic extraction time is 3h, the extract is discharged from the separation tank irregularly, collected and stored in the container, the extract is a dark red viscous substance, and the crude extract is obtained; then The crude extract was added to 20 times the volume of sodium hydroxide solution with a mass concentration of 4%, and the saponification reaction was carried out at 4°C under nitrogen-...

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Abstract

The invention provides essence containing natural astaxanthin. The essence is prepared by adding a free-state astaxanthin nano microemulsion into an esterified-state astaxanthin microcapsule system. The free-state astaxanthin nano microemulsion is prepared by adding free-state astaxanthin into carrier oil and dissolving to form a free-state astaxanthin oil solution, uniformly stirring and evaporating to remove a solvent under low-temperature and low-pressure conditions after stirring is completed; the esterified-state astaxanthin microcapsule system is obtained by adding esterified-state astaxanthin into a macromolecular substance water solution, then adding a wall material molecule water solution and a water-soluble antioxidant, stirring for sufficient dissolution, then adjusting the pH (Potential of hydrogen) of the system to 2.5-5.5 with acid and standing. The astaxanthin essence provided by the invention has remarkable antioxidative, anti-inflammatory and anti-wrinkle effects. Different molecular shapes of the astaxanthin and different delivery system designs are adopted, so that whole care of the astaxanthin essence is realized, and the skin care effect is more efficient; no greasy feeling is generated after the essence is used.

Description

technical field [0001] The invention belongs to the technical field of functional cosmetics, in particular to an essence containing natural astaxanthin. Background technique [0002] Astaxanthin, as a fat-soluble carotenoid, is widely distributed in marine animals and plants, microalgae and yeast. Its unique chemical structure endows it with the ability to effectively quench reactive oxygen species and has a variety of physiological functions. Studies have shown that astaxanthin is the strongest antioxidant found in nature so far. Its antioxidant capacity is 1000 times that of vitamin E, 800 times that of coenzyme Q10, 700 times that of anthocyanins, and 320 times that of tea polyphenols. , 200 times that of lutein, 100 times that of β-carotene, and 10 times that of lycopene, known as "super antioxidants". Its excellent antioxidant capacity endows it with powerful free radical scavenging, anti-inflammatory and anti-aging effects. At present, based on the powerful antioxid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/37A61K8/35A61K8/11A61K8/06A61Q17/04A61Q19/00A61Q19/08
CPCA61K8/35A61K8/37A61K8/11A61K8/068A61Q19/00A61Q19/08A61Q17/04A61K2800/56A61K2800/412
Inventor 谷彩霞刘舒婷周庆新朱文韬李玉环张兴静马腾王润雨
Owner RIZHAO POLYTECHNIC
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