The present application provides a kind of micro tablet, it includes the compound shown in formula I, filler and optionally pharmaceutically acceptable
adjuvant, wherein, the
diameter of the micro tablet is 1 ~ 3mm, the ratio of
diameter and thickness is 0.6 ~ 1.2, the tablet weight is 2.5 ~ 10mg, and includes 1 ~ 5mg compound shown in formula I.The present application also provides the preparation method and pharmaceutical use of the micro tablet.The micro tablet of the present application can realize small
dose direct precision dosing, easy to use;It is easy to swallow, can effectively improve the problem of poor
palatability of
cholic acid drugs, improve medication compliance;It can realize the effect of consistent
dissolution characteristics of different doses, ensure the stability of
treatment effect under different doses;It can reduce the use of
adjuvant, avoid the safety problem of children medication;High stability, conducive to storage and transportation, improve the safety of use;High
bioavailability, can more effectively realize
in vivo absorption and utilization;Effectively solve the content uniformity problem, reduce the difficulty of process, more suitable for industrial production.