Virginiamycin microemulsion and preparation method thereof

A virginiamycin and microemulsion technology, applied in the field of medicine, can solve problems such as restricting popularization and application, and achieve the effects of strong operability, full absorption and utilization, and improved bioavailability

Active Publication Date: 2014-12-17
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Since virginiamycin is very slightly soluble in water, it can only be administered by making a premix and adding it to the feed, which limits its application in the market

Method used

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  • Virginiamycin microemulsion and preparation method thereof
  • Virginiamycin microemulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-14

[0029] The preparation method of embodiment 1-14 virginiamycin microemulsion, comprises the following steps:

[0030] a) mixing virginiamycin with oil;

[0031] b) Add a co-surfactant to it, heat while stirring until the drug is completely dissolved, the heating temperature is ≤ 80°C, and the solution is clear and transparent by sampling;

[0032] c) Cool to room temperature, then add surfactant, stir evenly, the system remains clear and transparent, relatively viscous;

[0033] d) Slowly add deionized water, stir and mix while adding. At this time, the system is clear and transparent, and the sampling solution flows like a water sample.

Embodiment 15

[0035] The microemulsion products of Examples 1-14 were observed under a transmission electron microscope, and the scanning conditions were: HV=80.0kv; Direct Mag: 70 000×, figure 1 It is the transmission electron micrograph of the virginiamycin microemulsion that embodiment 1 makes, from figure 1 It can be seen that the virginiamycin droplets are spherical, with good dispersion and no adhesion, and the droplet diameters are distributed between 1 and 100 nm.

Embodiment 16

[0036] Example 16 Stability test

[0037] Get the microemulsion product of embodiment 1-14 to carry out time-lapse test, accelerated test, anti-freezing stability test and centrifuge stability test respectively, observe the stability of microemulsion of the present invention, confirm whether layering, turbidity or crystal are separated out etc. Instability occurs.

[0038] 1. Time-lapse test

[0039] The microemulsions of Examples 1-14 were stored for 6 months under the condition of natural changes at room temperature, and the properties and content changes of the microemulsions were investigated. The results showed that the appearance was persistently clear and transparent, and no demulsification such as turbidity, layering, and drug precipitation was found. , indicating good stability over time.

[0040] 2. Accelerated test

[0041] The microemulsions of Examples 1-14 were subpackaged in several glass bottles, placed in a temperature of 40°C after sealing, and stored ...

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Abstract

The invention provides a virginiamycin microemulsion and a preparation method thereof, and belongs to the technical field of medicines. The microemulsion is prepared from the following components in percentage by weight: 0.01-3.0 percent of virginiamycin serving as an active ingredient of the emulsion, 0.1-11.0 percent of oil, 18.0-35.0 percent of surfactant, 0-6 percent of co-surfactant and the balance of deionized water. The preparation method comprises the following steps: (a) mixing virginiamycin and oil; (b) adding co-surfactant into the mixture, heating to a temperature of less than or equal to 80 DEG C until the system is completely clear and transparent; (c) cooling to room temperature, adding surfactant, and mixing; (d) adding the deionized water, and mixing. The virginiamycin medicine is convenient in the using process due to the transformation on preparation, the antibacterial effect is remarkably improved, and the administration times can be reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a virginiamycin microemulsion and a preparation method thereof. Background technique [0002] Virginmycin is a polypeptide antibiotic isolated from bacteria of the genus Streptomyces when Professor Dai Soma of the University of Lubang in Belgium conducted a screening test on soil. Its mechanism of action is to inhibit the ribosomes of Gram-positive bacteria to prevent bacterial protein synthesis and achieve bactericidal purposes. When the drug enters the intestinal tract of animals, it selectively kills intestinal bacteria, kills harmful bacteria and retains probiotics, reduces the consumption of nutrients by bacteria, reduces the production of harmful substances, slows down intestinal peristalsis, and feed stays in the intestinal tract The longer the time, the more complete the absorption of nutrients, thereby promoting the growth of animals. [0003] The main tar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/12A61K9/107A61P31/04
Inventor 郭建军李会芳曹伟伟张法学
Owner HENAN SOAR VETERINARY PHARMA
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