Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Implantable bandage for promoting bone injury repair and preparation method thereof

A bone injury repair and bandage technology, applied in the field of biomedical implant materials, can solve problems such as the adverse effects of bone injury, endanger the healing efficiency of bone injury, and the lack of periosteum-derived stem cells, so as to avoid soft tissue ingrowth and isolation, and solve bone injury Delayed healing repair, improved biocompatibility

Active Publication Date: 2021-07-27
ZHEJIANG UNIV
View PDF10 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] One is that the continuous inflammatory response caused by muscle tissue trauma may have an adverse effect on the internal repair of bone damage, and the need for timely healing of muscle trauma and the prevention and control of infection
[0006] The second is that the blood supply in the bone defect is seriously affected after the periosteum is damaged. The reconstruction and repair process of the periosteum itself cannot provide positive support for the nutrition supply for the repair of the bone injury, and the lack of periosteum-derived stem cells will also endanger the improvement of the healing efficiency of the bone injury.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Implantable bandage for promoting bone injury repair and preparation method thereof
  • Implantable bandage for promoting bone injury repair and preparation method thereof
  • Implantable bandage for promoting bone injury repair and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Example 1: 0.04-8 μm, the particle size of the inorganic mineral particles is 0.02-40 μm.

[0095] 1) Mesoporous bioglass nanopowder with a particle size of 0.15-0.85 μm (chemical composition 28CaO-42SiO 2 -12B 2 o 3 -4P 2 o 5 -6MgO-1CuO-2ZnO-4Na 2 O-1K 2 O) join in the hyaluronic acid-gelatin composite aqueous solution that the mass ratio is 1:9 and stir evenly, the mass ratio of bioglass and organic matter is 1:20, be mixed with the organic-inorganic compound that bioglass concentration is 50mg / ml The solution is then transferred to the electrospinning liquid reservoir, the spinning distance is set to be 15cm, the spinning voltage is 16kV, and the electrospinning is carried out at a speed of 0.4 ml / hour, and then collected on a porous copper foil carrier with a thickness of 200 Micron level microfiber porous film;

[0096] 2) The organic matter used to prepare the poly L-lactide-caprolactone porous grid is directly placed in the material container of the three-...

Embodiment 2

[0100] 1) Mesoporous biological glass particles with a particle size of 0.50-1.20 μm (chemical composition 24CaO-48SiO 2 -12B 2 o 3 -2P 2 o 5 -6MgO-4ZnO-4Na 2 O) join in the sodium alginate-gelatin composite solution that the mass ratio is 2:5 and stir evenly, the mass ratio of superfine particle and organic matter is 1:15, is mixed with the organic-inorganic that superfine particle concentration is 20mg / ml The complex solution is then transferred to the electrospinning liquid reservoir, the spinning distance is set to 18cm, the spinning voltage is 18kV, and the electrospinning is carried out at a speed of 0.3 ml / hour, and then collected on an aluminum foil carrier with a thickness of 150 Micron level microfiber porous film;

[0101] 2) The organic matter used to prepare the polycaprolactone porous grid is directly placed in the material container of the three-dimensional printer, and the polymer is softened by heating and extruded out of the printing nozzle. The ultrafin...

Embodiment 3

[0105] 1) Mesoporous biological glass powder (24CaO-56SiO 2 -8B 2 o 3 -4MgO-2ZnO-6Na 2 O) join in the sodium alginate-gelatin-polyvinyl phosphate compound organic matter solution that the mass ratio is 2:8:1 and stir evenly, the mass ratio of superfine particle and organic matter is 1:15, is mixed with superfine particle concentration: The organic-inorganic composite solution of 20mg / ml is then transferred to the liquid reservoir of electrospinning, the spinning distance is set to be 16cm, the spinning voltage is 20kV, and the electrospinning is carried out at a speed of 0.4 ml / hour, and then Collect the superfine fiber porous film with a thickness of 280 microns on the aluminum foil drum carrier;

[0106] 2) The organic matter used to prepare the porous sodium carboxymethyl cellulose grid is directly placed in the material container of the three-dimensional printer, and the polymer is softened by heating and extruded out of the printing nozzle, so that the ultrafine fibers...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

The invention discloses an implantable bandage for promoting bone injury repair and a preparation method thereof. The bandage is composed of a porous grid sheet-shaped object and organic-inorganic composite superfine fiber porous film covering objects on the surfaces of the two sides of the porous grid sheet-shaped object, the lower layer is a superfine fiber porous network containing bioglass particles, the middle layer is a polymer porous grid, and the upper layer is a superfine fiber porous network containing inorganic mineral particles; inorganic matters in the superfine fibers on the surfaces of the two sides are bioglass particles for inhibiting inflammation, resisting infection and promoting soft tissue regeneration and repair and inorganic mineral particles for inhibiting inflammation and promoting bone regeneration and repair, and the bandage is prepared through three-dimensional printing and electrostatic spinning processes. The method is convenient to operate, has a remarkable inhibition effect on inflammation in soft and hard tissues such as muscles, periosteum and bones with various fractures or bone defects, promotes rapid healing and repair of the soft and hard tissues, is adjustable in degradation rate of the implantable bandage, and has a remarkable bacteriostasis effect on common pathogenic bacteria and fungi.

Description

technical field [0001] The invention belongs to the field of biomedical implant materials, and relates to an implant bandage and a preparation method thereof, in particular to an implant bandage material and a preparation method for promoting synergistic regeneration and repair of soft and hard tissues in bone damage. Background technique [0002] Bone injuries usually include fractures and bone defects, which can also be called bone trauma and bone loss. In my country, more than 100,000 people die every year from fractures or bone trauma caused by accidents such as traffic accidents, falls, bruises, and falls, and millions of people suffer from bone fractures caused by various operations, diseases, and inflammations. Defects or bone loss, especially in middle-aged and elderly people with various chronic diseases and inflammations that cause bone damage, poor blood supply and slow recovery, resulting in delayed fracture union, malunion or even nonunion (nonunion). Although c...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61F13/00
CPCA61F13/00991A61F2013/00548A61F13/01012
Inventor 苟中入杨贤燕徐三中
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products