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Application of baohuoside I in preparation of drug for preventing and treating cerebral arterial thrombosis

A technology for ischemic stroke and baohuoside, applied in the field of pharmacy, can solve the problems of unsatisfactory results, inability to provide comprehensive and effective protection from pathophysiological response, and single target

Inactive Publication Date: 2014-08-20
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, researchers have carried out a large number of clinical trials on neuroprotective agents, but the results are not satisfactory. The reason may be that traditional neuroprotective agents have a single target and cannot respond to the complex pathophysiological responses after cerebral ischemia. comprehensive and effective protection

Method used

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  • Application of baohuoside I in preparation of drug for preventing and treating cerebral arterial thrombosis
  • Application of baohuoside I in preparation of drug for preventing and treating cerebral arterial thrombosis
  • Application of baohuoside I in preparation of drug for preventing and treating cerebral arterial thrombosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0177] Embodiment 1 of the present invention: get baojoside I 5g, medical starch 75g, microcrystalline cellulose 20g, the medicinal starch is first dried, pass 120 mesh sieves, then mix with baojoside I and microcrystalline cellulose, pass Twice 120 mesh sieves, filled in hard capsules, made 1000 capsules of the present invention. Each hard capsule contains 0.5mg of the main ingredient.

Embodiment 2

[0178] Embodiment 2 of the present invention: get baojoside 15g, hypromellose 6g, sodium starch glycolate 10g, microcrystalline cellulose 8g, lactose 115g, starch 50g, magnesium stearate 1g; After mixing, put it into a high-speed blender, spray and add appropriate amount of water, granulate, control the water content at 3~4%, and then compress into tablets to make 1000 tablets, coated with film.

Embodiment 3

[0179] Embodiment 3 of the present invention: get baojoside 15g, add 400ml polyethylene glycol 200 to dissolve, then add appropriate amount of distilled water to dilute, then add appropriate amount of sucrose and adjust the volume to 1000ml, stir well, filter, fill into 10ml or 20ml each, sterile packaged.

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Abstract

The invention discloses application of baohuoside I in preparation of a drug for preventing and treating cerebral arterial thrombosis. The baohuoside I is adopted to prepare a drug for preventing and treating cerebral arterial thrombosis. The prepared pharmaceutical composition has a protective role on acute cerebral arterial thrombosis by verification of a series of animal experiments, and the measurement is associated with the baohuoside I for stopping reduction of PPARalpha and PPARgamma expression, and inhibiting of activation of an IkB / NF-kB channel, so as to inhibit overexpression of inflammatory factors such as 1L-1beta, TGFbeta1 and the like.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the application of baojoside I in the preparation of drugs for the prevention and treatment of ischemic stroke. Background technique [0002] Stroke, also known as cerebral apoplexy or cerebrovascular accident, is a disease of the central nervous system caused by narrowing, occlusion or rupture of intracerebral arteries due to various causes, which in turn causes acute cerebral blood circulation disturbance. Because of its high morbidity, high disability, and high mortality, stroke has become a major disease that threatens human health and affects the quality of life, bringing heavy burdens to society and families. In European and American countries, stroke has always been the third cause of death and the first cause of disability. The latest epidemiological data show that in the United States, about 8 million people suffer from stroke every year, and 1 out of every 19 deaths is due to s...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P9/10
Inventor 龚其海邓媛媛熊德庆石京山
Owner ZUNYI MEDICAL UNIVERSITY
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