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Nanometer aquogel with both pH and temperature sensitivity and its prepn process

A technology of nano-hydrogel and dissolution temperature, which is applied in the field of pH- and temperature-sensitive N-isopropylacrylamide nano-hydrogel and its preparation, and can solve the problem of not being able to reach the nanometer level, limiting applications, and single sensitive type and other problems, to achieve the effect of rapid response capability and simple synthesis process

Inactive Publication Date: 2006-10-18
CHINA PHARM UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Therefore, nano-hydrogels in the prior art are generally single-sensitive to temperature or pH. Even hydrogels with dual responsiveness to pH and temperature are too large to reach the nanoscale. In addition, the lowest The critical solution temperature is generally lower than the human body temperature, which limits its better application; so far, there is no N- Isopropylacrylamide-based nanohydrogels

Method used

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  • Nanometer aquogel with both pH and temperature sensitivity and its prepn process
  • Nanometer aquogel with both pH and temperature sensitivity and its prepn process
  • Nanometer aquogel with both pH and temperature sensitivity and its prepn process

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Experimental program
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Effect test

Embodiment 1

[0038] Dissolve 3.7770g of N-isopropylacrylamide, 0.18mL of acrylic acid, 0.0690g of N,N'-methylenebisacrylamide, 0.3366g of dodecylsulfuric acid in 230mL of aqueous solution and add to the have N 2 Catheter in a 500mL three-neck flask. Stir at a rate of 400 rpm, and feed N 2 After fully deoxidizing, heat with a water bath. Add 0.0624 g of an aqueous solution of potassium persulfate, adjust the volume of the reaction solution to 370 mL, and react at 70° C. for 4 h. The product obtained is fully dialyzed with distilled water (dialysis bag, molecular weight cut-off is 10,000), and then freeze-dried to obtain a PNIPAM-co-AA (acrylic acid) nano-hydrogel with a particle size of 110nm ± 15nm. The LCST is 35°C. Infrared spectrogram see figure 2 .

Embodiment 2

[0040] Dissolve 3.7770g of N-isopropylacrylamide, 0.81mL of acrylic acid, 0.0690g of N,N'-dodecylmethylenebisacrylic acid amine, and 0.6366 octaalkyl sodium sulfate in 230mL of aqueous solution and add an electric stirring device and a thermometer. and equipped with N 2 Catheter in a 500mL three-neck flask. Stir at a rate of 400 rpm, and feed N 2 After fully deoxidizing, heat with a water bath. Add 0.0624g of an aqueous solution of ammonium persulfate, adjust the volume of the reaction solution to 370mL, and react at 70°C for 4h. The obtained product was fully dialyzed with distilled water (dialysis bag, molecular weight cut-off is 10,000), and then freeze-dried to obtain a PNIPAM-co-AA (acrylic acid) nanohydrogel with a particle size of 48nm ± 10nm, and an LCST of 43.8°C.

Embodiment 3

[0042] Dissolve 3.7770g of N-isopropylacrylamide, 0.30mL of acrylamine, 0.0690g of N,N'-diallyl tartaric acid diamide, 0.6366g of sodium lauryl sulfate in 230mL of aqueous solution and add an electric stirring device and a thermometer. and equipped with N 2 Catheter in a 500mL three-neck flask. Stir at a rate of 400 rpm, and feed N 2 After fully deoxidizing, heat with a water bath. Add 0.0624g of an aqueous solution of N,N,N',N'-tetramethylethylenediamine, dilute the reaction solution to 370mL, and react at 70°C for 4h. The obtained product was fully dialyzed with distilled water (dialysis bag, molecular weight cut-off is 10,000), and then freeze-dried to obtain PNIPAM-co-NH with a particle size of 95nm±10nm 2 (Acylamine) nanohydrogel, LCST is 39.3°C.

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Abstract

The present invention relates to sensitive nanometer polymer material, and is especially nanometer N-isopropyl acrylamide aquogel with both pH and temperature sensitivity and its preparation process. The nanometer N-isopropyl acrylamide aquogel has granularity of 30-200 nm and lowest critical solution temperature (LCST) of 35-45 deg.c. The preparation process of the present invention can regulate the granularity and LCST flexibly.

Description

technical field [0001] The invention relates to the field of environment-sensitive polymer nanomaterials, in particular to pH- and temperature-sensitive N-isopropylacrylamide nano-hydrogels and a preparation method thereof. Background technique [0002] Poly N-isopropylacrylamide (PNIPAM) hydrogel is a widely studied class of temperature-sensitive materials. This type of hydrogel has a volume phase transition at its lowest critical solution temperature (LCST: 32°C): When the external temperature is lower than LCST, PNIPAM has hydrophilic properties, swells in aqueous solution, and contains a large proportion of water inside; when the external temperature is higher than LCST, PNIPAM becomes hydrophobic, and the internal water is squeezed out, and its volume changes. Small. [0003] CN01129696.8, CN01129694.1 disclose the preparation method of porous temperature-sensitive poly(N-isopropylacrylamide) hydrogel. CN03144329.X discloses a copolymerization gel of N-isopropylacryla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/06C08F2/26C08F216/06C08F220/56
Inventor 顾月清陈海燕钱志余李清增
Owner CHINA PHARM UNIV
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