Diagnostic agents for prenatal diagnosis of preterm delivery, fetal infection, and fetal damage, and diagnostic kit containing same

A technology of prenatal diagnosis and diagnostic agent, applied in the direction of disease diagnosis, biological testing, biochemical equipment and methods, etc.
CN1476537AInactive Publication Date: 2004-02-18SEOUL NAT UNIV R&DB FOUND
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SEOUL NAT UNIV R&DB FOUND
Publication Date
2004-02-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention is about a method for the prenatal diagnosis of preterm delivery, fetal infection, and fetal damage, and diagnostic reagent system and diagnostic kit for the diagnosis. The method, diagnostic reagent system, and kit are based on the finding that the level of MMP-8 in the amniotic fluid is significantly higher when the pregnant woman is at risk for preterm delivery, intrauterine infection, and fetal damage. The diagnostic reagent system and kit can be applied to the patients without, as well as with, clinical signs of preterm labor or premature rupture of fetal membranes. With the superiority in sensitivity and specificity as well as its less invasiveness compared to the conventional method of measuring fetal blood cytokine levels, this diagnostic reagent system and kit is very useful in the prenatal diagnosis of preterm delivery, fetal infection, and fetal damage.
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Description

field of invention

[0001] The present invention relates to a diagnostic agent system for prenatal diagnosis of premature birth, fetal infection and fetal injury, and a diagnostic kit using the reagent, more particularly, relates to amniotic fluid matrix metalloproteinase-8 (MMP-8) concentration as a measure of premature birth , Application of prenatal diagnostic markers for fetal infection and fetal injury. Background of the invention

[0002] It has long been recognized in the medical community that the prevention of preterm labor or premature rupture of membranes is more meaningful than its treatment after birth. However, many factors are currently known to cause preterm labor or premature rupture of membranes, making prevention of this unwanted event difficult. The traditional approach to preventing preterm birth has been to identify high-risk groups of women for whom special attention should be given based on knowledge of obstetrics and obstetrics, demographics, and var...

Claims

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