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100 results about "Preterm delivery" patented technology
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Preterm delivery. Childbirth that occurs between the date of fetal viability and the end of the 37th week of gestation.
Methods for reducing the occurrence of preterm delivery and other pregnancy-related conditions
The present invention relates to methods and kits for reducing the occurrence of preterm delivery and other pregnancy-related conditions in pregnant female subjects exhibiting one or more risk factors for preterm delivery and other pregnancy-related conditions. For example, the present invention relates to methods for reducing the occurrence of preterm delivery in a pregnant female subject having no history of preterm delivery and exhibiting one or more risk factors for preterm delivery (e.g., smoking during pregnancy). The methods and kits provide for the administration of a steroid hormone to the pregnant female subject.
Owner:LUMARA HEALTH IP
Biomarkers of preterm birth
InactiveUS20140186332A1Reduce riskIncreased riskPeptide/protein ingredientsMicrobiological testing/measurementGynecologyObstetrics
The present disclosure relates to biomarkers of preterm birth, biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides methods of determining whether a pregnant woman is at an increased risk for premature delivery. The present disclosure further provides methods for decreasing a pregnant woman's risk for premature delivery.
Owner:NX PRENATAL INC
Methods for inhibiting preterm labor and uterine contractility disorders and preventing cervical ripening
InactiveUS20130023505A1Inhibit uterine contractilityInhibit cervical ripeningOrganic active ingredientsPharmaceutical delivery mechanismMyometrial contractilityGynecology
The invention relates to methods and pharmaceutical compositions for inhibiting or preventing preterm birth, inhibiting or delaying cervical ripening, inhibiting myometrial contractility and treating or inhibiting uterine contractility disorders. The methods comprise administering an effective amount of a composition comprising steroid hormones such as soluble progesterone.
Owner:DIGNITY HEALTH
Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
This invention provides novel substituted tricyclic pyridyl carboxamides which act as oxytocin receptor competitive antagonists, as well as methods of their manufacture, pharmaceutical compositions and methods of their use in treatment, inhibition, suppression or prevention of preterm labor, dysmenorrhea, endometritis, suppression of labor at term prior to caesarean delivery, and to facilitate antinatal transport to a medical facility. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.
Owner:WYETH LLC
Assay for the detection of biomarkers associated with pregnancy related conditions
The invention relates to screening methods for determination of the risk of preterm delivery and / or pregnancy associated conditions. The methods involve detection of the level of one or more biomarkers in a biological sample from the patient. In particular, in embodiments of the invention there are provided methods for determining the risk of pre-eclampsia and other hypertensive disorders, and intrauterine growth retardation (IGUR).
Owner:NEWCASTE INNOVATION LTD
Preterm delivery diagnostic assay
InactiveUS20110144076A1Reduce riskOrganic active ingredientsNucleotide librariesObstetricsNucleic Acid Probes
The present invention in one aspect relates generally to the identification, provision and use of a plurality of biomarkers to provide risk assessment of a woman for preterm delivery, and products and processes related thereto. In one aspect, a novel plurality of biomarkers as described herein is provided to determine a risk for preterm delivery. In one aspect are methods for determining a risk of preterm delivery in a subject. In another aspect are methods of predicting the likelihood of preterm delivery in a subject. In yet another aspect are methods for identifying subjects at risk of preterm delivery, and kits for use in the method In yet another aspect are nucleic acid arrays comprising nucleic acid probes that hybridize to preterm delivery marker genes.
Owner:SWEDISH HEALTH SERVICES
Structured Triglycerides And Emulsions Comprising Same
InactiveUS20070281993A1Good source of energyNot increase blood triglyceride levelBiocideEdible oils/fats ingredientsParenteral nutritionEmulsion
The present invention relates to structured triglyceride, to parental nutrition emulsions comprising same, and use thereof. In particular, the invention relates to structured triglycerides comprising at least one medium chain C6-C12 fatty acid and at least one fatty acid selected from the group consisting of long chain C14-C18 or very long chain C20-C22 fatty acids, preferably each fatty acid is present in a predetermined position of the glycerol backbone. The parenteral nutrition emulsions are particularly useful for nourishing preterm-and term-infants, children, critically ill patients, and cancer patients.
Owner:HTL HIGH TECH LIPIDS
Structured triglycerides and emulsions comprising same
InactiveUS7919526B2Enhanced advantageFunction increaseBiocideEdible oils/fats ingredientsEmulsionParenteral nutrition
Owner:HTL HIGH TECH LIPIDS
Compositions and methods for diagnosing and preventing spontaneous preterm birth
InactiveUS20120046261A1Abundant resourcesIncrease expensesOrganic active ingredientsNucleotide librariesPreterm BirthsObstetrics
Disclosed herein are compositions and methods of identifying a subject at risk for preterm birth and selecting effective therapies for preventing preterm birth in the subject. The disclosed methods generally involve determining the identity of one or more nucleotides in the progesterone receptor (PR) gene of the subject.
Owner:UNIV OF UTAH RES FOUND
Diagnostic biomarker to identify women at risk for preterm delivery
InactiveUS20120238469A1Peptide librariesMicrobiological testing/measurementObstetricsDiagnostic biomarker
The invention relates to biomarkers associated with preterm delivery. More specifically, the invention provides methods of measuring biomarkers found in women that are at risk for preterm delivery.
Owner:CEDARS SINAI MEDICAL CENT
Biomarkers for intro-amniotic inflammation
InactiveUS20060127962A1Identifying riskBioreactor/fermenter combinationsBiological substance pretreatmentsProteomics methodsIntra-Amniotic
Biomarkers have been discovered that are capable of identifying intra-amniotic inflammation. A single biomarker or combination of biomarkers can be used to qualify the risk of preterm delivery in a patient, provided that at least one of the biomarkers is a calgranulin, preferably calgranulin A or C. The result is a rapid and reliable proteotmic approach to identifying intra-amniotic inflammation. In particular, the concentrations of the biomarkers correlate with the magnitude of intra-amniotic inflammation and, hence, of preterm delivery.
Owner:VERMILLION INC
Biomarkers of preterm birth
ActiveUS20150355188A1Decrease riskReduce riskOrganic active ingredientsBiocideIncreased riskTerm Birth
The present disclosure relates to biomarkers of preterm birth, biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides methods of determining whether a pregnant woman is at an increased risk for premature delivery. The present disclosure further provides methods for decreasing a pregnant woman's risk for premature delivery.
Owner:NX PRENATAL INC
Method and apparatus for assessing risk of preterm delivery
Owner:WISCONSIN ALUMNI RES FOUND
Diagnostic biomarker to identify women at risk for preterm delivery
Owner:CEDARS SINAI MEDICAL CENT
Method and apparatus for assessing risk of preterm delivery
ActiveUS20100222679A1High sensitivityUltrasonic/sonic/infrasonic diagnosticsCatheterUltrasound attenuationObstetrics
An apparatus for assessing the risk of preterm delivery and the success of induction of labor at term uses a steered ultrasound beam to assess microstructure of the cervix revealed by backscatter power attenuation at a range of angles. It is believed that objective and precise description of cervical microstructure will reveal stage of cervical remodeling an as such may reveal risk of preterm delivery and / or success of labor induction. The backscatter power loss can be combined with elasticity measurements to provide a more precise indication of tissue structure.
Owner:WISCONSIN ALUMNI RES FOUND
Methods and Kits for Predicting the Onset of Labour
InactiveUS20110223622A1Raise the ratioIncreased riskDisease diagnosisBiological testingEstriolObstetrics
The present invention relates to methods and kits useful for predicting the time of onset of labour in a pregnant subject. In particular, the invention relates to methods and kits for predicting the time of onset of labour wherein the levels of at least two hormones, selected from estriol, estradiol and progesterone, are determined and a ratio of said levels is calculated, and wherein the time of onset of labour is predicted by comparison of said ratio with a predetermined ratio. The invention further contemplates methods for preventing preterm delivery of an infant / offspring.
Owner:NEWCASTE INNOVATION LTD
Method and system for assessing preterm birth and other pathologies
The present invention is directed to an all-fiber-optic scanning endomicroscope capable of high-resolution second harmonic generation (SHG) imaging of biological tissues. The endomicroscope has an overall 2.0 mm diameter and consists of a single customized double-clad fiber, a compact rapid two-dimensional beam scanner, and a miniature compound objective lens for excitation beam delivery, scanning, focusing, and efficient SHG signal collection. Endomicroscopic SHG images of murine cervical tissue sections at different stages of normal pregnancy reveal progressive, quantifiable changes in cervical collagen morphology with resolution similar to that of bench-top SHG microscopy. A device according to an embodiment of the present invention can also be used to assess other pathologies, such as cancer. fibrosis, and inflammation. The present invention allows for diagnosis, monitoring of the effect of therapeutics, and surgical or interventional guidance. The present invention enables visualization of histology in-vivo, in the patient, and is label-free.
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE +1
Diagnostic agents for the prenatal diagnosis of preterm delivery, fetal infection, and fetal damage, and diagnostic kit containing the same
InactiveUS7232661B2Bioreactor/fermenter combinationsBiological substance pretreatmentsPrenatal diagnosisObstetrics
This invention is about a method for the prenatal diagnosis of preterm delivery, fetal infection, and fetal damage, and diagnostic reagent system and diagnostic kit for the diagnosis. The method, diagnostic reagent system, and kit are based on the finding that the level of MMP-8 in the amniotic fluid is significantly higher when the pregnant woman is at risk for preterm delivery, intrauterine infection, and fetal damage. The diagnostic reagent system and kit can be applied to patients with or without clinical signs of preterm labor or premature rupture of fetal membranes. With its superiority in sensitivity and specificity as well as its less invasiveness compared to the conventional method of measuring fetal blood cytokine levels, this diagnostic reagent system and kit is very useful in the prenatal diagnosis of preterm delivery, fetal infection, and fetal damage.
Owner:SEOUL NAT UNIV R&DB FOUND
Systems and methods of using machine learning analysis to stratify risk of spontaneous preterm birth
PendingUS20210057039A1Subject is at riskReduce riskOrganic active ingredientsComponent separationPattern recognitionPreterm Births
The present disclosure relates to systems and methods of using machine learning analysis to stratify the risk of spontaneous preterm birth (SPTB). In some variations, to select informative markers that differentiate SPTB from term deliveries, a processed quantification data of the markers can be subjected to univariate receiver operating characteristic (ROC) curve analysis. A Differential Dependency Network (DDN) can then applied in order to extract co-expression patterns among the markers. In order to assess the complementary values among selected markers and the range of their relevant performance, multivariate linear models can be derived and evaluated using bootstrap resampling.
Owner:NX PRENATAL INC
Genetic markers for assessing risk of premature birth resulting from preterm premature rupture of membranes
InactiveUS7807366B2High riskRisk of preterm delivery is normalSugar derivativesMicrobiological testing/measurementGeneticsIncreased risk
Owner:VIRGINIA COMMONWEALTH UNIV
Genetic markers for assessing risk of premature birth resulting from preterm premature rupture of membranes
InactiveUS20080254454A1High riskRisk of preterm delivery is normalSugar derivativesMicrobiological testing/measurementGeneticsIncreased risk
A method to identify women who are at risk for preterm delivery due to premature rupture of membranes (PPROM) is provided. The method entails detecting the presence of SERPINH1 gene variants that express low levels of the gene product, heat shock protein Hsp47. The occurrence of a T (rather than C) at a single nucleotide polymorphism (SNP) site at position −656 of the SERPINH1 gene promoter, together with the absence of a 12 base pair deletion at positions −694 to −683 of the promoter, result in an increased risk of PPROM. The method enables medical professionals to identify those at risk, and to provide suitable therapeutic intervention.
Owner:VIRGINIA COMMONWEALTH UNIV
Alpha-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
ActiveUS10555934B2Reduce riskProlong the term of pregnancyDispersion deliveryPeptide/protein ingredientsDiseaseAmino esters
Owner:XOMA (US) LLC
Device, wireless system and method for reducing the risk of hypoxia and/or bradycardia
ActiveCN105962924AReduce false alarmsDiagnostic recording/measuringSensorsSIDS - Sudden infant death syndromeProximal phalange
A device, a wireless system and a method for reducing the risk of hypoxia and / or bradycardia are provided; the wearable, wireless, non-invasive device applicable to the hand or foot, a wireless system, and a method for reducing the risk of different critical situations of hypoxia and / or bradycardia possibly occurring in victims of sudden infant death syndrome (SIDS), Pierre Robin Sequence patients, preterm babies, and adults, and for the prevention of the sleep apnea, is based on use of a sensor and a computing algorithm sufficient to reduce false alarms and save lives. The device is worn on the hand or foot of a user. Part of the device may be placed on the proximal phalange of a finger or a foot, or even in the palm. The electronics of the device may be placed inside gloves or booties of different sizes to accommodate the hands or feet of different wearers. The device measures blood oxygen saturation and heart rate through a sensor that is preferably a pulse oximeter.
Owner:APN INTPROP LLC
Methods for Evaluation of Gestational Progress and Preterm Abortion for Clinical Intervention and Applications Thereof
PendingUS20210398682A1Mechanical/radiation/invasive therapiesHealth-index calculationObstetricsAnalyte
Methods to compute gestational age and gestational health and applications thereof are described. Generally, systems utilize analyte measurements to determine a gestational age and gestational health, which can be used as a basis to perform interventions and treat individuals.
Owner:STATENS SERUM INST +1
Tools for Predicting the Risk of Preterm Birth
PendingUS20190072564A1Reduce riskNot at risk of errorMedical simulationMedical data miningPreterm BirthsAssay
The invention is directed to methods and compositions of matter for predicting the risk of preterm birth (PTB) in a subject and administering interventions to subjects at elevated risk of PTB. The inventions provide a convenient, non-invasive, and accurate means of assessing PTB risk in a subject, and further provide a means of treating subjects in need of treatment and selecting appropriate interventions to reduce such risk. The diagnostic tools include novel panels of biomarkers and other factors which can be used to accurately predict risk of PTB across a population, wherein elevated risk is due to a variety of underlying physiological pathways and processes. In another aspect, the scope of the invention encompasses assay kits which are useful in the fast, accurate, and inexpensive prediction of PTB risk by multiplexed measurement of PTB risk factors.
Owner:RGT UNIV OF CALIFORNIA +1
Caspase inhibitors in the treatment of infection-associated preterm delivery
Apoptotic processes induced by infection of, or injury to, fetal and placental tissues have been implicated in preterm delivery. Thus, modulation of apoptotis constitutes a strategy for improving pregnancy outcome in women with intrauterine infections. Caspase inhibitors, including the pancaspase inhibitor Z-VAD-FMK, can be used to prevent apoptosis and, thus, prevent preterm delivery. Accordingly, compositions and methods comprising caspase inhibitors for prevention of preterm delivery are provided.
Owner:CEDARS SINAI MEDICAL CENT
Diagnostic biomarker to predict women at risk for preterm delivery
InactiveUS20140051598A1Increased riskHigh and low expressionMicrobiological testing/measurementLibrary screeningChemokine Receptor AntagonistDiagnostic biomarker
The invention relates to biomarkers associated with preterm delivery. More specifically, the invention provides methods of measuring biomarkers including but not limited to cytokines, cytokine receptors, cytokine receptor antagonists, chemokines, chemokine receptors, and / or chemokine receptor antagonists found in women that are at risk for preterm delivery. The diagnostic methods may be performed on whole blood.
Owner:CEDARS SINAI MEDICAL CENT
Device and method of restoring microbiota of newborns
ActiveUS20190021703A1Improve scalabilityMicrobiological testing/measurementSurgeryDiseaseFull Term Neonate
The invention relates to methods and compositions for restoring normal microbiota in pre-term newborns or newborns delivered by Cesarean section and methods for preventing or ameliorating diseases associated with delivery by Cesarean section or pre-term birth comprising administering to said newborns at the time of birth or shortly thereafter an effective amount of a vaginal microbiota inoculum obtained from the newborn's mother or a donor or an effective amount of a probiotic composition. The invention also relates to a device for collecting maternal vaginal microbiota from the vaginal canal of a patient. The device can have a housing forming a cavity, an absorbent material removable disposed within the cavity, and a deployment element disposed in the housing and movable along a length of the housing. The movement of the deployment element can displace the absorbent material out of the cavity and in to the vaginal canal.
Owner:NEW YORK UNIV
Non-invasive biomarker to identify subject at risk of preterm delivery
ActiveUS9797903B2Raise the possibilityAvoids and mitigatesPeptide/protein ingredientsDisease diagnosisObstetricsLipocalin-type PGDS
Methods for diagnosis to allow prediction of the likelihood of preterm birth based upon the concentration of lipocalin-type prostaglandin D2 synthase (L-PGDS) in cervical vaginal secretions. In addition, specific prostaglandin D2 receptor antagonists may represent novel tocolytic therapeutics.
Owner:NYU WINTHROP HOSPITAL
Preterm milk formula
InactiveCN103002757AMilk preparationFood ingredient functionsExtremely low birth weight infantPhysiology
The present invention relates to a protein fortifier for use in varying the amount of protein in preterm infant nutrition, thereby adapting the formula or human milk to the nutritional needs of very low birth weight infants and extremely low birth weight infants.
Owner:NV NUTRICIA
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