37 results about "Postpartum haemorrhage" patented technology

A device (1) for staunching postpartum haemorrhage of the uterus (U). The device (1) comprises an inflatable internal balloon (2) having an inlet connected by a fitting (3) over a distal end (4) of a tubular conduit (5). The tubular conduit (5) has a proximal end (6) for connection to an inflation source for manually inflating the internal balloon (2). A non-return valve (8) is fitted in the conduit (5) at the proximal end (6). The device (1) has an inflatable external balloon (10) for indicating when the surface of the internal balloon (2) has engaged with the wall of the uterus (U). The external balloon (10) also acts as an indicator to indicate subsequent contraction of the uterus (U).

The invention relates to a medicine composition, which is characterized by consisting of oxytocin analogue, ergometrine or salt acceptable in pharmacy, a carrier acceptable in preparation process or excipient, antioxygen, a potential of hydrogen (pH)conditioning agent, solubilizer and other auxiliary materials. The medicine composition is used for prevention and cure of postpartum hemorrhage caused by uterine contraction and atony and active management at the third stage of childbirth and is contribute to postpartum functional recovery. The ergometrine and the oxytocin analogue are combined to increase the curative effect and reduce the untoward effect. The dosage form is a freeze-drying mode or a sterile split package mode, high temperature sterilization is avoided in the preparation process, the medicines are stored in a solid state, the integrated antioxygen is added, impurities are decreased, the medicine composition is stable, and storage and transportation at the room temperature are facilitated.

The invention relates to a stable pharmaceutical composition containing carbetocin, and a preparation method thereof. The stable pharmaceutical composition containing carbetocin contains carbetocin, a pH regulator, an isoosmotic regulator and pharmaceutically acceptable auxiliary materials. The composition is used for preventing uterine atony and postpartum hemorrhage after selective epidural or spinal anesthesia cesarean section. The pharmaceutical composition mainly exists in a liquid form and is used through parenteral administration forms, mainly injection and nasal spray.

An apparatus for detecting and notifying occurrence of post-partum haemorrhage in female patients is envisaged. Continued tracking of the blood discharged from a female patient's body during labor as well as postnatal operation procedures is provided for, and as soon as the amount of blood discharged from the body of the female patient exceeds a predetermined threshold value, a light-based alarm and sound-based alarm are triggered. The apparatus includes a first connector connected to the female patient when she is on a Labor Recovery Delivery bed, and a second connector woven onto an undergarment to be worn by the female patient. The first connector and second connector are connected to single use, disposable blood collection bags, whose weights are measured using weight sensors for an accurate calculation of the total amount of the blood lost by the female patient during labor operation procedures and postnatal operation procedures.

The invention relates to a severe postpartum hemorrhage risk prediction system for pregnant women with repeated caesarean section and a construction method thereof. The invention aims to evaluate andpredict various clinical characteristics and ultrasonic risk factors of severe postpartum hemorrhage of pregnant women with repeated caesarean section, and create an effective system for predicting severe postpartum hemorrhage risk for pregnant women with repeated caesarean section, so that high-risk lying-in women can be prepared and managed more effectively through multiple disciplines. Throughverification of external data, the prediction system has good capability of predicting severe postpartum hemorrhage, good fitting degree and high clinical net benefit. Moreover, according to a nomogram created by the prediction system, a clinical obstetrician can be simply and effectively helped to calculate the probability of serious postpartum hemorrhage of a certain pregnant woman with repeatedcaesarean section.

A device for monitoring a subject for postpartum hemorrhage is disclosed. It comprises an ultrasound transducer for applying ultrasound energy focused at a region of uterine musculature of the subject for creating an acoustic radiation force for generating a shear wave in the uterine musculature. A second ultrasound transducer radiates ultrasound energy into the subject and receives the echoed ultrasound energy. By analyzing a signal representative of the received echoed ultrasound energy the speed of propagation of the shear wave in the uterine musculature is determined. The value of the tone of the uterine musculature is estimated based on the speed of propagation of the shear wave and conveyed to a user. Further, a device for detecting and locating a hemorrhage and estimating its severity are also disclosed.

The invention discloses a traditional Chinese medicine for treating postpartum hemorrhage caused by blood stasis and qi obstruction. The traditional Chinese medicine comprises the following raw materials: pseudo-ginseng, madder, typhae pollen, lignum dalbergiae odoriferae, crinis carbonisatus, baked ginger, rhizoma corydalis, trogopterus dung, corydalis amabilis, salviae miltiorrhizae, herba leonuri, radix achyranthis bidentatae, caulis spatholobi, cowherb seed, wadalee-gum-tree, resina draconis, artemisia anomala, lucid ganoderma, valerian, tuber fleeceflower stem, longan aril, acanthopanax, ginseng, astragalus membranaceus, radix glycyrrhizae, rhodiola rosea, sea-buckthorn, cartialgenous, lycopus lucidus, teasel root, lotus leaf base, Parnassia wightiana Wall., winter cherry and balanophora polyandra griff. The traditional Chinese medicine has the beneficial effects of having the efficacies of dispersing blood stasis and stopping bleeding, and tonifying qi and dredging collaterals, is mainly used for treating postpartum hemorrhage, is wide in medicinal herbs resource, low in price, not easy to generate drug resistance, safe and effective due to the traditional Chinese medicinal materials, and has the functions of regulating qi and blood, improving blood circulation, stimulating uterine contractions and the like; the state of an illness is timely controlled; the recovery rate is increased; and the immunity of the whole organism is improved.

The invention relates to an injection containing carbetocin and a stabilizer and storable at a normal temperature. The injection can be stored at normal temperature and comprises carbetocin, the stabilizer, a pH regulator and water for injection, wherein the stabilizer is composed of compound amino acid, so the stability of the injection can be improved. The injection is used for preventing uterine tension insufficiency and postpartum hemorrhage.

The invention discloses a traditional Chinese medicine composition for treating postpartum hemorrhage .The traditional Chinese medicine composition is prepared from, by weight, 10-30 parts of herba leonuri, 10-20 parts of radix acanthopanacis semticosi, 10-20 parts of fructus jujubae, 5-15 parts of ophicalcite, 10-20 parts of herba portulacae, 10-20 parts of radix cyathulae, 10-20 parts of rhizoma curculiginis, 5-15 parts of flos sophorae, 10-20 parts of herba agrimoniae, 10-20 parts of Chinese rose flowers, 5-15 parts of trogopterus dung, 10-20 parts of magnetite, 10-20 parts of glossy privet fruit, 5-15 parts of herba lycopi, 10-20 parts of semen persicae, 10-20 parts of radix rehmanniae, 5-15 parts of cortex cinnamomi, 10-20 parts of folium nelumbinis, 10-20 parts of radix trichosanthis, 5-15 parts of radix notoginseng, 10-20 parts of cuttlefish bones, 10-20 parts of rhizoma acori graminei and 5-15 parts of licorice roots .The traditional Chinese medicine composition has the effects of astringing to stop bleeding, reinforcing the kidney and invigorating the spleen, invigorating qi and blood, nourishing yin and generating body fluid and strengthening and consolidating the body resistance and is significant in treatment effect and reliable in effect.

The invention discloses an abdominal compressor for preventing postpartum hemorrhage. The abdominal compressor comprises a fixed base plate; a bandage is arranged at each of two ends of the fixed base plate; a fixing piece is arranged at each of free ends of the two bandages; a threaded through hole is formed in the center of the fixed base plate; a pressing rod is in threaded connection in the threaded through hole; the upper end of the pressing rod upwards extends out of the fixed base plate and is fixedly provided with a pressing head; the lower end of the pressing rod downwards extends out of the fixed base plate and is connected with a movable pressing plate; the pressing rod is connected with the movable pressing plate in the mode that the pressing rod can freely rotate and cannot axially move through a bearing; a pressing air bag used for making contact with the abdomen of a patient is arranged at the bottom of the movable pressing plate; and the pressing air bag is connected with an air pump installed on the fixed base plate through an air pipe. The abdominal compressor has the advantages that the abdominal compressor is light in weight and convenient to carry and use, the accuracy of the pressing position can be effectively ensured, and the pressing force can be adjusted according to the individual difference of puerperae.

The adjustable uterine compression apparatus for postpartum hemorrhage includes at least one belt adapted for encircling the uterus transversely, the belt having keeper loops so that the belt can be cinched to continuously adjust the degree of compression applied to the uterine arteries. The belt may also be shortened and used to apply compression to the ovarian arteries. Preferably, a plurality of belts are applied spaced apart axially along the body and cervix of the uterus. The belts may be applied separately and independently, or may be embedded or incorporated into a sheet or vest that may be applied posteriorly behind the uterus and further secured by straps extending over the fundus that are cinched to at least one of the transverse belts to apply axial compression, in addition to transverse compression of the uterus. The belt(s) and vest may be made of polyglactin mesh, so that they are bioabsorbable.

The invention provides traditional Chinese medicine for preventing postpartum hemorrhage and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine comprises rhizoma angiopleris officinalis, physochlaina macrophylla, lethariella zahlbruckneria, hedysarum polybotrys, flemingia philippinensis, velutinous indigo root, Ficus harlandii Benth., auricularia polytricha, Ludwigia hyssopifolia, hair weed, Angelica niyida Wolff, myrtle, limonite, Elsholtzia cillata Hyland, wheatgrass, coelogyne fimbriata and Lepisorus pseudonudus. The traditional Chinese medicine has exact curative effect on preventing postpartum hemorrhage and is small in toxic and side effects.

The uterine cavity compression balloon comprises a tube body, a vagina water bag and a uterine cavity water bag, the tube body comprises a through tube, a main tube and an auxiliary tube, the main tube and the auxiliary tube are mounted in the through tube, the uterine cavity water bag and the vagina water bag sequentially wrap the outer side wall of the front portion of the through tube, the head of the main tube is flush with the tube wall of the through tube and communicated with the uterine cavity water bag, and the tail of the main tube extends out of the through tube and is connected with a connector. The head of the auxiliary tube is flush with the tube wall of the through tube and communicated with the vagina water bag, and the tail of the auxiliary tube extends out of the through tube and is communicated with the main tube through a connector. The double-water-bag design is adopted, the uterine cavity water bag can be effectively prevented from slipping, the compression hemostasis effect of the lower section of the uterus and the cervix uterus is enhanced through the interaction of the uterine cavity water bag and the vagina water bag, operation is easy and convenient, and the operation difficulty of uterine cavity filling hemostasis during delivery and postpartum hemorrhage is reduced.

The invention discloses a postpartum hemorrhage risk prediction method and early warning system based on a fetal supervision uterine contraction graph and high risk factors. The method comprises the following steps: S1, collecting data of a hospital fetal supervision uterine contraction graph and an electronic medical record system; S2, screening pregnant and lying-in women during vaginal delivery, and extracting required patient information; S3, establishing a hemorrhage risk prediction model within 24 hours after delivery of the puerpera by applying a machine learning method; S4, evaluating the prediction value of each model, and selecting an optimal prediction model. According to the method, the prediction model is established through a machine learning method, and the method is of great significance to clinical treatment decisions including timely identification of uterine contraction hypodynamia, prevention of soft birth canal injury, correction of blood coagulation dysfunction and the like and reduction of the occurrence rate of bleeding.

The present invention discloses a blood clam extract and the application thereof in medicaments for promoting the postpartum uterine contraction. The blood clam extract contains water-soluble materials extracted from the meat of the blood clam and has the uterine contraction function. The blood clam extract can be used for the treatment on uterus subinvolution after postpartum hemorrhage, drug abortion, and induced abortion.

The invention discloses a method and system for analyzing postpartum hemorrhage amount from amniotic fluid and blood mixture. The method comprises the following steps: collecting the amniotic fluid and blood mixture flowing out from pregnant and lying-in women in the delivery process through a liquid collection pad, and calculating the total amount of the amniotic fluid and blood mixture; acquiring a video image of the liquid collecting pad, selecting a plurality of frame images at different shooting moments, then identifying a mark point on each frame image, determining an ROI region, and then performing image segmentation processing to obtain a target sub-image corresponding to the ROI region on each mark area sub-image; performing image data processing to obtain a specific gravity value of amniotic fluid and blood in the amniotic fluid and blood mixture collected from a fluid collection pad corresponding to each target sub-image at a corresponding shooting moment, calculating an average value, and accurately distinguishing the amniotic fluid volume and the blood volume from the amniotic fluid and blood mixture based on the total amount of the amniotic fluid and blood mixture, and important significance is achieved for reducing the occurrence rate of postpartum hemorrhage of pregnant and lying-in women and the death rate of the pregnant and lying-in women suffering from postpartum.

The invention provides a traditional Chinese medicine composition for treating postpartum diseases. The traditional Chinese medicine composition comprises 20-40 parts of codonopsis pilosula, 20-40 parts of raw astragalus membranaceus, 10-30 parts of bighead atractylodes rhizomes, 10-30 parts of poria cocos, 10-30 parts of angelica sinensis, 10-30 parts of radix paeoniae alba, 10-30 parts of donkey-hide gelatin, 10-30 parts of morinda officinalis, 10-30 parts of cistanche, 10-30 parts of radix glehniae, 10-30 parts of cynanchum atratum, 10-30 parts of cacumen biotae, 10-30 parts of hairyvein agrimony, 10-30 parts of motherwort, 10-30 parts of ligusticum wallichii, 10-30 parts of dandelions, 10-30 parts of notopterygium roots, 10-30 parts of radix angelicae pubescentis, 10-30 parts of cassia twigs, 10-30 parts of curcuma aromatica, 10-30 parts of uniflower, 10-30 parts of rhizoma polygonate, 5-25 parts of rhizoma cyperi, 5-20 parts of beautiful sweetgum fruits and 10-20 parts of prepared liquorice roots. The traditional Chinese medicine composition for treating the postpartum diseases has a good curative effect on the postpartum diseases, can promote postpartum uterus involution, reduce postpartum hemorrhage, relieve postpartum body pain, adjust the mood of the puerpera, has the efficacy of promoting postpartum lactescence, and the like, can prevent postpartum body deficiency and anemia, and is favorable for postpartum physical and mental rehabilitation.

The invention relates to a traditional Chinese medicine composition for treating postpartum hemorrhage. The traditional Chinese medicine composition for treating postpartum hemorrhage is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10 to 30 parts of red ginseng, 5 to 25 parts of herba scutellariae barbatae, 5 to 25 parts of smoothfruit ventilago roots and stems, 5 to 20 parts of dried ginger, 5 to 25 parts of herba ecliptae, 5 to 25 parts of scarlet kadsura roots, 5 to 20 parts of cattail pollen, 5 to 25 parts of radix dipsaci, 5 to 20 parts of lycopus lucidus, 5 to 25 parts of aralia elata, 5 to 25 parts of colla carapacis et plastri testudinis, 5 to 20 parts of notoginseng, 5 to 25 parts of radix rubiae, 5 to 25 parts of ficus esquiroliana, 5 to 25 parts of radix et rhizoma rhei, 5 to 20 parts of toosendan fruit, 5 to 25 parts of prepared rehmannia roots, 5 to 25 parts of limonitum, 5 to 20 parts of colla corii asini, 5 to 25 parts of radix hemerocallis, 5 to 25 parts of wilson begonia rhizome, 5 to 20 parts of crinis carbonisatus, 5 to 25 parts of radix patriniae heterophylla and 5 to 15 parts of liquorice roots. The traditional Chinese medicine composition has the efficacies of nourishing yin, supplementing the kidney, soothing the liver, clearing the heat, invigorating the spleen, supplementing qi, activing the blood circulation, removing blood stasis, and stopping bleeding by astringency; and when the traditional Chinese medicine composition is used for treating postpartum hemorrhage, the curative effect is obvious, and the effect is reliable.

The invention is suitable for the technical field of clinical prediction, and provides a postpartum hemorrhage prediction method and device, a terminal and a storage medium, and the method comprises the steps: collecting the clinical data of pregnant and lying-in women according to a preset standard; obtaining a prenatal variable, an intranatal variable and a postnatal variable; constructing a first model based on an artificial neural network, a support vector machine and an extreme gradient propulsion algorithm in combination with antenatal variables; on the basis of an artificial neural network, a support vector machine and an extreme gradient propulsion algorithm, constructing a second model in combination with the prenatal variable and the intranatal variable; on the basis of an artificial neural network, a support vector machine and an extreme gradient propulsion algorithm, constructing a third model in combination with the prenatal variable and the intranatal variable; and based on the artificial neural network and an extreme gradient propulsion algorithm, constructing a fourth model in combination with the prenatal variable, the intranatal variable and the postnatal variable. The method can accurately and efficiently predict whether postpartum bleeding is caused or not and the severity of bleeding.

The invention discloses a lactation period nutrient composition, and a preparation method and anapplication thereof. Raw materials of the composition comprise calcium carbonate, ferrous fumarate, zincgluconate, copper gluconate, retinyl acetate, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, nicotinic acid, folic acid, L-ascorbic acid, vitamin K1, D-calcium pantothenate and D-alpha-tocopherol; and auxiliary materials of the composition comprise microcrystalline cellulose, polyvinylpolypyrrolidone, maltodextrin and the like. A gold ratio is adopted for physiological characteristics and nutritional requirements of lying-in women and newborns in the lactation period to supplement various vitamins and minerals required by puerperal lactation women, so that puerperal anemia, puerperal infection, depression and insomnia can be prevented, postpartum hemorrhage can be reduced, and the postpartum life quality can be improved; and nutrition needed by infants is supplemented to prevent newborn diarrhea, scurvy and VK1 deficiency bleeding and maintain neonatal nerve and cardiovascular system development, so the composition is an ideal maternal and infant nutrition health care product in the puerperium.

The present invention refers to the use of certain sulfated glycosaminoglycans for treatment or prevention of postpartum haemorrhage. The sulfated glycosaminoglycans have a reduced anticoagulant activity and are administered in combination with at least one uterotonic agent capable of promoting myometrial contractions of the uterus and thereby compress the vessels and cease the bleeding.

The invention discloses a postpartum hemorrhage risk prediction model suitable for grassroots and a construction method thereof, and belongs to the technical field of risk prediction. Comprising the following steps: collecting serious postpartum hemorrhage cases as test samples, and extracting clinical sizing classification variable indexes of each test sample; a statistical method is adopted to screen out risk factors influencing serious postpartum hemorrhage in the clinical styling classification variable indexes, wherein the risk factors comprise previous cesarean delivery times, existence of placenta implantation, existence of preposed placenta, pre-pregnancy BMI and pregnancy weeks; the factors for prenatal placenta implantation judgment are removed, and a Logistic regression early warning model for predicting serious postpartum hemorrhage is constructed according to OR values of the four high-risk factors. The method can effectively predict the occurrence risk of serious postpartum hemorrhage of primary medical institutions, effectively utilizes medical resources, and reduces the occurrence rate of postpartum hemorrhage of lying-in women and the mortality risk of pregnant and lying-in women.

The invention relates to a medicine composition for functional uterine hemorrhage and postpartum hemorrhage. A preparation method of the medicine composition comprises the following steps: taking 1000 g of clinopodium polycephalum, chopping, adding water for 1.5 hours' decocting twice, merging decoctions, filtering, concentrating to obtain a concentrate I of 1.15 g / ml, adding ethanol of which the weight is 1.7 times of that of the concentrate I, fully stirring, performing still standing for 24 h, taking an supernatant, conducting vacuum concentration to obtain a concentrate II 1.1 g / ml, adding water of which the weight is double of that of the concentrate II, fully stirring, performing still standing for 24 h, filtering, adding 290 ml of simple syrup and 2.5 g of sodium benzoate, adding water until 1000 ml, and conducting stirring, filling and sterilization to obtain the medicine composition. The prepared medicine composition is low in cost and wide in application prospect.

The invention provides a uterus massager for preventing and treating postpartum hemorrhage, and relates to the technical field of medical instruments. The uterus massager comprises a control module, abracket, a first hand model module, a second hand model module, a first driving module and a second driving module, wherein the control module, the first hand model module, the second hand model module, the first driving module and the second driving module are mounted on the bracket respectively; the first hand model module is provided with an arc-shaped edge imitating the outer edge of a palm;and the control module is connected with the first driving module and the second driving module respectively, the first driving module is connected with the first hand model module, and the second driving module is connected with the second hand model module. The uterus massager can be widely applied to uterus massage after delivery, the workload of medical staff is reduced, and the working efficiency of the medical staff is improved. Uterus contraction is promoted, postpartum hemorrhage is prevented and treated, and involution of the uterus is facilitated.

The invention discloses an application of estradiol and the derivatives thereof in preparation of the medicines for preventing and treating oxytocin receptor related diseases. The estradiol, the derivatives of the estradiol and salts of the derivatives can remarkably improve the level of oxytocin receptors in biological tissues, can be applied to the diseases caused by oxytocin receptor deficiencyto solve the problem of oxytocin receptor deficiency, and realize treatment of corresponding diseases; and meanwhile, the sensitivity of the tissues corresponding to the oxytocin receptors to oxytocin can be improved again, so that the oxytocin receptors respond to the original non-reactive oxytocin level again, namely the problem of oxytocin receptor desensitization in the prior art can be solved, and the treatment effect of related diseases is improved. The estradiol and the derivatives thereof not only can realize treatment, but also can realize the prevention effect of the diseases on thebasis of the same mechanism. For example, the inventor applies the estradiol and the derivatives of the estradiol and the salts of the derivatives of the estradiol to postpartum hemorrhage diseases,so that postpartum hemorrhage can be prevented or remarkably improved, and life risks and sequelae caused by postpartum hemorrhage to parturient pregnant women can be effectively avoided.