The invention discloses an operation fixing device for a clinical orthopedic spine trauma, and relates to the technical field of medical equipment. The operation fixing device comprises a surgical bedand a fixing set, wherein the fixing set is installed on the surgical bed; the fixing set is composed of a head fixing piece, a body fixing piece and a leg fixing piece which are provided with a fixator, a second fixator and a third fixator respectively; the fixator is composed of a spring, a movable column, an arc-shaped plate and a plurality of fixed columns; and the head fixing piece and the leg fixing piece are matched with the body fixing piece in a nested mode. According to the invention, the fixing set is installed on the surgical bed, so that the situation that when an emergency patient needs an operation, the fixing device is installed for a long time, and consequently the patient cannot be rescued urgently is avoided; the spring, the movable column, the fixed columns and the arc-shaped plate are connected in sequence, so that patients with different weights can be adapted conveniently; and through nesting fit between a movable plate and a movable groove, the fixing set can be adjusted conveniently according to patients with different heights, so that the fixing device can adapt to the patients with various heights, and the application range of the fixing device is widened.