A mouse pain experiment adjustable stimulus applicator

Abstract

This invention discloses an adjustable stimulation application device for mouse pain experiments, relating to the field of veterinary surgical instrument technology. It includes an operating base and a control device fixedly mounted on the operating base. A surgical fixation table for mounting and fixing a mouse device is fixedly mounted on the operating base. A fixing block is fixedly mounted on the operating base, with a longitudinal groove inside the fixing block. A horizontal adjustment mechanism is provided on the fixing block, and an insertion mechanism is provided on the horizontal adjustment mechanism. The insertion mechanism is used to insert into mouse tissue to apply pain stimulation to the mouse. A longitudinal adjustment part is provided on the fixing block for adjusting the position of the horizontal adjustment mechanism. This device can precisely control the application position and insertion depth of the pain stimulation, meeting the control requirements of different stimulation intensities in pain experiments, effectively improving the consistency and accuracy of stimulation application in mouse pain experiments, and reducing experimental errors caused by manual operation.

Description

Technical Field

[0001] This invention relates to the field of veterinary surgical instrument technology, and more particularly to an adjustable stimulation application device for mouse pain testing. Background Technology

[0002] In pharmacology, neuroscience, and pain medicine research, mouse pain experiments are a core method for elucidating pain mechanisms and screening analgesic drugs. In these experiments, the precision of pain stimulation application directly determines the reliability of the data. Standardized stimulation locations, controllable insertion depths, and gradient stimulation intensities are necessary to ensure experimental repeatability and inter-group comparability, and to avoid experimental errors caused by differences in human operation.

[0003] Currently, commercially available mouse pain stimulation devices have significant technical defects. Most existing devices are simple manual tools (such as sharp probes and fixed-size puncture needles), lacking precise positioning and depth adjustment structures. The stimulation position relies entirely on the operator's visual judgment and hand control, which can easily cause the stimulation point to shift due to slight mouse movement or tremors during operation. This makes it impossible to stably act on the target nerve or tissue area. The insertion depth is entirely controlled by the operator's feel, resulting in a difference of 0.5 to 1 mm in insertion depth between different experiments and between different operators, leading to uneven stimulation intensity. In some experiments, the insertion is too deep, causing tissue damage, or too shallow, failing to reach the effective stimulation threshold. Therefore, improvements are urgently needed. Summary of the Invention

[0004] In view of the shortcomings of the existing technology, the purpose of this invention is to provide an adjustable stimulation application device for mouse pain experiments, which aims to solve the above-mentioned technical problems.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: an adjustable stimulation application device for mouse pain experiment, comprising an operating base and a control device fixedly mounted on the operating base, wherein a surgical fixation table for mounting and fixing a mouse device is fixedly mounted on the operating base, a fixing block is fixedly mounted on the operating base, a longitudinal groove is formed in the fixing block, a horizontal adjustment mechanism is provided on the fixing block, an insertion mechanism is provided on the horizontal adjustment mechanism, the insertion mechanism is used to insert into mouse tissue to apply pain stimulation to the mouse, and a longitudinal adjustment part is provided on the fixing block for adjusting the position of the horizontal adjustment mechanism.

[0006] Preferably, the horizontal adjustment mechanism includes:

[0007] An L-shaped block is disposed on the fixing block, and one end of the L-shaped block extends into the longitudinal groove and is slidably connected to the longitudinal groove. A transverse groove is provided on the surface of the surgical fixation table facing the L-shaped block.

[0008] A horizontal adjustment section is provided on the L-shaped block, and the horizontal adjustment section is used to adjust the position of the insertion mechanism.

[0009] Preferably, the horizontal adjustment section includes:

[0010] A first motor is mounted on the L-shaped block and fixedly connected to the L-shaped block. The first motor is electrically connected to the control device.

[0011] A horizontal adjustment screw is located in the horizontal groove, and the end of the horizontal adjustment screw closer to the first motor is fixedly connected to the output end of the first motor, while the end of the horizontal adjustment screw away from the first motor is rotatably connected to the L-shaped block.

[0012] Preferably, the insertion mechanism includes:

[0013] A horizontal slider is slidably disposed in the horizontal groove. A first internal groove is provided on the surface of the horizontal slider near the operating base. The horizontal slider is threadedly connected to the horizontal adjustment screw.

[0014] A hydraulic push rod is located in the first built-in groove and is fixedly connected to the horizontal slider. The hydraulic push rod is electrically connected to the control device.

[0015] The bearing portion is mounted on the hydraulic push rod;

[0016] A fixing part is provided on the supporting part;

[0017] An auxiliary part is provided on the fixing part;

[0018] An insertion portion is provided on the supporting portion, and the insertion portion is used to penetrate mouse tissue for stimulation;

[0019] A pushing part is provided on the insertion part.

[0020] Preferably, the supporting part includes:

[0021] A support plate is fixedly mounted on the hydraulic push rod, and a second built-in groove is provided on the surface of the support plate near the operating base;

[0022] There are two connecting plates, and the two connecting plates are symmetrically distributed on the surface of the support plate near the operating base.

[0023] Preferably, the fixing part includes:

[0024] A fixing sleeve is located between two connecting plates and is fixedly connected to the adjacent connecting plate.

[0025] A limiting cylinder is fixedly inserted into a fixed sleeve. An annular groove is formed on the inner wall of the limiting cylinder, and multiple evenly distributed guide grooves are formed in the annular groove.

[0026] Preferably, the auxiliary part includes:

[0027] A fixed cylinder is slidably disposed inside the limiting cylinder. A first annular plate is fixedly disposed at the end of the fixed cylinder away from the operating base. The first annular plate is slidably connected to the annular groove.

[0028] The guide rods are multiple and evenly distributed on the surface of the first ring plate near the operating base. The guide rods are fixedly connected to the first ring plate and slidably connected to the guide groove.

[0029] A first spring is sleeved on the guide rod, and the first spring is always in a compressed state.

[0030] Preferably, the insertion portion includes:

[0031] The insertion needle is slidably positioned within the fixed cylinder;

[0032] A sliding plate is slidably disposed inside the fixed cylinder, and the sliding plate is fixedly connected to the end of the piercing needle away from the operating base. A second spring is provided on the surface of the sliding plate near the operating base. In the initial state, the surface of the sliding plate away from the operating base is flush with the surface of the first ring plate away from the operating base. The second spring is used to drive the piercing needle to reset.

[0033] Preferably, the pushing part includes:

[0034] An electric push rod is located in the second built-in groove and is fixedly connected to the support plate. The electric push rod is electrically connected to the control device.

[0035] A push rod is fixedly mounted on the output end of the electric push rod, and a second ring plate is fixedly mounted on the push rod. The push rod is used to push the insertion needle to slide inside the fixed cylinder.

[0036] A push cover is slidably sleeved on a push rod, and the push cover is used to push the fixed cylinder to slide towards the operating base;

[0037] The device has multiple fixing rods, which are evenly distributed inside the push cover and are fixedly connected to the push cover.

[0038] The third spring is sleeved on the fixed rod, and the ends of the third spring are fixedly connected to the push cover and the second ring plate respectively. The third spring is always in a compressed state, and the elastic coefficient of the third spring is greater than that of the first spring.

[0039] Preferably, the longitudinal adjustment section includes:

[0040] The second motor is fixedly mounted on the fixed block and electrically connected to the control device.

[0041] The longitudinal adjustment screw is located in the longitudinal groove, and the end of the longitudinal adjustment screw closer to the second motor is fixedly connected to the output end of the second motor. The end of the longitudinal adjustment screw away from the second motor is rotatably connected to the fixed block. The longitudinal adjustment screw is threadedly connected to the L-shaped block.

[0042] In summary, due to the adoption of the above technical solutions, the beneficial effects of the present invention are: the device can accurately control the application position and insertion depth of the pain stimulus, meet the control requirements of different stimulus intensities in pain experiments, effectively improve the consistency and accuracy of stimulus application in mouse pain experiments, and reduce experimental errors caused by manual operation. Attached Figure Description

[0043] To more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0044] Figure 1 A three-dimensional schematic diagram of an adjustable stimulation application device for a mouse pain experiment is shown.

[0045] Figure 2 A front view of an adjustable stimulus application device for a mouse pain experiment is shown.

[0046] Figure 3 A side view of an adjustable stimulus application device for a mouse pain experiment is shown.

[0047] Figure 4 It shows Figure 3 Sectional view of AA.

[0048] Figure 5 It shows Figure 4 Enlarged view of the local structure at point A in the middle.

[0049] Figure 6 A top view of an adjustable stimulus application device for a mouse pain experiment is shown.

[0050] Figure 7 A quarter-section view of the insertion mechanism is shown.

[0051] Figure 8 It shows Figure 7 Enlarged view of the local structure at point B.

[0052] Legend:

[0053] 1. Operating base; 2. Control device; 3. Surgical fixation table; 4. Fixing block; 5. Longitudinal groove; 6. L-shaped block; 7. Transverse groove; 8. First motor; 9. Transverse adjustment screw; 10. Transverse slider; 11. First internal groove; 12. Hydraulic push rod; 13. Bearing plate; 14. Second internal groove; 15. Connecting plate; 16. Fixing sleeve; 17. Limiting cylinder; 18. Annular groove; 19. Guide groove; 20. Fixing cylinder; 21. First annular plate; 22. Guide rod; 23. First spring; 24. Insertion needle; 25. Sliding plate; 26. Second spring; 27. Electric push rod; 28. Push rod; 29. ​​Second annular plate; 30. Push cover; 31. Fixing rod; 32. Third spring; 33. Second motor; 34. Longitudinal adjustment screw. Detailed Implementation

[0054] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0055] In the description of this invention, it should be understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0056] It should be noted that when a component is described as "fixed to" another component, it can be directly on the other component or may have a component in between. When a component is considered "connected to" another component, it can be directly connected to the other component or may have a component in between. When a component is considered "set on" another component, it can be directly set on the other component or may have a component in between. The terms "vertical," "horizontal," "left," "right," and similar expressions used in this document are for illustrative purposes only.

[0057] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this invention, "a plurality of" means two or more, unless otherwise explicitly specified.

[0058] Reference Figures 1 to 8 The present invention provides a further description of an adjustable stimulation application device for a mouse pain experiment.

[0059] An adjustable stimulation application device for mouse pain testing includes an operating base 1 and a control device 2 fixedly mounted on the operating base 1. A surgical fixation table 3 for mounting and fixing a mouse device is fixedly mounted on the operating base 1. A fixing block 4 is fixedly mounted on the operating base 1. A longitudinal groove 5 is formed within the fixing block 4. A horizontal adjustment mechanism is provided on the fixing block 4, the horizontal adjustment mechanism comprising:

[0060] L-shaped block 6 is disposed on the fixing block 4, and one end of L-shaped block 6 extends into the longitudinal groove 5 and is slidably connected to the longitudinal groove 5. A transverse groove 7 is provided on the surface of L-shaped block 6 facing the surgical fixation table 3.

[0061] A horizontal adjustment section is disposed on the L-shaped block 6. The horizontal adjustment section is used to adjust the position of the insertion mechanism. The horizontal adjustment section includes:

[0062] The first motor 8 is mounted on the L-shaped block 6 and is fixedly connected to the L-shaped block 6. The first motor 8 is electrically connected to the control device 2.

[0063] The horizontal adjustment screw 9 is located in the horizontal groove 7, and the end of the horizontal adjustment screw 9 near the first motor 8 is fixedly connected to the output end of the first motor 8, while the end of the horizontal adjustment screw 9 away from the first motor 8 is rotatably connected to the L-shaped block 6.

[0064] In use, the first motor 8 is started by the control device 2, which in turn starts the horizontal adjustment screw 9 fixedly connected to the output end of the first motor 8. Through the threaded transmission cooperation between the horizontal adjustment screw 9 and the horizontal slider 10, the horizontal slider 10 slides in the horizontal groove 7, thereby realizing the adjustment of the lateral position of the horizontal slider 10 set in the horizontal groove 7 on the L-shaped block 6, and completing the lateral adjustment of the pain stimulation application position.

[0065] This device features a lateral adjustment mechanism, allowing for flexible adjustment of the insertion mechanism's lateral position based on the size of the mouse and the desired stimulation location. This eliminates the need to reposition the mouse, improving the accuracy of position adjustment, saving experimental time, ensuring a smooth experimental process, and reducing the difficulty of experimental operation.

[0066] The fixed block 4 is provided with a longitudinal adjustment part for adjusting the position of the horizontal adjustment mechanism, the longitudinal adjustment part including:

[0067] The second motor 33 is fixedly mounted on the fixing block 4 and electrically connected to the control device 2;

[0068] The longitudinal adjustment screw 34 is located in the longitudinal groove 5, and the end of the longitudinal adjustment screw 34 near the second motor 33 is fixedly connected to the output end of the second motor 33. The end of the longitudinal adjustment screw 34 away from the second motor 33 is rotatably connected to the fixed block 4. The longitudinal adjustment screw 34 is threadedly connected to the L-shaped block 6.

[0069] In use, the control device 2 controls the second motor 33 to start, which in turn causes the longitudinal adjustment screw 34, which is fixedly connected to the output end of the second motor 33, to rotate synchronously. Through the threaded transmission between the longitudinal adjustment screw 34 and the L-shaped block 6, the L-shaped block 6 is driven to slide up and down along the longitudinal groove 5, thereby adjusting the longitudinal position of the entire transverse adjustment mechanism and the insertion mechanism. This adapts to the stimulation position requirements of mice of different sizes, and position calibration can be quickly completed without readjusting the fixed position of the mouse, further improving the efficiency of experimental operation and reducing position errors caused by manual adjustment.

[0070] This device features a longitudinal adjustment section, allowing for precise adjustment of the insertion mechanism's position in the longitudinal direction. Combined with a transverse adjustment mechanism, it enables multi-dimensional and precise control of the stimulation application location, further enhancing the device's adaptability and meeting the needs of mouse pain experiments with different specifications and experimental protocols.

[0071] The horizontal adjustment mechanism is provided with a piercing mechanism, the piercing mechanism comprising:

[0072] A horizontal slider 10 is slidably disposed in the horizontal groove 7. A first internal groove 11 is provided on the surface of the horizontal slider 10 near the operating base 1. The horizontal slider 10 is threadedly connected to the horizontal adjustment screw 9.

[0073] The hydraulic push rod 12 is located in the first built-in groove 11 and is fixedly connected to the horizontal slider 10. The hydraulic push rod 12 is electrically connected to the control device 2.

[0074] A support portion is disposed on the hydraulic push rod 12, and the support portion includes:

[0075] A support plate 13 is fixedly mounted on the hydraulic push rod 12, and a second built-in groove 14 is provided on the surface of the support plate 13 near the operating base 1.

[0076] There are two connecting plates 15, and the two connecting plates 15 are symmetrically distributed on the surface of the support plate 13 near the operating base 1.

[0077] A fixing part is disposed on the bearing part, the fixing part comprising:

[0078] The fixing sleeve 16 is located between the two connecting plates 15 and is fixedly connected to the adjacent connecting plate 15.

[0079] The limiting cylinder 17 is fixedly installed on the fixing sleeve 16. An annular groove 18 is provided on the inner wall of the limiting cylinder 17, and a plurality of evenly distributed guide grooves 19 are provided in the annular groove 18.

[0080] An auxiliary part is disposed on the fixing part, the auxiliary part comprising:

[0081] A fixed cylinder 20 is slidably disposed within the limiting cylinder 17. A first ring plate 21 is fixedly disposed at the end of the fixed cylinder 20 away from the operating base 1. The first ring plate 21 is slidably connected to the annular groove 18.

[0082] There are multiple guide rods 22, and the multiple guide rods 22 are evenly distributed on the surface of the first ring plate 21 near the operating base 1. The guide rods 22 are fixedly connected to the first ring plate 21 and slidably connected to the guide groove 19. With this arrangement, the multiple sets of guide rods 22 are evenly distributed, which makes the fixed cylinder 20 move smoothly, and the pressure on the mouse skin is uniform, without local pressure damage.

[0083] The first spring 23 is sleeved on the guide rod 22, and the first spring 23 is always in a compressed state.

[0084] An insertion portion, disposed on the support portion, is used to penetrate mouse tissue for stimulation, and the insertion portion includes:

[0085] The insertion needle 24 is slidably disposed inside the fixed cylinder 20. It should be noted that the diameter of the insertion needle 24 is ≤0.3mm, which is a minimally invasive insertion, resulting in less tissue damage to the mouse, thus enabling the mouse to recover quickly and reducing the loss of experimental animals.

[0086] A sliding plate 25 is slidably disposed inside the fixed cylinder 20, and the sliding plate 25 is fixedly connected to the end of the insertion needle 24 away from the operating base 1. A second spring 26 is provided on the surface of the sliding plate 25 near the operating base 1. In the initial state, the surface of the sliding plate 25 away from the operating base 1 is flush with the surface of the first ring plate 21 away from the operating base 1. The second spring 26 is used to drive the insertion needle 24 to reset. It should be noted that the second spring 26 resets quickly and retracts immediately after insertion to avoid traction damage to mouse tissue and reduce experimental stress in mice.

[0087] A pushing part is disposed on the insertion part, the pushing part comprising:

[0088] The electric push rod 27 is located in the second built-in groove 14 and is fixedly connected to the support plate 13. The electric push rod 27 is electrically connected to the control device 2.

[0089] A push rod 28 is fixedly mounted on the output end of the electric push rod 27. A second ring plate 29 is fixedly mounted on the push rod 28. The push rod 28 is used to push the insertion needle 24 to slide within the fixed cylinder 20.

[0090] A push cover 30 is slidably sleeved on a push rod 28. The push cover 30 is used to push the fixed cylinder 20 to slide towards the operating base 1.

[0091] There are multiple fixing rods 31, and the multiple fixing rods 31 are evenly distributed inside the push cover 30. The fixing rods 31 are fixedly connected to the push cover 30.

[0092] The third spring 32 is sleeved on the fixed rod 31, and the ends of the third spring 32 are fixedly connected to the push cover 30 and the second ring plate 29 respectively. The third spring 32 is always in a compressed state, and the elastic coefficient of the third spring 32 is greater than that of the first spring 23. This makes the step-by-step action orderly, first pre-fixing the skin and then inserting the needle, avoiding skin pulling and displacement, so as to improve the accuracy of the data.

[0093] When pain stimulation is required, the hydraulic push rod 12 is activated by the control device 2, causing the support plate 13, which is fixedly connected to the hydraulic push rod 12, to move closer to the surgical fixation table 3. This allows for initial adjustment of the height of the insertion mechanism. Then, the control device 2 activates the electric push rod 27, which pushes the push rod 28 towards the operating base 1. Because the elastic coefficient of the third spring 32 is greater than that of the first spring 23, the third spring 32 will first push the push cover 30 towards the operating base 1. The push cover 30 then pushes the fixing cylinder 20 along the axis of the limiting cylinder 17 towards the smaller... The mouse slides along the direction until the end of the fixed cylinder 20 contacts the mouse's skin. At this point, the fixed cylinder 20 stops moving, and the electric push rod 27 continues to push the push rod 28 to move. The third spring 32 is further compressed, and the end of the push rod 28 pushes the insertion needle 24 to extend from the end of the fixed cylinder 20 and pierce the corresponding tissue of the mouse to complete the application of pain stimulation. After the stimulation is completed, the output end of the electric push rod 27 retracts, the second spring 26 pushes the sliding plate 25 and the insertion needle 24 to reset, and then the first spring 23 pushes the first ring plate 21 to reset, so that the fixed cylinder 20, which is fixedly connected to the first ring plate 21, is reset, completing one stimulation operation.

[0094] This device features an insertion mechanism that allows the fixing cylinder 20 to first contact the mouse skin surface during stimulation application, fixing and limiting the skin in the stimulation area before insertion. This prevents the needle from moving the skin during insertion, reducing deviation in insertion position and improving the precision of stimulation application. It also reduces interference from mouse movement on experimental results, ensuring the accuracy of pain test data. Furthermore, the two-step stimulation process allows for precise control of insertion depth, meeting the stimulation requirements of different experimental intensities and adapting to diverse mouse pain test requirements.

[0095] Working principle: During operation, the device with the mouse to be fixed is installed on the surgical fixation table 3. Then, the hydraulic push rod 12 is activated by the control device 2, so that the support plate 13, which is fixedly connected to the hydraulic push rod 12, moves closer to the surgical fixation table 3, thereby making preliminary adjustment of the height position of the insertion mechanism.

[0096] Subsequently, the first motor 8 and the second motor 33 are activated by the control device 2. The first motor 8 drives the horizontal adjustment screw 9 to rotate, which in turn drives the horizontal slider 10 to slide along the horizontal groove 7. The second motor 33 drives the vertical adjustment screw 34 to rotate, which in turn drives the L-shaped block 6 to slide along the vertical groove 5. This precisely adjusts the horizontal position of the piercing mechanism relative to the mouse stimulation site, ensuring that the piercing position is aligned with the target area.

[0097] After the horizontal position of the insertion mechanism is adjusted, the control device 2 activates the electric push rod 27. The output end of the electric push rod 27 extends and drives the second ring plate 29 to move towards the mouse via the push rod 28. The third spring 32 first pushes the push cover 30 to move synchronously. The push cover 30 pushes the fixed cylinder 20 to slide towards the mouse along the axis of the limiting cylinder 17, so that the end of the fixed cylinder 20 abuts against the skin surface of the mouse stimulation site, pressing and fixing the area around the stimulation site. At this time, the first spring 23 is further compressed. Then the electric push rod 27 continues to push the push rod 28 to move. The second ring plate 29 compresses the third spring 32. The end of the push rod 28 pushes the sliding plate 25 and the insertion needle 24 to move towards the mouse. Finally, the insertion needle 24 extends from the end of the fixed cylinder 20 and pierces the target tissue of the mouse, completing the application of pain stimulation.

[0098] After stimulation, the output end of the electric push rod 27 retracts, the second spring 26 pushes the sliding plate 25 and the insertion needle 24 to reset, and then the first spring 23 pushes the first ring plate 21 to reset, so that the fixed cylinder 20 fixedly connected to the first ring plate 21 is reset, thus completing one stimulation operation.

[0099] The above description of the embodiments enables those skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. An adjustable stimulation application device for mouse pain testing, comprising an operating base (1) and a control device (2) fixedly mounted on the operating base (1), characterized in that, The operating base (1) is fixedly provided with a surgical fixation table (3) for installing and fixing a mouse device. The operating base (1) is fixedly provided with a fixing block (4). The fixing block (4) has a longitudinal groove (5) inside. The fixing block (4) is provided with a horizontal adjustment mechanism. The horizontal adjustment mechanism is provided with an insertion mechanism. The insertion mechanism is used to insert into the mouse tissue to apply pain stimulation to the mouse. The fixing block (4) is provided with a longitudinal adjustment part for adjusting the position of the horizontal adjustment mechanism.

2. The adjustable stimulation application device for mouse pain testing according to claim 1, characterized in that, The horizontal adjustment mechanism includes: An L-shaped block (6) is set on the fixing block (4), and one end of the L-shaped block (6) extends into the longitudinal groove (5) and is slidably connected to the longitudinal groove (5). A transverse groove (7) is opened on the surface of the L-shaped block (6) facing the surgical fixation table (3). A horizontal adjustment section is provided on the L-shaped block (6), and the horizontal adjustment section is used to adjust the position of the insertion mechanism.

3. The adjustable stimulation application device for mouse pain testing according to claim 2, characterized in that, The horizontal adjustment section includes: The first motor (8) is mounted on the L-shaped block (6) and fixedly connected to the L-shaped block (6). The first motor (8) is electrically connected to the control device (2). The horizontal adjustment screw (9) is located in the horizontal groove (7), and the end of the horizontal adjustment screw (9) close to the first motor (8) is fixedly connected to the output end of the first motor (8), while the end of the horizontal adjustment screw (9) away from the first motor (8) is rotatably connected to the L-shaped block (6).

4. The adjustable stimulation application device for mouse pain testing according to claim 3, characterized in that, The insertion mechanism includes: A horizontal slider (10) is slidably disposed in the horizontal groove (7). The surface of the horizontal slider (10) near the operating base (1) is provided with a first internal groove (11). The horizontal slider (10) is threadedly connected to the horizontal adjustment screw (9). The hydraulic push rod (12) is located in the first built-in groove (11) and is fixedly connected to the horizontal slider (10). The hydraulic push rod (12) is electrically connected to the control device (2). The bearing part is disposed on the hydraulic push rod (12); A fixing part is provided on the supporting part; An auxiliary part is provided on the fixing part; An insertion portion is provided on the supporting portion, and the insertion portion is used to penetrate mouse tissue for stimulation; A pushing part is provided on the insertion part.

5. The adjustable stimulation application device for mouse pain testing according to claim 4, characterized in that, The bearing portion includes: The support plate (13) is fixedly mounted on the hydraulic push rod (12), and the surface of the support plate (13) near the operating base (1) is provided with a second built-in groove (14). There are two connecting plates (15), and the two connecting plates (15) are symmetrically distributed on the surface of the bearing plate (13) near the operating base (1).

6. The adjustable stimulation application device for mouse pain testing according to claim 5, characterized in that, The fixing part includes: The fixing sleeve (16) is located between the two connecting plates (15) and is fixedly connected to the adjacent connecting plate (15); The limiting cylinder (17) is fixedly installed on the fixing sleeve (16). An annular groove (18) is provided on the inner wall of the limiting cylinder (17), and multiple evenly distributed guide grooves (19) are provided in the annular groove (18).

7. The adjustable stimulation application device for mouse pain testing according to claim 6, characterized in that, The auxiliary unit includes: A fixed cylinder (20) is slidably disposed inside the limiting cylinder (17). A first ring plate (21) is fixedly disposed at one end of the fixed cylinder (20) away from the operating base (1). The first ring plate (21) is slidably connected to the annular groove (18). The guide rod (22) has multiple rods, and the multiple guide rods (22) are evenly distributed on the surface of the first ring plate (21) near the operating base (1). The guide rod (22) is fixedly connected to the first ring plate (21), and the guide rod (22) is slidably connected to the guide groove (19). The first spring (23) is sleeved on the guide rod (22), and the first spring (23) is always in a compressed state.

8. The adjustable stimulation application device for mouse pain testing according to claim 7, characterized in that, The insertion portion includes: The insertion needle (24) is slidably positioned inside the fixed cylinder (20); The sliding plate (25) is slidably disposed inside the fixed cylinder (20), and the sliding plate (25) is fixedly connected to the end of the piercing needle (24) away from the operating base (1). A second spring (26) is provided on the surface of the sliding plate (25) near the operating base (1). In the initial state, the surface of the sliding plate (25) away from the operating base (1) is flush with the surface of the first ring plate (21) away from the operating base (1). The second spring (26) is used to drive the piercing needle (24) to reset.

9. The adjustable stimulation application device for mouse pain testing according to claim 8, characterized in that, The propulsion unit includes: An electric push rod (27) is located in the second built-in groove (14) and is fixedly connected to the bearing plate (13). The electric push rod (27) is electrically connected to the control device (2). A push rod (28) is fixedly mounted on the output end of the electric push rod (27). A second ring plate (29) is fixedly mounted on the push rod (28). The push rod (28) is used to push the piercing needle (24) to slide inside the fixed cylinder (20). A push cover (30) is slidably sleeved on a push rod (28). The push cover (30) is used to push the fixed cylinder (20) to slide towards the operating base (1). There are multiple fixing rods (31), and the multiple fixing rods (31) are evenly distributed inside the push cover (30). The fixing rods (31) are fixedly connected to the push cover (30). The third spring (32) is sleeved on the fixed rod (31), and the ends of the third spring (32) are fixedly connected to the push cover (30) and the second ring plate (29) respectively. The third spring (32) is always in a compressed state, and the elastic coefficient of the third spring (32) is greater than that of the first spring (23).

10. The adjustable stimulation application device for mouse pain testing according to claim 9, characterized in that, The longitudinal adjustment section includes: The second motor (33) is fixedly mounted on the fixed block (4) and electrically connected to the control device (2); The longitudinal adjustment screw (34) is located in the longitudinal groove (5), and the end of the longitudinal adjustment screw (34) near the second motor (33) is fixedly connected to the output end of the second motor (33), and the end of the longitudinal adjustment screw (34) away from the second motor (33) is rotatably connected to the fixed block (4), and the longitudinal adjustment screw (34) is threadedly connected to the L-shaped block (6).

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