The invention relates to a multi-point and multi-unit controlled large curvature three-dimensional drawing and bending forming device, and belongs to the technical field of metal profile drawing and bending forming. The forming device is mainly composed of base control units, multi-point forming dies, a worktable, a first hydraulic oil cylinder, a limiting element (a pin shaft, a bolt group, a second hydraulic cylinder, a positioning screw) and the other parts. The problem that a skeleton structure of a vehicle body cannot guarantee the consistence of the overall performance of the skeleton structure due to multi-stage forming is solved, a discrete adjustable shape segmented die base structure is designed, a die assembly deformation space in the profile three-dimensional bending process isexpanded, and the curvature radius of bending forming is increased; and the envelope surface shape formed by the multi-point dies on each base unit is adjusted shapes, and the manufacture of a largeintegral three-dimensional bending structural part, such as a three-dimensional bending U-shaped part, is realized. The multi-point and multi-unit controlled large curvature three-dimensional drawingand bending forming device can be widely used in the production of rail vehicle members, aerospace members and various complex and large deformation structural parts in various metal manufacturing industries.