Ginseng capsule and preparation process thereof

Abstract

The present application relates to the field of medical technology, and specifically discloses a ginseng capsule and a preparation process thereof, comprising the following steps: step S1, preparing a chitosan-acetic acid solution; step S2, preparing a ginseng capsule; the drug ingredients are prepared from the following components by mass: 22-30 parts of ginseng, 15-25 parts of turmeric, 12-18 parts of astragalus, 5-10 parts of quercetin, 3-6 parts of cassia twig, and 8-14 parts of fish oil microcapsules; the formula of the present application has simple ingredients and a clear mechanism of action, the prepared ginseng capsule is easy to take orally, the drug has a high solubility, the patient compliance is good, no other treatment methods are required, and the therapeutic effect on hypertension is significant.

Description

Technical Field

[0001] The present application relates to the field of medical technology, and more specifically, to a ginseng capsule and a preparation process thereof. Background Art

[0002] Hypertension can lead to coronary atherosclerotic heart disease (CHD), stroke, heart failure, renal insufficiency and other multi-organ damage, which seriously threatens people's life and health. At present, the clinical treatment of cardiovascular and cerebrovascular diseases mainly focuses on drugs targeting the cause, including antihypertensive drugs, statins, hypoglycemic drugs, etc., which can control symptoms and biochemical indicators, but it is difficult to stop the drug or restore the target organ function, and there are adverse reactions. Traditional Chinese medicine has a multi-component, multi-target, and multi-system regulatory effect in the treatment of hypertension, which can intervene as a whole and promote disease recovery.

[0003] Traditional Chinese medicine believes that "the heart stores the spirit" and "the brain is the home of the primordial spirit", so if the spirit of the brain is injured, it will affect the heart, and if the spirit of the heart is injured, it will affect the brain; the heart governs the blood vessels, and the qi and blood are sufficient to nourish the sea of ​​marrow, so the supply of qi, blood and body fluids to the brain depends on the heart. Adhering to the theoretical basis of "the heart and the brain are closely connected, and the spirit is naturally clear and awake", the traditional Chinese medicine prevention and treatment strategy of "treating the heart and the brain together" is proposed, which mainly includes taking traction, massage, acupuncture, fumigation and other treatment methods, while cooperating with the use of Chinese medicine preparations. However, the above-mentioned traction, massage, acupuncture, fumigation and other treatment methods usually require professional assistance. Although they can control the course of the disease to a certain extent, the treatment effect is slow to take effect, and it is usually difficult for patients to persist for a long time. Existing Chinese medicine preparations for the auxiliary treatment of hypertension usually contain multiple drug ingredients, and there are problems such as complex drug action mechanisms, inability to quickly and accurately treat, and poor stability of treatment effects. Based on the above statements, the present application provides a ginseng capsule and a preparation process thereof. Summary of the invention

[0004] In order to solve the problems that the current traditional Chinese medicine treatment of hypertension is mainly based on the prevention and treatment strategy of traditional Chinese medicine that treats both the heart and the brain, which has the disadvantages of long treatment cycle, poor patient compliance, and treating the symptoms but not the root cause, the present application provides a ginseng capsule and its preparation process.

[0005] A preparation process of ginseng capsules comprises the following steps:

[0006] Step S1, preparing chitosan-acetic acid solution: dissolving chitosan in acetic acid aqueous solution, stirring evenly, filtering through a microporous filter membrane to obtain chitosan-acetic acid solution, wherein the mass ratio of chitosan to acetic acid aqueous solution is 2-4:20;

[0007] Step S2, preparing ginseng capsules: adding gelatin to deionized water, heating to 65-75°C while stirring, stirring evenly, then adding drug components, fish oil microcapsules, adjuvants and emulsifiers, emulsifying reaction for 25-35 minutes, adjusting the pH to 5.8-6.2, adding chitosan-acetic acid solution dropwise while stirring, controlling the dripping to be completed within 30 minutes, continuing stirring for 20-30 minutes, then adding functionalized cellulose nanocrystals, continuing stirring for 3-4 hours, after the reaction is completed, centrifuging at room temperature, washing, and freeze-drying to obtain ginseng capsules, wherein the mass ratio of gelatin, deionized water, drug components, fish oil microcapsules, adjuvants, emulsifiers, chitosan-acetic acid solution and functionalized cellulose nanocrystals is 1-2: 60-80: 12-16: 4-5: 0.2-0.3: 0.02-0.04: 22-24: 0.6-0.8, and in the above reaction process, preparing ginseng capsules by complex coacervation.

[0008] The medicinal composition is prepared from the following components by weight: 22-30 parts of ginseng, 15-25 parts of turmeric, 12-18 parts of astragalus, 5-10 parts of quercetin and 3-6 parts of cassia twig.

[0009] Preferably, the medicinal ingredient is made of the following components by mass: 25 parts of ginseng, 20 parts of turmeric, 15 parts of astragalus, 8 parts of quercetin and 5 parts of cassia twig.

[0010] Preferably, the mass fraction of the acetic acid aqueous solution is 1-3%.

[0011] Preferably, the emulsifier is Tween-20 or Tween-40.

[0012] Preferably, the pore size of the microporous filter membrane is 0.2-0.4 μm.

[0013] Preferably, the auxiliary agent is prepared by mixing a filler, a disintegrant and a lubricant in a mass ratio of 1:1:1-2.

[0014] Preferably, the filler is at least one of microcrystalline cellulose, lactose and glucose.

[0015] Preferably, the disintegrant is sodium carboxymethyl starch or low-substituted hydroxypropyl cellulose.

[0016] Preferably, the lubricant is at least one of magnesium stearate, calcium stearate and talc.

[0017] Preferably, the pharmaceutical composition is prepared by the following steps:

[0018] According to the weight proportion, ginseng, turmeric, astragalus, quercetin and cassia twig are weighed, and the mixture is pulverized together and passed through a 100-200 mesh sieve to obtain a mixed powder; the mixed powder with a mass ratio of 1:9-11 is mixed with an ethanol aqueous solution with a mass fraction of 60-65%, and the mixture is subjected to ultrasonic and electrostatic field enhanced extraction, filtered through gauze, centrifuged, and the supernatant is collected to obtain a crude extract; the crude extract is filtered, freeze-dried, and the drug component is obtained.

[0019] Preferably, in the ultrasonic synergistic electrostatic field enhanced extraction process, the extraction time is 3-4h, the temperature is 50-60°C, the ultrasonic frequency is 20-40kHz, the rated output power is 500-600W, the action mode is uninterrupted continuous action, the static voltage is 15-25kV, and the pulse frequency of the electrostatic field is adjusted by a time controller.

[0020] Preferably, the functionalized cellulose nanocrystals are firstly prepared by acidifying microcrystalline cellulose with sulfuric acid to obtain cellulose nanocrystals, then reacting with octenyl succinic anhydride through a ring-opening esterification reaction to obtain carboxylated cellulose nanocrystals, and finally reacting with gallic acid through an esterification reaction to obtain the functionalized cellulose nanocrystals.

[0021] Preferably, the functionalized cellulose nanocrystals are prepared by the following method:

[0022] Step B1, mixing microcrystalline cellulose and sulfuric acid solution evenly, heating to 50-60°C, stirring for reaction for 1.5-2.5h, adding deionized water, standing for 4-6h, waiting for the reactant to precipitate, removing the supernatant, centrifuging and dialyzing the remaining suspension to neutrality, freeze-drying, and obtaining cellulose nanocrystals, wherein the mass ratio of microcrystalline cellulose, sulfuric acid solution and deionized water is 1:20-30:40-60; using microcrystalline cellulose as raw material, preparing cellulose nanocrystals by sulfuric acid hydrolysis method;

[0023] Step B2, ultrasonically dispersing cellulose nanocrystals and octenyl succinic anhydride in limonene, heating to 110-120° C. under nitrogen protection, stirring and reacting for 18-20 hours, standing for 4-6 hours after the reaction, filtering, washing and drying to obtain carboxylated cellulose nanocrystals, wherein the mass ratio of cellulose nanocrystals, octenyl succinic anhydride and limonene is 1:18-22:100-110, and utilizing the hydroxyl groups on the surface of the cellulose nanocrystals to undergo a ring-opening esterification reaction with the octenyl succinic anhydride to graft the molecular chains containing terminal carboxyl groups and unsaturated double bonds on the surface of the cellulose nanocrystals;

[0024] Step B3, add carboxylated cellulose nanocrystals and acetic acid to triethyl citrate, and add a mixed solution a of gallic acid and triethyl citrate dropwise while stirring, and control the dripping to be completed within 10 minutes. After the dripping is completed, the temperature is raised to 65-75°C, and the reaction is stirred for 6-8 hours. After the reaction is completed, the mixture is filtered, washed, dried, crushed, and sieved through a 30-50 mesh sieve to obtain functionalized cellulose nanocrystals, wherein the mass ratio of carboxylated cellulose nanocrystals, acetic acid, triethyl citrate and mixed solution a is 3-5:0.02-0.04:45-55:15-25, and the mass ratio of gallic acid and triethyl citrate in the mixed solution a is 0.4-0.6:20. In the above reaction process, triethyl citrate is used as a solvent and acetic acid is used as a catalyst, and the active hydroxyl groups on the carboxylated cellulose nanocrystals undergo esterification reaction with gallic acid to obtain functionalized cellulose nanocrystals.

[0025] Preferably, the mass fraction of the sulfuric acid solution is 60-66%.

[0026] Preferably, the fish oil microcapsules are prepared by a complex coacervation method using sodium starch octenylsuccinate, gum arabic and water-soluble arabinoxylan as wall materials and deep-sea fish oil as coating.

[0027] Preferably, the fish oil microcapsules are prepared by the following steps:

[0028] At room temperature, sodium starch octenyl succinate, gum arabic and water-soluble arabinoxylan are added to deionized water, stirred evenly, the pH value is adjusted to 4-5, deep-sea fish oil is added dropwise while stirring, and the dropping is controlled to be completed within 30 minutes. After the dropping is completed, emulsification reaction is carried out for 6-10 minutes, homogenization is carried out for 3-5 minutes, and spray drying is carried out to obtain fish oil microcapsules, wherein the mass ratio of sodium starch octenyl succinate, gum arabic, water-soluble arabinoxylan, deionized water and deep-sea fish oil is 1.2-1.4:2.4-2.6:1.4-1.6:12-16:0.3-0.5.

[0029] Preferably, the inlet air temperature of the spray drying is 130-150°C, the outlet air temperature is 65-75°C, the atomizer speed is 16000-20000rpm, and the feed speed is 25-35rpm.

[0030] A ginseng capsule prepared by the ginseng capsule preparation process.

[0031] In summary, the present application has the following beneficial effects: functionalized cellulose nanocrystals are added to the ginseng capsules prepared in the present invention, and the functionalized cellulose nanocrystals contain cellulose nanocrystal structures, flexible chains and polyphenol structures. The cellulose nanocrystal structure itself has good hydrophilicity, and the flexible chain has hydrophobicity. They can act as emulsifiers together to achieve uniform dispersion of drug ingredients and form a stable microemulsion system, thereby reducing the interfacial tension between the drug and the gastrointestinal fluid, promoting the release and absorption of drug ingredients, increasing the solubility and dissolution of drug ingredients, and improving the bioavailability and chemical stability of drug ingredients. At the same time, the presence of the cellulose nanocrystal structure can not only act as a wall material together with gelatin and chitosan, but the presence of the polyphenol structure can not only form hydrogen bonds with the hydroxyl groups in the drug ingredients, thereby improving their dispersibility, but also promote vasodilation, reduce the activity of platelets, and further reduce the risk of hypertension.

[0032] The medicinal ingredients of the ginseng capsule prepared in the present invention include ginseng, turmeric, astragalus, quercetin, cassia twig and fish oil microcapsules. Among them, ginsenosides, amino acids, vitamins and other ingredients in ginseng help to dilate blood vessels, reduce blood viscosity, thereby improving blood circulation and achieving the effect of lowering blood pressure. Curcumin, as a polyphenol compound, can not only reduce the synthesis and absorption of cholesterol, promote the metabolism of bile acid, regulate fatty acid synthesis and oxidation, thereby reducing the content of blood lipids, but also can prevent and improve hypertension by dilating coronary arteries and increasing myocardial blood supply. Astragalus has the effect of dilating blood vessels, can lower blood pressure, reduce the burden on the heart, and help improve the function of the cardiovascular system. Quercetin not only has extremely strong antioxidant properties, but can also remove free radicals in the body and reduce oxidative stress. It can not only reduce blood pressure by dilating blood vessels and inhibiting the renin-angiotensin-aldosterone system, but also reduce complement activity by inhibiting the mast cell granule reaction caused by IgE, thereby alleviating the inflammatory response and allergic symptoms in hypertension. Fish oil capsules are coated with sodium octenyl succinate starch, gum arabic and water-soluble arabinoxylan as wall materials. Fish oil microcapsules contain long-chain omega-3 fatty acids that can lower blood lipids and blood pressure, and water-soluble arabinoxylan that can not only lower cholesterol levels but also improve antioxidant properties. The combined effect of multiple raw materials can help improve overall physical fitness and effectively treat hypertension. DETAILED DESCRIPTION

[0033] In order to make the implementation methods of the present application easier to understand, the present application will be described in detail below in conjunction with specific examples. These examples are only for illustration and are not limited to the scope of application of the present application.

[0034] The contents of the main raw materials and their components used in the examples and comparative examples are as follows:

[0035] The ginseng is artificially grown ginseng in Changbai Mountain, Jilin Province. The deep-sea fish oil is 99% food-grade deep-sea fish oil produced by Guangdong Hongyou Biotechnology Co., Ltd. The water-soluble arabinoxylan is 80-mesh water-soluble arabinoxylan produced by Lanzhou Waterless Biotechnology Co., Ltd. The sodium octenyl succinate starch is food-grade sodium octenyl succinate starch powder produced by Shaanxi Chenming Biotechnology Co., Ltd. The gum arabic is food-grade gum arabic produced by Xi'an Lavia Biotechnology Co., Ltd. The ethanol involved in this application is all commercially available food-grade ethanol, and turmeric It is commercially available from Bozhou Renyi Chinese Medicine Sales Co., Ltd. under the brand name Renyi, with a purity of 100% and a moisture content of 0%. Astragalus is commercially available from Jilin Yilutang Trading Co., Ltd.; quercetin is commercially available from Hebei Hongtao Bioengineering Co., Ltd. with a CAS number of 117-39-5; cassia twig is commercially available from Yulin Ledu Trading Co., Ltd.; microcrystalline cellulose is commercially available from Shaanxi Chenming Biotechnology Co., Ltd. with a food grade grade; triethyl citrate is commercially available from Aladdin Reagent Network with a CAS number of 77-93-0. In addition, the raw materials not mentioned above are all commercially available.

[0036] The present application is further described in detail below with reference to the embodiments.

[0037] Preparation Examples 1-3 and Comparative Preparation Examples 1-2 provide methods for preparing functionalized cellulose nanocrystals.

[0038] Preparation Example 1

[0039] Functionalized cellulose nanocrystals were prepared by the following method:

[0040] Step B1, stirring microcrystalline cellulose and a 60% sulfuric acid solution at a rotation speed of 500 rpm for 35 minutes until uniform, heating to 50°C, stirring and reacting for 2.5 hours, then adding deionized water, standing for 4 hours, waiting for the reactant to precipitate, removing the supernatant, centrifuging and dialyzing the remaining suspension to neutrality, and then freeze-drying, controlling the freeze-drying temperature to -30°C, the vacuum degree to 11 Pa, and the drying time to 24 hours to obtain cellulose nanocrystals, wherein the mass ratio of microcrystalline cellulose, sulfuric acid solution and deionized water is 1:30:60;

[0041] Step B2, ultrasonically dispersing cellulose nanocrystals and octenyl succinic anhydride in limonene, heating to 110° C. under nitrogen protection, stirring and reacting for 20 hours, standing for 4 hours after the reaction, filtering, washing the filter cake with anhydrous ethanol and deionized water three times in sequence, and then drying at 50° C. to constant weight to obtain carboxylated cellulose nanocrystals, wherein the mass ratio of cellulose nanocrystals, octenyl succinic anhydride and limonene is 1:18:100;

[0042] Step B3, add carboxylated cellulose nanocrystals and acetic acid to triethyl citrate, control the rotation speed to 500rpm, and add a mixed solution a of gallic acid and triethyl citrate dropwise while stirring, and control the dripping to be completed within 10min. After the dripping is completed, the temperature is raised to 65°C, and the reaction is stirred for 6h. After the reaction is completed, the filter is filtered, and the filter cake is washed with anhydrous ethanol and deionized water for 3 times in sequence, and then dried at 45°C to constant weight, crushed, and passed through a 30-mesh sieve to obtain functionalized cellulose nanocrystals, wherein the mass ratio of carboxylated cellulose nanocrystals, acetic acid, triethyl citrate and mixed solution a is 3:0.02:45:15, and the mass ratio of gallic acid and triethyl citrate in the mixed solution a is 0.4:20.

[0043] Preparation Example 2

[0044] Functionalized cellulose nanocrystals were prepared by the following method:

[0045] Step B1, stirring microcrystalline cellulose and a 63% sulfuric acid solution at a rotation speed of 600 rpm for 25 minutes until uniform, heating to 55°C, stirring and reacting for 2 hours, then adding deionized water, standing for 5 hours, waiting for the reactant to precipitate, removing the supernatant, centrifuging and dialyzing the remaining suspension to neutrality, and then freeze-drying, controlling the freeze-drying temperature to -35°C, the vacuum degree to 12 Pa, and the drying time to 28 hours to obtain cellulose nanocrystals, wherein the mass ratio of microcrystalline cellulose, sulfuric acid solution and deionized water is 1:25:50;

[0046] Step B2, ultrasonically dispersing cellulose nanocrystals and octenyl succinic anhydride in limonene, heating to 115° C. and stirring for 19 hours under nitrogen protection, standing for 5 hours after the reaction, filtering, washing the filter cake with anhydrous ethanol and deionized water for 4 times, and then drying at 55° C. to constant weight to obtain carboxylated cellulose nanocrystals, wherein the mass ratio of cellulose nanocrystals, octenyl succinic anhydride and limonene is 1:20:105;

[0047] Step B3, add carboxylated cellulose nanocrystals and acetic acid to triethyl citrate, control the rotation speed to 550rpm, and add a mixed solution a of gallic acid and triethyl citrate dropwise while stirring, and control the dripping to be completed within 10min. After the dripping is completed, the temperature is raised to 70°C, and the reaction is stirred for 7h. After the reaction is completed, filter, wash the filter cake with anhydrous ethanol and deionized water for 4 times in sequence, and then dry it at 50°C to constant weight, crush it, and pass it through a 40-mesh sieve to obtain functionalized cellulose nanocrystals, wherein the mass ratio of carboxylated cellulose nanocrystals, acetic acid, triethyl citrate and mixed solution a is 4:0.03:50:20, and the mass ratio of gallic acid and triethyl citrate in the mixed solution a is 0.5:20.

[0048] Preparation Example 3

[0049] Functionalized cellulose nanocrystals were prepared by the following method:

[0050] Step B1, stirring microcrystalline cellulose and a 66% sulfuric acid solution at a rotation speed of 700 rpm for 15 minutes until uniform, heating to 60°C, stirring for reaction for 1.5 hours, adding distilled water to stop the reaction, standing for 4-6 hours, waiting for the reactant to precipitate, removing the supernatant, centrifuging and dialyzing the remaining suspension to neutrality, and then freeze-drying, controlling the freeze-drying temperature to -40°C, the vacuum degree to 13 Pa, and the drying time to 24 hours to obtain cellulose nanocrystals, wherein the mass ratio of microcrystalline cellulose, sulfuric acid solution and deionized water is 1:20:40;

[0051] Step B2, ultrasonically dispersing cellulose nanocrystals and octenyl succinic anhydride in limonene, heating to 120°C and stirring for reaction for 18 hours under nitrogen protection, standing for 6 hours after the reaction, washing the filter cake with anhydrous ethanol and deionized water for 5 times in sequence, and then drying at 60°C to constant weight to obtain carboxylated cellulose nanocrystals, wherein the mass ratio of cellulose nanocrystals, octenyl succinic anhydride and limonene is 1:22:110;

[0052] Step B3, add carboxylated cellulose nanocrystals and acetic acid to triethyl citrate, control the rotation speed to 600rpm, and add a mixed solution a of gallic acid and triethyl citrate dropwise while stirring, and control the dripping to be completed within 10min. After the dripping is completed, the temperature is raised to 75°C, and the reaction is stirred for 6h. After the reaction is completed, the filter is filtered, and the filter cake is washed with anhydrous ethanol and deionized water for 5 times in sequence, and then dried at 55°C to constant weight, crushed, and passed through a 50-mesh sieve to obtain functionalized cellulose nanocrystals, wherein the mass ratio of carboxylated cellulose nanocrystals, acetic acid, triethyl citrate and mixed solution a is 5:0.04:55:25, and the mass ratio of gallic acid and triethyl citrate in the mixed solution a is 0.6:20.

[0053] Comparative Preparation Example 1

[0054] Step B1, stirring microcrystalline cellulose and a 60% sulfuric acid solution at a rotation speed of 500 rpm for 35 minutes until uniform, heating to 50°C, stirring and reacting for 2.5 hours, then adding deionized water, standing for 4 hours, waiting for the reactant to precipitate, removing the supernatant, centrifuging and dialyzing the remaining suspension to neutrality, and then freeze-drying, controlling the freeze-drying temperature to -30°C, the vacuum degree to 11 Pa, and the drying time to 24 hours to obtain cellulose nanocrystals, wherein the mass ratio of microcrystalline cellulose, sulfuric acid solution and deionized water is 1:30:60;

[0055] Step B2, ultrasonically dispersing cellulose nanocrystals and succinic anhydride in limonene, heating to 110° C. under nitrogen protection, stirring and reacting for 20 hours, standing for 4 hours after the reaction, filtering, washing the filter cake with anhydrous ethanol and deionized water three times in sequence, and then drying at 50° C. to constant weight to obtain carboxylated cellulose nanocrystals, wherein the mass ratio of cellulose nanocrystals, succinic anhydride and limonene is 1:18:100;

[0056] Step B3, add carboxylated cellulose nanocrystals and acetic acid to triethyl citrate, control the rotation speed to 500rpm, and add a mixed solution a of gallic acid and triethyl citrate dropwise while stirring, and control the dripping to be completed within 10min. After the dripping is completed, the temperature is raised to 65°C, and the reaction is stirred for 6h. After the reaction is completed, the filter is filtered, and the filter cake is washed with anhydrous ethanol and deionized water for 3 times in sequence, and then dried at 45°C to constant weight, crushed, and passed through a 30-mesh sieve to obtain functionalized cellulose nanocrystals, wherein the mass ratio of carboxylated cellulose nanocrystals, acetic acid, triethyl citrate and mixed solution a is 3:0.02:45:15, and the mass ratio of gallic acid and triethyl citrate in the mixed solution a is 0.4:20.

[0057] Comparative Preparation Example 2

[0058] Functionalized cellulose nanocrystals were prepared by the following method:

[0059] Step B1, stirring microcrystalline cellulose and a 60% sulfuric acid solution at a rotation speed of 500 rpm for 35 minutes until uniform, heating to 50°C, stirring and reacting for 2.5 hours, then adding deionized water, standing for 4 hours, waiting for the reactant to precipitate, removing the supernatant, centrifuging and dialyzing the remaining suspension to neutrality, and then freeze-drying, controlling the freeze-drying temperature to -30°C, the vacuum degree to 11 Pa, and the drying time to 24 hours to obtain cellulose nanocrystals, wherein the mass ratio of microcrystalline cellulose, sulfuric acid solution and deionized water is 1:30:60;

[0060] Step B2, ultrasonically dispersing cellulose nanocrystals and octenyl succinic anhydride in limonene, heating to 110° C. under nitrogen protection, stirring and reacting for 20 hours, standing for 4 hours after the reaction, filtering, washing the filter cake with anhydrous ethanol and deionized water three times in sequence, and then drying at 50° C. to constant weight to obtain carboxylated cellulose nanocrystals, wherein the mass ratio of cellulose nanocrystals, octenyl succinic anhydride and limonene is 1:18:100;

[0061] Step B3, add carboxylated cellulose nanocrystals and acetic acid to triethyl citrate, control the rotation speed to 500rpm, and add a mixed solution a of lactic acid and triethyl citrate dropwise while stirring, and control the dripping to be completed within 10min. After the dripping is completed, the temperature is raised to 65°C, and the reaction is stirred for 6h. After the reaction is completed, the filter is filtered, and the filter cake is washed with anhydrous ethanol and deionized water for 3 times in sequence, and then dried at 45°C to constant weight, crushed, and passed through a 30-mesh sieve to obtain functionalized cellulose nanocrystals, wherein the mass ratio of carboxylated cellulose nanocrystals, acetic acid, triethyl citrate and mixed solution a is 3:0.02:45:15, and the mass ratio of lactic acid and triethyl citrate in the mixed solution a is 0.4:20.

[0062] Preparation Examples 4-6 and Comparative Preparation Example 3 provide methods for preparing fish oil microcapsules.

[0063] Preparation Example 4

[0064] Fish oil microcapsules are prepared by the following steps:

[0065] At room temperature, sodium starch octenyl succinate, gum arabic and water-soluble arabinoxylan are added to deionized water, and the speed is controlled to be 500 rpm and stirred for 30 minutes until uniform. The pH is adjusted to 4 with a 0.6M citric acid aqueous solution, and fish oil is added dropwise while stirring. The dripping is controlled to be completed within 30 minutes. After the dripping is completed, the speed is adjusted to 1400 rpm for emulsification reaction for 10 minutes, and the speed is maintained unchanged. The pressure is controlled to be 25 MPa and the temperature is 55°C for homogenization for 3 minutes, and spray drying is performed to obtain fish oil microcapsules, wherein the mass ratio of sodium starch octenyl succinate, gum arabic, water-soluble arabinoxylan, deionized water and fish oil is 1.2:2.4:1.4:12:0.3, and the specific process parameters of spray drying are an inlet air temperature of 130°C, an outlet air temperature of 65°C, an atomizer speed of 16000 rpm, and a feed rate of 25 rpm.

[0066] Preparation Example 5

[0067] Fish oil microcapsules are prepared by the following steps:

[0068] At room temperature, sodium starch octenyl succinate, gum arabic and water-soluble arabinoxylan are added to deionized water and stirred evenly. The pH is adjusted to 4.5 with a 0.8M citric acid aqueous solution, and fish oil is added dropwise while stirring. The dripping is controlled to be completed within 30 minutes. After the dripping is completed, the rotation speed is adjusted to 1500rpm for emulsification reaction for 8 minutes, and the rotation speed is maintained unchanged. The pressure is controlled to be 30MPa and the temperature is controlled to be 60℃ for homogenization for 4 minutes, and the fish oil microcapsules are spray-dried. The mass ratio of sodium starch octenyl succinate, gum arabic, water-soluble arabinoxylan, deionized water and fish oil is 1.3:2.5:1.5:14:0.4, and the specific process parameters of spray drying are an inlet air temperature of 140℃, an outlet air temperature of 80℃, an atomizer speed of 18000rpm, and a feed rate of 30rpm.

[0069] Preparation Example 6

[0070] Fish oil microcapsules are prepared by the following steps:

[0071] At room temperature, sodium starch octenyl succinate, gum arabic and water-soluble arabinoxylan are added to deionized water and stirred evenly. The pH is adjusted to 5 with a 1.0M citric acid aqueous solution, and fish oil is added dropwise while stirring. The dripping is controlled to be completed within 30 minutes. After the dripping is completed, the rotation speed is adjusted to 1600rpm for emulsification reaction for 6 minutes, and the rotation speed is maintained unchanged. The pressure is controlled to be 35MPa and the temperature is controlled to be 65℃ for homogenization for 5 minutes, and the fish oil microcapsules are spray-dried. The mass ratio of sodium starch octenyl succinate, gum arabic, water-soluble arabinoxylan, deionized water and fish oil is 1.4:2.6:1.6:16:0.5, and the specific process parameters of spray drying are as follows: an inlet air temperature of 140℃, an outlet air temperature of 80℃, an atomizer speed of 20000rpm, and a feed speed of 35rpm.

[0072] Comparative Preparation Example 3

[0073] Fish oil microcapsules are prepared by the following steps:

[0074] At room temperature, sodium starch octenyl succinate, gum arabic and glucose are added to deionized water, and the speed is controlled to be 500 rpm and stirred for 30 minutes until uniform, and the pH is adjusted to 4 with 0.6M citric acid aqueous solution, and fish oil is added dropwise while stirring, and the dripping is controlled within 30 minutes. After the dripping is completed, the speed is adjusted to 1400 rpm for emulsification reaction for 10 minutes, and the speed is maintained unchanged. The pressure is controlled to be 25 MPa and the temperature is 55°C for homogenization for 3 minutes, and spray drying is performed to obtain fish oil microcapsules, wherein the mass ratio of sodium starch octenyl succinate, gum arabic, glucose, deionized water and fish oil is 1.2:2.4:1.4:12:0.3, and the specific process parameters of spray drying are an inlet air temperature of 130°C, an outlet air temperature of 65°C, an atomizer speed of 16000 rpm, and a feed rate of 25 rpm.

[0075] Preparation Examples 7-9 provide methods for preparing the pharmaceutical ingredients.

[0076] Preparation Example 7

[0077] The drug component is prepared by the following steps:

[0078] Step A1, prepare the following raw materials by weight: 22 parts of ginseng, 15 parts of turmeric, 12 parts of astragalus, 5 parts of quercetin and 3 parts of cassia twig;

[0079] Step A2, weigh ginseng, turmeric, astragalus, quercetin and cassia twig by mass, grind them together and pass through a 200-mesh sieve to obtain a mixed powder; mix the mixed powder with a mass ratio of 1:9 and an ethanol aqueous solution with a mass fraction of 60%, perform ultrasound-assisted electrostatic field enhanced extraction, filter through gauze, centrifuge, collect the supernatant, and obtain a crude extract; filter the crude extract, and then freeze-dry it to obtain the drug component, wherein, in the ultrasound-assisted electrostatic field enhanced extraction process, the extraction time is 3h, the temperature is 50°C, the ultrasonic frequency is 20kHz, the rated output power is 500W, the action mode is uninterrupted continuous action, the static voltage is 15kV, the pulse frequency of the electrostatic field is adjusted by a time controller, the freeze-drying temperature is controlled to be -35°C, the vacuum degree is 13Pa, and the drying time is 32h.

[0080] Preparation Example 8

[0081] The drug component is prepared by the following steps:

[0082] Step A1, prepare the following raw materials by weight: 26 parts of ginseng, 20 parts of turmeric, 15 parts of astragalus, 8 parts of quercetin and 5 parts of cassia twig;

[0083] Step A2, weigh ginseng, turmeric, astragalus, quercetin, and cassia twig by mass, and grind them together to pass through a 150-mesh sieve to obtain a mixed powder; mix the mixed powder with a mass ratio of 1:10 and an ethanol aqueous solution with a mass fraction of 62%, perform ultrasound-assisted electrostatic field enhanced extraction, filter through gauze, centrifuge, collect the supernatant, and obtain a crude extract; filter the crude extract, and then freeze-dry it to obtain the drug component. During the ultrasound-assisted electrostatic field enhanced extraction process, the extraction time is 3.5 hours, the temperature is 55°C, the ultrasonic frequency is 30kHz, the rated output power is 550W, the action mode is uninterrupted continuous action, the static voltage is 20kV, and the pulse frequency of the electrostatic field is adjusted by a time controller to control the freeze-drying temperature to -32°C, the vacuum degree to 14Pa, and the drying time to 36 hours.

[0084] Preparation Example 9

[0085] The drug component is prepared by the following steps:

[0086] Step A1, prepare the following raw materials by weight: 30 parts of ginseng, 25 parts of turmeric, 18 parts of astragalus, 10 parts of quercetin and 6 parts of cassia twig;

[0087] Step A2, weigh ginseng, turmeric, astragalus, quercetin and cassia twig by mass, grind them together and pass through a 200-mesh sieve to obtain a mixed powder; mix the mixed powder with a mass ratio of 1:11 and an ethanol aqueous solution with a mass fraction of 65%, perform ultrasound-assisted electrostatic field enhanced extraction, filter through gauze, centrifuge, collect the supernatant, and obtain a crude extract; filter the crude extract, and then freeze-dry it to obtain the drug component. During the ultrasound-assisted electrostatic field enhanced extraction process, the extraction time is 4 hours, the temperature is 60°C, the ultrasonic frequency is 40kHz, the rated output power is 600W, the action mode is uninterrupted continuous action, the static voltage is 25kV, and the pulse frequency of the electrostatic field is adjusted by a time controller to control the freeze-drying temperature to -30°C, the vacuum degree to 15Pa, and the drying time to 40 hours.

[0088] Examples 1-3 and Comparative Examples 1-3 provide a preparation process for a ginseng capsule.

[0089] Example 1

[0090] This embodiment provides a preparation process of ginseng capsules, comprising the following steps:

[0091] Step S1, preparing chitosan-acetic acid solution: adding chitosan to 1% acetic acid aqueous solution by mass, stirring at a speed of 600 rpm for 40 min until uniform, filtering through a 0.2 μm microporous filter membrane to obtain a chitosan-acetic acid solution, wherein the mass ratio of chitosan to acetic acid aqueous solution is 2:20;

[0092] Step S2, preparing ginseng capsules: gelatin was added to deionized water, heated to 65°C while stirring, and stirred at a speed of 700 rpm for 30 min until uniform, and then the drug component prepared in Preparation Example 7, the fish oil microcapsules prepared in Preparation Example 4, the adjuvant and Tween-20 were added, and the speed was adjusted to 1200 rpm for emulsification reaction for 35 min, and the pH was adjusted to 5.8 with 0.6 M citric acid aqueous solution, and chitosan-acetic acid solution was added dropwise while stirring, and the dripping was controlled within 30 min, and the speed was adjusted to 400 rpm and continued to stir for 20 min, and then the functional prepared in Preparation Example 1 was added. The gelatinized cellulose nanocrystals were stirred for 3 hours. After the reaction, the mixture was centrifuged at room temperature, washed with anhydrous ethanol and deionized water for three times, and freeze-dried. The freeze-drying temperature was controlled to be -24°C, the vacuum degree was 11 Pa, and the drying time was 26 hours to obtain ginseng capsules, wherein the mass ratio of gelatin, deionized water, drug components, fish oil microcapsules, adjuvants, emulsifiers, chitosan-acetic acid solution and functionalized cellulose nanocrystals was 1:60:12:4:0.2:0.02:22:0.6, and the adjuvant was a mixture of microcrystalline cellulose, low-substituted hydroxypropyl cellulose and magnesium stearate in a mass ratio of 1:1:1.

[0093] Example 2

[0094] This embodiment provides a preparation process of ginseng capsules, comprising the following steps:

[0095] Step S1, preparing chitosan-acetic acid solution: adding chitosan to acetic acid aqueous solution with a mass fraction of 2%, stirring for 30 minutes at a speed of 700 rpm until uniform, and then filtering through a 0.3 μm microporous filter membrane to obtain chitosan-acetic acid solution, wherein the mass ratio of chitosan to acetic acid aqueous solution is 3:20;

[0096] Step S2, preparing ginseng capsules: gelatin was added to deionized water, the temperature was raised to 70°C while stirring, the speed was controlled to be 750 rpm and stirred for 25 min until uniform, then the drug component prepared in Preparation Example 8, the fish oil microcapsules prepared in Preparation Example 5, the adjuvant and Tween-40 were added, the speed was adjusted to 1300 rpm for emulsification reaction for 30 min, the pH was adjusted to 6.0 with 0.8 M citric acid aqueous solution, chitosan-acetic acid solution was added dropwise while stirring, and the dripping was controlled to be completed within 30 min, the speed was adjusted to 450 rpm and the stirring was continued for 25 min, and then the functional prepared in Preparation Example 2 was added The cellulose nanocrystals were stirred for 3.5 hours. After the reaction, the mixture was centrifuged at room temperature, washed with anhydrous ethanol and deionized water for four times, and freeze-dried. The freeze-drying temperature was controlled to be -26°C, the vacuum degree was 12 Pa, and the drying time was 28 hours to obtain ginseng capsules, wherein the mass ratio of gelatin, deionized water, drug components, fish oil microcapsules, adjuvants, emulsifiers, chitosan-acetic acid solution and functionalized cellulose nanocrystals was 1.5:70:14:4.5:0.25:0.03:23:0.7, wherein the adjuvant was lactose, and lactose and calcium stearate were mixed in a mass ratio of 1:1:1.5.

[0097] Example 3

[0098] This embodiment provides a preparation process of ginseng capsules, comprising the following steps:

[0099] Step S1, preparing chitosan-acetic acid solution: adding chitosan to 3% acetic acid aqueous solution, stirring at a speed of 800 rpm for 20 min until uniform, and then filtering through a 0.4 μm microporous filter membrane to obtain a chitosan-acetic acid solution, wherein the mass ratio of chitosan to acetic acid aqueous solution is 4:20;

[0100] Step S2, preparing ginseng capsules: gelatin was added to deionized water, the temperature was raised to 75°C while stirring, the speed was controlled to be 800 rpm and stirred for 20 min until uniform, then the drug component prepared in Preparation Example 9, the fish oil microcapsules prepared in Preparation Example 6, the adjuvant and Tween-20 were added, the speed was adjusted to 1400 rpm for emulsification reaction for 25 min, the pH was adjusted to 6.2 with 1.0 M citric acid aqueous solution, chitosan-acetic acid solution was added dropwise while stirring, and the dripping was controlled within 30 min, the speed was adjusted to 500 rpm and the stirring was continued for 30 min, and then the prepared in Preparation Example 3 was added The functionalized cellulose nanocrystals were stirred for 4 hours. After the reaction was completed, they were centrifuged at room temperature, washed with anhydrous ethanol and deionized water for 5 times, and freeze-dried. The freeze-drying temperature was controlled at -28°C, the vacuum degree was 13 Pa, and the drying time was 30 hours to obtain ginseng capsules, wherein the mass ratio of gelatin, deionized water, drug components, fish oil microcapsules, adjuvants, emulsifiers, chitosan-acetic acid solution and functionalized cellulose nanocrystals was 2:80:16:5:0.3:0.04:24:0.8, wherein the adjuvant was a mixture of glucose, sodium carboxymethyl starch and talc in a mass ratio of 1:1:2.

[0101] Comparative Example 1

[0102] This comparative example provides a preparation process of ginseng capsules, comprising the following steps:

[0103] Step S1, preparing chitosan-acetic acid solution: adding chitosan to 1% acetic acid aqueous solution by mass, stirring at a speed of 600 rpm for 40 min until uniform, filtering through a 0.2 μm microporous filter membrane to obtain a chitosan-acetic acid solution, wherein the mass ratio of chitosan to acetic acid aqueous solution is 2:20;

[0104] Step S2, preparing ginseng capsules: gelatin was added to deionized water, the temperature was raised to 65°C while stirring, the speed was controlled to be 700 rpm and stirred for 30 min until uniform, and then the drug component prepared in Preparation Example 7, the fish oil microcapsules prepared in Preparation Example 4, the adjuvant and Tween-20 were added, the speed was adjusted to 1200 rpm for emulsification reaction for 35 min, the pH was adjusted to 5.8 with 0.6 M citric acid aqueous solution, chitosan-acetic acid solution was added dropwise while stirring, and the dripping was controlled within 30 min, the speed was adjusted to 400 rpm and the stirring was continued for 20 min, and then the comparative preparation example 1 was added The obtained functionalized cellulose nanocrystals were stirred for 3 hours. After the reaction, they were centrifuged at room temperature, washed with anhydrous ethanol and deionized water for three times, and freeze-dried. The freeze-drying temperature was controlled to be -24°C, the vacuum degree was 11 Pa, and the drying time was 26 hours to obtain ginseng capsules, wherein the mass ratio of gelatin, deionized water, drug ingredients, fish oil microcapsules, adjuvants, emulsifiers, chitosan-acetic acid solution and functionalized cellulose nanocrystals was 1:60:12:4:0.02:22:0.6, and the adjuvant was a mixture of microcrystalline cellulose, low-substituted hydroxypropyl cellulose and magnesium stearate in a mass ratio of 1:1:1.

[0105] Comparative Example 2

[0106] This comparative example provides a preparation process of ginseng capsules, comprising the following steps:

[0107] Step S1, preparing chitosan-acetic acid solution: adding chitosan to 1% acetic acid aqueous solution by mass, stirring at a speed of 600 rpm for 40 min until uniform, filtering through a 0.2 μm microporous filter membrane to obtain a chitosan-acetic acid solution, wherein the mass ratio of chitosan to acetic acid aqueous solution is 2:20;

[0108] Step S2, preparing ginseng capsules: gelatin was added to deionized water, the temperature was raised to 65°C while stirring, the speed was controlled to be 700 rpm and stirred for 30 min until uniform, then the drug component prepared in Preparation Example 7, the fish oil microcapsules prepared in Preparation Example 4, the adjuvant and Tween-20 were added, the speed was adjusted to 1200 rpm for emulsification reaction for 35 min, the pH was adjusted to 5.8 with 0.6 M citric acid aqueous solution, chitosan-acetic acid solution was added dropwise while stirring, and the dripping was controlled to be completed within 30 min, the speed was adjusted to 400 rpm and the stirring was continued for 20 min, and then the comparative preparation example 2 was added The obtained functionalized cellulose nanocrystals were stirred for 3 hours. After the reaction, they were centrifuged at room temperature, washed with anhydrous ethanol and deionized water for three times, and freeze-dried. The freeze-drying temperature was controlled to be -24°C, the vacuum degree was 11 Pa, and the drying time was 26 hours to obtain ginseng capsules, wherein the mass ratio of gelatin, deionized water, drug ingredients, fish oil microcapsules, adjuvants, emulsifiers, chitosan-acetic acid solution and functionalized cellulose nanocrystals was 1:60:12:4:0.02:22:0.6, and the adjuvant was a mixture of microcrystalline cellulose, low-substituted hydroxypropyl cellulose and magnesium stearate in a mass ratio of 1:1:1.

[0109] Comparative Example 3

[0110] This comparative example provides a preparation process of ginseng capsules, comprising the following steps:

[0111] Step S1, preparing chitosan-acetic acid solution: adding chitosan to 1% acetic acid aqueous solution by mass, stirring at a speed of 600 rpm for 40 min until uniform, filtering through a 0.2 μm microporous filter membrane to obtain a chitosan-acetic acid solution, wherein the mass ratio of chitosan to acetic acid aqueous solution is 2:20;

[0112] Step S2, preparing ginseng capsules: gelatin was added to deionized water, the temperature was raised to 65°C while stirring, the speed was controlled to be 700 rpm and stirred for 30 min until uniform, and then the drug component prepared in Preparation Example 7, the fish oil microcapsules prepared in Comparative Preparation Example 3, the adjuvant and Tween-20 were added, the speed was adjusted to 1200 rpm for emulsification reaction for 35 min, the pH was adjusted to 5.8 with 0.6 M citric acid aqueous solution, chitosan-acetic acid solution was added dropwise while stirring, and the dripping was controlled within 30 min, the speed was adjusted to 400 rpm and the stirring was continued for 20 min, and then the preparation in Preparation Example 1 was added. The obtained functionalized cellulose nanocrystals were stirred for 3 hours. After the reaction, they were centrifuged at room temperature, washed three times with anhydrous ethanol and deionized water respectively, and freeze-dried. The freeze-drying temperature was controlled to be -24°C, the vacuum degree was 11 Pa, and the drying time was 26 hours to obtain ginseng capsules, wherein the mass ratio of gelatin, deionized water, drug components, adjuvants, emulsifiers, chitosan-acetic acid solution and functionalized cellulose nanocrystals was 1:60:12:0.2:0.02:22:0.6, and the adjuvant was microcrystalline cellulose, low-substituted hydroxypropyl cellulose and magnesium stearate mixed in a mass ratio of 1:1:1.

[0113] 1. Treatment effect test

[0114] The therapeutic effect tests were performed on the drug components prepared in Preparation Examples 1-3 of the present application and Comparative Preparation Examples 1-3, respectively.

[0115] 1. Experimental content: The experimental animals were provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., 7-week-old salt-resistant rats weighing 190-210g (license number SCXK (Beijing) 2016-0006), a total of 6, half male and half female, as a blank control group, 7-week-old salt-sensitive rats weighing 190-210g (license number SCXK (Beijing) 2016-0006), a total of 42, half male and half female, randomly divided into 7 groups, 6 rats in each group, named Preparation Examples 1-3 Group, Comparative Preparation Examples 1-3 Group and Model Group, the above rats were placed at a temperature of 22±1°C and a humidity of 45±5%, and adaptively raised for one week. The intelligent non-invasive sphygmomanometer was used for detection, and there was no difference among the groups.

[0116] 2. Establishment of hypertension disease model: Except for the blank control group, all rats were constructed with a hypertension disease model. The specific method was as follows: the rats were fed with 8% NaCl high-salt feed (provided by Beijing Keao Xieli Feed Co., Ltd.) for 28 days, during which the blood pressure of the rats was monitored with an intelligent non-invasive sphygmomanometer to establish a hypertensive rat model.

[0117] 3. Model evaluation method: When the blood pressure value of the rats rises to above 140 mmHg / 90 mmHg 28 days after modeling, it is determined to be a hypertensive rat model.

[0118] 4. Drug treatment: The model rats were treated 2 weeks after the modeling was completed. Specifically, the rats in the Preparation Example 1-3 and the Comparative Preparation Example 1-3 groups were orally treated with 80 mg / kg / d of the drug components prepared in the Preparation Example 1-3 and the Comparative Preparation Example 1-3 of the present application (prepared with ultrapure water to a drug solution with a mass concentration of 10%), and the blank control group and the model group were given an equal amount of ultrapure water by gavage, and the drug treatment was continued for 5 weeks.

[0119] 5. Measurement of blood pressure in rats

[0120] Measurement method: In a quiet and closed environment, connect the power supply, turn on the host, wait for the set temperature to rise to 39°C, place the rat in the system fixed container, pass the sensor through the rat's tail and fix it at the root of the rat's tail, with appropriate tightness, wait for the animal to be quiet, the tail cuff inflation system automatically pressurizes and deflates, observe the rat's blood pressure waveform on the blood pressure meter display and record it, repeat the measurement 3 times for each rat and take the average value. The measurement time for each rat is 30 minutes to avoid the influence of rat restlessness on blood pressure.

[0121] 6. Statistical methods

[0122] All data were statistically analyzed using SPSS 25.0 software. ±s), LSD test was used for homogeneity of variance among groups, Tamhane's T2(M) test was used for unequal variance, and t-test was used, with P<0.05 as the difference being considered statistically significant.

[0123] Table 1 Comparison of blood pressure changes in rats in each group before and after treatment

[0124] ( ±s, m / s)

[0125]

[0126] Note: Compared with the same group before treatment, P<0.05.

[0127] It can be seen from the data shown in Table 1 above that the drug ingredients prepared in Preparation Examples 1-3 of the present application can significantly improve the changes in blood pressure of rats compared with Comparative Preparation Examples 1-3, and the changes in blood pressure of rats treated with the drug ingredients in Preparation Examples 1-3 of the present application are similar to those of the blank control group; that is, the present application controls the formula ratio, combines the various medicinal flavors according to the relationship between the various medicinal properties of the drugs, and then uses them in ginseng capsules, which can significantly improve the bioavailability of the active ingredients of the drugs, and the therapeutic effect is stable and reliable, and the therapeutic effect on hypertension is significant.

[0128] 2. Drug Dissolution Test

[0129] The dissolution rates of the ginseng capsules prepared in Examples 1-3 of the present application and Comparative Examples 1-3 were tested respectively.

[0130] Test method: One ginseng capsule prepared in Example 1-3 and Comparative Example 1-3 was placed in 1000 mL of sodium dihydrogen phosphate buffer solution at pH 6.8, and stirred at 100 rpm for 120 min using a paddle method. The test results are shown in Table 2 below:

[0131] Table 2 Drug dissolution

[0132]

[0133] From the results shown in Table 2 above, it can be seen that the solubility of the ginseng capsules prepared in Examples 1-3 of the present application is significantly higher than that in Comparative Examples 1-3.

[0134] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. A process for preparing ginseng capsules, characterized in that: The following steps are involved: Step S1, preparing chitosan-acetic acid solution: dissolving chitosan in acetic acid aqueous solution, stirring evenly, filtering through a microporous filter membrane to obtain chitosan-acetic acid solution, wherein the mass ratio of chitosan to acetic acid aqueous solution is 2-4:20; Step S2, preparing ginseng capsules: adding gelatin to deionized water, heating to 65-75° C. while stirring, stirring evenly, then adding drug components, fish oil microcapsules, adjuvants and emulsifiers, emulsifying reaction for 25-35 minutes, adjusting the pH to 5.8-6.2, adding chitosan-acetic acid solution dropwise while stirring, controlling the dripping to be completed within 30 minutes, continuing stirring for 20-30 minutes, then adding functionalized cellulose nanocrystals, continuing stirring for 3-4 hours, centrifuging at room temperature after the reaction, washing, freeze-drying, and obtaining ginseng capsules, wherein the mass ratio of gelatin, deionized water, drug components, fish oil microcapsules, adjuvants, emulsifiers, chitosan-acetic acid solution and functionalized cellulose nanocrystals is 1-2: 60-80: 12-16: 4-5: 0.2-0.3: 0.02-0.04: 22-24: 0.6-0.8; The medicinal composition is prepared from the following components by weight: 22-30 parts of ginseng, 15-25 parts of turmeric, 12-18 parts of astragalus, 5-10 parts of quercetin and 3-6 parts of cassia twig.

2. The preparation process of ginseng capsule according to claim 1, characterized in that: The pharmaceutical composition is prepared by the following steps: According to the weight proportion, ginseng, turmeric, astragalus, quercetin and cassia twig are weighed, and the mixture is pulverized together and passed through a 100-200 mesh sieve to obtain a mixed powder; the mixed powder with a mass ratio of 1:9-11 is mixed with an ethanol aqueous solution with a mass fraction of 60-65%, and the mixture is subjected to ultrasonic and electrostatic field enhanced extraction, filtered through gauze, centrifuged, and the supernatant is collected to obtain a crude extract; the crude extract is filtered, freeze-dried, and the drug component is obtained.

3. The preparation process of ginseng capsule according to claim 2, characterized in that: In the ultrasonic synergistic electrostatic field enhanced extraction process, the extraction time is 3-4h, the temperature is 50-60°C, the ultrasonic frequency is 20-40kHz, the rated output power is 500-600W, the action mode is uninterrupted continuous action, the static voltage is 15-25kV, and the pulse frequency of the electrostatic field is adjusted by a time controller.

4. The preparation process of ginseng capsule according to claim 1, characterized in that: The fish oil microcapsules are prepared by the following steps: At room temperature, sodium starch octenyl succinate, gum arabic and water-soluble arabinoxylan are added to deionized water, stirred evenly, the pH value is adjusted to 4-5, deep-sea fish oil is added dropwise while stirring, and the dropping is controlled to be completed within 30 minutes. After the dropping is completed, emulsification reaction is carried out for 6-10 minutes, homogenization is carried out for 3-5 minutes, and spray drying is carried out to obtain fish oil microcapsules, wherein the mass ratio of sodium starch octenyl succinate, gum arabic, water-soluble arabinoxylan, deionized water and deep-sea fish oil is 1.2-1.4:2.4-2.6:1.4-1.6:12-16:0.3-0.

5.

5. The preparation process of ginseng capsule according to claim 4, characterized in that: The spray drying has an inlet air temperature of 130-150°C, an outlet air temperature of 65-75°C, an atomizer rotation speed of 16000-20000rpm, and a feed speed of 25-35rpm.

6. The preparation process of ginseng capsule according to claim 1, characterized in that: The functionalized cellulose nanocrystals are firstly prepared by acidifying microcrystalline cellulose with sulfuric acid to obtain cellulose nanocrystals, then undergoing a ring-opening esterification reaction with octenyl succinic anhydride to obtain carboxylated cellulose nanocrystals, and finally undergoing an esterification reaction with gallic acid to obtain the functionalized cellulose nanocrystals.

7. The process for preparing ginseng capsule according to claim 6, characterized in that: The functionalized cellulose nanocrystals are prepared by the following method: Step B1, mixing microcrystalline cellulose and sulfuric acid solution evenly, heating to 50-60° C., stirring to react for 1.5-2.5 hours, then adding deionized water, standing for 4-6 hours, waiting for the reactant to precipitate, removing the supernatant, centrifuging and dialyzing the remaining suspension to neutrality, and freeze-drying to obtain cellulose nanocrystals, wherein the mass ratio of microcrystalline cellulose, sulfuric acid solution and deionized water is 1:20-30:40-60; Step B2, ultrasonically dispersing cellulose nanocrystals and octenyl succinic anhydride in limonene, heating to 110-120° C. and stirring for reaction for 18-20 hours under nitrogen protection, standing for 4-6 hours after the reaction, filtering, washing, and drying to obtain carboxylated cellulose nanocrystals, wherein the mass ratio of cellulose nanocrystals, octenyl succinic anhydride, and limonene is 1:18-22:100-110; Step B3, add carboxylated cellulose nanocrystals and acetic acid to triethyl citrate, and add a mixed solution a of gallic acid and triethyl citrate dropwise while stirring, and control the dripping to be completed within 10 minutes. After the dripping is completed, the temperature is raised to 65-75°C, and the reaction is stirred for 6-8 hours. After the reaction is completed, the mixture is filtered, washed, dried, crushed, and sieved through a 30-50 mesh to obtain functionalized cellulose nanocrystals, wherein the mass ratio of carboxylated cellulose nanocrystals, acetic acid, triethyl citrate and mixed solution a is 3-5:0.02-0.04:45-55:15-25, and the mass ratio of gallic acid and triethyl citrate in the mixed solution a is 0.4-0.6:

20.

8. The preparation process of ginseng capsule according to claim 1, characterized in that: The auxiliary agent is prepared by mixing a filler, a disintegrant and a lubricant in a mass ratio of 1:1:1-2.

9. A ginseng capsule prepared by the ginseng capsule preparation process according to any one of claims 1 to 8.

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