Long pepper extract, preparation method thereof, medicament composition and uses thereof

A technology for extracts and compositions, applied in the field of longum extracts, can solve the problems of product safety, toxic solvent residues, low technology content, etc., and achieve the effects of ensuring safety and avoiding organic solvent residues

Active Publication Date: 2009-01-28
北京云威科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] Disclosed in CN 1322543A is carried out ethanol extraction to the longan, and the method for purifying the longan amide alkaloid by saponification, the shortcoming of this method is: (1) used poisonous and carcinogenic solvent benzene in saponification, can cause production Environmental pollution can cause poisoning of production workers, can bring toxic solvent residues, and bring safety problems to products; (2) the technology content of this method is low, and the active ingredient content of the extract is also low, only 6-8%, so the product The effect will not be very good, and you need to take a large amount of extracts, which is more likely to cause safety problems
The disadvantages are: (1) silica gel, alumina column chromatography and high pressure liquid chromatography are not easy to be industrialized; (2) there are environmental problems in using a large amount of silica gel and alumina; (3) the product cost is high; (4) it is difficult to obtain relatively Active parts of polyamide alkaloids

Method used

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  • Long pepper extract, preparation method thereof, medicament composition and uses thereof
  • Long pepper extract, preparation method thereof, medicament composition and uses thereof
  • Long pepper extract, preparation method thereof, medicament composition and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Weigh 7.37kg of longan longan (purchased from Anguo, Hebei), crush it at 20 mesh, add 58.96L of 70% ethanol, soak overnight, stir and extract at room temperature for 4 hours, suction filter, and carry out the second extraction respectively for the residue after the first extraction, Add 44.22L of 70% ethanol to each portion, stir and extract at room temperature for 2h, filter with suction, combine the two extraction filtrates, concentrate to dryness under reduced pressure, and obtain extract (A), weighing 880g; extract (A), place it, and precipitate piperine, suction filtration, remove the precipitate, the mother liquor is evaporated on the water bath to remove the residual ethanol until there is no alcohol smell, and obtain 750g of Piper longum ethanol extract extract (B), and carry out content determination, the result is that the Piper longum ethanol extract extract The total content of eight active ingredients in (B) is 14.11%.

[0055] Prepare 2.2L of 10% KOH solut...

Embodiment 2

[0060] Weigh 7.37 kg of longan longan (purchased from Anguo, Hebei), crush it at 20 mesh, add 58.96 L of 95% ethanol, soak overnight, stir and extract at room temperature for 4 hours, suction filter, and carry out the second extraction respectively for the residue after the first extraction, Add 44.22L of 95% ethanol to each portion, stir and extract at room temperature for 2h, filter with suction, combine the two extraction filtrates, and concentrate to dryness under reduced pressure to obtain extract (A), weighing 662g; piperine, suction filtration, remove the precipitate, the mother liquor is evaporated on the water bath to remove the residual ethanol until there is no alcohol taste, and obtain 556g of Piper longum ethanol extract extract (B), and carry out content determination, the result is that the Piper longum ethanol extract extract The total content of eight active ingredients in (B) is 22.45%.

[0061] Prepare 3.3L of 8% KOH solution, weigh 556g of ethanol extract e...

Embodiment 3

[0064] Weigh 7.37 kg of longan longan (purchased from Anguo, Hebei), crush it at 20 mesh, add 58.96 L of 100% ethanol, soak overnight, stir and extract at room temperature for 4 hours, and suction filter, the residue after the first extraction is respectively extracted for the second time, Add 44.22L of 100% ethanol to each portion, stir and extract at room temperature for 2h, filter with suction, combine the two extraction filtrates, concentrate to dryness under reduced pressure to obtain extract (A), weigh 650g; extract (A), place it, and precipitate piperine, suction filtration, remove the precipitate, the mother liquor is evaporated on the water bath to remove the residual ethanol until there is no alcohol smell, and obtain 550g of the ethanol extract of Piper longum ethanol (B), and carry out content determination, the result is that the ethanol extract of Piper longum ethanol The total content of eight active ingredients in (B) is 20.67%.

[0065] Prepare 5.5L of 20% KOH...

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PUM

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Abstract

The invention relates to a long pepper extract, a preparation method and a medicine combination thereof. The long pepper extract mainly contains methyl piperate and seven piperlongumine compounds, namely, peperlomguminine, piperine, decadiene amide, pepper nonine alkali, quinia, octadecyl triene amide and eicosatriene amide; by weight percentage, the total weight of the eight compounds accounts for 29.07-87.80 % of the total weight of the long pepper extract, wherein, peperlomguminine accounts for 0.95-3.43 % of the total weight of the long pepper extract, piperine accounts for 14.52-42.78 %, methyl piperate 0.82-3.11%, decadiene amide 1.36-4.27%, pepper nonine alkali 2.96-8.03%, quinia 1.04-3.26%, octadecyl triene amide 3.17-10.94% and eicosatriene amide 4.25-12.42%. The invention also provides the preparation method of the long pepper extract, the medicine combination and the application thereof.

Description

technical field [0001] The invention relates to a Piper longum extract, a preparation method thereof, a pharmaceutical composition containing the Piper longum extract and applications thereof. Background technique [0002] Piper Longum (Piper Longum L.) is the near-ripe or mature fruit of Piper Longum L. The fruit is harvested when it turns from green to black, removed from impurities, and dried in the sun. [0003] The functions and indications of Piper longum are warming the middle and dispelling cold, lowering Qi and relieving pain. For cold pain in the abdomen, vomiting, diarrhea, migraine; external treatment of toothache. [0004] The chemical components in Piper longum mainly include amide alkaloids, volatile oils, acids, esters, lignans and other components. Among them, the main active ingredients that have been studied in depth are amide alkaloids, methyl piperonate and volatile oils. Among them, amide alkaloids mainly play a role in reducing blood lipids, cardiov...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/67A61K9/20A61K9/48A61K9/16A61K9/14A61K9/08A61K9/10A23F3/34A61P3/06A61P29/00A61P1/04A61K131/00
Inventor 廖幼鸣王海燕赵颖涛王红刘林刘晔杨福艳田宇熊善丽由丽双韩雪王洪权
Owner 北京云威科技有限公司
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