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Quality detection method of Zhenlong brain-refreshment preparation

A quality inspection method, Zhenlong Xinnao technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems that the quality cannot be well controlled, and the quality of preparations cannot be fully controlled.

Active Publication Date: 2012-02-15
JINHE TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current quality testing standards for Zhenlong Xingnao Capsules include the identification of saffron, pearl, bile acid and cinnamon aldehyde, which cannot fully control the quality of the preparation
At present, there are no related documents and patent reports on the content determination of Zhenlong Xinnao preparation, and the content determination in its quality standard is only the content determination of cinnamon, which cannot control its quality well

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0166] Quality testing method of Zhenlong Xingnao Capsules

[0167] Identification:

[0168] Get product content powder 3g, add ethanol solution 20ml respectively, ultrasonic extraction 30 minutes, filter, and filtrate is concentrated to 10ml, as need testing solution. Take 0.5 g of Piper longum reference medicinal material, and prepare the reference medicinal material solution in the same way. Take another appropriate amount of piperine reference substance, put it in a brown measuring bottle, add absolute ethanol to make a solution containing 0.5mg per 1ml, and use it as the reference substance solution. According to the thin-layer chromatography test, draw the above-mentioned 3 kinds of solutions each 10 mu l, 10 mu l, 5 mu l. Spot on the same silica gel G thin-layer plate, use xylene-ethyl acetate-acetone (6:4:1) as the developing agent, develop, take out, dry in the air, and spray with 10% volume percentage of sulfuric acid ethanol solution color. In the chromatogram...

Embodiment 2

[0182] Quality testing method of Zhenlong Xingnao Capsules

[0183] identify

[0184] Take 1g of product content powder, add 10ml of ethyl acetate, ultrasonically treat for 30 minutes, filter, and concentrate the filtrate to 1ml as the test solution. Take another 0.25 g of cinnamon as a reference drug, and make a solution of the reference drug in the same way. According to thin-layer chromatography Chinese Pharmacopoeia 2010 edition an appendix VI B test, respectively draw above-mentioned 3 kinds of solutions each 10 mu l Spot on the same silica gel G thin-layer plate, use petroleum ether (60-90°C)-ethyl acetate (8.5:1) as developing solvent, take it out, dry it in the air, spray dinitrophenylhydrazine test solution to develop color, Heat until the spots are clear. In the chromatogram of the test product, spots of the same color appear on the positions corresponding to the chromatogram of the control medicinal material.

[0185] Take 2g of product content powder, add 10ml ...

Embodiment 3

[0205] Quality testing method of Zhenlong Xinnao Extract Granules

[0206] This product is a granule preparation made from Zhenlong Xingnao prescription medicinal materials after extraction and processing.

[0207] identify

[0208] Take 3g of this product powder, add 20ml of ethanol solution respectively, ultrasonically extract for 30 minutes, filter, and the filtrate is concentrated to 10ml, as the test solution. Take 0.5 g of Piper longum reference medicinal material, and prepare the reference medicinal material solution in the same way. Take another appropriate amount of piperine reference substance, put it in a brown measuring bottle, add absolute ethanol to make a solution containing 0.5mg per 1ml, and use it as the reference substance solution. According to the thin-layer chromatography test, draw the above-mentioned 3 kinds of solutions each 10 mu l, 10 mu l, 5 mu l. Spot on the same silica gel G thin-layer plate, use xylene-ethyl acetate-acetone (6:4:1) as the de...

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Abstract

The invention discloses a quality detection method of a Zhenlong brain-refreshment preparation. The method provided by the invention comprises a discrimination method of piper longum, banksia rose, Chinese cassia tree, gallic acid, cardamom, clove, pearl, cholic acid, stigma croci and cinnamaldehyde as well as a discrimination method of piperine in piper longum, cholic acid in cow-bezoar, cinnamaldehyde in Chinese cassia tree, and crocin-I and crocin-II in stigma crociand. Through a test research, by the discrimination methods in the quality detection method of the test article chromatograph,spots with the same color are shown on the corresponding position of control article chromatograph without the interference of negative control. The method is convenient and feasible with strong character. The content detection method provided by the invention is used to detect the contents of piperine, cholic acid, crocin-I and crocin-II in the Zhenlong brain-refreshment preparation. The result shows that the method has good linear relation, high accuracy of a recovery test and good repeatability and stability, and can be used to accurately and rigorously control the quality of the Zhenlong brain-refreshment preparation.

Description

technical field [0001] The invention belongs to a quality detection method of medicines, in particular to a quality detection method of Zhenlong Xingnao preparation. Background technique [0002] Cerebral apoplexy, poor speech, hemiplegia, crooked mouth and eyes are common and frequently-occurring diseases in clinical practice. The medicine has the effects of resuscitating the mind, eliminating heat and dredging the collaterals, and has a significant effect on symptoms such as hemiplegia and aphasia caused by localized neurological dysfunction caused by brain tissue ischemia and hypoxia. Zhenlong Xingnao Capsule is recorded in the national drug standard, standard number: WS-10708(ZD-0708)-2002. It has the effects of resuscitating the mind, eliminating heat and dredging the collaterals. It is used for stroke caused by phlegm and blood stasis, astringent speech, hemiplegia, and crooked eyes and mouth. [0003] Due to its good effect and advanced dosage form, Zhenlong Xingnao...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/90
Inventor 孙泰俊孙绪丁邵成雷单玉刚周忠山
Owner JINHE TIBETAN MEDICINE
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