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Compound turmeric lipid cubic liquid crystalline nano-particles and preparation method thereof

A compound curcumin lipid and nanoparticle technology, which is applied in the directions of bulk delivery, digestive system, cardiovascular system diseases, etc., can solve the problems of affecting use, low bioavailability in vivo, and poor stability.

Inactive Publication Date: 2015-05-20
崔景朝
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Studies in recent years have shown that curcumin has a wide range of pharmacological effects, such as anti-tumor, improving cardiovascular function, anti-inflammation, anti-virus, liver protection, and enhancing immunity. It has good pharmacological activity and application prospects, but curcumin has hydrophobic However, the disadvantages of strong drug resistance, low oral absorption, poor stability and low bioavailability in vivo have seriously affected its clinical use.

Method used

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  • Compound turmeric lipid cubic liquid crystalline nano-particles and preparation method thereof
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  • Compound turmeric lipid cubic liquid crystalline nano-particles and preparation method thereof

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Embodiment 1

[0029] 1.1, the composition of compound curcumin lipid cubic liquid crystal nanoparticles described in the present embodiment:

[0030]

[0031]

[0032] The preparation method of compound curcumin lipid cubic liquid crystal nanoparticles described in the present embodiment may further comprise the steps:

[0033] (1) Weigh the lipid material phytantriol in the proportion of the prescription into a vial, add the above-mentioned curcumin and piperine, then add 2.5 mL of absolute ethanol, and ultrasonicate for 30 minutes to fully dissolve it, as phase A;

[0034] (2) Weigh 25mg of F127 (purchased from BASF China Co., Ltd.) into a 100ml beaker, add 20mL of distilled water, and heat to dissolve in a water bath at 60°C, as phase B;

[0035] (3) Slowly add phase A to phase B, stir at 500r / min at room temperature for 3h, then sonicate in a 300W ice bath on a cell sonicator for 5min, sonicate 30 times (interval 5s), and obtain compound turmeric with uniform size Lipid Cubic Liq...

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Abstract

The invention provides compound turmeric lipid cubic liquid crystalline nano-particles and a preparation method thereof. The compound turmeric lipid cubic liquid crystalline nano-particles comprise the following components in parts by weight: 0.05-0.15g of phytantriol, 20-30mg of F127, 5-7mg of turmeric, 1-3mg of piperine and 15-25mL of water. Compared with a raw medicine group consisting of turmeric and piperine, the compound turmeric lipid cubic liquid crystalline nano-particles provided by the invention are significantly improved to show the properties that the in-vitro stability and solubility of turmeric can be improved on the one hand, the in-vivo bioavailability of turmeric can be significantly improved on the other hand, slow release and targeting effects can also be achieved, and the curative effects of turmeric on therapy in vivo can be enhanced so as to lay a foundation for turmeric to play the extensive pharmacological effects of resisting tumor, improving cardiovascular functions, resisting inflammation, resisting virus, protecting the liver and enhancing the immunity.

Description

technical field [0001] The invention relates to a compound turmeric lipid cubic liquid crystal nanoparticle and a preparation method thereof. Background technique [0002] Curcumin (curcumin) is a natural active ingredient extracted from turmeric. It is also widely found in other plants of the genus Curcuma. It is currently widely used as a pigment, food additive and seasoning. It has a wide range of sources, is safe and non-toxic. Studies in recent years have shown that curcumin has a wide range of pharmacological effects, such as anti-tumor, improving cardiovascular function, anti-inflammation, anti-virus, liver protection, and enhancing immunity. It has good pharmacological activity and application prospects, but curcumin has hydrophobic However, the disadvantages of strong drug resistance, low oral absorption, poor stability and low bioavailability in vivo have seriously affected its clinical use. Piperine is known as a natural glucuronidase inhibitor, and the combinati...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/12A61K47/22A61P9/00A61P35/00A61P29/00A61P31/12A61P1/16A61P37/04
Inventor 崔景朝
Owner 崔景朝
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