Piper hancei total alkaloid extract and uses thereof

A technology of total alkaloids and extracts, applied in the field of medicine

Inactive Publication Date: 2009-04-08
JIANGXI HERBFINE HI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Betels mainly contain alkaloids, organic acids, sterols and their glycosides, etc. So f

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Get 2 kg of Chinese Betelgeuse medicinal material, add 90% ethanol 3L, reflux extraction 3 times, extract 1.5 hours each time, reclaim solvent under reduced pressure, extract adds 0.5% hydrochloric acid aqueous solution to disperse and dissolve, makes acid aqueous solution concentration be 0.165mg / ml (in total alkaloid meter), centrifuged at a speed of 3000 rpm for 30min, and the supernatant was passed through 100ml D101-CC macroporous strongly acidic cation exchange resin, the adsorption flow rate was 10BV / h, and the diameter-to-height ratio of the resin column was 1:10 , sample loading is 25.65mg / ml (in total alkaloid amount), 50% ethanol elutes 5 times of resin volume and removes impurities, and the flow rate of removing impurities is 10BV / h, 70% ammoniacal ethanol (ammonia concentration is 1% ) to elute 7 times the resin volume, the elution flow rate is 10BV / h, collect 70% ammonia ethanol eluent, recover the solvent, and dry under reduced pressure, which is the total...

Embodiment 2

[0048] Get 2 kg of Chinese betel medicinal material, add 70% ethanol 4L, reflux extraction 3 times, extract 1.5 hours each time, reclaim solvent under reduced pressure, extract adds 1% hydrochloric acid aqueous solution to disperse and dissolve, makes acid aqueous solution concentration be 0.33mg / ml (in total alkaloid meter), centrifuged at a speed of 3000 rpm for 30min, and the supernatant was passed through 100ml D101-CC macroporous strongly acidic cation exchange resin, the adsorption flow rate was 5BV / h, and the diameter-to-height ratio of the resin column was 1:8 , the sample loading is 29.60mg / ml (in total alkaloid amount), water elution is carried out impurity removal by 10 times of resin volume, the flow rate of impurity removal is 10BV / h, and 90% ammoniacal ethanol (ammonia concentration is 0.5%) washes Remove 5 times the volume of the resin, the elution flow rate is 10BV / h, collect the 90% ammonia ethanol eluate, recover the solvent, and dry under reduced pressure to ...

Embodiment 3

[0051] Get 2 kg of Chinese betel medicinal material, add 50% ethanol 5L, reflux extraction 2 times, extract 2 hours each time, reclaim solvent under reduced pressure, extract adds 1.5% hydrochloric acid aqueous solution to disperse and dissolve, makes acid aqueous solution concentration be 0.495mg / ml (in total alkaloid meter), centrifuged at a speed of 3000 rpm for 30min, and the supernatant was passed through 100ml D101-CC macroporous strongly acidic cation exchange resin, the adsorption flow rate was 3BV / h, and the diameter-to-height ratio of the resin column was 1:6 , the sample load is 22.45mg / ml (in total alkaloid amount), 10% ethanol elutes 6 times of resin volume and carries out impurity removal, and the impurity removal flow rate is 5BV / h, and 50% ammoniacal ethanol (ammonia concentration is 0.3% ) to elute 7 times the resin volume, the elution flow rate is 10BV / h, collect 50% ammonia ethanol eluent, recover the solvent, and dry under reduced pressure, which is the tota...

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PUM

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Abstract

The invention discloses a total alkaloids extractive of piper hancei and application thereof, belongs to the technical field of medicine, and in particular relates to a total alkaloids extractive of traditional Chinese medicine piper hancei and application thereof. The extractive is obtained from the traditional Chinese medicine piper hancei, and comprises the following alkaloid components: sinoacutine amide, hairy grama piperine, long pepper amide A, pepper a-amanitine, Guinea pepper, piperine, piperettine, piperovatine, N-p-tonka-bean acyl tyramine, N-trans- asafetida acyl tyramine, birthwort lactam AIIIa, birthwort lactam II, and 2E, 4E-N- isobutyl-7-3,4-methinedioxy phenyl-2, 4-diene heptamide, long pepper nerinine and a derivate thereof, wherein the total content of the total alkaloids components is counted by 5 to 100 percent by weight.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a total alkaloid extract of traditional Chinese medicine yam and its application. Background technique [0002] Betel is the stem, leaf or root of Piperaceae plant Betel, harvested in autumn, with pungent and warm nature. It has the effects of expelling wind and dampness, promoting blood circulation and reducing swelling, promoting qi and relieving pain, resolving phlegm and relieving cough. It is mainly used to treat wind-cold-damp arthralgia, stomach pain, dysmenorrhea, bruises, wind-cold cough and dyspnea, and hernia pain. Modern pharmacological studies have shown that betel can inhibit platelet aggregation induced by platelet activating factor (PAF), and inhibit the inflammatory response caused by PAF. Commonly used among the people to treat bruises, rheumatic arthralgia, etc. Betelwort mainly contains alkaloids, organic acids, sterols and glycosides, and so on...

Claims

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Application Information

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IPC IPC(8): A61K36/67A61P29/00A61K125/00A61K127/00A61K135/00
Inventor 冯育林杨世林王跃生范玫玫罗晓健饶毅张小娟钱霞
Owner JIANGXI HERBFINE HI TECH
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