Water-soluble nanometer sustained-release functional coenzyme Q10 micro-capsule, method for preparing same and application of water-soluble nanometer sustained-release functional coenzyme Q10 micro-capsule

A nano-sustained-release and functional technology, applied in the field of preparation of coenzyme Q10 microcapsules, can solve the problems of poor water solubility, low bioavailability and instability, and achieve the effects of complete release, good stability and easy processing.

Active Publication Date: 2017-05-31
XIAMEN KINGDOMWAY BIOTECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to provide a water-soluble nano-sustained-release functional coenzyme Q10 microcapsules and its preparation m

Method used

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  • Water-soluble nanometer sustained-release functional coenzyme Q10 micro-capsule, method for preparing same and application of water-soluble nanometer sustained-release functional coenzyme Q10 micro-capsule
  • Water-soluble nanometer sustained-release functional coenzyme Q10 micro-capsule, method for preparing same and application of water-soluble nanometer sustained-release functional coenzyme Q10 micro-capsule
  • Water-soluble nanometer sustained-release functional coenzyme Q10 micro-capsule, method for preparing same and application of water-soluble nanometer sustained-release functional coenzyme Q10 micro-capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The 240Kg coenzyme Q10 crystals were ground together with 16Kg piperine, 40Kg lecithin, 40Kg natural VE, and 654Kg soybean oil in a nanomill at a temperature of 25° C. to a crystal particle size of 5 μm or less to obtain a coenzyme Q10 dispersion.

[0037] Dissolve 1000Kg of modified starch (T809) and 10Kg of sucrose ester (HLB value 13-16) in 3000Kg of water to prepare an aqueous solution of modified starch, and keep it at 40°C for later use.

[0038] The coenzyme Q10 dispersion is heated to 50°C, and after the coenzyme Q10 dispersion is completely dissolved, it is cooled to 40°C and kept warm for use.

[0039] The aforementioned Coenzyme Q10 dispersion was added to the modified starch aqueous solution, sheared at 10000 rpm for 30 minutes, and homogenized at 60 MPa for 3 times to obtain a nano-dispersed Coenzyme Q10 emulsion at the outlet.

[0040] The above-mentioned nano-dispersed coenzyme Q10 emulsion was spray-fluidized double-packed drying, and corn starch was used as the ...

Embodiment 2

[0042] Combine 20Kg of coenzyme Q10 crystals, 2Kg of piperine, 30Kg of lecithin, 4Kg of natural VE, 10Kg of monoglycerides, 1Kg of rosemary extract (containing 10% carnosic acid), and 498Kg of olive oil in a nanomill at a temperature of 20°C Down-grind to a crystal particle size of 5 μm or less to obtain a Coenzyme Q10 dispersion.

[0043] Dissolve 400Kg of modified starch (T809) and 35Kg of sucrose esters (HLB value 13-16) in 1500Kg of water to prepare a modified starch aqueous solution, and keep it at 45°C for later use.

[0044] The coenzyme Q10 dispersion is heated to 35°C, and after the coenzyme Q10 dispersion is completely dissolved, it is cooled to 30°C and kept warm for later use.

[0045] The aforementioned Coenzyme Q10 dispersion was added to the modified starch aqueous solution, sheared at 10000 rpm for 30 minutes, and homogenized at 80 MPa for 3 times, to obtain a nano-dispersed Coenzyme Q10 emulsion at the outlet.

[0046] The above-mentioned nano-dispersed coenzyme Q10 e...

Embodiment 3

[0048] The 400Kg coenzyme Q10 crystals were ground together with 20Kg piperine, 40Kg lecithin, 80Kg natural VE, 20Kg 2,6-di-tert-butyl-p-cresol, 60Kg sucrose acetate isobutyrate, and 880Kg isopropyl myristate. Grinding at a temperature of 15°C in the machine to a crystal particle size of 5 μm or less, to obtain a Coenzyme Q10 dispersion.

[0049] Dissolve 400Kg of modified gum arabic (A-2010) and 100Kg of poloxamer 188 in 2000Kg of water to prepare an aqueous solution of modified gum arabic and keep it at 35°C for later use.

[0050] The coenzyme Q10 dispersion is heated to 45°C, and after the coenzyme Q10 dispersion is completely dissolved, it is cooled to 35°C and kept warm for later use.

[0051] The aforementioned Coenzyme Q10 dispersion was added to the modified gum arabic aqueous solution, sheared for 30 minutes at 10000 rpm, and homogenized at 65 MPa for 3 times to obtain a nano-dispersed Coenzyme Q10 emulsion at the outlet.

[0052] The above-mentioned nano-dispersed coenzyme ...

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Abstract

The invention discloses a water-soluble nanometer sustained-release functional coenzyme Q10 micro-capsule, a method for preparing the same and application of the water-soluble nanometer sustained-release functional coenzyme Q10 micro-capsule. The water-soluble nanometer sustained-release functional coenzyme Q10 micro-capsule comprises, by weight, 1-20% of coenzymes Q10, 0.1-1% of piperine, 0.05-5% of antioxidants, 30-60% of carrier oil, 0.05-5% of oil-phase surfactants, 0.05-5% of water-phase surfactants and 20-50% of water-phase wall materials. The water-soluble nanometer sustained-release functional coenzyme Q10 micro-capsule, the method and the application have the advantages that the water-soluble nanometer sustained-release functional coenzyme Q10 micro-capsule is good in stability and convenient to process, and components can be prevented from being destroyed.

Description

[0001] Technical field: [0002] The invention relates to the preparation field of coenzyme Q10 microcapsules. [0003] Background technique: [0004] Coenzyme Q10 (Coenzyme Q10, CoQ10) is a fat-soluble quinone compound widely found in the body, and its chemical name is 2,3-dimethoxy-5-methyl-6-decisopentenyl-1,4 -Benzoquinone, a fat-soluble antioxidant that exists in the mitochondria of cells, is one of the most important antioxidants in the body. Coenzyme Q10 is an essential element for energy production in the human body. It exists in the cell membrane of various organs and can improve myocardial metabolism. , Strengthen the heart function; and its strong antioxidant function can protect the body cells from the damage of free radicals and improve the body's immunity. With the continuous disclosure of the important biological functions and health effects of coenzyme Q10, coupled with its non-toxic, non-teratogenic effects and no obvious side effects, in recent years, it has been w...

Claims

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Application Information

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IPC IPC(8): A61K9/66A61K31/122A61K31/4525A61P37/04
CPCA61K9/0002A61K9/5036A61K9/5089A61K31/122A61K31/4525A61K2300/00
Inventor 刘锦洪林木荣陈中科
Owner XIAMEN KINGDOMWAY BIOTECH CO LTD
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