Medicinal composition and use thereof

A technology of composition and application, applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., can solve the problem that oral arginine cannot achieve pharmacological effects, etc., and achieves improved cyclic metabolic pathways in vivo, improved health care, and high safety. Effect

Inactive Publication Date: 2008-09-17
ZHEJIANG ADAMERCK BIOPHARMLABS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The animal experiment that the present invention carries out, finds that oral arginine does not reach expected pharmacological effect

Method used

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  • Medicinal composition and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Preparation of pharmaceutical compositions

[0055] Accurately weigh natural amino acids and natural extracts, place them in a mixer and mix thoroughly to form active ingredients, add an appropriate amount of 10% CMC, stir for 15 minutes to make a soft material, pass through a 14-mesh sieve, and dry in vacuum at 50C for 2-3 hours. After adding other relevant excipients, pass through a 16-mesh sieve, granulate and mix uniformly to form a pharmaceutical composition. After the content of the active ingredient is determined, it is pressed into tablets or filled into capsules.

[0056] Table 1. Active ingredient formulation (weight ratio)

[0057] Sample serial number

[0058] Following example B~E is by composition of the present invention, and active ingredient is natural amino acid and natural extract form through stirring.

Embodiment 2

[0059] Example 2 tablet

[0060] components

[0061] Active ingredients, micronized cellulose, lactose, cross-linked polyvinylpyrrolidone are sieved through a 500 micron sieve and mixed with a suitable mixer. The magnesium stearate is sieved through a 250 micron sieve and then blended with the active ingredient and the mixture is compressed using a suitable press to form tablets.

Embodiment 3

[0062] Example 3 chewable tablet

[0063] Component

[0064] The first four materials are mixed and granulated with polyvinylpyrrolidone solution, and the rest of the reagents (sieved with a 250 micron sieve in advance) are added and mixed evenly. The resulting powder is compressed into tablets.

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Abstract

A medical composition for treating sexual disfunction, impotence, immunodeficiency, chronic fatigue, and hepal and renal disfunction is prepared from ornithin and citrulline or their salts, jujube, ginkgo seed and ginseng. Its advantages are high curative effect and no toxic by-effect.

Description

technical field [0001] The present invention relates to a pharmaceutical composition and its application. Specifically, it relates to a pharmaceutical composition prepared by adding auxiliary materials to active ingredients formed from natural amino acids and natural extracts. The preferred natural amino acids are ornithine and citrulline; the preferred natural extracts are jujube, ginkgo and ginseng. Background technique [0002] The mechanism of action of the active ingredients of the pharmaceutical composition is as follows: [0003] 1. Natural amino acids [0004] The preferred natural amino acids consisting of ornithine and citrulline are involved in at least three important cyclic metabolic pathways. These metabolic pathways are the urea cycle, the citric acid cycle and the nitric oxide cycle. The purpose of taking ornithine and citrulline is to obtain endogenous biomolecular messenger nitric oxide through related metabolic pathways, and strengthen various biologic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/725A61K36/258A61K36/16A61K31/195A61P15/08
Inventor 漆又毛揭清
Owner ZHEJIANG ADAMERCK BIOPHARMLABS
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