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Ozonized compound containing an olefin double bond

A compound and ozonation technology, applied in the field of medicine, can solve the problems of unclear specific mechanism, difficulty in ensuring the effective concentration of gas entering the body, etc.

Pending Publication Date: 2018-05-08
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The function of ozone gas may be realized through the following three ways: (1), ozone generates substances similar to active oxygen through biochemical reactions in the body (hydroxyl radical OH - , superoxide anion O 2 - etc.), extensively affects the redox system of the body; (2), ozone can cause the aggregation of endothelial progenitor cells and promote the generation of nitric oxide (NO), which can relax blood vessels; (3), ozone can induce bone marrow stem cells to At the site of vascular injury, it promotes the repair and reconstruction of damaged blood vessels, but the specific mechanism is still unclear
[0003] There are many defects in the above route of administration: contact with too many substances along the way, it is difficult to ensure the effective concentration of gas entering the body
However, adding ozone to the compound containing olefinic double bonds in claim 2 enters the body through direct oral administration to produce efficacy, and there is no report yet

Method used

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  • Ozonized compound containing an olefin double bond
  • Ozonized compound containing an olefin double bond
  • Ozonized compound containing an olefin double bond

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Preparation of ozonated linalool enteric-coated capsules

[0021] 1. Preparation of ozone gas. The invention adopts medical oxygen to prepare ozone gas through an ozone generator.

[0022] It is selected from the DRO3-A ozone machine (power≦55W) designed and produced by Xi'an Derun Biotechnology Co., Ltd.

[0023] 2. The whole process of preparing ozonated linalool enteric-coated capsules must be carried out at 20-25°C to ensure that the ozone will not undergo pyrolysis.

[0024] 3. Put 3kg of linalool into the reaction kettle; 3 / h flow rate was added, and the total reaction time was 20 hours. After the reaction is over, the residual gas is inactivated.

[0025] 4. The obtained ozonated linalool concentration is 40 mg / L, and it can be stored stably for ten months at 25°C.

[0026] 5. Preparation of ozonated linalool enteric-coated capsules.

[0027] (1) Preparation of capsule material: Weigh water, gelatin, glycerin and glutinous rice flour or starch in...

Embodiment 2

[0030] Example 2 Preparation of ozonated uniconazole enteric-coated capsules

[0031] 1. Preparation of ozone gas. The invention adopts medical oxygen to prepare ozone gas through an ozone generator.

[0032] It is selected from the DRO3-A ozone machine (power≦55W) designed and produced by Xi'an Derun Biotechnology Co., Ltd.

[0033] 2. The whole process of preparing ozonated uniconazole enteric-coated capsules must be carried out at 20-25°C to ensure that the ozone will not undergo pyrolysis reaction.

[0034] 3. Put 2kg of uniconazole + 1 kg of ethyl acetate into the reaction kettle; 3 / h flow rate was added, and the total reaction time was 20 hours. After the reaction is over, the residual gas is inactivated.

[0035] 4. The obtained ozonated uniconazole concentration is 30 mg / L, and it can be stored stably for ten months at 25°C.

[0036] 5. Preparation of ozonated uniconazole enteric-coated capsules.

[0037] (1) Preparation of capsule material: Weigh water, gelatin...

Embodiment 3

[0040] Example 3 Preparation of ozonated cholestyramine enteric-coated capsules

[0041] 1. Preparation of ozone gas. The invention adopts medical oxygen to prepare ozone gas through an ozone generator.

[0042] It is selected from the DRO3-A ozone machine (power≦55W) designed and produced by Xi'an Derun Biotechnology Co., Ltd.

[0043] 2. The whole process of preparing ozonated cholestyramine enteric-coated capsules must be carried out at 20-25°C to ensure that no pyrolysis reaction of ozone occurs.

[0044] 3. Put cholestyramine 2kg+ethyl acetate 1 kg into the reaction kettle; 3 / h flow rate was added, and the total reaction time was 20 hours. After the reaction is over, the residual gas is inactivated.

[0045] 4. The obtained ozonated cholestyramine has a concentration of 30 mg / L and can be stored stably for ten months at 25°C.

[0046] 5. Preparation of ozonated cholestyramine enteric-coated capsules.

[0047] (1) Preparation of capsule material: Weigh water, gelati...

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Abstract

The present invention relates to an ozonized compound containing an olefin double bond, specifically to ozone addition of a compound containing an olefin double bond. According to the present invention, the obtained ozonized compound containing the olefin double bond prevents and treats infectious diseases, autoimmune diseases, ischemic diseases, retinal degenerative diseases, skin diseases, lungdiseases, kidney diseases, hematologic diseases, neurodegenerative diseases, cancer, orthopedic surgical diseases, back pains, chronic fatigue syndromes, trauma / burn and emergency surgery, surgery andorgan transplantation, and prolapse of intervertebral disc through an oral route.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the ozone addition of compounds containing olefin double bonds, and the obtained ozonated compound containing olefin double bonds can prevent and treat various diseases through oral route. Background technique [0002] Velio Bocci in the book "Ozone Therapy" outlines the use of low doses of ozone gas to perform many beneficial functions without side effects, namely ozone therapy (see "Oxygen-Ozone Therapy" by Velio Bocci, Peking University Medical Press , 2004). Ozone therapy can be achieved through a variety of routes of administration, and produce different effects for different diseases. Ozonated oil is used externally as an antibacterial agent, deodorant and in the treatment of skin diseases such as bedsores and ulcers. Therefore, ozone is known to have oxidizing and antibacterial effects. The ozonated oil was directly administered into the stomach for the tre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61K47/54A61K47/58A61P31/20A61P1/16A61P37/02A61P9/10A61P17/06A61P11/06A61P13/12A61P25/28A61P19/08A61P31/00A61P33/00A61P17/00A61P11/00A61P7/00A61P35/00A61P29/00A61P39/00A61P17/02A61P37/06
CPCA61K33/00
Inventor 李新平侯建生周博
Owner NORTHWEST A & F UNIV
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