Dicyclohexyl trifluoromethanesulfonate ammonium salt and application thereof

Abstract

The invention relates to a dicyclohexyl trifluoromethanesulfonate ammonium salt and application thereof. The dicyclohexyl trifluoromethanesulfonate ammonium salt is prepared from trifluoromethanesulfonate and dicyclohexylamine. The dicyclohexyl trifluoromethanesulfonate ammonium salt can be applied to catalyzing the condensation reaction of three components such as aldehydes, amide and phenol, the condensation reaction of the three components such as the aldehydes, the amide and the phenol takes the phenol, the aldehydes and the amine as raw materials and is completely finished in an organic solvent under the action of the dicyclohexyl trifluoromethanesulfonate ammonium salt, and the reaction solution is separated and purified to obtain the corresponding multi-component condensation product. The invention develops a novel trifluoromethanesulfonate ammonium salt, promotes the application of a new generation of acid organic catalyst in the multi-component reaction, and promotes the further development of the multi-component reaction.

Description

(1) Technical field [0001] The invention relates to a novel ammonium trifluoromethanesulfonate-dicyclohexyltrifluoromethanesulfonate ammonium salt and its application as a catalyst in the three-component condensation reaction of aldehyde, amide and phenol. (2) Background technology [0002] Ammonium trifluoromethanesulfonate is a new type of acidic organic catalyst. Compared with the traditional Lewis acid (such as aluminum trichloride) and the newly developed rare earth metal Lewis acid catalyst, this organic catalyst has the advantages of being stable to water, requiring only a catalytic amount, no heavy metal pollution, recyclable and cheap. Therefore, it is an efficient green catalyst with good practical application prospects. Since the research team led by Tanabe used diphenylammonium trifluoromethanesulfonate (DPAT) for the first time in 2000 to catalyze the esterification reaction of equivalent carboxylic acids and alcohols, ammonium trifluoromethanesulfonate has bee...

AI Technical Summary

Problems solved by technology

[0004] Aminophenol, which is obtained from the three-component condensation reaction of aldehyde, amide and phenol, is a drug intermediate widely used in medicine. The traditional synthesis method mainly uses acidic catalysts to catalyze the synthesis, such as iodine, ferric chloride, p-toluenesulfonate Acid, etc., but it has disadvantages such as long reaction time, difficult recovery of catalyst, and not wide applicability of substrates.

Images