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Method for extracting and separating cannabidiol

A technology of cannabidiol and separation method, which is applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of high cost, low separation purity of cannabidiol, few times of use of fillers, etc., and achieves purification High yield, reduce the loss of cannabidiol, and reduce the cost of separation and purification

Inactive Publication Date: 2019-07-30
栾云鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are some reports on the process of extracting cannabidiol from industrial hemp in the current public information. By comparing the existing process routes, it is found that the existing technology mainly has a low separation purity of cannabidiol, and THC can still be detected. , the number of fillers used is small, and the cost is high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A method for extracting and separating cannabidiol, comprising the following steps

[0023] (1) Pulverization: take the flowers and leaves of industrial hemp as raw materials, dry them at 40-60°C until the moisture content is less than 10%, and then grind them into coarse powder of flowers and leaves;

[0024] (2) Extraction: The coarse powder of industrial hemp flowers and leaves obtained in step (1) is extracted with 3 times the amount of petroleum ether under heat reflux for 3 times, each reflux extraction is 2 hours, the extracts are combined, and the extraction solvent is recovered to obtain concentrated immersion of industrial hemp paste;

[0025] (3) Enrichment: The industrial hemp extract concentrated liquid extract obtained in step (2) is subjected to AB-8 macroporous resin chromatography, first eluted with 30% ethanol, then 80% ethanol, and monitored by chromatography Fractions are combined with cannabidiol-containing part of the eluate and concentrated to ob...

Embodiment 2

[0028] A method for extracting and separating cannabidiol, comprising the following steps

[0029] (1) Pulverization: take the flowers and leaves of industrial hemp as raw materials, dry them at 65°C until the water content is less than 5%, and then grind them into coarse powder of flowers and leaves;

[0030] (2) Extraction: The coarse powder of industrial hemp flowers and leaves obtained in step (1) is extracted twice with 10 times the amount of ethanol under heat reflux, each time for 3 hours, the extracts are combined, and the extraction solvent is recovered to obtain concentrated liquid extract of industrial hemp ;

[0031] (3) Enrichment: The industrial hemp extract concentrated liquid extract obtained in step (2) is subjected to D101 macroporous resin chromatography, first eluted with 40% concentration of ethanol, and then eluted with 65% concentration of ethanol, and the fraction is monitored by chromatography. Combine the eluate containing cannabidiol and concentrate...

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Abstract

The invention relates to a method for extracting and separating cannabidiol. The method comprises the following steps of 1) pulverization, wherein dried industrial cannabis flowers and leaves are pulverized into granules by using a grinding disperser; 2) extraction, wherein ethyl alcohol, petroleum ether or solvent naphtha is taken as a single solvent or a mixed solvent to perform reflux extraction on the materials; 3) enrichment, wherein an industrial hemp fluid extract obtained by extraction and concentration is subjected to macroporous resin chromatography, and an eluate is collected in stages to obtain a cannabidiol enrichment; 4) separation, wherein the cannabidiol enrichment is subjected to silica gel column chromatography, and an eluate is collected in stages, concentrated, dried and crystallized to obtain the cannabidiol. The product has the advantages that the purity is higher, the extraction is convenient and fast, and the purification cost is lower.

Description

technical field [0001] The invention belongs to the technical field of extracting and purifying plant components, and in particular relates to a method for extracting and separating cannabidiol. Background technique [0002] Marijuana (Cannabis sativa L.) is an ancient plant with medicinal development value. Cannabidiol (CBD) is a monomer extracted from marijuana. It is the first cannabinoid drug approved by FDA. , has anti-spasm, anti-anxiety, anti-inflammatory, anti-oxidation, anti-rheumatic, anti-tumor and other pharmacological effects; the application of CBD in the medical field is mainly based on its protective effect on the nervous system; The dual inhibition of enzymes exerts analgesic and anti-inflammatory effects, and the effect is stronger than that of aspirin, which is well-known and widely used; GABA neurotransmitters in the human brain have a calming effect, inhibiting the excitability of the brain center, and CBD can help control GABA nerves The consumption of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C37/70C07C37/82C07C39/23
CPCC07C37/004C07C39/23
Inventor 栾云鹏郑双庆李志朋李襄
Owner 栾云鹏
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