Macromolecule thiolated modified derivatives and cross-linking material thereof

A polymer compound and polymer technology, applied in the field of compounds, can solve the problems of ineffective biomedical applications, poor chemical reaction performance, restricted collision probability, etc., to achieve adjustable performance, high yield, side chain chemistry, etc. Flexible and changeable structure
CN101200504AActive Publication Date: 2008-06-18BIOREGEN BIOMEDICAL (CHANGZHOU) CO LTD
2 Cites 69 Cited by

Patent Information

Authority / Receiving Office
CN Ā· China
Patent Type
Applications(China)
Current Assignee / Owner
BIOREGEN BIOMEDICAL (CHANGZHOU) CO LTD
Publication Date
2008-06-18

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The present invention discloses a macromolecular sulfydryl modified derivative with general formula (I) or (II) as well as corresponding dithio-bond cross-linking material and corresponding cross-linking material of sulfydryl reaction active cross linker. Wherein, R1 and R2 include alkylidene, substituted alkylidene, aromatic base, polyether polyols, etc. and R1 and R2 can have the same or different chemical structure; P refers to macromolecular compound residue including carboxyl in the side chain and the molecular weight of the macromolecular sulfydryl modified derivative is 10 to 5 million. The side-chain chemical structure of the macromolecular sulfydryl modified derivative with general formula (I) or (II) is flexible and changeable with notable advantages of adjustable performance, mild preparation conditions, high production rate, high modification and controllability. The cross-linking material of the macromolecular sulfydryl modified derivative provided by the present invention can be used to inhibit the attachment of cells and used as the matrix for cell adhesion and growth.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The present invention relates to compounds, in particular to macromolecule mercapto-modified derivatives; in addition, the present invention also relates to the corresponding disulfide bond cross-linking materials and mercapto-reactive cross-linking agent cross-linking materials of the macromolecule mercapto-modified derivatives. Background technique

[0002] Polymer thiol-modified derivatives have many important biomedical applications, such as chemically active modification of various small molecule drugs and polypeptide protein drugs, preparation of various cross-linked polymer materials, and so on. These new materials can be used as cell growth matrix, wound repair regeneration matrix, drug sustained release carrier, wound dressing, in situ embedding cell matrix, etc., and have important uses in the field of biomedicine. However, so far, there are few types of such thiol-modified polymer derivatives, and only the polymer mercapto-modified derivativ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More