The invention discloses a chemical topping method of cotton, comprising the following steps of: a, 3-5 days before and after the first bloom period of the cotton, spraying mepiquat chloride to carry out basic chemical control so that the cotton can grow stably without growing vigorously, wherein the dosage of the mepiquat chloride is 4-10g/mu; b, before and after the full bloom period of the cotton, spraying chemical topping agent on leaf surfaces, wherein the spray should be higher than the cotton plants, the dosage of the chemical topping agent is 40-80ml/mu and 15-30kg of water is mixed; and c, 3-15 days after the spraying of the chemical topping agent, spraying the mepiquat chloride to stabilize the chemical control of plant type, wherein the dosage of the plant type is 8-15g/mu, and the topping agent comprises the following components is percentage by weight: 20-30% of mepiquat chloride emulsion, 40-60% of water and 15-25% of flumetralin emulsion. Through the method, the automatic topping of the cotton can be realized, the topping quality can be ensured, the topping uniformity of cotton fields can be improved, the labor efficiency can be improved and the labor intensity can be lightened.