Veterinarian virus kind biological product heat resisting freeze drying protective agent and its preparation technique

A heat-resistant freeze-drying and protective agent technology, which is applied in antiviral agents, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as detailed reports on methods that have not been seen

Inactive Publication Date: 2003-07-02
卫广森
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However, there is no detailed report on the method

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[0006] Heat-resistant freeze-drying protective agent for veterinary virus biological products. The components of the protective agent include commonly used gelatin, sucrose, skimmed milk powder, and dextrin. It is characterized in that the composition ratio of various heat-resistant freeze-drying protective agents is: (1 ) Chicken Newcastle disease attenuated freeze-dried vaccine: gelatin 1.5-2%, sucrose 5-6%, dextrin 5-10%, PVP (K90) 2-5%, sorbitol 2%, sodium glutamate 1-2%; ( 2) Infectious bursal disease attenuated virus (B87) freeze-dried vaccine: skimmed milk powder 5%, dextrin 5%, beef peptone 1-3%, sucrose 5-6%, sorbitol 2%, sodium glutamate 1 -3%, Vc0.1%; (3) chicken infectious bronchitis (H120, H52, nephrotic branch W93) freeze-dried vaccine: gelatin 1.5-2%, bovine serum albumin 1-2%, sucrose 5-6 %, PVP (K90) 5%, casein peptone 2%, sorbitol 1-3%, sodium glutamate 1-2%, Vc0.1-0.3%; (4) Chicken Newcastle disease, chicken infectious bronchitis (H120, H52) Double freeze-d...

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Abstract

A freeze-dried high-temp. resistant protecting agent for virus-type biologic products for veterinary medicine is prepared from several components through proportionally mixing. It features that each of its components is sterilized separately. For the components which can be sterilized under high temp., they are dissolved in distilled water according to the proportion of formulation and are sterilized at 116 deg.C for 30-40 min; and for those which do not resist the high temp., they are also dissolved in distilled water according the proportion of formulation and are filtered with 0.22 micron pore diameter filter membrane to remove bacteria; and then the two parts are mixed to obtain the freeze-dried high-temp. resistant, protecting agent. The mentioned two parts are added to the virus antigen liquid according to a proportion of 1:1 and after packaging, they are freeze-dried. The product can be stored at 2-8 deg.C for 24 months.

Description

Technical field [0001] The invention relates to a freeze-drying technology of biological products, a preservation auxiliary agent and a manufacturing method thereof. Background technique [0002] The commonly used protective agents for veterinary biological products in my country are mainly 5% sucrose skimmed milk, 5-10% sucrose, and 1.5-3% gelatin. -9 months, must be used up as soon as possible at room temperature. This brings many difficulties and inconveniences to the preservation, transportation, use, etc. of veterinary biological products. At the same time, energy consumption and storage costs are high due to the necessity of low-temperature preservation. [0003] At present, almost all veterinary biological freeze-dried products in developed countries in the world are stored at 2-8°C for more than 24 months. But there is no detailed report on the method. Chinese patent CN1176827A "A Manufacturing Method for Freeze-dried Live Vaccines for Animals" proposes to use poly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K39/00A61K47/36A61K47/42A61K47/46A61P31/12
Inventor 卫广森王文成张万林
Owner 卫广森
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