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Compound florfenicol injection as well as preparation method and application thereof

A technology of compound florfenicol and florfenicol, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, antibacterial drugs, etc., to achieve the effect of simple preparation method, scientific formula and broad market prospect

Active Publication Date: 2014-01-22
TIANJIN ZHONGSHENG TIAOZHAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a single Florfenicol injection can only solve the antibacterial effect of the antibacterial drug itself, and cannot maximize its clinical therapeutic effect. Therefore, the research on the Florfenicol compound preparation will be of great significance. Important practical significance for production

Method used

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  • Compound florfenicol injection as well as preparation method and application thereof
  • Compound florfenicol injection as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A compound florfenicol injection, ph=4-6, each 1000ml includes the following components by weight:

[0027] 50g of florfenicol, 5g of toadstool, 5g of oxymatrine, 654-215g, VB15g, 800ml of the first organic solvent, 100ml of propylene glycol, 0.1g of sodium formaldehyde sulfoxylate and appropriate amount of ph regulator dilute hydrochloric acid and dilute hydroxide Sodium, wherein, the first organic solvent is dimethylacetamide and absolute ethanol, and the volume ratio is dimethylacetamide: absolute ethanol=1:9.

[0028] The preparation method of above-mentioned compound recipe Florfenicol injection, concrete preparation steps are as follows:

[0029] (1) Weigh the formulated amount of florfenicol, 654-2 and toad venom successively and dissolve them in the first organic solvent whose volume ratio of the formulated amount is dimethylacetamide: absolute ethanol = 1:9;

[0030] (2) Weigh the formulated amount of VB1 and oxymatrine and dissolve them in the formulated amou...

Embodiment 2

[0034] A compound florfenicol injection, ph=4-6, each 1000ml includes the following components by weight:

[0035] Florfenicol 300g, Bufona 2.5g, Oxymatrine 15g, 654-25g, Vitamin B110g, Dimethylformamide 400ml, Glycerol Methylal 500ml, Thioglycerol 1g and appropriate amount of ph regulator citric acid and lemon Sodium acid.

[0036] A preparation method of compound florfenicol injection, the specific preparation steps are as follows:

[0037] (1) Weigh the formulated amount of florfenicol, 654-2 and toad venom successively and dissolve them in the formulated amount of dimethylformamide;

[0038] (2) Weigh the formulated amount of VB1 and oxymatrine successively and dissolve them in the formulated amount of glycerin formal;

[0039] (3) Combine the solutions obtained in step (1) and step (2), mix evenly, add the formula amount of thioglycerol, and dissolve completely;

[0040] (4) Add a ph regulator to adjust the ph to 4-6, and finally adjust the volume to 1000ml with glycer...

Embodiment 3

[0042] A compound florfenicol injection, ph=4-6, each 1000ml includes the following components by weight:

[0043] Florfenicol 150g, Bufoni 4g, oxymatrine 10g, 654-210g, vitamin B17.5g, dimethyl sulfoxide 600ml, polyethylene glycol 400-300ml, thiourea 0.3g and appropriate amount of ph regulator tartaric acid and tartaric acid sodium.

[0044] A preparation method of compound florfenicol injection, the specific preparation steps are as follows:

[0045] (1) Weigh the formula amount of florfenicol, 654-2 and toad venom successively dissolved in the formula amount of dimethyl sulfoxide;

[0046] (2) Weigh the formula quantity of VB1 and oxymatrine and dissolve them in the formula quantity polyethylene glycol 400 successively;

[0047] (3) Combine the solutions obtained in step (1) and step (2), mix evenly, add the formula amount of thiourea, and dissolve completely;

[0048] (4) Add a ph regulator to adjust the ph to 4-6, and finally use polyethylene glycol 400 to adjust the v...

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Abstract

The invention provides compound florfenicol injection as well as a preparation method and application thereof. Each 1000ml of injection comprises 50-300g of florfenicol, 2.5-5g of venenum bufonis, 5-15g of oxymatrine, 5-15g of 654-2, 5-10g of vitamin B1, 0.1-1g of antioxidant, 100ml-800ml of first organic solvent, 100ml-800ml of second organic solvent and 0.1-1g of antioxidant. The compound florfenicol injection is prepared in a step-by-step dissolution mixing manner. The compound florfenicol injection is scientific in formula and has stable property; the components of the compound florfenicol injection have mutual enhancing effects so as to make up for the deficiency. The compound florfenicol injection has a relatively good antibacterial effect, relatively low toxic and side effects and a relatively short treatment course and can be used for preventing and treating diseases with respiratory symptoms, digestive tract symptoms and / or hyperpyrexia symptoms, which are caused by colibacillosis, salmonellosis, pasteurellosis and the like of beast and birds.

Description

technical field [0001] The invention relates to a drug injection and its preparation method and application, in particular to a compound florfenicol injection and its preparation method and application. Background technique [0002] In recent years, with the improvement of people's living standards, the demand for livestock products has increased, and the vast market space has accelerated the development of animal husbandry, and the stock of livestock and poultry has increased year by year. But various diseases of livestock and poultry such as the respiratory tract and digestive tract that follow follow take place thereupon. At present, there is no ideal drug with broad-spectrum therapeutic effect for the treatment of such diseases in the market. Therefore, there is an urgent need for a drug suitable for market requirements with good drug efficacy, stable properties and broad antibacterial spectrum. [0003] Florfenicol is a new broad-spectrum antibacterial drug of chloram...

Claims

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Application Information

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IPC IPC(8): A61K35/56A61K9/08A61P31/04A61P31/00A61P1/12A61K31/165A61K31/46A61K31/4375A61K31/51A61K35/65
CPCY02A50/30
Inventor 朱士江焦伟丽程雪娇王建焦晓军季坤王勇余贵菊李超斯李丽琴甄盼盼王猛姜淋洁
Owner TIANJIN ZHONGSHENG TIAOZHAN BIOTECH
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