Bivalent gene engineering vaccine of fowl infectious bursal disease and pasteurellosis

A genetically engineered vaccine and bursal disease technology, which is applied in the field of new bivalent genetic engineering vaccines for avian infectious bursal disease and pasteurellosis, and can solve problems such as virulent dissemination
CN1522760AInactive Publication Date: 2004-08-25YANGTZE UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
YANGTZE UNIVERSITY
Publication Date
2004-08-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention discloses an avian infectious cloaced bursa disease and pasteurellosis bivalent gene engineering vaccine, relating to avian gene engineering vaccine. Said new vaccine is a pasteurella multocida C47-16 / p GEX-KG-VP2, CCTCC No:M203056, on pGEX-KG plasmid is connected an infectious cloacal bursa VP2 protein gene, after induced expression said vaccine can be used for immuniza chicken by means of oral administration or injection mode to make chicken body interior produce antibody for resisting infectious cloacal bursa virus, and when a standard strong strain is used to challenge virus, it can provide protection action for chicken. At the same time said carrier bacterium self-body is a safe effective low viulent vaccine strain for preventing pasteurellosis, so that said vaccine strain also can provide protection for resisting avian pasteurellosis.
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Description

technical field

[0001] The invention relates to a new poultry genetic engineering vaccine. Specifically, it relates to a new bivalent genetically engineered vaccine for avian infectious bursal disease and pasteurellosis. Background technique

[0002] Infectious bursal disease virus (IBDV), which belongs to the double-stranded RNA virus family, can cause infectious bursal disease or Gumboro disease in chickens and turkeys. It causes immunosuppression in chickens aged 3 to 12 weeks by destroying B lymphocytes in chicken bursa.

[0003] The genome of IBDV consists of two segments of double-stranded RNA. The smaller segment (A) encodes VP1, a dsRNA-dependent RNA polymerase. The larger stretch (B) contains 2 open reading frames. Box 1 codes for the VP5 protein. Box 2 codes for a polyprotein, which can be automatically processed into three viral proteins by proteolytic enzymes, namely: VP2, VP4, and VP3. Among them, VP2 and VP3 are the main structural proteins of the virus. ...

Claims

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