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Rumen-protected coated enrofloxacin mini-pill and preparation method thereof

A technology of enrofloxacin and rumen passage, which is applied in the field of rumen-coated enrofloxacin pellets and its preparation, can solve the problems of animals not ruminating, digestive disorders, etc., and achieve low production cost, reasonable formula, and technological process simple effect

Active Publication Date: 2015-12-02
四川省川龙动科药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a rumen-passed enrofloxacin pellet and its preparation method, which can solve the problems that the existing medicines are easy to cause animals not to ruminate and have digestive disorders

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A kind of rumen-coated enrofloxacin pellets, by weight, consists of 10% enrofloxacin, 12.4% microcrystalline cellulose, 12% flour, 5% medicinal talcum powder, 35% Composition of corn starch, 0.6% hydroxypropyl methylcellulose, and 25% coating layer. Among them, the coating layer is composed of 9% acrylic resin IV, 4.5% ethyl cellulose, 1.5% talcum powder (particle size 1200 mesh) and 85% ethanol.

[0032] The specific preparation method is as follows:

[0033] Prepare pellet core:

[0034] (1) Mix enrofloxacin, microcrystalline cellulose, flour, medicinal talcum powder, and cornstarch evenly to prepare a mixture;

[0035] (2) Prepare an aqueous solution of hydroxypropyl methylcellulose with a concentration of 1.5%, and add it to the mixture as a binder to obtain a soft material;

[0036] (3) Put the soft material into the extruder. At this time, the speed of the extruder is 40r / min, and the hole diameter is 0.8mm, and the strip material is obtained, and then added to...

Embodiment 2

[0043] Compared with Example 1, this example differs only in that the proportion of enrofloxacin pellets coated with rumen passage is different. The proportion of this example is as follows:

[0044] A kind of rumen-coated enrofloxacin pellets, by weight, consists of 5% enrofloxacin, 20% microcrystalline cellulose, 16% flour, 15% medicinal talcum powder, 28% Composition of corn starch, 1% hydroxypropyl methylcellulose, and 15% coating layer. Among them, the coating layer is composed of 9% acrylic resin IV, 4.5% ethyl cellulose, 1.5% talcum powder (particle size 1200 mesh) and 85% ethanol.

Embodiment 3

[0046] Compared with Example 1, this example differs only in that the proportion of enrofloxacin pellets coated with rumen passage is different. The proportion of this example is as follows:

[0047] A kind of rumen-coated enrofloxacin pellets, by weight, consists of 15% enrofloxacin, 14% microcrystalline cellulose, 10% flour, 4% medicinal talcum powder, 33% Composition of corn starch, 1% hydroxypropyl methylcellulose, and 23% coating layer. Among them, the coating layer is composed of 9% acrylic resin IV, 4.5% ethyl cellulose, 1.5% talcum powder (particle size 1200 mesh) and 85% ethanol.

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Abstract

The invention discloses a rumen-protected coated enrofloxacin mini-pill and a preparation method thereof, and solves the problems of conventional medicines that animals are easily caused to not ruminate and have digestive disorders. The rumen-protected coated enrofloxacin mini-pill is prepared from the following raw materials by weight: 5-15% of enrofloxacin, 60-80% of an auxiliary material and 10-25% of coating layer. The invention further provides the preparation method for the rumen-protected coated enrofloxacin mini-pill. Through oral medication, a medicinal component is not released in the rumen, and the medicinal component, namely enrofloxacin, is released when being dissolved after reaching the true stomach, so that an antibacterial action is directly played in intestinal tracts; enrofloxacin can also be used for treatment of general infection diseases of mycoplasma, pasteurellosis and the like after being absorbed into blood through intestinal tracts; animal rumination is completely unaffected, and the use is very convenient.

Description

technical field [0001] The invention relates to a rumen-passed coated enrofloxacin pellet and a preparation method thereof. Background technique [0002] In recent years, the incidence of diseases in ruminants (dairy cows, beef cattle, sheep, deer, etc.) is relatively high, especially in calves and lambs, such as diarrhea, pasteurellosis, mycoplasma pneumonia, etc., which cause the death of calves and lambs common causes of. Due to the special digestive physiological structure of ruminants, there are many microorganisms related to digestion in the rumen, which are very sensitive to antibiotics. Therefore, bacterial diarrhea and systemic infectious diseases in ruminants cannot be solved by oral administration of antibacterial drugs, and can only be treated by injection of antibacterial drugs. [0003] At present, when ruminants (dairy cows, beef cattle, sheep, deer, etc.) have bacterial diarrhea and systemic infection diseases, if the antibacterial liquid is taken orally, s...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/496A61P31/04A61P1/12
Inventor 靳茹文严根文林芝
Owner 四川省川龙动科药业有限公司
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