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A kind of rumen-coated amoxicillin pellet and preparation method thereof

A technology of amoxicillin pellets and amoxicillin, which is applied in the direction of bulk transportation, digestive system, and active ingredients of heterocyclic compounds, can solve the problems of animals not ruminating, digestive disorders, etc., and achieve low production cost, reasonable formula, The effect of simple process

Active Publication Date: 2018-02-06
四川省川龙动科药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a rumen-passed coated amoxicillin pellet and its preparation method, which solves the problems that the existing medicines are easily lead to the animals not ruminating and digestive disorders

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A kind of rumen-coated amoxicillin pellet, by weight, consists of 10% amoxicillin, 15% microcrystalline cellulose, 8% dextrin, 7% soluble starch, 34% cornstarch, 1% hydroxypropyl methylcellulose, 25% coating layer composition. Among them, the coating layer is composed of 9% acrylic resin IV, 4.5% ethyl cellulose, 1.5% talcum powder (particle size 1200 mesh) and 85% ethanol.

[0032] The specific preparation method is as follows:

[0033] Prepare pellet core:

[0034] (1) Mix amoxicillin, microcrystalline cellulose, dextrin, soluble starch, and cornstarch evenly to prepare a mixture;

[0035] (2) Prepare a hydroxypropyl methylcellulose aqueous solution with a concentration of 2%, and add it to the mixture as a binder to obtain a soft material;

[0036] (3) Put the soft material into the extruder. At this time, the speed of the extruder is 45r / min, and the hole diameter is 0.8mm, and the strip material is obtained, and then added to the spheronizer with the fan frequen...

Embodiment 2

[0043] Compared with Example 1, the present embodiment differs only in that the proportioning of a rumen-passed amoxicillin pellet is different, and the proportioning of the present embodiment is as follows:

[0044] A kind of rumen-coated amoxicillin pellets, by weight, by 5% amoxicillin, 20% microcrystalline cellulose, 15% dextrin, 15% soluble starch, 28% cornstarch, 2% hydroxypropyl methylcellulose, 15% coating layer composition. Wherein, the coating layer is composed of 9% acrylic resin IV, 4.5% ethyl cellulose, 1.5% talcum powder and 85% ethanol.

Embodiment 3

[0046] Compared with Example 1, the present embodiment differs only in that the proportioning of a rumen-passed amoxicillin pellet is different, and the proportioning of the present embodiment is as follows:

[0047] A kind of rumen-coated amoxicillin pellets, by weight, by 15% amoxicillin, 14% microcrystalline cellulose, 10% dextrin, 10% soluble starch, 30% cornstarch, 1% hydroxypropyl methylcellulose, 20% coating layer composition. Wherein, the coating layer is composed of 9% acrylic resin IV, 4.5% ethyl cellulose, 1.5% talcum powder and 85% ethanol.

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Abstract

The invention discloses a rumen-passing-coated amoxicillin pellet and a preparation method thereof, which solves the problems that the existing medicines easily cause animals not to ruminate and have digestive disorders. By weight, the invention is prepared from 5% to 20% of amoxicillin, 55% to 80% of auxiliary materials and 10% to 25% of a coating layer. The present invention also provides a preparation method of the above-mentioned rumen-passed coated amoxicillin pellets. The present invention is administered orally, does not release the active ingredient in the rumen (pH6.5-7.0), dissolves and releases the active ingredient amoxicillin after reaching the abomasum (pH2.0-3.0), and directly exerts antibacterial properties in the intestinal tract It does not affect the rumination of animals at all and is very convenient to use.

Description

technical field [0001] The invention relates to a rumen-passed coated amoxicillin pellet and a preparation method thereof. Background technique [0002] In recent years, the incidence of diarrhea in ruminants (dairy cows, beef cattle, sheep, deer, etc.) is high, especially in calves and lambs, which is the most common cause of death of calves and lambs. Due to the special digestive physiological structure of ruminants, there are many microorganisms related to digestion in the rumen, which are very sensitive to antibiotics. Therefore, the bacterial diarrhea disease of ruminants cannot be solved by the method of oral antibacterial drug treatment, and bacterial diarrhea can only be treated by injection of antibacterial drugs. [0003] At present, when ruminants (dairy cows, beef cattle, sheep, deer, etc.) have bacterial diarrhea, if the antibacterial liquid is taken orally, some microorganisms in the rumen will be killed, resulting in animals not ruminating and digestive disor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/43A61P31/04A61P1/12
Inventor 林芝靳茹文严根文
Owner 四川省川龙动科药业有限公司
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