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Swine pasteurellosis bivalent inactivated vaccine and preparation method thereof

A bivalent inactivated vaccine, pasteurellosis swine technology, applied in the direction of antibacterial drugs, pharmaceutical formulations, bacterial antigen components, etc.

Inactive Publication Date: 2010-07-07
广东永顺生物制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the only vaccines used on the market to control Pasteurella disease are live vaccines that prevent Pasteurella capsular group A and B bacteria respectively, and can only prevent one kind of bacterial infection.
In addition, the existing Pasteurella vaccine is a live bacterial vaccine, using live bacteria as the immunogen, there is a certain degree of shedding of the virus

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] This product is made of pathogenic Pasteurella capsular group A and B group virulent strains, which are inoculated in a suitable medium for culture. After the culture is inactivated by formaldehyde solution, it is concentrated with aluminum hydroxide gel to produce bivalent inactivated bacteria. Live vaccine for the prevention of bacterial diseases caused by Pasteurella capsular group A and B infection. The strains used in the manufacture and inspection of this product are virulent strains such as capsule A group Pasteurella multocida P71 strain and capsule B group Pasteurella multocida C44-1 strain, all of which are identified by the China Veterinary Drug Administration , storage and supply.

[0030] 1 strain

[0031] The strains used in the manufacture and inspection of this product are virulent strains of Pasteurella capsular group A and group B. In order to obtain strains with strong immunogenicity, each strain is preserved by freeze-drying after rejuvenation of se...

Embodiment 2

[0065] Example 2 Efficacy Research

[0066] With 20 healthy susceptible pigs, 2ml of the vaccine prepared in Example 1 was injected intramuscularly, containing 1 dose; after 21 days, each virulent strain was used for virulent challenge.

[0067] Pasteurella strain P71:

[0068] Select 5 immunized pigs, together with 5 control pigs with the same conditions, inject P71 strain virulent bacteria liquid, observe for 10 days, more than 4 / 5 of the control pigs died, and more than 4 / 5 of the immunized pigs were protected.

[0069] Pasteurella strain C44-1:

[0070] Select 5 immunized pigs, together with 5 control pigs with the same conditions, and inject C44-1 strain virulent bacteria solution intravenously, and observe for 10 days. More than 4 / 5 of the control pigs died, and more than 4 / 5 of the immunized pigs were protected.

[0071] result:

[0072]

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PUM

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Abstract

The invention provides a swine pasteurellosis bivalent inactivated vaccine, which can prevent infection caused by two different capsule serotypes of pasteurella multocida, reaches the effect that one stitch of vaccine can prevent multiple infections, reduces the cost, does not have the hidden trouble of dispersing toxin and is safe and reliable. The invention also provides a preparation method for the swine pasteurellosis bivalent inactivated vaccine.

Description

technical field [0001] The invention relates to the field of veterinary biological products, in particular to a bivalent inactivated vaccine for pasteurellosis in pigs. Background technique [0002] Pasteurellosis is one of the main bacterial infectious diseases of pigs in my country. [0003] Pasteurellosis is a bacterial disease caused by Pasteurella multocida infection, which can cause sepsis and pneumonia. Pasteurella can be divided into four capsular serotypes A, B, D, and E according to the capsule. Pasteurellosis occurs all over the world, especially in tropical areas. Pasteurellosis that has been prevalent at present is dominated by groups A and B, and a small amount of group D. [0004] Pasteurella can cause mixed infections in pigs, which often lead to high morbidity and high mortality in pigs. Due to mixed infections and abuse of antibiotics, the phenomenon of one disease with multiple types, one disease with multiple diseases, and one disease with multiple dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/102A61K39/116A61P31/04
Inventor 以体强林旭埜张毓金游启有杨球郭沈涛
Owner 广东永顺生物制药股份有限公司
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