Doxycycline hydrochloride soluble powder and preparation method thereof

Abstract

The present invention provides doxycycline hydrochloride soluble powder. The doxycycline hydrochloride soluble powder is composed of the following raw materials in mass percentages: 45-55% of doxycycline hydrochloride and 45-55% of anhydrous glucose. The present invention also provides a preparation method of the doxycycline hydrochloride soluble powder. The doxycycline hydrochloride soluble powder can effectively treat respiratory diseases caused by treatment of pig and chicken gram-positive bacteria and negative bacteria of escherichia coli, salmonellosis, pasteurellosis and mycoplasma, hasa good therapeutic effect, is quick in effects, can address both symptoms and root causes, reduces stress response when diseases occur, prevents and treats concomitant and secondary infections of themycoplasma and chlamydia, uses conventional equipment during preparation, and is simple in production method, low in material cost, and suitable for industrialized mass production of antibiotic premixes of poultry and livestock.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a doxycycline hydrochloride soluble powder and a preparation method thereof. Background technique [0002] Doxycycline hydrochloride is a tetracycline antibiotic. Doxycycline reversibly binds to the receptor on the 30S subunit of the bacterial ribosome, interferes with tRNA and mRNA to form a ribosome complex, prevents peptide chain elongation and inhibits protein synthesis, thereby rapidly inhibiting bacterial growth and reproduction. Doxycycline inhibits both Gram-positive and Gram-negative bacteria. Bacteria are cross-resistant to doxycycline and oxytetracycline. [0003] The mixed infection of porcine pneumonia and mycoplasma pneumonia is a complex disease of pigs. Porcine pneumonia is a respiratory disease caused by Salmonella, and mycoplasma pneumonia is a respiratory disease caused by mycoplasma, also known as swine panting disease. The disease i...

AI Technical Summary

Problems solved by technology

[0003] The mixed infection of porcine pneumonia and mycoplasma pneumonia is a complex disease of pigs. Porcine pneumonia is a respiratory disease caused by Salmonella, and mycoplasma pneumonia is a respiratory disease caused by mycoplasma, also known as swine panting disease. The disease is the most common respiratory disease of pigs. Due to the continuous expansion of the breeding scale in recent years and the current basic knowledge of farmers and breeding enterprises or the defects in other aspects of facilities and disinfection, these two infectious diseases exist in the breeding area at the same time. , and then developed into a mixed infection, which brought great losses to the pig industry

[0004] At present, the first choice for the treatment of swine panting disease is to control pathogens and kill pathogenic microorganisms, such as doxycycline hydrochloride, ofloxacin and other drugs generally used, through long-term single use, pathogenic microorganisms have high drug resistance to drugs, At the same time, because the clinical symptoms after infection cannot be controlled, side effects such as prolongation of treatment, decreased feed intake due to clinical discomfort, slow down the recovery of the body, or cause other infections, make the disease more complicated and more difficult to treat