Doxycycline hydrochloride soluble powder and preparation method thereof

A doxycycline hydrochloride, soluble technology, applied in the direction of tetracycline active ingredients, powder delivery, pharmaceutical formulations, etc., can solve the problems of slow recovery of the body, causing other infections, unsuitable feed intake, etc., to reduce stress response, Good palatability and long-lasting effective blood concentration

Inactive Publication Date: 2019-05-03
江西九信药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The mixed infection of porcine pneumonia and mycoplasma pneumonia is a complex disease of pigs. Porcine pneumonia is a respiratory disease caused by Salmonella, and mycoplasma pneumonia is a respiratory disease caused by mycoplasma, also known as swine panting disease. The disease is the most common respiratory disease of pigs. Due to the continuous expansion of the breeding scale in recent years and the current basic knowledge of farmers and breeding enterprises or the defects in other aspects of facilities and disinfection, these two infectious diseases exist in the breeding area at the same time. , and then developed into a mixed infection, w

Method used

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Examples

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Effect test

Embodiment 1

[0025] A doxycycline hydrochloride soluble powder is composed of the following raw materials in mass percentage: 50% doxycycline hydrochloride and 50% anhydrous glucose.

[0026] The preparation of the doxycycline hydrochloride soluble powder of embodiment 1 comprises the following steps:

[0027] 1) Weigh doxycycline hydrochloride and anhydrous glucose according to the proportion, place them in a pulverizer and pulverize them, and sieve after pulverization, with a mesh size of 60-80 mesh;

[0028] 2) Put the doxycycline hydrochloride and anhydrous glucose after step 1) crushed and sieved into trays and send them to a hot air circulation oven for drying for 1-2 hours. The drying temperature is 70°C, and the trays are turned over every 0.5 hours;

[0029] 3) Put the dried doxycycline hydrochloride and anhydrous glucose into the V-shaped mixer barrel in proportion, and mix for 20-40 minutes to obtain doxycycline hydrochloride soluble powder.

Embodiment 2

[0031] A doxycycline hydrochloride soluble powder is composed of the following raw materials in mass percentage: 55% doxycycline hydrochloride, 45% anhydrous glucose.

[0032] The preparation of the doxycycline hydrochloride soluble powder of embodiment 2 comprises the following steps:

[0033] 1) Weigh doxycycline hydrochloride and anhydrous glucose according to the proportion, place them in a pulverizer and pulverize them, and sieve after pulverization, with a mesh size of 60-80 mesh;

[0034] 2) Put the pulverized and sieved doxycycline hydrochloride and anhydrous glucose into a V-shaped mixer barrel, and mix for 20-40 minutes to obtain doxycycline hydrochloride soluble powder.

Embodiment 3

[0036] A doxycycline hydrochloride soluble powder is composed of the following raw materials in mass percentage: doxycycline hydrochloride 45%, anhydrous glucose 55%.

[0037] The preparation of the doxycycline hydrochloride soluble powder of embodiment 3 comprises the following steps: Doxycycline hydrochloride, anhydrous glucose are sieved respectively, and number of meshes is 60-80 mesh; Then take doxycycline hydrochloride, anhydrous glucose in proportion; Put the anhydrous glucose into the V-shaped mixer barrel, and mix for 20-40 minutes to obtain doxycycline hydrochloride soluble powder.

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Abstract

The present invention provides doxycycline hydrochloride soluble powder. The doxycycline hydrochloride soluble powder is composed of the following raw materials in mass percentages: 45-55% of doxycycline hydrochloride and 45-55% of anhydrous glucose. The present invention also provides a preparation method of the doxycycline hydrochloride soluble powder. The doxycycline hydrochloride soluble powder can effectively treat respiratory diseases caused by treatment of pig and chicken gram-positive bacteria and negative bacteria of escherichia coli, salmonellosis, pasteurellosis and mycoplasma, hasa good therapeutic effect, is quick in effects, can address both symptoms and root causes, reduces stress response when diseases occur, prevents and treats concomitant and secondary infections of themycoplasma and chlamydia, uses conventional equipment during preparation, and is simple in production method, low in material cost, and suitable for industrialized mass production of antibiotic premixes of poultry and livestock.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a doxycycline hydrochloride soluble powder and a preparation method thereof. Background technique [0002] Doxycycline hydrochloride is a tetracycline antibiotic. Doxycycline reversibly binds to the receptor on the 30S subunit of the bacterial ribosome, interferes with tRNA and mRNA to form a ribosome complex, prevents peptide chain elongation and inhibits protein synthesis, thereby rapidly inhibiting bacterial growth and reproduction. Doxycycline inhibits both Gram-positive and Gram-negative bacteria. Bacteria are cross-resistant to doxycycline and oxytetracycline. [0003] The mixed infection of porcine pneumonia and mycoplasma pneumonia is a complex disease of pigs. Porcine pneumonia is a respiratory disease caused by Salmonella, and mycoplasma pneumonia is a respiratory disease caused by mycoplasma, also known as swine panting disease. The disease i...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/26A61K31/65A61P31/04
Inventor 陈峰蔡兰兰周卫平周海云
Owner 江西九信药业有限公司
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