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Compound sulfachlorpyridazine sodium powder for preventing and treating pasteurella infection of livestock and poultry

A technology of sulfachlorperazine sodium and chlorperazine sodium powder, which is applied in the field of drugs for preventing and treating Pasteurella infection in livestock and poultry, can solve problems such as failure to prevent and treat Pasteurella infection in livestock and poultry, and achieve health care prevention and treatment using safety, Easy to mix evenly, good fluidity effect

Inactive Publication Date: 2013-01-02
金河牧星(重庆)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Simultaneously, there is no sulfachlordazine sodium powder preparation for preventing and treating Pasteurella infection in livestock and poultry in the prior art

Method used

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  • Compound sulfachlorpyridazine sodium powder for preventing and treating pasteurella infection of livestock and poultry
  • Compound sulfachlorpyridazine sodium powder for preventing and treating pasteurella infection of livestock and poultry
  • Compound sulfachlorpyridazine sodium powder for preventing and treating pasteurella infection of livestock and poultry

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Formula

[0025] Sulfachlordazine sodium 60g, indomethacin potassium 2g, bentonite 5g, sodium citrate 5g, sodium carboxymethylcellulose 3g, sodium saccharin 2g, soluble starch 23g.

[0026] 2: Preparation method

[0027] The first step: take the bentonite, sodium citrate, and sodium carboxymethylcellulose of the prescription amount and grind them, pass through an 80-mesh sieve after grinding, and then stir and mix for 15 minutes to obtain A powder without patterns and stains, which is set aside;

[0028] Step 2: take the prescribed amount of sulfachlordazine sodium, indomethacin potassium and saccharin sodium and pulverize, pass through an 80-mesh sieve after pulverization, and then stir and mix for 15 minutes to obtain B powder without patterns and color spots, which is set aside;

[0029] Step 3: Add the above-mentioned B powder to the A powder according to the method of equal addition and stir evenly, then add enough soluble starch and continue to stir and mix fo...

Embodiment 2

[0031] 1. Formula

[0032] Sulfachlordazine sodium 62.5g, indomethacin potassium 3g, bentonite 7.5g, sodium citrate 7.5g, sodium carboxymethylcellulose 4g, sucrose 3g, anhydrous glucose 12.5g.

[0033] 2: Preparation method: the same as the method described in Example 1, only the corrective agent sodium saccharin is replaced with sucrose, and other carrier soluble starch is replaced with anhydrous glucose.

Embodiment 3

[0035] 1. Formula

[0036] Sulfachlordazine sodium 65g, indomethacin potassium 4g, bentonite 10g, sodium citrate 10g, sodium carboxymethylcellulose 5g, sucrose 4g, anhydrous glucose 2g.

[0037] 2: Preparation method: the same as the method described in Example 1, only the corrective agent sodium saccharin is replaced with sucrose, and other carrier soluble starch is replaced with anhydrous glucose.

[0038] Stability test of compound sulfachlorperazine sodium powder

[0039] 1. Materials and methods: get the compound sulfachlordazine sodium powder of embodiment 1-3, carry out high-temperature, high-humidity, and strong-light acceleration experiments according to the drug stability test method in the first appendix of "Chinese Veterinary Pharmacopoeia" 2010 edition, and pack according to commercially available , placed in a drug stability test box (Chongqing Yongsheng Experimental Instrument Factory) with a temperature of 40±2°C, a relative humidity of 75±5%, and an illuminat...

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PUM

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Abstract

The invention relates to compound sulfachlorpyridazine sodium powder for preventing and treating pasteurella infection of livestock and poultry. The compound sulfachlorpyridazine sodium powder comprises the following components by weight: 60-65 parts of sulfachloropyridazine sodium, 2-4 parts of indometacin potassium, 10-25 parts of suspending agents, 2-4 parts of flavoring agents and acceptable carriers accounting for parts added to be 100 parts. The compound sulfachlorpyridazine sodium powder has definite effect on pasteurellosis of various animals and is suitable for being popularized and applied to breeding of livestock and poultry. According to the compound sulfachlorpyridazine sodium powder, the sulfachloropyridazine sodium and the indometacin potassium are compatible for use, so that when antibacterial and anti-inflammatory effects are achieved, the indometacin potassium serving as the antibacterial synergist of the sulfachloropyridazine sodium can have an synergistic effect to strengthen the drug effect of the main drug. The compound sulfachlorpyridazine sodium powder can be taken orally or mixed in feeds or drinking water, is good in absorption and safe in usage, does not produce drug resistance easily, can be used for health protection, prevention and treatment for a long time, has good palatability, flowability and suspension water-soluble performance, and is various in clinical dosing mode and convenient to dose.

Description

technical field [0001] The invention relates to a compound sulfachlordazine sodium powder, and also relates to a medicine for preventing and treating Pasteurella infection in livestock and poultry. Background technique [0002] The antibacterial spectrum of sulfachlordazine sodium is similar to that of sulfamethoxine. It is one of the sulfa drugs with the strongest antibacterial effect in the body. It has a strong inhibitory effect on most Gram-positive and negative bacteria. Resistance is slower. The blood concentration is high, the acetylation rate is low, and it is not easy to produce crystalluria. [0003] Pasteurellosis is a septic infectious disease of various animals caused by Pasteurella multocida. When factors such as climate, seasonal changes, long-distance transportation, parasitic infection, and malnutrition lead to a decrease in animal body resistance, the Pasteurella bacteria present in the respiratory tract and tonsils of healthy carrier animals will become ...

Claims

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Application Information

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IPC IPC(8): A61K31/635A61K31/405A61K9/14A61P31/04
Inventor 陈益德秦斌胡学全
Owner 金河牧星(重庆)生物科技有限公司
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