Eye drop and its preparing method and use

A technology of eye drops and distilled water, which is applied in the field of medicine, can solve the problems of local immunity decline, etc., and achieve the effects of reducing toxic and side effects, prolonging the residence time, and reducing the amount of medication

Inactive Publication Date: 2007-10-03
ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term use of the above three eye drops may cause a decrease in local immunity, followed by the risk of infectious corneal ulcers

Method used

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  • Eye drop and its preparing method and use
  • Eye drop and its preparing method and use
  • Eye drop and its preparing method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The eye drop of the present invention contains 0.001 g of doxycycline hydrochloride, 0.075 g of sodium chloride, and pH 5.5-6.0, based on 10 ml of eye drop.

[0033] Preparation method 1: Take 0.01 g of doxycycline hydrochloride and 0.75 g of sodium chloride, add 50 ml of distilled water to dissolve evenly, add distilled water to 100 ml, adjust the pH value to 5.5-6.0 during the process, and then use a 0.2um microporous filter Sterilize by membrane filtration, pack into 10 ml / branch, and obtain the eye drops of the present invention.

[0034] Preparation method 2: Take 0.001 g of doxycycline hydrochloride to make sterile micropowder, seal it in a sterile vial; dissolve 0.075 g of sodium chloride in 10 ml of distilled water, adjust the pH value to 5.5-6.0, and then use 0.2um The solution of the eye drops of the present invention can be obtained through microporous membrane filter sterilization and sealing. Before use, the doxycycline hydrochloride micropowder is dissolv...

Embodiment 2

[0036] The eye drop of the present invention contains 0.001 g of doxycycline hydrochloride, 0.01 g of sodium hyaluronate, 0.075 g of sodium chloride, and a pH of 5.5 to 6.0, based on 10 milliliters of the eye drop.

[0037] Preparation method 1: Take 0.01 g of doxycycline hydrochloride, 0.1 g of sodium hyaluronate, and 0.75 g of sodium chloride, add 50 ml of distilled water to dissolve evenly, add distilled water to 100 ml, adjust the pH value to 5.5-6.0 during the process, and then Use a 0.2um microporous membrane to filter and sterilize, and pack into 10 ml / support to obtain the eye drops of the present invention.

[0038] Preparation method 2: take 0.001 g of doxycycline hydrochloride to make sterile micropowder, and seal it in a sterile vial; take 0.01 g of sodium hyaluronate and 0.075 g of sodium chloride, dissolve them in 10 ml of distilled water, and adjust the pH value to 5.5~ 6.0, then use a 0.2um microporous membrane to filter and sterilize and seal to obtain the sol...

Embodiment 3

[0040] The eye drops of the present invention contain 0.001 g of doxycycline hydrochloride, 0.075 g of sodium chloride, 0.05 g of hydroxypropyl methylcellulose, and a pH of 5.5 to 6.0, based on 10 ml of eye drops.

[0041] Preparation method 1: Take 0.01 g of doxycycline hydrochloride, 0.75 g of sodium chloride, and 0.5 g of hydroxypropyl methylcellulose, add 50 ml of distilled water to dissolve evenly, add distilled water to 100 ml, and adjust the pH value during the process to 5.5~ 6.0, then filter and sterilize with a microporous membrane of 0.2um, and pack into 10 milliliters / support to obtain the eye drops of the present invention.

[0042] Preparation method 2: Take 0.001 g of doxycycline hydrochloride to make sterile micropowder, seal it in a sterile vial; dissolve 0.075 g of sodium chloride and 0.05 g of hydroxypropyl methylcellulose in 10 ml of distilled water, and adjust the pH value to 5.5-6.0, and then filter and sterilize with a 0.2um microporous membrane to obtai...

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Abstract

The present invention belongs to the field of medicine technology, relates to one kind of eye drop, and is especially one kind of eye drop for treating xerophthalmia, blepharitis, tarsal gland dysfunction and other eye surface inflammations and its preparation process and use. The eye drop contains osmotic buffering agent, distilled water, and vibramycin hydrochloride. The preparation process includes the following steps: dissolving vibramycin hydrochloride and osmotic buffering agent in distilled water; adding distilled water to required volume and regulating pH to 5.5-6.0; membrane filtering to sterilize and packing. Or, the eye drop is prepared through preparing abacterial vibramycin hydrochloride powder; dissolving osmotic buffering agent in distilled water and regulating pH to 5.5-6.0; membrane filtering to sterilize and dissolving vibramycin hydrochloride powder in the distilled water solution.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to an eye drop, in particular to an eye drop for treating ocular surface inflammatory diseases such as dry eye, blepharitis, and meibomian gland dysfunction, as well as a preparation method and application thereof. Background technique [0002] Dry eye is a general term for a class of diseases that cause ocular discomfort and ocular surface damage caused by abnormal tear quality and (or) quantity and abnormal tear dynamics. It is one of the most common ocular surface diseases. Dry eye not only affects people's quality of life, but severe dry eye can also cause keratitis, corneal neovascularization, corneal ulcer, etc., which seriously endanger vision. Therefore, dry eye has received unprecedented attention in the past ten years. The traditional drug treatment for dry eye is the use of artificial tears and the promotion of tear secretion, but the effect is not good. [0003] The occ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/65A61K9/08A61P27/02
Inventor 刘祖国邹文进肖启国
Owner ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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