218 results about "Extracellular polysaccharide" patented technology

The present invention relates to the screening of functional probiotics and its application, and specifically provides a strain of Lactobacillus casei RH99 that produces high extracellular polysaccharides and relieves vaginitis, and its preservation number is CGMCC No.32108. The Lactobacillus casei can inhibit the growth of Gardnerella, Candida albicans, and Peptostreptococcus and their biofilm generation ability; the extracellular polysaccharides produced by it have a significant promoting effect on the biofilm formation of Lactobacillus casei itself. RH99 is inoculated into the vagina, and its strain, the metabolites (exocellular polysaccharides) produced, and the core monosaccharide (D-mannitol) can all inhibit the colonization of pathogenic bacteria and promote the colonization of lactic acid bacteria; and RH99 can also relieve vaginitis by inhibiting inflammatory factors. It can be seen that RH99 can inhibit the growth of pathogenic bacteria + inhibit biofilm formation + inhibit pathogenic bacteria adhesion + inhibit the level of inflammatory factors through key core metabolites, and realize the all-round inhibition of four-in-one.

The present invention discloses a fermented mucus lactobacillus and its application. The present invention provides a fermented mucus lactobacillus A10 with high extracellular polysaccharide production, and its deposit number is CCTCC NO: M20242082. The fermented mucus lactobacillus A10 has strong bile salt and gastrointestinal digestion tolerance, and has obvious antibacterial effects on Escherichia coli and Staphylococcus aureus. The extracellular polysaccharide synthesized by the fermented mucus lactobacillus A10 is a Wzy type extracellular polysaccharide, which is a heteropolysaccharide composed of rhamnose, galactose, glucose, mannose, and glucuronic acid. It has good thermal stability and antioxidant activity, and can significantly scavenge free radicals. The fermented mucus lactobacillus A10 extracellular polysaccharide provided by the present invention can exert antioxidant activity by activating the Keap1-Nrf2 / ARE signaling pathway, and is expected to be developed into a natural antioxidant that interacts with Keap1-Nrf2 in a targeted manner.

The invention discloses an oral care composition and a preparation method thereof, the oral care composition comprises a friction agent, a periodontal repair agent, a thickening agent, a humectant and a foaming agent, the friction agent comprises a dental plaque release agent, and the dental plaque release agent is configured to destroy a bacterial extracellular polysaccharide matrix in dental plaque; the periodontal repair agent comprises at least one of the following components: an inflammation inhibitor, a tissue repair promoter, a mucous membrane stimulation alleviator and a bacteriostatic agent. The oral care composition contains the dental plaque release agent and the periodontal repair agent, and can synergistically improve periodontal health.

The invention relates to the technical field of microorganisms, in particular to bifidobacterium bifidum BGLP1 capable of regulating sugar digestion and producing GLP-1 at high yield and application of the bifidobacterium bifidum BGLP1. The preservation number of the bifidobacterium bifidum BGLP1 is CGMCC (China General Microbiological Culture Collection Center) No.35718, and the bifidobacterium bifidum BGLP1 can be used for preparing the feed additive. The strain has the capability of inhibiting alpha-glucosidase and alpha-amylase; sTC-1 cells are stimulated to secrete GLP-1, and the blood glucose reducing pathway capacity of the intestinal tract is activated; the activity of pancreatic lipase is obviously inhibited, and the dietary fat absorption capability can be effectively reduced; redundant cane sugar is converted into exopolysaccharide, so that the probiotic function capability is improved; the capability of converting white fat into brown fat is promoted; macrophages are activated, and the body immune function is improved. In addition, the bifidobacterium bifidum BGLP1 also has relatively strong intestinal colonization ability, has good tolerance in artificial gastric juice and artificial intestinal juice, and can smoothly reach the intestinal tract of a human body.

The invention relates to the technical field of water-soluble fertilizers, in particular to an amino acid water-soluble fertilizer and a preparation method thereof. The amino acid water-soluble fertilizer is prepared from the following raw materials in parts by weight: 60-80 parts of an amino acid solution, 20-30 parts of a nitrogen-phosphorus-potassium fertilizer, 6-10 parts of filler, 4-6 parts of a fermentation material, 2-4 parts of brown sugar, 2-4 parts of ethylenediaminetetraacetic acid ferric sodium salt and 0.6-0.8 part of a microbial agent. According to the amino acid water-soluble fertilizer, the filler is added in the preparation process of the amino acid water-soluble fertilizer, after balsa wood is soaked with sodium hydroxide, lignin is partially degraded, a honeycomb-shaped porous structure is formed, the purpose of increasing the specific surface area is achieved, and the effect of adsorbing nitrogen and potassium ions can be achieved; and after the microbial inoculum is inoculated, mycelia are planted in pores of the filler and secrete exopolysaccharide to wrap fertilizer particles, so that the effect of reducing leaching loss is achieved, the retention time of the fertilizer in soil is delayed, and the loss rate of the fertilizer is effectively reduced.

The invention relates to the technical field of microorganisms, in particular to compound probiotics capable of degrading indole and preventing or relieving nephropathy and application of the compound probiotics. The compound probiotics comprise bifidobacterium animalis subsp. Lactis YYS-J9 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) NO.28185 and bifidobacterium longum subsp. Longum YYS-BSM8 with the preservation number of CGMCC NO.28611. The invention further discloses a preparation method of the compound probiotics. Compared with the use of a single YYS-J9 strain or YYS-BSM8 strain, the two strains have synergistic effects after being compounded, the viable count is remarkably increased after mixed culture, the inhibition effect on pathogenic enterobacteria and the adhesion to intestinal cells are remarkably enhanced, the degradation capacity on indole and oxalic acid is higher, the proliferation and phagocytic activity of macrophages is remarkably improved, and the application range of the YYS-J9 strain and the YYS-BSM8 strain is widened. And when being applied to food, health-care products or medicines, the exopolysaccharide can be used for effectively preventing or improving nephropathy and kidney stone, regulating intestinal health and improving intestinal immunity.

The invention discloses lactobacillus plantarum YBE2 and application thereof.According to the lactobacillus plantarum YBE2 for high yield of extracellular polysaccharide mainly containing rhamnose, different cholate types can be degraded at the same time, glycocholic acid is specifically hydrolyzed, and the lactobacillus plantarum YBE2 has the effects of lowering cholesterol and relieving acute inflammation at the same time. Meanwhile, the plant lactobacillus YBE2 can reduce the deposition of fat in the belly of the cage rearing broiler chicken, improve intramuscular fat, promote the deposition of fatty acid in muscles, reduce the total bile acid of plasma, triglyceride and low-density lipoprotein cholesterol, and remarkably improve the lipid metabolism and muscle quality of meat poultry, and can be widely applied to the breeding of the cage rearing broiler chicken, promote the healthy breeding of the meat poultry and improve the quality of the meat poultry. The culture benefit is improved.

The invention relates to the technical field of mineral processing, and particularly provides a combined reagent system for flotation and magnesium reduction of talc-containing copper-molybdenum ore and application of the combined reagent system. The combined reagent system comprises a flotation collecting agent (faint yellow to orange transparent liquid, 40%-50% of active ingredients and less than or equal to 3% of free alkali) with active ingredients in the formula 1 and a flotation depressing agent (light yellow powder, extracellular polysaccharide extract of xanthomonas, the weight-average molecular weight of 1000-1500000 Daltons and rich in hydroxyl, carboxyl and pyruvic acid groups) with a structural formula in the formula 2, and the flotation depressing agent comprises extracellular polysaccharide extract of xanthomonas, the weight-average molecular weight of xanthomonas and the weight-average molecular weight of xanthomonas and is rich in hydroxyl, carboxyl and pyruvic acid groups. Through the synergistic adsorption effect of the combined reagent, the flotation grade and the recovery rate of the copper sulfide molybdenum ore are remarkably improved under the condition that the pH is 8-11. The combined reagent system has the advantages of being high in flotation efficiency, high in selectivity, low in reagent cost, environmentally friendly, high in industrial applicability and the like.

The invention discloses high-yield exopolysaccharide lactic acid bacteria and application thereof, the high-yield exopolysaccharide lactic acid bacteria (Lactobacillus plantarum) Y-18 has the preservation number of CCTCC NO: M 2025180, the preservation time is January 16, 2025, the preservation unit is China Center for Type Culture Collection, the address is Life Science College, Wuhan University, Luojia Hill, Wuchang District, Wuhan City, Hubei Province, the high-yield exopolysaccharide lactic acid bacteria are applied to fermentation to produce exopolysaccharide, and the yield is up to 8.69 mg / ml.

The invention provides a grifola frondosa liquid culture medium as well as a culture method and application thereof, and relates to the technical field of fermentation. The invention provides a grifola frondosa liquid culture medium, which contains glucose, peptone, KH2P2O4, MgSO4, vitamin B1, gibberellin and tyrosol, can significantly improve the growth of grifola frondosa thalli and the secretion of exopolysaccharides, and can be used for the preparation of food, drugs and health care products.

The invention relates to the technical field of microorganisms, and discloses brevibacillus megatherium, a fungicide containing the brevibacillus megatherium, application of the brevibacillus megatherium and the fungicide and a method for preventing and treating plant diseases. The preservation number of the brevibacillus formmosus is CGMCC (China General Microbiological Culture Collection Center) No.32491, and the brevibacillus formmosus can be used for preparing the bacillus formmosus. The invention also provides a method for preventing and treating plant diseases. The method comprises the step of irrigating plants by using the brevibacillus beautiful and the fungicide. The brevibacillus megaterium has the effects of promoting growth and preventing diseases, has a relatively high bacteriostasis rate on phytophthora nicotianae, can efficiently antagonize black shank caused by phytophthora nicotianae, and has relatively strong capability of secreting auxin and exopolysaccharide.

The invention discloses a lactobacillus rhamnosus Z160 strain and an application of the lactobacillus rhamnosus Z160 strain in preparation of selenium-rich exopolysaccharides. The Z160 strain is separated from fermented pickled Chinese cabbages and is preserved in Guangdong Microbial Culture Collection Center on September 5, 2024, and the preservation number is GDMCC NO: 65104. When the Z160 strain is cultured, the yield of the exopolysaccharide can be increased by adding a selenium source, the obtained exopolysaccharide is high in selenium content and has good antioxidant and cholesterol-reducing activity, the Z160 strain can be used for preparing the selenium-rich exopolysaccharide, and the prepared selenium-rich polysaccharide can also be used for preparing products for preventing and treating hyperlipidemia and prolonging the life of animals. Besides, the selenium-rich exopolysaccharide prepared from the Z160 strain can inhibit formation of biofilms of pathogenic bacteria such as Listeria monocytogenes, and the obtained polysaccharide can be used for preventing and treating diseases related to the biofilms, cleaning and maintaining instruments polluted by the biofilms and the like.

The invention provides lactobacillus plantarum capable of producing exopolysaccharides and application of the lactobacillus plantarum in preparation of texture-enhanced fermented vegetable products, and belongs to the technical field of fermented food processing, and the preservation number of the lactobacillus plantarum is GDMCC NO: 63769. The invention also provides a preparation method of the fermented vegetables. The preparation method comprises the following steps: 1) mixing the pretreated vegetables with the salt brine to obtain a vegetable salt brine mixture; and (2) inoculating lactobacillus plantarum SAAS-B-MRS-20230301-5 into the vegetable salt brine mixture, and carrying out fermentation, so as to obtain the fermented vegetables. The lactobacillus plantarum with high exopolysaccharide yield is used for preparing the fermented vegetables, so that the industrial problem of texture deterioration of quickly fermented vegetable products can be more conveniently and quickly solved.

The present invention relates to a strain of Paenibacillus polymyxa with disease prevention, stress resistance and growth promotion and its application, belonging to the field of microbial technology. The Paenibacillus polymyxa SS44 has the characteristics of degrading protein, degrading fat, degrading cellulose, releasing potassium, fixing nitrogen, decomposing organic phosphorus, dissolving inorganic phosphorus and producing extracellular polysaccharide. It can antagonize the pathogenic fungi Fusarium oxysporum and Fusarium fujikuroi that can cause potato wilt, sweet potato root rot, soybean root rot, alfalfa root rot, etc. Moreover, this strain can improve sandy soil and has a good growth promotion effect on wheat, soybean and corn in saline-alkali soil and sandy barren soil environments, with very broad application prospects.

The invention belongs to the technical field of biology, and particularly relates to application of an ags1 gene segment in regulating monascus exopolysaccharide synthesis. According to the invention, the ags1 gene segment related to synthesis of a mycelium aggregation factor-cell wall alpha-1, 3-glucan is found from monascus for the first time, and experimental research finds that compared with an initial strain, the content of exopolysaccharides in liquid fermentation liquor of monascus recombinant bacteria of which the gene segment is knocked out is remarkably increased, and the content of the exopolysaccharides in the liquid fermentation liquor is remarkably reduced. The content of extracellular polysaccharide in liquid fermentation liquor of monascus recombinant bacteria overexpressing the gene segment is reduced, but the relative content of galactomannan in the extracellular polysaccharide is increased, so that the monascus recombinant bacteria have higher immunocompetence.

The invention discloses double-milk-source fermented milk of double-peak camel milk and brown milk and a preparation method of the double-milk-source fermented milk, and the preparation method comprises the following steps: mixing raw materials: mixing the double-peak camel milk and the brown milk according to a mass ratio to obtain double-milk-source mixed milk; pretreatment: sequentially carrying out homogenization treatment and heat treatment on the double-milk-source mixed milk; strain inoculation: inoculating the pretreated double-milk-source mixed milk with a fermentation strain, wherein the fermentation strain comprises a core strain and an auxiliary strain; the core strains are lactobacillus and streptococcus thermophilus which have tolerance to antibacterial components of the camel milk, and the core strains contain strains capable of producing exopolysaccharides. Through scientific matching of lactobacillus, streptococcus thermophilus and specific auxiliary strains which have tolerance to antibacterial components of the camel milk, the inhibition effect of natural antibacterial components such as lysozyme and lactoferrin in the camel milk on conventional strains is successfully overcome.

The invention relates to the technical field of microorganisms, in particular to compound probiotics for relaxing bowel and improving intestinal immunity and application thereof. The compound probiotics comprise a plant lactobacillus BXM2 strain with the preservation number of CGMCC (China General Microbiological Culture Collection Center) NO.16436 and a bifidobacterium longum subsp. Longum YYS-BSM8 strain with the preservation number of CGMCC NO.28611, and the ratio of the viable count of the plant lactobacillus BXM2 to the viable count of the bifidobacterium longum subsp. Longum YYS-BSM8 is (1-10): (1-10). After the two bacteria are compounded and combined, the gastrointestinal motility efficiency of zebra fish is accelerated, constipation is relieved, enteropathogenic bacteria are inhibited, the adhesive force of intestinal cells is improved, exopolysaccharides are produced at high yield, proliferation and phagocytic activity of macrophages are promoted, oxidative damage is remarkably relieved, and synergistic interaction is achieved in the aspects of improving the intestinal motility efficiency, relieving constipation and improving body immunity; the important application value is realized.

The invention discloses a Dunella strain, polysaccharide produced by the Dunella strain and application of the Dunella strain. The preservation number of the Duronella G3 is CCTCC (China Center For Type Culture Collection) NO: M 2024137, and the exopolysaccharide TDG3 produced by the Duronella G3 is used as a TLR4 / DC-SIGN dual receptor agonist and has the effect of remarkably reducing body weight. The exopolysaccharide TDG3 disclosed by the invention can obviously reduce the appetite of mice, reduce the food intake, reduce the body weight and reduce the content of adipose tissues, can also relieve or prevent liver fatty degeneration caused by obesity, is safe and non-toxic, is suitable for preparing the medicines for reducing fat and losing weight, and has a relatively good clinical application value and a wide application prospect.

The invention relates to lactobacillus reuteri SAU-R-8 which is derived from Tibet naturally-fermented sour yak milk and is used for producing exopolysaccharides and application of the lactobacillus reuteri SAU-R-8 in reducing uric acid, and belongs to the technical field of microorganisms. The strain is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.30373, and the preservation date is April 19, 2024. The lactobacillus reuteri SAU-R-8 provided by the invention is screened from yak yogurt naturally fermented from herdsmen in the Sankarst region of Tibet, the yield of exopolysaccharides in an MRS culture medium reaches 318.57 mg / L, nucleoside substances such as inosine and guanosine can be efficiently degraded, purine substances such as guanine can be efficiently absorbed, the activity of xanthine oxidase can be inhibited, and the lactobacillus reuteri SAU-R-8 can be used for preparing the yak yogurt. The method can be further applied to product development for relieving or treating hyperuricemia.

The invention discloses a thallus-exopolysaccharide co-embedded envelope state microcapsule and a preparation method thereof, and belongs to the technical field of microcapsule preparation. The preparation method comprises the following steps: (1) dissolving sodium alginate, pectin and whey protein isolate, stirring for 3-4 hours, and sterilizing to obtain a composite wall material solution; and (2) inoculating the activated bacterial liquid into a composite wall material solution, then adding the enveloping matrix exopolysaccharide, uniformly stirring and mixing, then adding a calcium chloride solution to form gel, then removing redundant gel, and cleaning to prepare the thallus-exopolysaccharide co-embedded enveloping state microcapsule. The co-embedded microcapsule prepared by the invention not only has good storage stability, high temperature resistance, osmotic pressure stress resistance and the like, but also can effectively promote the proliferation of thalli.

The invention discloses antibacterial mouthwash as well as a preparation method and application thereof, and belongs to the technical field of daily chemical products. According to the invention, egg white lysozyme, ferulic acid and grape seed procyanidine are taken as core components, and the mouthwash with an efficient bacteriostatic effect is developed. And the antibacterial rates of streptococcus mutans and porphyromonas gingivalis are 96.88% and 96.30% respectively. Researches show that bacterial biofilms can be destroyed by using the mouthwash, and the biofilm quantity is reduced by 53.7% after the bacterial biofilms are treated for 24 hours; extracellular polysaccharide is inhibited, the content of water-insoluble glucan is reduced by 62.3%, and synthesis of a key cariogenic matrix is hindered; the acid production capacity is regulated and controlled, the pH change of 24-hour culture is only 1.50, and xylitol competitively inhibits glycolysis and cooperates with ferulic acid to block bacterial metabolism. The mouthwash prepared by the invention avoids the problem of enzyme activity inhibition of the ionic surfactant of the traditional mouthwash, takes effect more quickly, and provides a basis for developing natural, safe and efficient functional mouthwash.

The invention relates to the technical field of microbial fermentation and food processing, and particularly discloses Weissella fusiformis JMF-006 as well as a mutagenesis method and application thereof. The invention provides a Weissella fusiformis JMF-006 with the exopolysaccharide yield of 20-25g / L. The Weissella fusiformis JMF-006 is obtained by breeding through a mutation breeding method of a high-yield EPS strain, and the mutation breeding method can also be used for culturing other high-yield EPS strains. The invention provides a strain composition, the strain composition comprises Weissella fusiformis JMF-006 or a high-yield EPS strain, other lactic acid bacteria strains (such as lactobacillus plantarum JMF-001 and lactobacillus casei JMF-002) can be further compounded, and the obtained strain composition has more excellent fermentation performance. When the Weissella fusiformis JMF-006, the high-yield EPS strain and the strain composition provided by the invention are applied to the fermentation process of food-derived drinks, a fermented product with stable properties and better flavor can be obtained, and the technical problems that the yield of extracellular polymeric substances is low, the fermentation performance is poor and the application range is narrow in an existing lactic acid bacteria starter are solved.

The invention discloses an extraction method of tremella sporocarp extracellular polysaccharide and application of the tremella sporocarp extracellular polysaccharide in skin repair, and relates to a Ni < 2 + > modified tannic acid modified mesoporous material and a method for preparing high-purity tremella sporocarp extracellular polysaccharide through physical adsorption of protein, the method comprises the following steps: covering the surface of a mesoporous SBA-15 material with tannic acid, and then adding Ni < 2 + > ions for unsaturated chelating; the Ni < 2 + > modified tannic acid modified mesoporous protein adsorption material is prepared; the method comprises the following steps: fully soaking tremella, fully dissolving tremella sporocarp extracellular polysaccharide in water, concentrating and centrifugally separating the sporocarp extracellular polysaccharide solution to remove particle impurities, and removing protein through a mesoporous protein adsorption material. The method adopts pure physical extraction of tremella sporocarp exopolysaccharide, and has the characteristics of simple process, capability of improving resource utilization, suitability for factory continuous production, no organic solvent residue, high product purity, good skin health effect and the like.

The invention relates to a method for purifying mine gushing water. The method comprises the following steps: mixing filamentous microalgae and to-be-treated mine gushing water for purification treatment. According to the method, filamentous microalgae are adopted to purify the to-be-treated mine gushing water, extracellular polysaccharide secreted by the filamentous microalgae growing in the mine gushing water can adsorb suspended solids in the mine gushing water, and meanwhile, the filamentous microalgae grow in the mine gushing water to be bent and wound algae filaments can also remove the suspended solids in the mine gushing water; therefore, the purification effect of the mine gushing water is effectively improved. Moreover, compared with traditional inorganic flocculants and organic polymer flocculants, the filamentous microalgae adopted in the invention have no chemical residues, and have less pollution to the environment and less toxicity to the ecological environment.

The present invention discloses a bacillus producing moisturizing and anti-inflammatory polysaccharides and its application, and relates to the technical field of microorganisms. Bacillus sp. The extracellular polysaccharide produced by ZR001 has the effects of skin moisturizing and anti-inflammatory, and can be widely used in the fields of medicine, cosmetics and skin care products. The present invention also discloses a method for applying Bacillus Bacillus sp. ZR001 Method for producing extracellular polysaccharides by optimizing Bacillus Bacillus sp. ZR001 culture medium and culture conditions greatly increased the production of extracellular polysaccharides, up to 25.8g / L.

The invention discloses a freeze-dried tablet for improving the immunity of pets and a preparation process of the freeze-dried tablet, and belongs to the technical field of pet food manufacturing. The preparation process comprises the following steps: inoculating lactobacillus plantarum on the surface of sporoderm-broken ganoderma lucidum spore powder, producing stress conditions by intermittently spraying a nutrient solution, inducing thalli to proliferate and secrete exopolysaccharide (EPS) to form an active biological membrane, and obtaining a biological membrane-base material composite functional body; and mixing with the basic meat material, and freeze-drying to obtain the finished product. The probiotics are actively induced to form an endogenous biological membrane protection layer, so that the stress resistance of the probiotics is fundamentally improved. The prepared freeze-dried tablet is high in viable count (greater than or equal to 101CFU / g) and strong in gastric acid tolerance (survival rate gt, 80%), can be stored at normal temperature for a long time (survival rate gt, 79% after 12 months), can efficiently deliver viable bacteria to intestinal tracts of pets and exert an immunological enhancement function, and solves the technical problems that existing probiotic products are low in survival rate and limited in efficacy exertion.

The invention discloses a method for rapidly optimizing calcareous sand fixing bacteria based on extracellular polysaccharide content detection, which is used for optimizing bacterial strains with excellent sand fixing performance and rapidly providing microbial resources for reducing coral island soil erosion. The method provided by the invention can shorten the subsequent inspection on the calcareous sand consolidation capacity of the strain, can judge the sand consolidation capacity of the strain only by accurately measuring the exopolysaccharide content of the purified strain, can greatly save the time cost, provides a large number of strain resources for sand consolidation and erosion prevention of the coral island, and has a wide application prospect. The method has the advantages of simple operation, low cost, easy popularization and the like.

The present application relates to the technical field of microorganisms, and particularly relates to a bifidobacterium BGLP1 capable of regulating sugar digestion and high GLP-1 production and application thereof. Bifidobacterium bifidum The bifidobacterium BGLP1 (CGMCC No. 35718) has the abilities of inhibiting alpha-glucosidase and alpha-amylase, stimulating STC-1 cells to secrete GLP-1 and activating the intestinal glucose-lowering pathway, significantly inhibiting pancreatic lipase activity and effectively reducing dietary fat absorption, converting excess sucrose into extracellular polysaccharides to increase the probiotic function, promoting the conversion of white fat into brown fat, and activating macrophages and improving the immune function of the body. In addition, the bifidobacterium BGLP1 has strong intestinal colonization ability, has good tolerance in artificial gastric juice and artificial intestinal juice, and can successfully reach the human intestinal tract.

The present invention discloses a riclin-based calcipotriol nanoemulsion, the raw materials of which include: calcipotriol, oil, and an aqueous solution containing an emulsifier; wherein the emulsifier is composed of an extracellular polysaccharide riclin and polyethylene glycol in a weight volume ratio of 12.5mg:0-0.02ml; the structural formula of the extracellular polysaccharide riclin is shown in formula (I). The present invention also discloses a method for preparing the above-mentioned riclin-based calcipotriol nanoemulsion, comprising the following steps: mixing an aqueous solution containing an emulsifier with oil dissolved with calcipotriol, and ultrasonically homogenizing to obtain the riclin-based calcipotriol nanoemulsion. The present invention also discloses the use of the above-mentioned riclin-based calcipotriol nanoemulsion in the preparation of a drug for treating psoriasis. The riclin-based calcipotriol nanoemulsion of the present invention has good stability, strong anti-psoriasis effect, rapid absorption, and low irritation to the body.

The invention belongs to the field of microorganisms, and particularly discloses lactobacillus bulgaricus for producing extracellular polysaccharide (EPS) and application of the lactobacillus bulgaricus. According to the invention, lactobacillus bulgaricus with high yield of exopolysaccharides is screened out from dairy fan fermentation acid water of traditional dairy products in Yunnan China, and the preservation number of the lactobacillus bulgaricus is CGMCC (China General Microbiological Culture Collection Center) NO: 29906. The content of crude extracellular polysaccharide extracted by the strain can reach 400mg / L, and the strain has great application value.