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Repairing gel containing growth factors and preparation method of repairing gel

A growth factor and gel technology, applied in the field of medicine, can solve the problems of high viscosity of carbomer gel, poor repair effect, poor use feeling, etc., to control wound infection, accelerate wound healing, and have excellent bacteriostatic properties. Effect

Active Publication Date: 2016-08-03
湖北兵兵药业(集团)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this invention, carbomer is used as a thickener, and chitosan is used to wrap hexagonal mesoporous silicon loaded with growth factors to form a repair gel. The growth factors in the repair gel do not completely penetrate the chitosan matrix, and the growth It is difficult for the factor to seep out and reach the skin surface to repair the skin, and the repair effect is not good; due to the high viscosity of carbomer gel, it is difficult to apply and the feeling of use is not good

Method used

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  • Repairing gel containing growth factors and preparation method of repairing gel
  • Repairing gel containing growth factors and preparation method of repairing gel
  • Repairing gel containing growth factors and preparation method of repairing gel

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preparation example Construction

[0054] The preparation method of embodiment 1~7 repairing gel of the present invention:

[0055] A) Take the alkaline polysaccharide and add it to deionized water, mix and stir evenly to obtain an alkaline polysaccharide solution, take the cellulose derivative water-soluble polymer and add it to deionized water, mix and stir evenly to obtain a cellulose derivative water-soluble polymer solution; the above two solutions are uniformly mixed and swelled to obtain a basic polysaccharide / cellulose derivative water-soluble polymer scaffold;

[0056] B) Take carbomer, add it into deionized water while stirring, swell for 24 hours, add the above-mentioned basic polysaccharide / cellulose derivative water-soluble polymer support, stir for 15 minutes, continue to add natural plant polysaccharides, exopolysaccharides Natural water-soluble polymer, humectant, transdermal absorbent, hyaluronic acid and penetration enhancer, stirred for 30 minutes, added pH adjuster to adjust the pH to 7.0, t...

Embodiment 4

[0088] Example 4 group: external application of the repair gel prepared in Example 4 of the present invention;

Embodiment 5

[0089] Example 5 group: external application of the repair gel prepared in Example 5 of the present invention;

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Abstract

The invention belongs to the medicine field, and particularly relates to repairing gel containing growth factors and a preparation method of the repairing gel .The repairing gel is prepared from 0.001%-0.02% of the growth factors, 0.05%-1% of alkaline polysaccharides, 0.5%-2% of a cellulose derivative water-soluble polymer, 0.05%-2% of natural plant polysaccharides, 0.01%-1% of a natural water-soluble polymer of extracellular polysaccharides, 0.1%-2% of carbomer, 12%-40% of a wetting agent, 0.05%-4% of a pH regulating agent, 0.01%-2% of hyaluronic acid, 0.6%-3% of a transdermal absorption agent, 0.1%-0.3% of a penetration enhancer and the balance deionized water .The repairing gel has the excellent antibacterial effect and the good moisture absorption performance and can significantly increase the cure rate of a wound surface, shorten the healing time of the wound surface and prevent scar formation.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a repair gel containing growth factors and a preparation method thereof. Background technique [0002] The skin is composed of epidermis, dermis and subcutaneous tissue. Its function is to protect internal tissues from external damage; perform metabolism such as absorption, perspiration, secretion of sebum and excretion of waste; the skin can also regulate body temperature, feel pain, touch, pressure, warm, cold and other stimuli, and have immune effects. It is inevitable that people will suffer from traumas of different severity in their life, especially trauma, natural disasters and surgical trauma after illness are often unavoidable. When the skin damage reaches a certain level, due to the fibroproliferative reaction, the skin wound repair will end in scar formation. Various body surface scars will destroy the original skin integrity, damage the appearance, and bring phys...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0014A61L26/0023A61L26/0066A61L26/008A61L2300/404A61L2300/414C08L5/08C08L1/08C08L33/02
Inventor 王海波王中元张慧芳黄强于志敏
Owner 湖北兵兵药业(集团)有限公司
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