Application of hesperetin, tangeretin and glycyrrhetinic acid in inhibiting chloride ion channels

A chloride ion channel and glycyrrhetic acid technology is applied in the fields of climate change adaptation, medical preparations containing active ingredients, digestive system, etc. It can solve the problem of insufficient selectivity of CFTR chloride ion channel, and achieve a simple and easy detection method. purchased effect

Inactive Publication Date: 2018-11-16
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the research on CFTR chloride channel blockers is still going on, and because the selectiv

Method used

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  • Application of hesperetin, tangeretin and glycyrrhetinic acid in inhibiting chloride ion channels
  • Application of hesperetin, tangeretin and glycyrrhetinic acid in inhibiting chloride ion channels
  • Application of hesperetin, tangeretin and glycyrrhetinic acid in inhibiting chloride ion channels

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Embodiment

[0020] 1) Experimental part

[0021] 1) Preparation of raw materials: male healthy adult Kunming mice, weighing 18-20g, SPF grade (provided by the Experimental Animal Center of Guangdong Southern Medical University); DPC (Sigma Aldrich Company, the United States); glycyrrhetinic acid (purchased from Chengdu Ruifen Si Biotechnology Co., Ltd.); hesperetin (purchased from Chengdu Pusi Biotechnology Co., Ltd.); hesperetin (purchased from Chengdu Alpha Biotechnology Co., Ltd.); dimethyl sulfoxide (analytical grade, Tianjin Zhiyuan Reagent Company), absolute ethanol (analytical grade, Tianjin Zhiyuan Reagent Company); platinum wire, Ag / AgCl electrode, suede (Shanghai Chenhua Instrument Co., Ltd.); α-Al2O3 powder (particle size 0.3 µm, Shanghai Chenhua Instrument Co., Ltd.); 3 mm glassy carbon electrode (Shanghai Sanmush Industrial Co., Ltd.); CHI660E electrochemical workstation (Shanghai Chenhua Instrument Co., Ltd.); B-220 constant temperature water bath (Shanghai Yarong Biochemica...

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Abstract

The invention discloses an application of hesperetin, tangeretin and glycyrrhetinic acid in inhibiting chloride ion channels, wherein the chloride ion channels can be inhibited; the invention discloses the application in development of drugs for treatment of diarrhea, heart disease, lung disease, stomach disease, brain disease, mental disease, rhinitis, otology diseases and ocular diseases. The detection verification method has raw materials easy to obtain, and the detection method is simple.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of hesperetin, hesperetin and glycyrrhetinic acid in inhibiting chloride ion channels. Background technique [0002] Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride ion channel structurally belonging to the ATP-binding cassette transporter, widely expressed in various epithelial cell membranes, most commonly found in the intestinal tract, The respiratory tract, secretory glands, biliary tract, and testis play important roles in the transepithelial transport of chloride ions, fluid flow, regulation of ion concentrations, and electrolyte and fluid secretion in the small intestine and pancreas. When the function of CFTR chloride ion channel declines, it will lead to cystic fibrosis, which is more common in Caucasians; when the function of CFTR chloride ion channel is hyperactive, it will lead to intestinal electrolyte and fluid secretion disorders,...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K31/56A61P1/12A61P1/04A61P9/04A61P9/12A61P11/00A61P7/10A61P11/06A61P11/02A61P25/18A61P27/02A61P27/06
CPCA61K31/352A61K31/56A61P1/04A61P1/12A61P7/10A61P9/04A61P9/12A61P11/00A61P11/02A61P11/06A61P25/18A61P27/02A61P27/06A61K2300/00Y02A40/70
Inventor 李康蔡欣叶建平黄煜恒
Owner GUANGDONG PHARMA UNIV
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