Application of hesperetin, tangeretin and glycyrrhetinic acid in inhibiting chloride ion channels

Abstract

The invention discloses an application of hesperetin, tangeretin and glycyrrhetinic acid in inhibiting chloride ion channels, wherein the chloride ion channels can be inhibited; the invention discloses the application in development of drugs for treatment of diarrhea, heart disease, lung disease, stomach disease, brain disease, mental disease, rhinitis, otology diseases and ocular diseases. The detection verification method has raw materials easy to obtain, and the detection method is simple.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of hesperetin, hesperetin and glycyrrhetinic acid in inhibiting chloride ion channels. Background technique [0002] Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride ion channel structurally belonging to the ATP-binding cassette transporter, widely expressed in various epithelial cell membranes, most commonly found in the intestinal tract, The respiratory tract, secretory glands, biliary tract, and testis play important roles in the transepithelial transport of chloride ions, fluid flow, regulation of ion concentrations, and electrolyte and fluid secretion in the small intestine and pancreas. When the function of CFTR chloride ion channel declines, it will lead to cystic fibrosis, which is more common in Caucasians; when the function of CFTR chloride ion channel is hyperactive, it will lead to intestinal electrolyte and fluid secretion disorders,...

AI Technical Summary

Problems solved by technology

[0003] At present, the research on CFTR chloride channel blockers is still going on, and because the selectivity of DPC to CFTR chloride channel is not strong enough, there are many limitations in clinical application.

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