9 results about "Chloride channel" patented technology

The application discloses a method for precisely regulating wax synthesis of plant leaves based on light-controlled chloride ion channel protein and belongs to the technical field of genetic engineering. The specific process is as follows: the light-controlled chloride ion channel protein opens or closes the ion channel under irradiation of different light, and the extracellular flow of chloride ions is promoted or terminated, so that the effect of promoting or terminating the wax synthesis is achieved. According to the principle of optogenetics, the application realizes the precise, reversible and space-time controllable regulation of the wax synthesis of the plant leaves, and assists in mining more genes related to the wax synthesis of the plants, thereby providing technical support for improving the adaptation ability of the plants to adversity.

This invention belongs to the field of pesticide technology, specifically relating to an insecticidal composition containing cybenzoxasulfyl and its application. The insecticidal composition comprises active ingredient A and active ingredient B, wherein active ingredient A is cybenzoxasulfyl; active ingredient B is selected from one or more of the following compounds: acetylcholinesterase inhibitors, nicotinic acetylcholine receptor (nAChR) channel blockers, nicotinic acetylcholine receptor (nAChR) allosteric modulator site I, nicotinic acetylcholine receptor (nAChR) competitive modulators, glutamate-gated chloride channel (GluCl) allosteric modulators, etc. This composition has a reasonable composition, good insecticidal effect, low application cost, and features reduced application amount, crop safety, and reduced pesticide residues.

Disclosed in the present invention are a γ-aminobutyric acid gated chloride ion channel allosteric modulator compound and the use thereof, i.e., (S)-4-(5-(3-chloro-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-yl)-2-methyl-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)benzamide. The compound has an excellent control effect on pests such as thysanoptera, acarina and lepidoptera, is very friendly to bees, has high environmental ecological safety, can be used for preparing efficient, low-toxicity and safe insecticides, and has wide application prospects in agricultural production.

An insecticidal composition containing cybenzoxasulfyl and the use thereof. The insecticidal composition contains active ingredient A and active ingredient B, wherein active ingredient A is cybenzoxasulfyl, and active ingredient B is selected from one or more of the following compounds: an acetylcholinesterase inhibitor, a nicotinic acetylcholine receptor (nAChR) channel blocker, nicotinic acetylcholine receptor (nAChR) allosteric modulator site I, a nicotinic acetylcholine receptor (nAChR) competitive modulator, a glutamate-gated chloride channel (GluCl) allosteric modulator, etc. The composition has reasonable components, good insecticidal effects, and low administration costs, and also has the characteristics of a reduced application amount, safety to crops, reduced pesticide residues, etc.

This invention relates to the biomedical field and discloses the application of the Ano5 gene as a therapeutic target for osteoporosis. This invention utilizes a previously constructed... Year 5 Gene knockout mouse model, construction Year 5 ‑ / ‑ The +OVX mouse model was used to clearly demonstrate the effects of inhibiting Ano5 on osteoporosis at the imaging, histological, biomechanical, serological, and molecular levels. Further research is needed on the inhibition... Year 5 The effects and molecular mechanisms of osteoporosis development, and using osteoclast ferroptosis as a starting point, reveal... Year 5 The mechanism by which gene defects inhibit bone resorption by promoting ferroptosis provides a theoretical basis for treating osteoporosis by targeting the chloride channel protein ANO5. This will contribute to the development of new targets for chloride channels in the treatment of osteoporosis.

An insecticidal composition containing oxazosulfyl and a use thereof, relating to the technical field of pesticides. The insecticidal composition comprises an active ingredient A and an active ingredient B, wherein the active ingredient A is oxazosulfyl; and the active ingredient B is selected from one or more of the following compounds: an acetylcholinesterase inhibitor, a nicotinic acetylcholine receptor (nAChR) channel blocker, an nAChR allosteric modulator site I, an nAChR competitive modulator, a glutamate-gated chloride channel (GluCl) allosteric modulator, etc. The composition has a reasonable formulation, good insecticidal efficacy, and low application costs, and has the characteristics of reduced application amount, safety to crops, reduced pesticide residue, etc.

The present application provides a steroid compound for treating central nervous system diseases, having a 9β, 10α structure and having the following structural formula: which acts as a GABA modulator, prolongs the opening time of chloride ion channel activated by GABA, modulates the excitability of central nervous system (CNS), treats and prevents CNS related disorders; and the 9β, 10α steroid compound of the present application has a sedative effect and can be used as a sedative.

The present invention relates to pesticide mixtures comprising as active compound I a carboxamide derivative active as an insecticide and at least one active compound II selected from group M comprising acetylcholine esterase inhibitors, GABA-regulated chloride channel antagonists, sodium channel modulators, nicotinic acetylcholine receptor agonists / antagonists, allosteric nicotinic acetylcholine receptor activators, chloride channel activators, juvenile hormone mimics, homopteran feeding blockers, mite growth inhibitors, mitochondrial ATP synthase inhibitors, oxidative phosphorylation uncouplers, chitin biosynthesis inhibitors, molting disruptors, ecdyson receptor agonists, octamine receptor agonists, MET inhibitors, voltage-gated sodium channel blockers, lipid synthesis inhibitors,ryanodine receptor modulators and other compounds defined in the description, in synergistically effective amounts. The invention also relates to methods and the use of these mixtures to combat and control insects, arachnids, or nematodes in plants, and to protect these plants against pest infestation, in particular also to protect plant propagation material, such as seeds.

This invention belongs to the field of pesticide technology, specifically relating to an insecticidal composition containing oxazolidinone and its application. The insecticidal composition comprises active ingredient A and active ingredient B, wherein active ingredient A is oxazolidinone; active ingredient B is selected from one or more of the following compounds: acetylcholinesterase inhibitors, nicotinic acetylcholine receptor (nAChR) channel blockers, nicotinic acetylcholine receptor (nAChR) allosteric modulator site I, nicotinic acetylcholine receptor (nAChR) competitive modulators, glutamate-gated chloride channel (GluCl) allosteric modulators, etc. This composition has a reasonable composition, good insecticidal effect, low application cost, and features reduced application amount, crop safety, and reduced pesticide residues.