Plant-derived anti-allergy soothing composition and application thereof

Abstract

The invention discloses a plant-sourced anti-allergy soothing composition and application thereof, and belongs to the field of cosmetic processing.The plant-sourced anti-allergy soothing composition is prepared from hydrolyzed corn starch, saururus chinensis extract, carrot root extract and water-soluble hesperidin. Active ingredients of plant sources are deeply studied, and the anti-allergy soothing composition has the advantages that the plant-sourced anti-allergy soothing composition is prepared from the hydrolyzed corn starch, the saururus chinensis extract, the carrot root extract and the water-soluble hesperidin; a series of plant extracts with a synergistic effect are screened out, the plant-source multi-dimensional composition for relieving itching and repairing red is successfully researched and developed, and through the synergistic effect of the hydrolyzed corn starch, the saururus chinensis extract, the carrot root extract and the water-soluble hesperidin, the composition has the effects of relieving and repairing skin in a multi-dimensional mode, relieving itching and repairing red. In addition, the composition can repair the skin barrier for a long time and improve the tolerance of the skin, and meanwhile, the composition has good safety and stability and is suitable for various skin types, especially sensitive skin.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and in particular relates to a plant-derived anti-allergic soothing composition and application thereof. Background Art

[0002] As people pay more and more attention to skin health, the demand for skin care products that can soothe, reduce redness and relieve itching is also growing. Although some existing skin care products have the effects of soothing and reducing redness, these products often have certain limitations.

[0003] First, many existing redness-reducing products rely primarily on chemically synthesized ingredients. While these ingredients may be effective in the short term, long-term use can cause skin irritation or even allergic reactions. Second, while some naturally derived soothing ingredients are relatively mild, their effectiveness is often less pronounced, failing to meet consumers' demand for fast and effective redness reduction.

[0004] Furthermore, existing redness-reducing and soothing products have limitations in their mechanisms of action. They typically only address one or a few specific skin issues, but are ineffective in addressing multiple skin issues.

[0005] Therefore, developing a plant-derived composition that can simultaneously meet multiple skin needs, has a significant soothing and redness-removing effect, and is mild and non-irritating has become one of the current research hotspots in the field of skin care products. Summary of the Invention

[0006] The object of the present invention is to provide a plant-derived anti-allergic soothing composition and its application, so as to solve the problems raised in the above background technology.

[0007] To achieve the above object, the present invention adopts the following technical solutions:

[0008] A plant-derived anti-allergic soothing composition comprises the following components: hydrolyzed corn starch, Saururus chinensis extract, carrot root extract and water-soluble hesperidin.

[0009] Preferably, the mass ratio of the components of the composition is: 0.5-2 parts of hydrolyzed corn starch; 0.3-2 parts of Saururus chinensis extract; 0.05-0.5 parts of carrot root extract; and 0.005-0.05 parts of water-soluble hesperidin.

[0010] Preferably, the mass ratio of the components of the composition is: 1 part of hydrolyzed corn starch; 1 part of Saururus chinensis extract; 0.25 part of carrot root extract; and 0.025 part of water-soluble hesperidin.

[0011] The invention discloses an application of a plant-derived anti-allergic soothing composition in skin care products, comprising auxiliary materials and functional ingredients. The functional ingredient is the plant-derived anti-allergic soothing composition, and the mass addition amount of the plant-derived anti-allergic soothing composition is 1.0% to 5.0%.

[0012] Preferably, the excipients include solvents, moisturizers, emulsifiers, chelating agents and preservatives.

[0013] Preferably, the skin care product is a cream, lotion, lotion, essence, gel or facial mask.

[0014] Technical effects and advantages of the present invention:

[0015] Through in-depth research on active ingredients from plant sources, the present invention screened out a series of synergistic plant extracts and successfully developed a plant-derived multi-dimensional soothing, anti-itching and redness-repairing composition. This composition, through the synergistic effect of hydrolyzed corn starch, Saururus chinensis extract, carrot root extract and water-soluble hesperidin, not only has multi-dimensional soothing and skin repairing effects, but also can long-term repair the skin barrier and improve skin tolerance. At the same time, this composition has good safety and stability and is suitable for all skin types, especially sensitive skin. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 Comparison of skin redness before use (left) and 28 days after use (right). DETAILED DESCRIPTION

[0017] The following is a combination of the embodiments of the present invention Figure 1 , the technical solutions in the embodiments of the present invention are clearly and completely described. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. The specific embodiments described here are only used to explain the present invention and are not used to limit the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0018] The invention discloses a plant-derived anti-allergic soothing composition, comprising the following components: hydrolyzed corn starch, saururus chinensis extract, carrot root extract, and water-soluble hesperidin, wherein the mass ratio of the components is: 0.5-2 parts of hydrolyzed corn starch; 0.3-2 parts of saururus chinensis extract; 0.05-0.5 parts of carrot root extract; and 0.005-0.05 parts of water-soluble hesperidin.

[0019] Furthermore, the mass ratio of the components of the composition is: 1 part of hydrolyzed corn starch; 1 part of Saururus chinensis extract; 0.25 part of carrot root extract; and 0.025 part of water-soluble hesperidin.

[0020] Hydrolyzed corn starch: The hydrolyzed corn starch used in this invention comes from Shengde Baitai, and its trade name is BioEase TM MY-75(N) uses bio-enzymatic hydrolysis in its extraction process to decompose corn starch into a low-molecular sugar mixture under the action of specific enzymes. This process can ensure the purity and activity of the product while reducing energy consumption and environmental pollution.

[0021] Its main active ingredient is maltotetraose, a linear water-soluble oligosaccharide linked by α-1,4-glycosidic bonds. TM MY-75(N) competitively binds to NK-1 receptors, blocking the binding of substance P to NK-1 receptors, thereby inhibiting the release of histamine from mast cells and alleviating itching and inflammation. It has good moisturizing and film-forming properties, can lock in moisture, while inhibiting the production of inflammatory factors and alleviating skin inflammation. In addition, BioEase TM MY-75(N) can reduce the irritation of surfactants to the skin and improve skin tolerance. TM MY-75(N) can also play a significant soothing role by reducing the expression of the inflammatory secretion gene IL-8 and the capsaicin receptor TRPV1.

[0022] Saururus chinensis extract: Saururus chinensis extract is rich in a variety of active ingredients, including phenols, flavonoids and alkaloid compounds. These ingredients can act on targets related to the skin's inflammatory response and free radical production, and exert anti-inflammatory, antioxidant and soothing effects. For example, flavonoids can inhibit the production of inflammatory factors and reduce the skin's inflammatory response; phenolic compounds have strong antioxidant capacity, can scavenge free radicals, and protect the skin from oxidative damage. The Saururus chinensis extract used in the present invention is derived from Shanghai Jiakai Biotechnology Co., Ltd., and its trade name is Erythcalm SC. The extraction process is biphasic gradient extraction and molecular imprinting purification technology. The main components extracted are lignans and terpenes, which can effectively inhibit the activation of ADRB2, HRH1, TRPV1 and EDNRA, thereby reducing the release of vasodilator factor CGRP and alleviating the redness of the skin due to irritation.

[0023] Carrot root extract: The carrot root extract used in the present invention is derived from Vytrusbiotech, with the trade name SensiaCarota-2. The carrot root cell culture is optimized through the PRCF strategy, and the cells are subjected to stress treatments such as light radiation, oxidative stress and temperature increase to stimulate them to produce defensive compounds. The cell structure is destroyed by mechanical means to release the active ingredients, and the extract is separated by solvent extraction and filtration. The main active ingredients are polyphenols, fatty acids (such as linoleic acid), phytosterols and other active ingredients. Polyphenols (such as flavonoids and phenolic acids) exert antioxidant and anti-inflammatory effects by scavenging free radicals and inhibiting the production of inflammatory factors. At the same time, they regulate the neurogenic inflammation-related pathways of the skin (such as the CGRP signaling pathway) to relieve sensitive symptoms such as stinging and tightness; fatty acids can repair the skin barrier, enhance moisturizing, anti-inflammatory, and promote skin health. Its effects are related to regulating the metabolism and signal transduction of skin cells; phytosterols synergistically resist oxidation, repair skin, and relieve irritation, which may involve mechanisms such as regulating the fluidity and stability of skin cell membranes. These ingredients work synergistically with each other to give the extract antioxidant, anti-inflammatory, repair and skin barrier protection effects through multiple pathways, making it perform excellently in sensitive skin care, relieving redness, dryness, stinging and other discomforts, and improving skin tolerance and health.

[0024] Water-soluble hesperidin: Water-soluble hesperidin is a flavonoid with high solubility and stability. It acts on targets related to vascular permeability and inflammatory responses, reducing vascular leakage, combating inflammation, and promoting microcirculation. By modulating signaling pathways in endothelial cells, water-soluble hesperidin enhances capillary resistance, thereby alleviating skin erythema and inflammation. Furthermore, it possesses antioxidant properties, scavenging free radicals and protecting the skin from oxidative damage.

[0025] The synergistic effect of these four raw materials is that: hydrolyzed corn starch competitively binds to NK-1 receptors, blocking the binding of substance P to NK-1 receptors, thereby inhibiting the release of histamine from mast cells, reducing itching and inflammation, while providing good moisturizing and film-forming properties, reducing the irritation of surfactants to the skin, and improving skin tolerance; Saururus chinensis extract is rich in a variety of active ingredients, which can inhibit the production of inflammatory factors and reduce the inflammatory response of the skin. It also has strong antioxidant capacity, can scavenge free radicals, and protect the skin from oxidative damage. Its main components, lignans and terpenes, can effectively inhibit the activation of ADRB2, HRH1, TRPV1 and EDNRA, thereby reducing The release of the vasodilator CGRP relieves redness caused by skin irritation. The polyphenols in carrot root extract exert antioxidant and anti-inflammatory effects by scavenging free radicals and inhibiting the production of inflammatory factors. They also regulate the skin's neurogenic inflammatory pathways, alleviating sensitive symptoms such as stinging and tightness. Fatty acids repair the skin barrier, enhance moisturizing, and fight inflammation, promoting skin health. Phytosterols synergistically provide antioxidant, skin-repairing, and irritation relief. Water-soluble hesperidin regulates the signaling pathways of vascular endothelial cells, enhancing capillary resistance, thereby reducing skin erythema and inflammation. It also possesses antioxidant properties, scavenging free radicals and protecting the skin from oxidative damage. This multi-target synergistic effect makes the combination significantly effective in relieving itching, soothing, and reducing redness, while maintaining good safety and stability. It provides a comprehensive and effective solution for sensitive skin care, significantly improving skin comfort and health.

[0026] In addition, the present invention also discloses an application of a plant-derived anti-allergic soothing composition, including auxiliary materials and functional ingredients. The functional ingredient is a plant-derived anti-allergic soothing composition, and the mass addition amount of the plant-derived anti-allergic soothing composition is 1.0% to 5.0%. The auxiliary materials include solvents, moisturizers, emulsifiers, chelating agents and preservatives. The skin care products are creams, lotions, lotions, essences, gels or facial masks.

[0027] Example 1 is a cream containing the above-mentioned plant-derived anti-allergic soothing composition, and the types of raw materials and the composition by weight are as follows:

[0028] Category A: Prolivemvp (cetearyl olivate, sorbitan olivate) 2%, behenyl alcohol 0.5%, triethylhexanoin 5.5%, pentaerythritol tetraethylhexanoate 1.2%, squalane 0.3%, tocopheryl acetate 0.3%;

[0029] Category B: Acrylates / C10-30 Alkyl Acrylate Crosspolymer 0.2%, Xanthan Gum 0.1%, Sodium Polyacrylate 0.4%, Glycerin 5%, Butylene Glycol 3%, Sodium Stearoyl Glutamate 0.15%. After removing all the raw materials from categories A, B, C, and D, the remainder is water.

[0030] Category C: p-hydroxyacetophenone 0.5%, octanoylhydroxamic acid 0.05%;

[0031] Category D: hydrolyzed corn starch 1%; Saururus chinensis extract 0.5%; carrot root extract 0.05%; water-soluble hesperidin 0.005%.

[0032] The preparation method is as follows:

[0033] 1. Weigh Class A raw materials into a container, stir and heat to 80-85℃ until completely dissolved;

[0034] 2. Weigh Class B raw materials into a container, stir and heat to 80-85°C, homogenize evenly and add step 1. After homogenizing evenly, add Class C raw materials, stir evenly and cool down.

[0035] 3. When the temperature drops below 45°C, add Class D ingredients and stir evenly to obtain the desired cream.

[0036] Example 2

[0037] The difference from Example 1 is that the mass composition of Class D is: 1% hydrolyzed corn starch; 1% Saururus chinensis extract; 0.2% carrot root extract; and 0.05% water-soluble hesperidin.

[0038] Example 3

[0039] The difference from Example 1 is that the mass composition of Class D is: 2% hydrolyzed corn starch; 1% Saururus chinensis extract; 0.05% carrot root extract; and 0.05% water-soluble hesperidin.

[0040] Comparative Example 1

[0041] The difference from Example 1 is that the mass fraction of Class D is as follows: hydrolyzed corn starch 0%; Saururus chinensis extract 0.5%; carrot root extract 0.05%; and water-soluble hesperidin 0.005%.

[0042] Comparative Example 2

[0043] The difference from Example 1 is that the mass fraction of type D is as follows: hydrolyzed corn starch 1%; Saururus chinensis extract 0%; carrot root extract 0.05%; water-soluble hesperidin 0.005%.

[0044] Comparative Example 3

[0045] The difference from Example 1 is that the mass composition of Class D is: hydrolyzed corn starch 1%; Saururus chinensis extract 0.5%; carrot root extract 0%; and water-soluble hesperidin 0.005%.

[0046] Comparative Example 4

[0047] The difference from Example 1 is that the mass composition of type D is: hydrolyzed corn starch 1%; Saururus chinensis extract 0.5%; carrot root extract 0.05%; water-soluble hesperidin 0%.

[0048] The specific compositions of the compounds of category D in different examples are shown in Table 1 below:

[0049]

[0050] Table 1

[0051] Epidermal water loss rate test:

[0052] 1. Test Instrument

[0053] VapoMeter (DELFIN, Finland)

[0054] Facial image analyzer VISIA-CR (CANFIELD Scientific, Inc., USA)

[0055] 2. Experimental Principle

[0056] Transepidermal Water Loss: Test three times using a VapoMeter and take the average value. Parameter Explanation: The lower the transepidermal water loss (TEWL), the less water loss from the epidermis and the better the skin barrier.

[0057] Result judgment: After using the product, the transepidermal water loss rate in the test area was significantly reduced, and the skin barrier was improved, indicating that the test sample has a repair effect.

[0058] Facial redness test: Use VISIA-CR to photograph your face and analyze the redness of your facial skin.

[0059] Parameter explanation: The smaller the redness a value, the less red the skin is and the better the soothing effect.

[0060] Result judgment: After using the product, the redness a value of the test area decreased significantly, indicating that the test sample has the effect of soothing facial skin.

[0061] 3. Test population:

[0062] There were 7 groups with 28 people in each group, including volunteers aged 18-60 who met the experimental requirements.

[0063] 4. Test conditions:

[0064] At room temperature of 20±2°C and relative humidity of 50±10%, real-time dynamic monitoring is performed and the subjects sit quietly for 30 minutes before testing the relevant data.

[0065] 5. Testing Process

[0066] This experiment was divided into seven groups: Groups 1-7 used Example 1, Example 2, Example 3, Comparative Example 1, Comparative Example 2, Comparative Example 3, and Comparative Example 4, respectively. The skin was applied twice daily, morning and evening, for four weeks, and the TEWL values were recorded. Each volunteer's face was then photographed using VISIA-CR, with one area on each cheek selected. The facial skin redness a value was recorded and archived.

[0067] 6. Experimental Results

[0068]

[0069]

[0070] Table 2

[0071] Experimental results

[0072] From the test results in Table 2, we can see that:

[0073] Example 1: After 14 days of use, the TEWL value increased from 17.2±1.0 g / m 2 h decreased to 15.2±0.8g / m 2 h, the decrease rate was 11.6%; the redness a value decreased from 12.2±0.9 to 11.5±0.8, and the improvement rate was 5.7%. After 28 days of use, the TEWL value was 13.5±0.7g / m 2 h, a decrease rate of 21.5%; the redness a value was 10.7±0.7, and the improvement rate was 12.3%. The effect of Example 1 was the weakest among the three examples, but it was still able to effectively improve the skin barrier function and reduce redness. Its ingredient combination also had a certain synergistic effect.

[0074] Example 2: 14 days after use, the TEWL value increased from 18.5±1.2 g / m 2 h decreased to 15.8±1.0g / m 2 h, a decrease rate of 14.6%; the redness a value decreased from 12.8±1.1 to 11.9±1.0, an improvement rate of 7.0%. After 28 days of use, the TEWL value further decreased to 14.2±0.9g / m 2h, a decrease rate of 23.2%; the redness a value dropped to 11.0±0.9, an improvement rate of 14.1%. This shows that Example 2 is effective in improving the skin barrier and soothing skin redness, and the effect becomes more obvious with the extension of use time. The synergistic effect of its ingredients plays a key role in skin repair and soothing. Figure 1 , which is a before-and-after comparison of facial redness images of the volunteers in this part. It can be clearly seen from the figure that the volunteers with more serious facial redness have a very significant effect in soothing and repairing skin redness after using the composition of the present invention for 28 days.

[0075] Example 3: After 14 days of use, the TEWL value increased from 17.8±1.1 g / m 2 h decreased to 15.5±0.9g / m 2 h, the decrease rate was 12.9%; the redness a value decreased from 12.5±1.0 to 11.7±0.9, and the improvement rate was 6.4%. After 28 days of use, the TEWL value was 13.8±0.8g / m 2 h, a decrease rate of 22.5%; the redness a value was 10.8±0.8, and the improvement rate was 13.6%. The efficacy of Example 3 was slightly inferior to that of Example 2, but it still showed good repair and soothing effects, and had a positive effect on improving the skin barrier and alleviating redness.

[0076] Compared with the results of the embodiment, the TWEL value and the reduction rate of the facial redness a value of the comparative example are both lower, indicating that the lack of specific ingredients leads to limited efficacy, and the product's effect on improving the skin barrier and redness is greatly reduced.

[0077] Itch relief test

[0078] 1. Experimental Methods

[0079] In order to more comprehensively evaluate the efficacy of the product, an antipruritic test was added. 28 volunteers with skin itching symptoms were selected and randomly divided into 7 groups, 4 people in each group. The cream products prepared by Example 1, Example 2, Example 3 and Comparative Example 1, Comparative Example 2, Comparative Example 3, Comparative Example 4 and a blank control (a cream containing only excipients) were used respectively. After cleaning the skin, the volunteers applied the product to the itchy area. After 30 minutes, 0.01% histamine solution was applied to the test area to induce pruritus. The pruritus degree score was recorded at 15 minutes and 30 minutes after histamine stimulation (using visual analog scale, i.e., VAS score, 0 points means no itch, 10 points means unbearable itch).

[0080] 2. Experimental Results

[0081]

[0082]

[0083] Table 3

[0084] 3. Results Analysis

[0085] Refer to Table 3

[0086] Examples: Examples 1, 2, and 3 demonstrated excellent antipruritic effects, with pruritus scores significantly lower than those of the other groups 15 and 30 minutes after use. Example 2 achieved the lowest scores at both time points, demonstrating the most significant antipruritic effect. This may be due to the synergistic effect of the ingredients in the products, which rapidly alleviated histamine-induced pruritus.

[0087] Comparative Examples: Comparative Examples 1, 2, 3, and 4 showed significantly weaker antipruritic effects than the Example products. These products' ratings remained high 15 and 30 minutes after use, indicating that the lack of specific ingredients significantly impacted their antipruritic abilities.

[0088] Blank control: The blank control group had the highest score, indicating that the itching sensation caused by histamine was the most intense when no active ingredient was used.

[0089] In general, the products of the examples showed significant effects in the antipruritic test, especially Example 2, which further demonstrated the advantage of the synergistic effect of the ingredients in the composition of the present invention in alleviating skin itching.

[0090] Finally, it should be noted that the above are only preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or make equivalent replacements for some of the technical features therein. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A plant-derived anti-allergic soothing composition, characterized by: It includes the following ingredients: hydrolyzed corn starch, Saururus chinensis extract, carrot root extract, and water-soluble hesperidin.

2. The plant-derived anti-allergic soothing composition according to claim 1, characterized in that: The mass ratio of each component of the composition is: 0.5-2 parts hydrolyzed corn starch; 0.3-2 parts of Saururus chinensis extract; Carrot root extract 0.05-0.5 parts; Water-soluble hesperidin 0.005-0.05 parts.

3. The plant-derived anti-allergic soothing composition according to claim 1, characterized in that: The mass ratio of each component of the composition is: 1 part hydrolyzed corn starch; 1 part of Saururus chinensis extract; 0.25 parts of carrot root extract; 0.025 parts of water-soluble hesperidin.

4. The use of a plant-derived anti-allergic soothing composition according to any one of claims 1 to 3, characterized in that: The invention comprises auxiliary materials and functional ingredients, wherein the functional ingredient is the plant-derived anti-allergic soothing composition according to any one of claims 1 to 3, and the mass addition amount of the plant-derived anti-allergic soothing composition is 1.0% to 5.0%.

5. The use of a plant-derived anti-allergic soothing composition according to claim 4, characterized in that: The auxiliary materials include solvents, moisturizers, emulsifiers, chelating agents and preservatives.

6. The use of a plant-derived anti-allergic soothing composition according to claim 4, characterized in that: The skin care product is a cream, lotion, water, essence, gel or facial mask.

Images