Qi-tonifying and bone-strengthening pill and preparation method thereof

Abstract

The invention discloses qi-tonifying and bone-strengthening pills and a preparation method thereof, and belongs to the technical field of bone fracture pills. The qi-tonifying and bone-strengthening pill is prepared from the following raw materials: semen cuscutae, herba epimedii, cynomorium songaricum, salted radix dipsaci, scalded rhizoma drynariae, radix polygoni multiflori preparata, radix rehmanniae preparata, fructus lycii, wine-processed glossy privet fruit, herba ecliptae, raspberry, deer-horn glue, tortoise-shell glue, radix astragali preparata, radix angelicae sinensis, radix salviae miltiorrhizae, rhizoma dioscoreae, pericarpium citri reticulatae, fried semen ziziphi spinosae and radix glycyrrhizae preparata. The preparation method of the qi-tonifying and bone-strengthening pill comprises the following steps: adding water into the scalded rhizoma drynariae, and decocting; respectively crushing semen cuscutae, fried spina date seeds and dried orange peel; decocting the raw materials except deer-horn glue and tortoise-shell glue with the crushed semen cuscutae and fried spina date seeds in water, and concentrating the filtrate; and melting deer-horn glue and tortoise-shell glue in the concentrated liquid medicine, adding the crushed dried orange peel and a proper amount of refined honey, uniformly stirring, pelleting and drying to obtain the medicine. The qi-tonifying and bone-strengthening pill is mainly used for treating liver and kidney deficiency type arthralgia, poor rehabilitation in the later period of fracture and other symptoms, and has the functions of tonifying kidney and qi, and strengthening bones and promoting reunion of tendons.

Description

Technical Field ,

[0007]

[0001] The present invention belongs to the technical field of bone injury pills, and particularly relates to Yiqi Zhuanggu Pills and a preparation method thereof. Background Art

[0002] After fracture treatment by surgery, drug adjuvant therapy is still required. Drug adjuvant therapy is divided into chemical drugs, hormonal drugs and traditional Chinese medicine preparations. Chemical drugs and hormone therapy have a rapid onset of action, but are prone to adverse reactions and patient intolerance. China has very rich traditional Chinese medicine resources. Traditional Chinese medicine treatment can promote fracture healing from multiple links and multiple targets, running through each period of fracture healing. Searching for drugs that promote fracture healing from natural resources has become a direction for clinical treatment.

[0003] At present, there are many domestic developed similar products, and the common ones are externally applied ointments (such as bone sticking ointment, bone-connecting and tendon-continuing ointment) or powders (such as Wuling Powder, Sanqi Detumescence and Analgesia Powder), and most of the oral ones are decoctions (such as Taohong Siwu Decoction, Wuling Powder combined with Taohong Siwu Decoction with added flavor), etc., while the type of solid pills is relatively rare. At the same time, the above-mentioned externally applied ointments, powders and decoctions are mostly prepared by in-hospital prescriptions, and it is rare to be put into use in the form of medical institution preparations. Summary of the Invention

[0004] The present invention provides an Yiqi Zhuanggu Pill and a preparation method thereof to solve the above technical problems.

[0005] To solve the above technical problems, the present invention adopts the following technical solutions: The Yiqi Zhuanggu Pill comprises the following raw materials: Cuscuta chinensis, Epimedium brevicornu, Cynomorium songaricum, Radix Dipsaci seu Asparagi (processed with salt), Rhizoma Drynariae (processed with stir-frying), Radix Polygoni Multiflori Praeparata, Radix Rehmanniae Praeparata, Lycium barbarum, Glossy Privet Fruit (processed with wine), Eclipta prostrata, Rubus idaeus, Colla Cornus Cervi, Colla Plastri Testudinis, Astragalus membranaceus (processed with honey), Angelica sinensis, Salvia miltiorrhiza, Dioscorea opposita, Pericarpium Citri Reticulatae, Semen Ziziphi Spinosae (processed with stir-frying), Glycyrrhiza uralensis (processed with honey).

[0006] Furthermore, the Yiqi Zhuanggu Pill comprises the following raw materials in parts by weight: Cuscuta chinensis 0.8 - 2, Epimedium brevicornu 0.6 - 1.5, Cynomorium songaricum 0.8 - 1.5, Radix Dipsaci seu Asparagi (processed with salt) 0.6 - 1.5, Rhizoma Drynariae (processed with stir-frying) 1 - 2.3, Radix Polygoni Multiflori Praeparata 1 - 2.3, Radix Rehmanniae Praeparata 1 - 2.3, Lycium barbarum 0.6 - 1.5, Glossy Privet Fruit (processed with wine) 0.8 - 2.5, Eclipta prostrata 1 - 2.5, Rubus idaeus 1.7 - 2.6, Colla Cornus Cervi 0.2 - 0.5, Colla Plastri Testudinis 0.2 - 0.5, Astragalus membranaceus (processed with honey) 0.6 - 1.5, Angelica sinensis 0.6 - 1.5, Salvia miltiorrhiza 0.6 - 1.5, Dioscorea opposita 0.6 - 1.5, Pericarpium Citri Reticulatae 0.3 - 0.8, Semen Ziziphi Spinosae (processed with stir-frying) 0.6 - 1.5, Glycyrrhiza uralensis (processed with honey) 0.3 - 0.8.

[0007] Furthermore, the Qi-boosting and bone-strengthening pill comprises the following ingredients in parts by weight: Cuscuta chinensis 1-1.3, Epimedium brevicornu 0.8-1.2, Cynomorium songaricum 1-1.3, Dipsacus asper 0.8-1.2, Drynaria fortunei 1.3-1.5, Polygonum multiflorum 1.2-1.6, Rehmannia glutinosa 1.25-1.6, Lycium barbarum 0.8-1.2, Ligustrum lucidum 1.1-1.4, Eclipta prostrata 1.1-1.4, Rubus idaeus 1.8-2.2, Cervi cornu gelatin 0.2-0.35, Tortoise shell gelatin 0.2-0.35, Astragalus membranaceus 0.8-1.2, Angelica sinensis 0.8-1.2, Salvia miltiorrhiza 0.8-1.2, Dioscorea opposita 0.8-1.2, Citrus reticulata 0.4-0.6, Ziziphus jujuba var. spinosa 0.8-1.2, and Glycyrrhiza uralensis 0.4-0.6.

[0008] Furthermore, the Qi-boosting and bone-strengthening pill comprises the following ingredients in parts by weight: Cuscuta chinensis 1.156g, Epimedium brevicornu 0.975g, Cynomorium songaricum 1.156g, Dipsacus asper 0.975g, Drynaria fortunei 1.450g, Polygonum multiflorum 1.450g, Rehmannia glutinosa 1.450g, Lycium barbarum 0.975g, Ligustrum lucidum 1.382g, Eclipta prostrata 1.382g, Rubus idaeus 1.925g, Cervi cornu glue 0.294g, Tortoise shell glue 0.294g, Astragalus membranaceus 0.975g, Angelica sinensis 0.975g, Salvia miltiorrhiza 0.975g, Dioscorea opposita 0.975g, Citrus reticulata peel 0.476g, Ziziphus jujuba var. spinosa 0.975g, Glycyrrhiza uralensis 0.476g.

[0009] Furthermore, 10-20 pills of the Qi-Boosting and Bone-Strengthening Pills constitute 1g.

[0010] This invention also provides a method for preparing Qi-boosting and bone-strengthening pills, comprising the following steps: S1. Weigh out the dried herb *Drynaria fortunei*, add water and decoct for 10-20 minutes; weigh out the dodder seed, stir-fried jujube seed, and dried tangerine peel, and grind them into powder separately. S2. Weigh out Epimedium, Salt-processed Dipsacus, Cynomorium, Processed Polygonum multiflorum, Processed Glycyrrhiza uralensis, Rehmannia glutinosa, Dioscorea opposita, Rubus idaeus, Lycium barbarum, Wine-processed Ligustrum lucidum, Eclipta prostrata, Processed Astragalus membranaceus, Salvia miltiorrhiza, Angelica sinensis, and crushed Cuscuta chinensis and stir-fried Ziziphus jujuba seeds. Add them to the decocted Drynaria fortunei, add water and continue to decoct for 15-30 minutes. Filter and collect the filtrate. The residue can be decocted again with water 2-3 times. Combine the filtrates from each decoction and concentrate to obtain concentrated medicinal liquid. S3. Weigh out the deer antler glue and tortoise shell glue, melt them in the combined concentrated medicine solution, then add the crushed dried tangerine peel, stir well to obtain a mixture; S4. Take an appropriate amount of refined honey, mix it with the mixture in S3, stir evenly, make into pills, dry, and obtain Yiqi Zhuanggu Pills.

[0011] Furthermore, the concentrated drug solution is 0.2-0.4 times the volume of the combined filtrate.

[0012] Furthermore, the raw materials include the following parts by weight: Cuscuta chinensis 0.8-2, Epimedium brevicornu 0.6-1.5, Cynomorium songaricum 0.8-1.5, Dipsacus asper 0.6-1.5, Drynaria fortunei 1-2.3, Polygonum multiflorum 1-2.3, Rehmannia glutinosa 1-2.3, Lycium barbarum 0.6-1.5, Ligustrum lucidum 0.8-2.5, Eclipta prostrata 1-2.5, Rubus idaeus 1.7-2.6, Cervi cornu glue 0.2-0.5, Tortoise shell glue 0.2-0.5, Astragalus membranaceus 0.6-1.5, Angelica sinensis 0.6-1.5, Salvia miltiorrhiza 0.6-1.5, Dioscorea opposita 0.6-1.5, Citrus reticulata peel 0.3-0.8, Ziziphus jujuba var. spinosa 0.6-1.5, Glycyrrhiza uralensis 0.3-0.8.

[0013] Furthermore, the raw materials include the following parts by weight: Cuscuta chinensis 1.156, Epimedium brevicornu 0.975, Cynomorium songaricum 1.156, Dipsacus asper 0.975, Drynaria fortunei 1.450, Polygonum multiflorum 1.450, Rehmannia glutinosa 1.450, Lycium barbarum 0.975, Ligustrum lucidum 1.382, Eclipta prostrata 1.382, Rubus idaeus 1.925, Cervi cornu glue 0.294, Tortoise shell glue 0.294, Astragalus membranaceus 0.975, Angelica sinensis 0.975, Salvia miltiorrhiza 0.975, Dioscorea opposita 0.975, Citrus reticulata peel 0.476, Ziziphus jujuba var. spinosa 0.975, Glycyrrhiza uralensis 0.476.

[0014] Furthermore, 10-20 pills of the Qi-Boosting and Bone-Strengthening Pills constitute 1g.

[0015] 1. Description of the properties and flavors of each medicinal herb Cuscuta seed is sweet and warm in nature, and enters the liver, kidney, and spleen meridians. Its main functions are: tonifying the kidneys and securing essence, nourishing the liver and improving eyesight, stopping diarrhea and calming the fetus. It is used for kidney deficiency causing lower back pain, impotence and seminal emission, frequent urination and enuresis, blurred vision and tinnitus due to liver and kidney insufficiency, diarrhea due to spleen and kidney yang deficiency, and threatened abortion.

[0016] Epimedium is pungent and sweet in nature, and warm in flavor. It enters the liver and kidney meridians. Its main functions are to tonify kidney yang, strengthen tendons and bones, and dispel wind and dampness.

[0017] Salt-processed Dipsacus, bitter, sweet, and pungent in nature, slightly warm in flavor, enters the liver and kidney meridians; its main functions are: tonifying the liver and kidneys, strengthening tendons and bones, healing fractures, and stopping metrorrhagia. It is used for soreness and weakness of the lower back and knees due to liver and kidney deficiency, rheumatic pain, traumatic injuries, fractures and tendon injuries, and excessive metrorrhagia.

[0018] Cynomorium songaricum, sweet in nature and warm in flavor, enters the liver, kidney, and large intestine meridians; its main functions are to tonify kidney yang, replenish essence and blood, and moisten the intestines to relieve constipation. It is used for impotence and infertility due to kidney yang deficiency and deficiency of essence and blood, weakness of the lower back and knees, and constipation due to intestinal dryness.

[0019] Drynaria fortunei (Tang Gu Sui Bu) is bitter and warm in nature, and enters the liver and kidney meridians. Its main functions are to tonify the kidneys and strengthen bones, promote healing of injuries and relieve pain. It is used for lower back pain and tinnitus due to kidney deficiency, loose teeth, injuries from falls and blows, fractures, alopecia areata, and vitiligo.

[0020] Processed Polygonum multiflorum is sweet and astringent in nature, slightly warm in taste, and enters the liver and kidney meridians. Its main functions are: tonifying the liver and kidneys, replenishing essence and blood, blackening hair, strengthening muscles and bones, and resolving turbidity and lowering lipids. It is used for blood deficiency with sallow complexion, dizziness, blurred vision, premature graying of hair, soreness and weakness of the lower back and knees due to liver and kidney deficiency, and hyperlipidemia.

[0021] Rehmannia glutinosa (processed) is sweet in nature and slightly warm in flavor; it enters the liver and kidney meridians; its main functions are to nourish blood and yin, and replenish essence and marrow. It is used for blood deficiency and chlorosis, palpitations, irregular menstruation, night sweats and tidal fever due to kidney yin deficiency, soreness and weakness of the lower back and knees, premature graying of hair due to deficiency of essence and blood, dizziness and tinnitus.

[0022] Angelica sinensis is sweet and pungent in nature, and warm in flavor. It enters the liver, heart, and spleen meridians. Its main functions are to nourish and invigorate blood, regulate menstruation and relieve pain, and moisten the intestines to relieve constipation. It is used for blood deficiency and chlorosis, dizziness and palpitations, irregular menstruation, amenorrhea and dysmenorrhea due to blood deficiency and blood stasis, abdominal pain due to deficiency and cold, traumatic injuries, and constipation due to intestinal dryness.

[0023] Goji berries are sweet and neutral in nature, and enter the liver and kidney meridians. They are primarily used to nourish the liver and kidneys, benefit essence and improve eyesight. They are indicated for dizziness, blurred vision, lower back and knee weakness, seminal emission, thirst, and cough due to yin deficiency of the liver and kidneys.

[0024] Ligustrum lucidum (purple privet fruit) is sweet and bitter in nature, cool in taste, and enters the liver and kidney meridians. Its main functions are to nourish the liver and kidneys, improve eyesight, and darken hair. It is used for dizziness, tinnitus, lower back and knee weakness, premature graying of hair, and blurred vision due to liver and kidney yin deficiency.

[0025] Eclipta prostrata, sweet and sour in nature, cold in taste, enters the liver and kidney meridians; its main functions are to nourish the liver and kidneys, cool the blood and stop bleeding. It is used for dizziness and vertigo due to liver and kidney yin deficiency, premature graying of hair, and hematemesis, epistaxis, hematuria, and metrorrhagia due to yin deficiency and blood heat.

[0026] Astragalus membranaceus (processed with honey) is sweet in nature and slightly warm in flavor. It enters the spleen and lung meridians. Its main functions are: tonifying qi and raising yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing swelling, generating fluids and nourishing blood, promoting circulation and relieving pain, promoting pus drainage and detoxification, and astringing sores and promoting tissue regeneration. It is used for qi deficiency and fatigue, poor appetite and loose stools, rectal prolapse and organ prolapse due to qi sinking, spontaneous sweating due to qi deficiency, and sallow complexion due to deficiency of both qi and blood.

[0027] Yam is sweet and neutral in nature, and enters the spleen, lung, and kidney meridians. Its main functions are to tonify the spleen and stomach, promote the production of body fluids and benefit the lungs, and tonify the kidneys and astringe essence. It is used for spleen deficiency with poor appetite and chronic diarrhea, lung deficiency with cough and wheezing, kidney deficiency with seminal emission, leukorrhea, frequent urination, and thirst due to deficiency heat.

[0028] Fried jujube seeds are sweet and sour in nature, neutral in flavor, and enter the liver, gallbladder, and heart meridians. They are primarily used to nourish the heart and liver, calm the mind and soothe the nerves, astringe sweat, and promote the production of body fluids. They are indicated for insomnia due to deficiency and restlessness, palpitations and excessive dreaming, excessive sweating due to physical weakness, and thirst due to fluid depletion.

[0029] Raspberry is sweet and sour in nature, and warm in flavor. It enters the liver, kidney, and bladder meridians. Its main functions are to benefit the kidneys, strengthen essence, reduce urination, nourish the liver, and improve eyesight. It is used for seminal emission and frequent urination due to kidney deficiency, and for blurred vision due to liver and kidney insufficiency.

[0030] Deer antler glue is sweet and salty in nature, and warm in flavor. It enters the liver and kidney meridians. Its main functions are to warm and tonify the liver and kidneys, and nourish essence and blood. It is used for soreness and coldness of the lower back and knees, impotence and seminal emission due to liver and kidney deficiency, chlorosis due to blood deficiency, dizziness and tinnitus, metrorrhagia and leukorrhea.

[0031] Tortoise shell glue is sweet and salty in nature, cool in taste, and enters the liver, kidney, and heart meridians. Its main functions are to nourish yin, nourish blood, and stop bleeding. It is used for yin deficiency with tidal fever, night sweats, soreness and weakness of the lower back and knees, blood deficiency with chlorosis, metrorrhagia, and leukorrhea.

[0032] Dried tangerine peel is pungent and bitter in nature, and warm in flavor. It enters the spleen and lung meridians. Its main functions are to regulate qi and strengthen the spleen, dry dampness and resolve phlegm. It is used for abdominal distension, poor appetite, vomiting and diarrhea, and cough with excessive phlegm.

[0033] Salvia miltiorrhiza, bitter in nature and slightly cold in taste, enters the heart and liver meridians; its main functions are: to invigorate blood and remove blood stasis, to regulate menstruation and relieve pain, to clear the heart and relieve irritability, and to cool the blood and reduce swelling. It is used for chest pain and heart pain due to blood stasis, abdominal and hypochondriac pain, dysmenorrhea and amenorrhea, pain due to heat arthralgia, insomnia due to heart irritability, and carbuncles and boils.

[0034] Prepared licorice root is sweet in nature and neutral in flavor; it enters the heart, lung, spleen, and stomach meridians; its main functions are: tonifying the spleen and stomach, replenishing qi and restoring pulse, clearing heat and detoxifying, resolving phlegm and relieving cough, relieving spasms and pain, and harmonizing other herbs. It is used for spleen and stomach weakness, fatigue, palpitations, shortness of breath, cough with excessive phlegm, abdominal and limb spasms and pain, and to alleviate the toxicity and harshness of other drugs.

[0035] 2. Analysis of Prescription Compatibility Principles The formula uses Cuscuta chinensis, Epimedium, and Cynomorium songaricum to warm the kidneys and invigorate Yang, serving as the principal herbs. Salt-processed Dipsacus asper, scalded Drynaria fortunei to tonify the kidneys, and processed Polygonum multiflorum to strengthen bones and tendons; Rehmannia glutinosa, Lycium barbarum, Ligustrum lucidum, Nelumbo nucifera, and Rubus idaeus to nourish the liver and kidney Yin, serving as the assistant herbs. Deer antler glue and tortoise shell glue connect the Ren and Du meridians; Astragalus membranaceus, Angelica sinensis, and Salvia miltiorrhiza promote blood circulation, assisting the principal and assistant herbs. Dioscorea opposita and Citrus reticulata regulate Qi and strengthen the spleen, preventing the other herbs from being too greasy and damaging the spleen; Ziziphus jujuba var. spinosa nourishes Yin and calms the mind, also serving as assistant herbs. Glycyrrhiza uralensis harmonizes the other herbs, serving as the guiding herb. The entire formula tonifies both Yin and Yang, benefits both the liver and kidneys, strengthens bones and generates marrow, accelerates calcium salt deposition, increases bone morphogenetic protein content, regulates related signaling pathways, and increases trace element content, thereby accelerating fracture healing. In summary, the formula of Yiqi Zhuanggu Wan is well-matched, warming the kidneys and tonifying yang, nourishing kidney yin, and also taking into account the effects of promoting qi and blood circulation, strengthening the spleen and stomach, and calming the mind. The whole formula tonifies yin and yang, benefits the liver and kidneys, and strengthens bones and generates marrow.

[0036] Compared with the prior art, the present invention has the following beneficial effects: The Qi-Boosting and Bone-Strengthening Pill of this invention is mainly used to treat symptoms such as joint pain due to liver and kidney deficiency and poor recovery after fracture. It has the functions of tonifying the kidney and boosting qi, strengthening bones and tendons.

[0037] In the treatment of patients, the efficacy rate was 76.31%, the effective rate was 9.65%, and the total effective rate reached 85.96%, demonstrating a relatively significant effect. Detailed Implementation

[0038] For better understanding of the present invention, it is illustrated by the following examples which fall within the scope of protection of the present invention but do not limit the scope of protection of the present invention.

[0039] Example The Yiqi Zhuanggu Pills comprise the following raw materials: Cuscuta chinensis, Epimedium brevicornu, Cynomorium songaricum, Radix Dipsaci (processed with salt), Rhizoma Drynariae (processed with vinegar), Radix Polygoni Multiflori Praeparata, Radix Rehmanniae Praeparata, Lycium barbarum, Glossy Privet Fruit (processed with wine), Eclipta prostrata, Rubus idaeus, Colla Corii Cervi, Colla Carapacis et Plastri Testudinis, Astragalus membranaceus (processed with honey), Angelica sinensis, Salvia miltiorrhiza, Dioscorea opposita, Pericarpium Citri Reticulatae, Semen Ziziphi Spinosae (processed), Glycyrrhiza uralensis (processed).

[0040] The Yiqi Zhuanggu Pills comprise the following raw materials in parts by weight: Cuscuta chinensis 0.8 - 2, Epimedium brevicornu 0.6 - 1.5, Cynomorium songaricum 0.8 - 1.5, Radix Dipsaci (processed with salt) 0.6 - 1.5, Rhizoma Drynariae (processed with vinegar) 1 - 2.3, Radix Polygoni Multiflori Praeparata 1 - 2.3, Radix Rehmanniae Praeparata 1 - 2.3, Lycium barbarum 0.6 - 1.5, Glossy Privet Fruit (processed with wine) 0.8 - 2.5, Eclipta prostrata 1 - 2.5, Rubus idaeus 1.7 - 2.6, Colla Corii Cervi 0.2 - 0.5, Colla Carapacis et Plastri Testudinis 0.2 - 0.5, Astragalus membranaceus (processed with honey) 0.6 - 1.5, Angelica sinensis 0.6 - 1.5, Salvia miltiorrhiza 0.6 - 1.5, Dioscorea opposita 0.6 - 1.5, Pericarpium Citri Reticulatae 0.3 - 0.8, Semen Ziziphi Spinosae (processed) 0.6 - 1.5, Glycyrrhiza uralensis (processed) 0.3 - 0.8.

[0041] The Yiqi Zhuanggu Pills comprise the following raw materials in parts by weight: Cuscuta chinensis 1 - 1.3, Epimedium brevicornu 0.8 - 1.2, Cynomorium songaricum 1 - 1.3, Radix Dipsaci (processed with salt) 0.8 - 1.2, Rhizoma Drynariae (processed with vinegar) 1.3 - 1.5, Radix Polygoni Multiflori Praeparata 1.2 - 1.6, Radix Rehmanniae Praeparata 1.25 - 1.6, Lycium barbarum 0.8 - 1.2, Glossy Privet Fruit (processed with wine) 1.1 - 1.4, Eclipta prostrata 1.1 - 1.4, Rubus idaeus 1.8 - 2.2, Colla Corii Cervi 0.2 - 0.35, Colla Carapacis et Plastri Testudinis 0.2 - 0.35, Astragalus membranaceus (processed with honey) 0.8 - 1.2, Angelica sinensis 0.8 - 1.2, Salvia miltiorrhiza 0.8 - 1.2, Dioscorea opposita 0.8 - 1.2, Pericarpium Citri Reticulatae 0.4 - 0.6, Semen Ziziphi Spinosae (processed) 0.8 - 1.2, Glycyrrhiza uralensis (processed) 0.4 - 0.6.

[0042] The Yiqi Zhuanggu Pills comprise the following raw materials in parts by weight: Cuscuta chinensis 1.156, Epimedium brevicornu 0.975, Cynomorium songaricum 1.156, Radix Dipsaci (processed with salt) 0.975, Rhizoma Drynariae (processed with vinegar) 1.450, Radix Polygoni Multiflori Praeparata 1.450, Radix Rehmanniae Praeparata 1.450, Lycium barbarum 0.975, Glossy Privet Fruit (processed with wine) 1.382, Eclipta prostrata 1.382, Rubus idaeus 1.925, Colla Corii Cervi 0.294, Colla Carapacis et Plastri Testudinis 0.294, Astragalus membranaceus (processed with honey) 0.975, Angelica sinensis 0.975, Salvia miltiorrhiza 0.975, Dioscorea opposita 0.975, Pericarpium Citri Reticulatae 0.476, Semen Ziziphi Spinosae (processed) 0.975, Glycyrrhiza uralensis (processed) 0.476.

[0043] 10 - 20 grains of the Yiqi Zhuanggu Pills are 1 g.

[0044] Preparation method of Yiqi Zhuanggu Pills, comprising the following steps: S1. Weigh stir-fried Drynaria rhizome, add water and decoct for 10 - 20 min first; weigh Cuscuta chinensis, stir-fried Ziziphus jujuba var. spinosa seeds, and dried tangerine peel, and powder them separately; S2. Weigh Epimedium brevicornum, Radix Dipsaci, Cynomorium songaricum, processed Polygonum multiflorum, roasted Licorice root, Rehmannia glutinosa, Chinese yam, Rubus idaeus, Lycium barbarum, Glossy privet fruit, Eclipta prostrata, roasted Astragalus membranaceus, Salvia miltiorrhiza, Angelica sinensis, as well as the powdered Cuscuta chinensis and stir-fried Ziziphus jujuba var. spinosa seeds, add them together to the decocted soup of Drynaria rhizome, add water and continue to decoct for 15 - 30 min; filter to obtain the filtrate, the residue can be decocted with water for 2 - 3 more times, combine the filtrates of each decoction, concentrate to obtain the concentrated medicinal liquid; S3. Weigh deer horn glue and tortoise shell glue, melt them in the combined concentrated medicinal liquid, then add the powdered dried tangerine peel, and stir evenly to obtain a mixture; S4. Take an appropriate amount of refined honey, mix it with the mixture of S3, stir evenly, make pills, and dry to obtain Yiqi Zhuanggu Pills.

[0045] The concentrated medicinal liquid is 0.2 - 0.4 times the volume of the combined filtrate.

[0046] 10 - 20 pills of Yiqi Zhuanggu Pills are 1 g.

[0047] Example 1 Yiqi Zhuanggu Pills comprise the following raw materials in parts by weight: Cuscuta chinensis 0.8, Epimedium brevicornum 0.6, Cynomorium songaricum 0.8, Radix Dipsaci 0.6, stir-fried Drynaria rhizome 1, processed Polygonum multiflorum 1, Rehmannia glutinosa 1, Lycium barbarum 0.6, Glossy privet fruit 0.8, Eclipta prostrata 1, Rubus idaeus 1.7, deer horn glue 0.2, tortoise shell glue 0.2, roasted Astragalus membranaceus 0.6, Angelica sinensis 0.6, Salvia miltiorrhiza 0.6, Chinese yam 0.6, dried tangerine peel 0.3, stir-fried Ziziphus jujuba var. spinosa seeds 0.6, roasted Licorice root 0.3.

[0048] Preparation method of Yiqi Zhuanggu Pills, comprising the following steps: S1. Weigh stir-fried Drynaria rhizome, add water and decoct for 20 min first; weigh Cuscuta chinensis, stir-fried Ziziphus jujuba var. spinosa seeds, and dried tangerine peel, and powder them separately; S2. Weigh Epimedium brevicornum, Radix Dipsaci, Cynomorium songaricum, processed Polygonum multiflorum, roasted Licorice root, Rehmannia glutinosa, Chinese yam, Rubus idaeus, Lycium barbarum, Glossy privet fruit, Eclipta prostrata, roasted Astragalus membranaceus, Salvia miltiorrhiza, Angelica sinensis, as well as the powdered Cuscuta chinensis and stir-fried Ziziphus jujuba var. spinosa seeds, add them together to the decocted soup of Drynaria rhizome, add water and continue to decoct for 20 min; filter to obtain the filtrate, the residue can be decocted with water for 3 more times, combine the filtrates of each decoction, concentrate to obtain the concentrated medicinal liquid; S3. Weigh deer horn glue and tortoise shell glue, melt them in the combined concentrated medicinal liquid, then add the powdered dried tangerine peel, and stir evenly to obtain a mixture; S4. Take an appropriate amount of refined honey, mix it with the mixture of S3, stir evenly, make pills, and dry to obtain Yiqi Zhuanggu Pills.

[0049] The concentrated medicinal liquid is 0.3 times the volume after the filtrates are combined.

[0050] 15 pills of the Yiqi Zhuanggu Pills weigh 1 g.

[0051] Example 2 The Yiqi Zhuanggu Pills comprise the following raw materials in parts by weight: Cuscuta chinensis 1, Epimedium brevicornu 0.8, Cynomorium songaricum 1, Dipsacus asperoides C. Y. Cheng et T. M. Ai 0.8, Drynaria fortunei (Kunze) J. Sm. 1.3, Polygonum multiflorum Thunb. preparata 1.2, Rehmannia glutinosa Libosch. 1.25, Lycium barbarum L. 0.8, Ligustrum lucidum W. T. Aiton var. lucidum forma ligustrina 1.1, Eclipta prostrata L. 1.1, Rubus idaeus L. 1.8, Colla Corii Cervi 0.25, Colla Carapacis et Plastri Testudinis 0.2, Astragalus membranaceus (Fisch.) Bunge var. mongholicus (Bunge) Hsiao et K. T. Hsia 0.8, Angelica sinensis (Oliv.) Diels 0.8, Salvia miltiorrhiza Bunge 0.8, Dioscorea opposita Thunb. 0.8, Citrus reticulata Blanco cv. Suavissima 0.4, Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chow 0.8, Glycyrrhiza uralensis Fisch. 0.4.

[0052] The preparation method is the same as that of Example 1.

[0053] Example 3 The Yiqi Zhuanggu Pills comprise the following raw materials in parts by weight: Cuscuta chinensis 1.156, Epimedium brevicornu 0.975, Cynomorium songaricum 1.156, Dipsacus asperoides C. Y. Cheng et T. M. Ai 0.975, Drynaria fortunei (Kunze) J. Sm. 1.450, Polygonum multiflorum Thunb. preparata 1.450, Rehmannia glutinosa Libosch. 1.450, Lycium barbarum L. 0.975, Ligustrum lucidum W. T. Aiton var. lucidum forma ligustrina 1.382, Eclipta prostrata L. 1.382, Rubus idaeus L. 1.925, Colla Corii Cervi 0.294, Colla Carapacis et Plastri Testudinis 0.294, Astragalus membranaceus (Fisch.) Bunge var. mongholicus (Bunge) Hsiao et K. T. Hsia 0.975, Angelica sinensis (Oliv.) Diels 0.975, Salvia miltiorrhiza Bunge 0.975, Dioscorea opposita Thunb. 0.975, Citrus reticulata Blanco cv. Suavissima 0.476, Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chow 0.975, Glycyrrhiza uralensis Fisch. 0.476.

[0054] The preparation method is the same as that of Example 1.

[0055] Example 4 The Yiqi Zhuanggu Pills comprise the following raw materials in parts by weight: Cuscuta chinensis 1.3, Epimedium brevicornu 1.2, Cynomorium songaricum 1.3, Dipsacus asperoides C. Y. Cheng et T. M. Ai 1.2, Drynaria fortunei (Kunze) J. Sm. 1.5, Polygonum multiflorum Thunb. preparata 1.6, Rehmannia glutinosa Libosch. 1.6, Lycium barbarum L. 1.2, Ligustrum lucidum W. T. Aiton var. lucidum forma ligustrina 1.4, Eclipta prostrata L. 1.4, Rubus idaeus L. 2.2, Colla Corii Cervi 0.35, Colla Carapacis et Plastri Testudinis 0.35, Astragalus membranaceus (Fisch.) Bunge var. mongholicus (Bunge) Hsiao et K. T. Hsia 1.2, Angelica sinensis (Oliv.) Diels 1.2, Salvia miltiorrhiza Bunge 1.2, Dioscorea opposita Thunb. 1.2, Citrus reticulata Blanco cv. Suavissima 0.6, Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chow 1.2, Glycyrrhiza uralensis Fisch. 0.6.

[0056] The preparation method is the same as that of Example 1.

[0057] Example 5 The Yiqi Zhuanggu Pills comprise the following raw materials in parts by weight: Cuscuta chinensis 2, Epimedium brevicornu 1.5, Cynomorium songaricum 1.5, Dipsacus asperoides C. Y. Cheng & T. M. Ai processed with salt 1.5, Drynaria fortunei (Kunze) J. Sm. processed by stir-frying with vinegar 2.3, Polygonum multiflorum Thunb. processed 2.3, Rehmannia glutinosa Libosch. processed 2.3, Lycium barbarum L. 1.5, Ligustrum lucidum W. T. Aiton processed with wine 2.5, Eclipta prostrata L. 2.5, Rubus idaeus L. 2.6, Colla Cornus Cervi 0.5, Colla Carapacis et Plastri Testudinis 0.5, Astragalus membranaceus (Fisch.) Bunge processed with honey 1.5, Angelica sinensis (Oliv.) Diels 1.5, Salvia miltiorrhiza Bunge 1.5, Dioscorea opposita Thunb. 1.5, Citrus reticulata Blanco 0.8, Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chow processed with honey 1.5, Glycyrrhiza glabra L. processed with honey 0.8.

[0058] The preparation method is the same as that in Example 1.

[0059] Control Example 1 The honey pills are made from the following raw materials in parts by weight: Codonopsis pilosula 0.975, Astragalus membranaceus (Fisch.) Bunge 0.975, Atractylodes macrocephala Koidz. 0.476, Angelica sinensis (Oliv.) Diels 0.975, Eucommia ulmoides Oliv. 0.975, Polygala tenuifolia Willd. 0.476, Rehmannia glutinosa Libosch. 1.450, Lycium barbarum L. 0.975, Placenta hominis 0.476, Dioscorea opposita Thunb. 0.975, Colla Cornus Cervi 0.294, Colla Plastri Testudinis 0.294.

[0060] Control Example 2 The honey pills are made from the following raw materials in parts by weight: Cuscuta chinensis 1.156, Epimedium brevicornu 0.975, Dipsacus asperoides C. Y. Cheng & T. M. Ai processed with salt 0.975, Cynomorium songaricum 1.156, Codonopsis pilosula 0.975, Astragalus membranaceus (Fisch.) Bunge 0.975, Atractylodes macrocephala Koidz. 0.476, Angelica sinensis (Oliv.) Diels 0.975, Eucommia ulmoides Oliv. 0.975, Polygala tenuifolia Willd. 0.476, Rehmannia glutinosa Libosch. 1.450, Lycium barbarum L. 0.975, Placenta hominis 0.476, Dioscorea opposita Thunb. 0.975, Colla Cornus Cervi 0.294, Colla Plastri Testudinis 0.294.

[0061] Experiment I. Product Test 1. Long-term stability test: Under the packaging conditions of clinical drugs, the above three batches of samples were placed in a stability test chamber (temperature 25°C ± 2°C, relative humidity 60% ± 5). Except for being examined once in the current month (0 month), they were examined once every 3 months and 6 months. The inspection results of each batch are shown in Tables 1 - Table 3 respectively.

[0062] 2. Accelerated stability test: Under the packaging conditions of clinical drugs, the above three batches of samples were placed in a stability test chamber. The temperature of the thermostat was adjusted so that the samples were under the conditions of 40 ± 2°C and relative humidity 75% ± 5%. Except for being examined once in the current month (0 month), they were examined once every 3 months and 6 months. The inspection results of each batch are shown in Tables 4 - Table 6 respectively.

[0063] 3. Test samples: The Yiqi Zhuanggu Pills prepared in Example 3 were selected, with batch numbers: 230405, 230406, 230407. Three samples were taken from each batch, and the average value was taken for the test results.

[0064] 4. Investigation items: Examination of appearance, disintegration time limit, moisture content, extract, and microbial limit. The detection basis for each item is as follows: Disintegration time limit: Chinese Pharmacopoeia (2020 Edition), Part IV, General Chapter 0921, Disintegration Time Limit Test Method; Moisture content: According to the Chinese Pharmacopoeia (2020 edition), Part IV, General Chapter 0832, drying method; Extractives: Chinese Pharmacopoeia (2020 Edition), Part IV, General Chapter 2201, Hot Extraction Method, using ethanol as the solvent; Total aerobic bacteria count, total mold and yeast count: Chinese Pharmacopoeia (2020 edition), Part IV, General Chapter 1105, Plate Method; Escherichia coli, Salmonella, and bile-resistant Gram-negative bacteria: Chinese Pharmacopoeia (2020 Edition), Part IV, General Chapter 1106, Control Bacteria Test Method.

[0065] Table 1. Results of Long-Term Stability Test for Batch No. 1230405

[0066] Table 2230406 Batch No. Long-term stability test results

[0067] Table 3230407 Batch No. Long-term stability test results

[0068] Table 4230405 Batch Number Accelerated Stability Test Results

[0069] Table 5230406 Batch No. Accelerated Stability Test Results

[0070] Table 6. Accelerated stability test results for batch number 6230407

[0071] 5. Results Analysis The long-term stability test and accelerated stability test of Yiqi Zhuanggu Pills were conducted for 6 consecutive months. As shown in Tables 1-6, the influence of packaging materials that come into direct contact with the drug on the stability of the drug was observed. The properties and inspection of the three batches of samples all met the requirements, indicating that the quality of this product is stable within 6 months.

[0072] II. Clinical Trials 1. Test Description Comparative Example 1: 63 patients with symptoms such as joint pain due to liver and kidney deficiency, including 36 males and 27 females, aged 18-52 years, with a mean age of (36.2 ± 12.8) years.

[0073] Comparative Example 2: 75 patients with symptoms such as joint pain due to liver and kidney deficiency, including 43 males and 32 females, aged 19-55 years, with a mean age of (37.6 ± 13.5) years.

[0074] Example 3 patient information: 114 patients with symptoms such as joint pain due to liver and kidney deficiency, including 64 males and 50 females, aged 16-60 years, with an average age of (39.2+14.5) years.

[0075] SPSS statistical software analysis showed no statistically significant differences among patients in Comparative Example 1, Comparative Example 2, and Example 3 (p>0.05).

[0076] 2. Instructions for use The pills prepared using Example 1, Comparative Example 2, and Example 3 were administered orally at a dose of 9g each time, 3 times a day, for 3 weeks. Each dose consisted of 20-21 pills weighing 1g.

[0077] 3. Effectiveness Evaluation Observe the treatment effects and incidence of adverse reactions in each group of patients, and evaluate the treatment effect: 1) Pain Scale (VAS) The visual acuity chart based on the VAS level developed by the National Institutes of Health was used, and observations were conducted at three time points: week 1, week 2, and week 3 of medication.

[0078] 0 points: Painless, the patient feels no pain at all; 1-3 points: Mild pain, relatively mild, with little impact on daily life; 4-6 points: Moderate pain, significant pain that affects daily activities and sleep; 7-10 points: Severe pain, intense pain, seriously affecting quality of life.

[0079] 2) Traditional Chinese Medicine Symptom Scoring Observations were conducted at three time points: week 1, week 2, and week 3 of medication.

[0080] 0 points: No symptoms of lower back and knee pain or numbness in the limbs; joints are flexible and flexible; no nocturia. 1-3 points: Occasionally there are symptoms of soreness and weakness in the lower back and knees, and numbness in the limbs. The joints are relatively flexible in flexion and extension. There is very little urination at night (once / night). 4-6 points: persistent soreness and weakness in the lower back and knees, numbness in the limbs without relief; difficulty in flexing and extending joints, and frequent urination at night (2 times / night). 7-10 points: Severe lower back and knee pain, numbness in the limbs, strong pain when bending and straightening joints, and frequent urination at night (≥3 times / night).

[0081] 3) Overall efficacy evaluation After the medication is finished, the number of patients who showed no effect, had an effect, or showed a significant effect will be counted.

[0082] ①Significant effect: Clinical symptoms disappear, joint function returns to normal, and movement is free; ② Effective: Clinical symptoms are relieved, function is basically restored, joint function is relatively good, but there is mild soreness or discomfort when walking for a long time or squatting and standing up; ③ Ineffective: No significant change in symptoms.

[0083] 4. Data Statistics After the medication was completed, no adverse reactions such as diarrhea, gastrointestinal bleeding, dizziness, headache, or rash occurred in any of the patients in each group. Vital signs such as body temperature, respiration, pulse, blood pressure, and heart rate remained within the normal range, confirming the safety of the medication.

[0084] The scores of patients in each group were statistically analyzed, and the mean, standard deviation, and p-value were calculated respectively. The pain scores and TCM syndrome scores of each group are shown in Tables 7 and 8.

[0085] Table 7 Comparison of VAS pain scores

[0086] Table 8 Comparison of TCM syndrome scores

[0087] As can be seen from the data in Tables 7 and 8, Example 3 showed the best therapeutic effect, with the largest difference between the treatment results before and after Comparative Example 1 and Comparative Example 2, indicating a significant difference.

[0088] The number of ineffective, effective, and significantly effective cases in each group was statistically analyzed, and the overall effective rate of each group was calculated using the following formula: Overall effectiveness rate = (effective + significantly effective) / (effective + significantly effective + ineffective) * 100% Detailed data on the effectiveness of medication in each group are shown in Table 9.

[0089] Table 9. Effectiveness of medication in each group

[0090] 5. Results Analysis The ingredients of Comparative Example 1 were: Codonopsis pilosula, Astragalus membranaceus, Atractylodes macrocephala, Angelica sinensis, Eucommia ulmoides, Polygala tenuifolia, Rehmannia glutinosa, Lycium barbarum, Placenta hominis, Dioscorea opposita, Cervi cornu colla, and Testudinis plastrum colla. When the prepared honey pills were used on patients, a large number of patients did not respond to the medication; as shown in Table 9, the ineffectiveness rate was nearly 42.86%. During follow-up, patients were observed to frequently experience symptoms such as physical weakness, fatigue, and lower back and knee pain.

[0091] Comparative Example 2 was based on the formulation of Comparative Example 1, with the addition of Cuscuta chinensis, Epimedium, Cynomorium songaricum, and Dipsacus asperoides. At the same time, because Placenta hominis was banned, it was removed.

[0092] The ingredients of Comparative Example 2 were: Cuscuta chinensis, Epimedium brevicornu, Cynomorium songaricum, Dipsacus asperoides (processed with salt), Codonopsis pilosula, Astragalus membranaceus, Atractylodes macrocephala, Angelica sinensis, Eucommia ulmoides, Polygala tenuifolia, Rehmannia glutinosa (processed), Lycium barbarum, Dioscorea opposita, deer antler glue, and tortoise shell glue. The prepared honey pills were administered to patients. As shown in Table 9, the overall effective rate increased from 57.14% in Comparative Example 1 to 77.33%, indicating a significant improvement. During follow-up, improvements were observed in the patients' physical condition and mental state; however, some patients experienced additional symptoms such as dizziness, insomnia, forgetfulness, poor blood circulation, and muscle and bone pain.

[0093] Compared with the formulation in ratio 2, Example 3 added Drynaria fortunei, processed Polygonum multiflorum, Ligustrum lucidum, Eclipta prostrata, Rubus idaeus, Astragalus membranaceus, Salvia miltiorrhiza, Ziziphus jujuba var. spinosa, Glycyrrhiza uralensis, and Citrus reticulata.

[0094] As shown in Table 9, after medication, the number of patients in Example 3 group showed a significant increase compared to 77.33% in Control Group 2, with a total effective rate of 85.96%; no adverse symptoms were observed during follow-up observation.

[0095] It should be noted that, in this document, relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitation, the phrase "comprising an element defined as..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0096] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A Qi-Boosting and Bone-Strengthening Pill, characterized in that... Including the following raw materials: The ingredients include: Cuscuta chinensis, Epimedium, Cynomorium songaricum, Salt-processed Dipsacus asper, Hot-processed Drynaria fortunei, Processed Polygonum multiflorum, Rehmannia glutinosa, Lycium barbarum, Wine-processed Ligustrum lucidum, Eclipta prostrata, Rubus idaeus, Deer antler glue, Tortoise shell glue, Processed Astragalus membranaceus, Angelica sinensis, Salvia miltiorrhiza, Dioscorea opposita, Tangerine peel, Fried Ziziphus jujuba var. spinosa, Processed Glycyrrhiza uralensis.

2. The Qi-Boosting and Bone-Strengthening Pill according to claim 1, characterized in that, Including the following parts by weight of raw materials: Cuscuta chinensis 0.8-2g, Epimedium brevicornu 0.6-1.5g, Cynomorium songaricum 0.8-1.5g, Dipsacus asper 0.6-1.5g, Drynaria fortunei 1-2.3g, Polygonum multiflorum 1-2.3g, Rehmannia glutinosa 1-2.3g, Lycium barbarum 0.6-1.5g, Ligustrum lucidum 0.8-2.5g, Eclipta prostrata 1-2.5g, Rubus idaeus 1.7-2.6g, Cervi cornu glue 0.2-0.5g, Tortoise shell glue 0.2-0.5g, Astragalus membranaceus 0.6-1.5g, Angelica sinensis 0.6-1.5g, Salvia miltiorrhiza 0.6-1.5g, Dioscorea opposita 0.6-1.5g, Citrus reticulata peel 0.3-0.8g, Ziziphus jujuba var. spinosa 0.6-1.5g, Glycyrrhiza uralensis 0.3-0.8g.

3. The Qi-Boosting and Bone-Strengthening Pill according to claim 1, characterized in that, Including the following parts by weight of raw materials: Cuscuta chinensis 1-1.3, Epimedium brevicornu 0.8-1.2, Cynomorium songaricum 1-1.3, Dipsacus asper 0.8-1.2, Drynaria fortunei 1.3-1.5, Polygonum multiflorum 1.2-1.6, Rehmannia glutinosa 1.25-1.6, Lycium barbarum 0.8-1.2, Ligustrum lucidum 1.1-1.4, Eclipta prostrata 1.1-1.4, Rubus idaeus 1.8-2.2, Cervi cornu glue 0.2-0.35, Tortoise shell glue 0.2-0.35, Astragalus membranaceus 0.8-1.2, Angelica sinensis 0.8-1.2, Salvia miltiorrhiza 0.8-1.2, Dioscorea opposita 0.8-1.2, Citrus reticulata peel 0.4-0.6, Ziziphus jujuba var. spinosa 0.8-1.2, Glycyrrhiza uralensis 0.4-0.

6.

4. The Qi-Boosting and Bone-Strengthening Pill according to claim 1, characterized in that, Including the following parts by weight of raw materials: Cuscuta chinensis 1.156g, Epimedium brevicornu 0.975g, Cynomorium songaricum 1.156g, Dipsacus asper 0.975g, Drynaria fortunei 1.450g, Polygonum multiflorum 1.450g, Rehmannia glutinosa 1.450g, Lycium barbarum 0.975g, Ligustrum lucidum 1.382g, Eclipta prostrata 1.382g, Rubus idaeus 1.925g, Cervi cornu glue 0.294g, Tortoise shell glue 0.294g, Astragalus membranaceus 0.975g, Angelica sinensis 0.975g, Salvia miltiorrhiza 0.975g, Dioscorea opposita 0.975g, Citrus reticulata peel 0.476g, Ziziphus jujuba var. spinosa 0.975g, Glycyrrhiza uralensis 0.476g.

5. The Qi-Boosting and Bone-Strengthening Pill according to claim 1, characterized in that, The Yiqi Zhuanggu Pill contains 1g for 10-20 pills.

6. A method for preparing Yiqi Zhuanggu Pills, characterized in that, Includes the following steps: S1. Weigh out the dried herb *Drynaria fortunei*, add water and decoct for 10-20 minutes; weigh out the dodder seed, stir-fried jujube seed, and dried tangerine peel, and grind them into powder separately. S2. Weigh out Epimedium, Salt-processed Dipsacus, Cynomorium, Processed Polygonum multiflorum, Processed Glycyrrhiza uralensis, Rehmannia glutinosa, Dioscorea opposita, Rubus idaeus, Lycium barbarum, Wine-processed Ligustrum lucidum, Eclipta prostrata, Processed Astragalus membranaceus, Salvia miltiorrhiza, Angelica sinensis, and crushed Cuscuta chinensis and stir-fried Ziziphus jujuba seeds. Add them to the decocted Drynaria fortunei, add water and continue to decoct for 15-30 minutes. Filter and collect the filtrate. The residue can be decocted again with water 2-3 times. Combine the filtrates from each decoction and concentrate to obtain concentrated medicinal liquid. S3. Weigh out the deer antler glue and tortoise shell glue, melt them in the combined concentrated medicine solution, then add the crushed dried tangerine peel, stir well to obtain a mixture; S4. Take an appropriate amount of refined honey, mix it with the mixture in S3, stir evenly, make into pills, dry, and obtain Yiqi Zhuanggu Pills.

7. The method for preparing Yiqi Zhuanggu Pills according to claim 6, characterized in that, The concentrated drug solution is 0.2-0.4 times the volume of the combined filtrate.

8. The method for preparing Yiqi Zhuanggu Pills according to claim 7, characterized in that, The raw materials include the following parts by weight: Cuscuta chinensis 0.8-2g, Epimedium brevicornu 0.6-1.5g, Cynomorium songaricum 0.8-1.5g, Dipsacus asper 0.6-1.5g, Drynaria fortunei 1-2.3g, Polygonum multiflorum 1-2.3g, Rehmannia glutinosa 1-2.3g, Lycium barbarum 0.6-1.5g, Ligustrum lucidum 0.8-2.5g, Eclipta prostrata 1-2.5g, Rubus idaeus 1.7-2.6g, Cervi cornu glue 0.2-0.5g, Tortoise shell glue 0.2-0.5g, Astragalus membranaceus 0.6-1.5g, Angelica sinensis 0.6-1.5g, Salvia miltiorrhiza 0.6-1.5g, Dioscorea opposita 0.6-1.5g, Citrus reticulata peel 0.3-0.8g, Ziziphus jujuba var. spinosa 0.6-1.5g, Glycyrrhiza uralensis 0.3-0.8g.

9. The method for preparing the Qi-Boosting and Bone-Strengthening Pill according to claim 8, characterized in that, The raw materials include the following parts by weight: Cuscuta chinensis 1.156g, Epimedium brevicornu 0.975g, Cynomorium songaricum 1.156g, Dipsacus asper 0.975g, Drynaria fortunei 1.450g, Polygonum multiflorum 1.450g, Rehmannia glutinosa 1.450g, Lycium barbarum 0.975g, Ligustrum lucidum 1.382g, Eclipta prostrata 1.382g, Rubus idaeus 1.925g, Cervi cornu glue 0.294g, Tortoise shell glue 0.294g, Astragalus membranaceus 0.975g, Angelica sinensis 0.975g, Salvia miltiorrhiza 0.975g, Dioscorea opposita 0.975g, Citrus reticulata peel 0.476g, Ziziphus jujuba var. spinosa 0.975g, Glycyrrhiza uralensis 0.476g.

10. The method for preparing Yiqi Zhuanggu Pills according to any one of claims 1-9, characterized in that, The Yiqi Zhuanggu Pill contains 1g for 10-20 pills.

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